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1. 发明授权

US07182933B2 Targeting drug/gene carriers to irradiated tissue 失效
标题翻译：将药物/基因载体靶向辐照的组织
公开(公告)号：US07182933B2
公开(公告)日：2007-02-27
申请号：US09975899
申请日：2001-10-12
申请人： Douglas J. Goetz , Mohammad F. Kiani
发明人： Douglas J. Goetz , Mohammad F. Kiani
IPC分类号： A61K49/00 , A61K39/395 , A61K9/27
CPC分类号： A61K9/5153 , A61K47/6843 , A61K47/6849 , A61K2039/505 , C07K16/18 , C07K16/2821
摘要： The present invention provides a biomolecular carrier of pharmaceuticals, comprising: a biomolecule carrier bearing molecules that bind to a cellular adhesion molecule expressed on endothelial cell; and a pharmaceutical. The present invention also provides a method of treating a pathophysiological state in an individual in need of such treatment, comprising the steps of: irradiating a target tissue or organ in said individual; and administering to said individual the biomolecular carrier disclosed herein.
摘要翻译：本发明提供了一种药物的生物分子载体，其包含：携带分子的生物分子载体，其结合在内皮细胞上表达的细胞粘附分子; 和制药。本发明还提供一种治疗需要这种治疗的个体的病理生理状态的方法，包括以下步骤：照射所述个体中的靶组织或器官; 并向所述个体施用本文公开的生物分子载体。

2. 发明申请

US20060141576A1 Variants of corticotropin releasing hormone receptor type 1 and uses thereof 审中-公开
公开(公告)号：US20060141576A1
公开(公告)日：2006-06-29
申请号：US11358841
申请日：2006-02-21
申请人： Alexander Pisarchik , Andrzej Slominski
发明人： Alexander Pisarchik , Andrzej Slominski
IPC分类号： C12P21/06 , C07H21/04 , C07K14/72 , C07K16/28
CPC分类号： C07K14/72 , A61K38/00 , C07K14/723
摘要： The present invention identifies four new isoforms of human corticotropin releasing hormone receptor type 1 (CRH-R1e, 1f, 1g and 1h) and three new isoforms of mouse corticotropin releasing hormone receptor type 1 (mCRH-R1c, 1e and 1f). The data indicate that polymorphism of CRH-R1 expression is related to anatomic location, skin physiological or pathologic status, specific cell type, external stress (UV), and that cAMP dependent pathways and TPA may regulate CRH-R1.

3. 发明申请

US20030138419A1 Recombinant antibody fusion proteins and methods for detection of apoptotic cells 审中-公开
标题翻译：重组抗体融合蛋白和检测凋亡细胞的方法
公开(公告)号：US20030138419A1
公开(公告)日：2003-07-24
申请号：US10295757
申请日：2002-11-15
申请人： The University of Tennessee Research Corporation
发明人： Marko Z. Radic , Brian A. Cocca
IPC分类号： A61K039/395 , C07K016/30
CPC分类号： C07K16/28 , C07K2317/622
摘要： Recombinant antibody single chain variable fragments (scFv) useful for detecting apoptotic cells are disclosed. The antibodies selectively bind on the surface of apoptotic cells. Methods of generating and employing the antibodies are also provided. Methods of detecting modulation of apoptosis are disclosed. Methods of evaluating the efficacy of a candidate therapeutic compound adapted to effect a change in apoptosis are also disclosed. Additionally, a kit for the detection of apoptotic cells is also disclosed.
摘要翻译：公开了可用于检测凋亡细胞的重组抗体单链可变片段（scFv）。抗体选择性结合凋亡细胞的表面。还提供产生和使用抗体的方法。公开了检测凋亡调节的方法。还公开了评估适于影响凋亡变化的候选治疗化合物的功效的方法。此外，还公开了用于检测凋亡细胞的试剂盒。

4. 发明授权

US6099282A Multihole melt blown die nosepiece 失效
标题翻译：多孔熔喷头
公开(公告)号：US6099282A
公开(公告)日：2000-08-08
申请号：US295023
申请日：1999-04-20
申请人： Mancil W. Milligan
发明人： Mancil W. Milligan
IPC分类号： D01D4/02 , D01D5/098 , B28B17/00
CPC分类号： D01D5/0985 , D01D4/025
摘要： The present invention relates to a die for use in textile processes involving nonwoven melt blown fabrics. In a melt blown process, molten polymer resin is injected into a melt blown die and ejected from the die in the form of filaments. The present invention is directed to an improved die nosepiece comprising a multiplicity of adjacent holes offset with respect to each other at an angle greater than or equal to 5.degree. and less than 90.degree., through which resin filaments are ejected.
摘要翻译：本发明涉及一种用于涉及非织造熔喷织物的纺织工艺中的模具。在熔喷法中，将熔融聚合物树脂注入熔喷模具中，并以丝状从模具中排出。本发明涉及一种改进的模头装置，其包括以大于或等于5度且小于90度的角度相对于彼此偏移的多个相邻孔，树脂细丝通过该角度被弹出。

5. 发明授权

US6074818A Fingerprinting of nucleic acids, products and methods 失效
标题翻译：指纹核酸，产品和方法
公开(公告)号：US6074818A
公开(公告)日：2000-06-13
申请号：US139459
申请日：1993-10-20
申请人： Gustavo Caetano-Anolles , Brant J. Bassam , Peter M. Gresshoff
发明人： Gustavo Caetano-Anolles , Brant J. Bassam , Peter M. Gresshoff
IPC分类号： G01N33/50 , C07H21/00 , C07H21/04 , C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6853 , Y10S435/81
摘要： Improvements to nucleic acid fingerprinting are disclosed. The method generates profiles of increased fidelity characteristic of the nucleic acids analyzed. Novel primers and other means are taught. Useful products are disclosed.
摘要翻译：公开了对核酸指纹图谱的改进。该方法产生所分析的核酸的增强的保真特征的分布。教导了新型底漆和其他方法。有用的产品被公开。

6. 发明授权

US6059935A Discharge method and apparatus for generating plasmas 失效
标题翻译：用于产生等离子体的放电方法和装置
公开(公告)号：US6059935A
公开(公告)日：2000-05-09
申请号：US218572
申请日：1998-12-22
申请人： Paul D. Spence
发明人： Paul D. Spence
IPC分类号： B01J19/08 , H01J37/32
CPC分类号： H01J37/3244 , H01J37/32 , H01J37/32027 , H01J37/32082 , H01J37/3277 , H01J37/32825 , Y10S422/906
摘要： Two methods and corresponding electrode designs are provided for the generation of a plasma, for example, at or about one atmosphere. Using these methods, various webs, films and three-dimensional objects are beneficially treated in a reduced amount of time. A first method utilizes a repetitive, asymmetric voltage pulse to generate a plasma discharge between two electrodes. An asymmetric voltage pulse is used to generate a discharge in which a substrate can be exposed predominately to either positive or negative plasma species depending on the voltage polarity used. A second method uses the gap capacitance of an electrode pair and an external inductor in shunt to form a resonant LC circuit. The circuit is driven by a high power radio frequency source operating at 1 to 30 MHz to generate a uniform discharge between the electrode pair. Both methods have temperature controlled discharge surfaces with supply gas temperature, humidity and flow rate control. The gas flow is typically sufficient to cause a turbulent flow field in the discharge region where materials are treated. Electrode pairs implement these methods and include a metal faced electrode and a dielectric covered electrode, one or both of which have a series of holes extending through the electrode face for supply gas flow. The second of the above-described methods will also operate with paired, metal faced electrodes, but under more restricted operating conditions.
摘要翻译：提供两种方法和相应的电极设计用于产生等离子体，例如在一个或大约一个大气压下。使用这些方法，以减少的时间量有利地处理各种网，膜和三维物体。第一种方法利用重复的非对称电压脉冲在两个电极之间产生等离子体放电。使用非对称电压脉冲来产生放电，其中基于所使用的电压极性，衬底可以主要暴露于正或负等离子体物质。第二种方法使用分流器中的电极对和外部电感器的间隙电容来形成谐振LC电路。该电路由工作于1至30MHz的高功率射频源驱动，以在电极对之间产生均匀的放电。两种方法都具有温度控制的排放表面，供应气体温度，湿度和流量控制。气流通常足以在排出区域引起湍流流场，其中材料被处理。电极对实现这些方法，并且包括金属面电极和电介质覆盖电极，其中一个或两个具有延伸穿过电极面的一系列孔，用于供应气体流动。上述方法中的第二种也将使用成对的金属面对电极操作，但是在更受限制的操作条件下。

7. 发明授权

US5881919A Liquid injection system for sprayers 失效
标题翻译：喷雾器液体注射系统
公开(公告)号：US5881919A
公开(公告)日：1999-03-16
申请号：US959419
申请日：1997-10-28
申请人： Alvin R. Womac , Ray A. Maynard, II
发明人： Alvin R. Womac , Ray A. Maynard, II
IPC分类号： B05B7/04 , B05B7/24 , B05B9/04 , B67D5/52
CPC分类号： B05B7/24 , B05B7/0425 , B05B9/0413
摘要： The present invention is directed to a system for direct injection of chemicals or other additives in a liquid solution into a spray nozzle. The injection system of the present invention may be mounted adjacent, or in close proximity, to the spray nozzles of a sprayer. The present invention comprises a variable speed/stroke diaphragm pump capable of providing a double pumping action such that a liquid solution may be continuously pumped at a controllable rate to one or more spray nozzles of a sprayer.
摘要翻译：本发明涉及一种用于将液体溶液中的化学物质或其它添加剂直接注入喷嘴的系统。本发明的注射系统可以安装在喷雾器的喷嘴附近或附近。本发明包括可变速/行程隔膜泵，其能够提供双重泵送作用，使得液体溶液可以以可控速率连续泵送到喷雾器的一个或多个喷嘴。

8. 发明授权

US5567585A Method and kit for silver staining, developing an image and visualizing biological materials 失效
标题翻译：用于银染的方法和试剂盒，开发图像和可视化生物材料
公开(公告)号：US5567585A
公开(公告)日：1996-10-22
申请号：US258553
申请日：1994-06-09
申请人： Gustavo Caetano-Anolles , Brant J. Bassam , Peter M. Gresshoff
发明人： Gustavo Caetano-Anolles , Brant J. Bassam , Peter M. Gresshoff
IPC分类号： C12Q1/68 , G01N27/447 , G01N27/26
CPC分类号： G01N27/44726 , C12Q1/6816
摘要： A silver staining method is provided for staining an organic molecule capable of binding silver. An improved image is developed and visualized. A kit useful in practicing the method is described. A permanent record of the image of the profile of the stained molecules is obtained.
摘要翻译：提供银染色方法来染色能够结合银的有机分子。改进的图像被开发和可视化。描述了在实践该方法中有用的试剂盒。获得染色分子轮廓图像的永久记录。

9. 发明授权

US5456972A Method and apparatus for glow discharge plasma treatment of polymer materials at atmospheric pressure 失效
标题翻译：聚合物材料在大气压下辉光放电等离子体处理的方法和装置
公开(公告)号：US5456972A
公开(公告)日：1995-10-10
申请号：US68739
申请日：1993-05-28
申请人： John R. Roth , Peter P. Tsai
发明人： John R. Roth , Peter P. Tsai
IPC分类号： B29C59/14 , B64C23/00 , D04H1/56 , H01J37/32 , H05B7/16 , D03D3/00
CPC分类号： H01J37/32174 , B29C59/14 , B64C23/005 , D04H1/56 , H01J37/32082 , H01J37/3277 , H05B7/16 , A61N1/44 , B29C2059/145 , B29K2023/12 , H01J2237/336 , Y10S428/903 , Y10T442/3976 , Y10T442/68
摘要： Polymer materials such as film and fabrics, woven, non-woven and meltblown, may be non-destructively surface treated to improve water wettability by exposure to a glow discharge plasma sustained at substantially atmospheric pressure in a modified gas atmosphere comprising helium or argon.
摘要翻译：无纺布和熔喷的聚合物材料如织物，织物和熔喷可被非破坏性地表面处理以通过在包括氦或氩的改性气体气氛中暴露于维持大气压的辉光放电等离子体来提高水的润湿性。

10. 发明授权

US5427335A Method for producing extreme microgravity in extended volumes 失效
标题翻译：扩展体积产生极微重力的方法
公开(公告)号：US5427335A
公开(公告)日：1995-06-27
申请号：US912903
申请日：1992-07-13
申请人： Alvin J. Sanders , William E. Deeds , Mark E. Rupright
发明人： Alvin J. Sanders , William E. Deeds , Mark E. Rupright
IPC分类号： B64G1/10 , B64G1/24 , B64G1/28 , B64G1/34 , B64G1/46 , B64G1/66 , C30B30/08
CPC分类号： C30B30/08 , B64G1/105 , B64G1/24 , B64G1/28 , B64G1/34 , B64G1/46 , B64G1/66
摘要： An apparatus and method for use thereof in the creating of a nanogravity environment substantially throughout a working volume sufficient for performing a desired operation and existing for a length of time sufficient for performing the desired operation are disclosed. Involved in the creation of the nanogravity environment are the use of an apparatus in which the mass density of the walls are distributed (either directly or by the attachment of compensating masses) so that the surface density of the mass is directly proportional to the electric charge density along the walls which would be sufficient to neutralize the interior electric field, the orbiting of the apparatus around a planetary mass, and the minimization of disruptive accelerations on the apparatus by the selective transfer of the momentum of solar photons to the apparatus.
摘要翻译：本发明公开了一种用于创建纳米重力环境的装置和方法，该环境基本上在整个工作容积中足以执行所需操作并存在足以执行所需操作的时间长度。涉及纳米重力环境的创造是使用这样的装置，其中壁的质量密度分布（直接地或通过补偿质量的附着），使得质量的表面密度与电荷成正比沿着壁的密度足以中和内部电场，围绕行星体的轨道运动，并且通过选择性地将太阳光子的动量转移到设备来最小化装置上的破坏加速度。

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