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1. 发明授权

US07485324B2 Use of exogenous gaseous nitric oxide in the treatment and disinfection of biofilms 有权
标题翻译：使用外源性一氧化氮在生物膜的处理和消毒中
公开(公告)号：US07485324B2
公开(公告)日：2009-02-03
申请号：US10953827
申请日：2004-09-29
申请人： Chris Miller , Abdi Ghaffari , Ali Ardakani , Bruce Murray , Doug Hole
发明人： Chris Miller , Abdi Ghaffari , Ali Ardakani , Bruce Murray , Doug Hole
IPC分类号： A61K33/00 , A01N25/00 , A01N59/00
CPC分类号： A61K33/00
摘要： The administration of gaseous nitric oxide as a biocidal moiety is proffered as a de novo treatment in the control and eradication of biofilms. The present invention relates to the use or methods of application of exogenous nitric oxide gas (gNO) as a stand alone biocidal agent or in cohort with any or all adjunct vehicles in the control of biofilms generated by microbial organisms, i.e., bacteria, protozoa, amoeba, fungi etc. Further, the present invention introduces the concept of utilization and methods of application of gaseous nitric oxide in control and eradication of biofilm forming microorganisms. Noteworthy areas of application are offered as examples. They include, and are not limited to, air and/or water heating/cooling distribution systems in facilities such as hospitals and laboratories, surfaces of medical devices, household surfaces, dental plaque, dental and/or medical water treatment lines, industrial pipelines, water treatment and distribution facilities and fluids sterilization. Various specialized delivery apparatus will be designed to facilitate nitric oxide gas administration to each specific unique application.
摘要翻译：作为杀生物部分的气态一氧化氮的施用作为在控制和根除生物膜中的从头处理提供。本发明涉及外源一氧化氮气体（gNO）作为独立杀生物剂或与任何或所有辅助载体一起应用于控制微生物生物体生物膜（即细菌，原生动物，变形虫，真菌等。此外，本发明介绍了气体一氧化氮在控制和根除生物膜形成微生物中的应用概念和应用方法。值得注意的应用领域为例。它们包括但不限于医院和实验室等设施中的空气和/或水加热/制冷分配系统，医疗器械表面，家庭表面，牙菌斑，牙科和/或医疗水处理线，工业管道，水处理和分配设施和流体灭菌。将设计各种专门的输送装置，以便于每个特定独特应用的一氧化氮气体管理。

2. 发明申请

US20060068031A1 Use of exogenous gasoues nitric oxide in the treatment and disinfection of biofilms 有权
标题翻译：使用外源性一氧化氮在生物膜的处理和消毒中
公开(公告)号：US20060068031A1
公开(公告)日：2006-03-30
申请号：US10953827
申请日：2004-09-29
申请人： Chris Miller , Abdi Ghaffari , Ali Ardakani , Bruce Murray , Doug Hole
发明人： Chris Miller , Abdi Ghaffari , Ali Ardakani , Bruce Murray , Doug Hole
IPC分类号： A61K33/00
CPC分类号： A61K33/00
摘要： The administration of gaseous nitric oxide as a biocidal moiety is proffered as a de novo treatment in the control and eradication of biofilms. The present invention relates to the use or methods of application of exogenous nitric oxide gas (gNO) as a stand alone biocidal agent or in cohort with any or all adjunct vehicles in the control of biofilms generated by microbial organisms, i.e., bacteria, protozoa, amoeba, fungi etc. Further, the present invention introduces the concept of utilization and methods of application of gaseous nitric oxide in control and eradication of biofilm forming microorganisms. Noteworthy areas of application are offered as examples. They include, and are not limited to, air and/or water heating/cooling distribution systems in facilities such as hospitals and laboratories, surfaces of medical devices, household surfaces, dental plaque, dental and/or medical water treatment lines, industrial pipelines, water treatment and distribution facilities and fluids sterilization. Various specialized delivery apparatus will be designed to facilitate nitric oxide gas administration to each specific unique application.
摘要翻译：作为杀生物部分的气态一氧化氮的施用作为在控制和根除生物膜中的从头处理提供。本发明涉及外源性一氧化氮气体（gNO）作为独立杀生物剂或与任何或所有辅助载体一起应用于控制微生物生物体生物膜（即细菌，原生动物，变形虫，真菌等。此外，本发明介绍了气体一氧化氮在控制和根除生物膜形成微生物中的应用概念和应用方法。值得注意的应用领域为例。它们包括但不限于医院和实验室等设施中的空气和/或水加热/制冷分配系统，医疗器械表面，家庭表面，牙菌斑，牙科和/或医疗水处理线，工业管道，水处理和分配设施和流体灭菌。将设计各种专门的输送装置，以便于每个特定独特应用的一氧化氮气体管理。

3. 发明申请

US20080233212A9 Use of exogenous gaseous nitric oxide in the treatment and disinfection of biofilms 有权
标题翻译：使用外源性一氧化氮在生物膜的处理和消毒中
公开(公告)号：US20080233212A9
公开(公告)日：2008-09-25
申请号：US10953827
申请日：2004-09-29
申请人： Chris Miller , Abdi Ghaffari , Ali Ardakani , Bruce Murray , Doug Hole
发明人： Chris Miller , Abdi Ghaffari , Ali Ardakani , Bruce Murray , Doug Hole
IPC分类号： A61K33/00
CPC分类号： A61K33/00
摘要： The administration of gaseous nitric oxide as a biocidal moiety is proffered as a de novo treatment in the control and eradication of biofilms. The present invention relates to the use or methods of application of exogenous nitric oxide gas (gNO) as a stand alone biocidal agent or in cohort with any or all adjunct vehicles in the control of biofilms generated by microbial organisms, i.e., bacteria, protozoa, amoeba, fungi etc. Further, the present invention introduces the concept of utilization and methods of application of gaseous nitric oxide in control and eradication of biofilm forming microorganisms. Noteworthy areas of application are offered as examples. They include, and are not limited to, air and/or water heating/cooling distribution systems in facilities such as hospitals and laboratories, surfaces of medical devices, household surfaces, dental plaque, dental and/or medical water treatment lines, industrial pipelines, water treatment and distribution facilities and fluids sterilization. Various specialized delivery apparatus will be designed to facilitate nitric oxide gas administration to each specific unique application.
摘要翻译：作为杀生物部分的气态一氧化氮的施用作为在控制和根除生物膜中的从头处理提供。本发明涉及外源一氧化氮气体（gNO）作为独立杀生物剂或与任何或所有辅助载体一起应用于控制微生物生物体生物膜（即细菌，原生动物，变形虫，真菌等。此外，本发明介绍了气体一氧化氮在控制和根除生物膜形成微生物中的应用概念和应用方法。值得注意的应用领域为例。它们包括但不限于医院和实验室等设施中的空气和/或水加热/制冷分配系统，医疗器械表面，家庭表面，牙菌斑，牙科和/或医疗水处理线，工业管道，水处理和分配设施和流体灭菌。将设计各种专门的输送装置，以便于每个特定独特应用的一氧化氮气体管理。

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