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    • 1. 发明申请
    • Medicinal composition
    • 药用成分
    • US20050239861A1
    • 2005-10-27
    • US10526780
    • 2002-09-12
    • Akihiko KitajimaOsamu KamodaAkihiro OhsakoToshiharu Yanagi
    • Akihiko KitajimaOsamu KamodaAkihiro OhsakoToshiharu Yanagi
    • A61P1/14C07D207/14A61K31/40
    • A61K31/40C07D207/14G01R33/3415G01R33/3806G01R33/5611
    • The present invention relates to an ameliorant for improving the movement of the digestive tract comprising, as an active ingredient, 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-2-hydroxymethyl-4-pirrolidinyl]benzamide or an acid addition salt thereof which is a metabolite of 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide or an acid addition salt thereof, having high biding affinity for a serotonin receptor 4 (5HT4) and causing no arteritis and thrombus formation; a medicinal composition for improving the movement of the digestive tract comprising the said ameliorant and a pharmaceutically acceptable carrier; and a treating method for promoting the movement of the digestive tract, which comprises using the said medicinal composition for improving the movement of the digestive tract.
    • 本发明涉及用于改善消化道运动的改善剂,其包含作为活性成分的4-氨基-5-氯-2-甲氧基-N - [(2S,4S)-2-羟甲基-4-吡咯烷基 ]苯甲酰胺或其酸加成盐,其为4-氨基-5-氯-2-甲氧基-N - [(2S,4S)-1-乙基-2-羟甲基-4-吡咯烷基]苯甲酰胺或酸的代谢物 其加成盐对5-羟色胺受体4(5HT 4+)具有高亲和力,并且不引起动脉炎和血栓形成; 用于改善消化道运动的药物组合物,其包含所述改善剂和药学上可接受的载体; 以及用于促进消化道运动的治疗方法,其包括使用所述药物组合物来改善消化道的移动。
    • 4. 发明授权
    • Arc welding machine and method
    • 电弧焊机及方法
    • US5283419A
    • 1994-02-01
    • US890573
    • 1992-05-28
    • Seigo HagiwaraHidetoshi OoyamaAkihiko Kitajima
    • Seigo HagiwaraHidetoshi OoyamaAkihiko Kitajima
    • B23K9/09B23K9/095
    • B23K9/095B23K9/09
    • An arc welding machine includes a transformer a diode for rectification connected to the secondary winding of the transformer, two capacitors connected in series with each other and in parallel with the diode, and the first and second switching elements connected in series with each other and in parallel with the diode. This machine also includes an electrode having one end connected at a location intermediately of the two switching elements and the other end opposed to an object to be welded, first and second drive circuits connected to the first and second switching elements, respectively, an oscillating circuit for determining the width of pulses of the first and second drive circuits, and a timer circuit for inputting to the oscillating circuit signals required to make the oscillating circuit periodically repeat oscillating and stop operations. The object is connected at a location intermediately of the two capacitors. The second drive circuit outputs inverted signals of the first drive circuit. By this construction, an alternating current and a direct current alternately flow between the electrode and the object during welding.
    • 电弧焊机包括变压器,用于整流的二极管,连接到变压器的次级绕组,两个彼此串联连接并与二极管并联的电容器,以及第一和第二开关元件彼此串联连接 与二极管并联。 该机器还包括电极,其一端连接在两个开关元件的中间位置,另一端与被焊接物体相对,分别连接到第一和第二开关元件的第一和第二驱动电路,振荡电路 用于确定第一和第二驱动电路的脉冲宽度;以及定时器电路,用于向振荡电路输入使振荡电路周期性重复振荡和停止操作所需的信号。 物体连接在两个电容器的中间位置。 第二驱动电路输出第一驱动电路的反相信号。 通过这种结构,在焊接期间,交流和直流在电极和物体之间交替流动。
    • 7. 发明授权
    • Medicinal composition
    • 药用成分
    • US07485665B2
    • 2009-02-03
    • US10526780
    • 2002-09-12
    • Akihiko KitajimaOsamu KamodaAkihiro OhsakoToshiharu Yanagi
    • Akihiko KitajimaOsamu KamodaAkihiro OhsakoToshiharu Yanagi
    • A61K31/40C07D207/04
    • A61K31/40C07D207/14G01R33/3415G01R33/3806G01R33/5611
    • The present invention relates to an ameliorant for improving the movement of the digestive tract comprising, as an active ingredient, 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-2-hydroxymethyl-4-pyrrolidinyl]benzamide or an acid addition salt thereof which is a metabolite of 4-amino-5-chloro-2-methoxy-N-[(2S,4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide or an acid addition salt thereof, having high biding affinity for a serotonin receptor 4 (5HT4) and causing no arteritis and thrombus formation; a medicinal composition for improving the movement of the digestive tract comprising the said ameliorant and a pharmaceutically acceptable carrier; and a treating method for promoting the movement of the digestive tract, which comprises using the said medicinal composition for improving the movement of the digestive tract.
    • 本发明涉及一种用于改善消化道运动的改善剂,其包含作为活性成分的4-氨基-5-氯-2-甲氧基-N - [(2S,4S)-2-羟甲基-4-吡咯烷基 ]苯甲酰胺或其酸加成盐,其为4-氨基-5-氯-2-甲氧基-N - [(2S,4S)-1-乙基-2-羟甲基-4-吡咯烷基]苯甲酰胺或酸的代谢物 其加成盐对5-羟色胺受体4(5HT4)具有高亲和力,不引起动脉炎和血栓形成; 用于改善消化道运动的药物组合物,其包含所述改善剂和药学上可接受的载体; 以及用于促进消化道运动的治疗方法,其包括使用所述药物组合物来改善消化道的移动。