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1. 发明公开

US20240005597A1 MODELLING AN ENVIRONMENT USING IMAGE DATA 审中-公开
公开(公告)号：US20240005597A1
公开(公告)日：2024-01-04
申请号：US18469392
申请日：2023-09-18
申请人： Imperial College Innovations Limited
发明人： Edgar SUCAR , Shikun LIU , Joseph ORTIZ , Andrew DAVISON
IPC分类号： G06T17/00 , G06T7/11 , G06T7/50 , G06T7/70 , G06V10/75
CPC分类号： G06T17/00 , G06T7/11 , G06T7/50 , G06T7/70 , G06V10/751 , G06T2207/20084
摘要： A method comprising obtaining image data captured by a camera device. The image data represents an observation of an environment. A two-dimensional representation of at least part of the environment is obtained using a model of the environment. The method includes evaluating a difference between the two-dimensional representation and at least part of the observation. The at least part of the observation is of the at least part of the environment represented by the two-dimensional representation. Based on the difference, a portion of the image data is selected for optimising the model. The portion of the image data represents a portion of the observation of the environment. The method comprises optimising the model using the portion of the image data.

2. 发明公开

US20240005173A1 Verifying Neural Networks 审中-公开
公开(公告)号：US20240005173A1
公开(公告)日：2024-01-04
申请号：US18039997
申请日：2021-12-02
申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED
发明人： Alessio LOMUSCIO , Patrick HENRIKSEN , Panagiotis KOUVAROS
IPC分类号： G06N3/10 , G06N3/048
CPC分类号： G06N3/10 , G06N3/048
摘要： Systems and methods are provided for verifying the transformational robustness of a neural network. Data is obtained representing a trained neural network, a set of algebraic constraints on the output of the network, and a range of inputs to the neural network over which the algebraic constraints are to be verified, such that the data defines a transformational robustness verification problem. A set of complementary constrains on the pre-activation of a node in the network are then determined such that for any input in the range of inputs, at least one of the complementary constraints is satisfied. A plurality of child verification problems are generated based on the transformational robustness verification problem and the set of complementary constraints. For each child verification problem, it is determined whether a counter-example to the child verification problem exists. Based on the determination of whether counter-examples to the child verification problems exist, it is determined whether the neural network is transformationally robust.

3. 发明公开

US20230389901A1 SAMPLING CATHETER 审中-公开
公开(公告)号：US20230389901A1
公开(公告)日：2023-12-07
申请号：US18206206
申请日：2023-06-06
申请人： Hunt Developments (UK) Limited , Imperial College Innovations Limited
发明人： Duncan Hunt , Toby Hunt , Trevor Hunt , Trevor T. Hansel
IPC分类号： A61B10/00
CPC分类号： A61B10/0045
摘要： The invention relates to a catheter for obtaining a sample of mucosal lining fluid from a precise airway or gastrointestinal location in a patient. The catheter comprises a sampling tube and a sampling head, which is in fluid connection with the sampling tube and which has a permeable material in an interior cavity. The sampling head is closed by an exterior wall in which there are a plurality of small apertures such that fluid enters the catheter when the interior pressure is reduced. The catheter can deploy directly through the mouth or nose or via an instrument such as an endoscope, laryngoscope or tracheal tube.

4. 发明授权

US11820792B2 Cancer treatment 有权
公开(公告)号：US11820792B2
公开(公告)日：2023-11-21
申请号：US16607653
申请日：2018-04-24
申请人： Imperial College Innovations Limited
发明人： Amin Hajitou , Keittisak Suwan , Mariam Albahrani , Sajee Waramit
IPC分类号： A61K48/00 , A61K35/76 , A61K38/20 , C12N7/01 , C12N15/11 , C12N15/19 , C12N15/86 , C07K14/525 , C07K14/54 , C12N7/00 , A61K38/00 , A61K33/243
CPC分类号： C07K14/525 , C07K14/5406 , C07K14/5434 , C12N7/00 , C12N15/111 , C12N15/86 , A61K33/243 , A61K38/00 , C07K2319/02 , C12N2750/14143 , C12N2750/14152 , C12N2750/14171 , C12N2800/202 , C12N2800/24 , C12N2800/50 , C12N2810/405 , C12N2820/60
摘要： The present invention provides phagemid vectors and associated phagemid particles for cancer treatment, and in particular, to the use of novel phagemid particles and associated expression systems for the treatment, prevention, amelioration, or management of cancer. In particular, the invention relates to the use of phagemid particles and expression systems for the delivery of transgenes encoding cytokines, for the treatment, prevention, amelioration, or management of cancer. The invention also extends to the use of phagemid particles and expression systems for the delivery of transgenes, and for the combination of such treatment with the use of adoptively transferred T cells, for the treatment, prevention, amelioration, or management of cancer.

5. 发明公开

US20230277192A1 ACTUATOR HANDLE FOR SURGICAL TOOLS 审中-公开
公开(公告)号：US20230277192A1
公开(公告)日：2023-09-07
申请号：US18016774
申请日：2021-07-19
申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED
发明人： Timothy CONSTANDINOU , Jinendra EKANAYAKE , Matthew L. CAVUTO
IPC分类号： A61B17/128 , A61B17/122
CPC分类号： A61B17/1285 , A61B17/1227 , A61B2017/00367
摘要： An actuator handle for a hand-held surgical tool, the actuator handle comprising: a body part adapted to be gripped by a user's hand, the body part having an end effector mounted or mountable thereon; an actuating member alongside the body part and arranged to be operably moveable by a single finger of the said hand, in a substantially linear manner between first and second positions relative to the body part, for actuating the end effector in use; and one or more coupling components coupled to the actuating member, for mechanically transmitting motive force from the actuating member to the end effector upon movement of the actuating member between the first and second positions by the user in use. A surgical clip, for example for use in aneurysm clipping, is also provided, the clip comprising: first and second clipping arms that are mutually openable and closable; biasing means arranged to resiliently bias the first and second clipping arms into a closed configuration; and first and second engagement fixtures respectively coupled to the first and second clipping arms and arranged such that first and second gripping arms of a complementary surgical clip deployment tool can grip the clip and open the clipping arms by applying a lateral force to the first and second engagement fixtures; wherein each of the first and second engagement fixtures comprises at least part of a ball or at least part of a loop or cup, with which each of the arms of said surgical clip deployment tool can engage in a substantially ball-and-socket manner.

6. 发明公开

US20230241761A1 A JOINT LOCKING MECHANISM 审中-公开
公开(公告)号：US20230241761A1
公开(公告)日：2023-08-03
申请号：US18007207
申请日：2021-07-13
申请人： Imperial College Innovations Limited
发明人： Shen Treratanakulchai , Guang-Zhong Yang
IPC分类号： B25J3/04 , A61B34/35 , B25J13/02
CPC分类号： B25J3/04 , A61B34/35 , B25J13/02 , A61B2034/301
摘要： A joint locking mechanism comprising: a locking gear rotatable about a rotation axis; a locking latch removably engageable with the locking gear and movable relative to the rotation axis between first and second latch positions; and a bias couplable to the locking latch such that the locking latch is biased towards the first latch position, wherein in the first latch position the locking latch is engaged with the locking gear such that the locking gear is locked in position relative to the rotation axis and in the second latch position the locking latch is spaced apart from the locking gear such that the locking gear is rotatable about the rotation axis.

7. 发明公开

US20230227807A1 METHOD FOR IDENTIFYING RNA BINDING PROTEIN BINDING SITES ON RNA 审中-公开
公开(公告)号：US20230227807A1
公开(公告)日：2023-07-20
申请号：US17997787
申请日：2021-05-07
申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED
发明人： Christopher Sibley
IPC分类号： C12N15/10 , C12Q1/6806 , C12Q1/6876 , C12Q1/6869
CPC分类号： C12N15/1006 , C12N15/1096 , C12Q1/6806 , C12Q1/6876 , C12Q1/6869 , C12Q2600/16
摘要： The invention relates to methods for purifying and isolating at least one RNA molecule which interacts with an RNA-binding protein (RBP). The invention also provides nucleic acid adaptors and primers for use in such methods.

8. 发明授权

US11702470B2 Use of CXCL13 binding molecules to promote peripheral nerve regeneration 有权
公开(公告)号：US11702470B2
公开(公告)日：2023-07-18
申请号：US17341546
申请日：2021-06-08
申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED
发明人： Simone Di Giovanni , Luming Zhou
IPC分类号： C07K16/24 , A61P25/28 , A61K39/00
CPC分类号： C07K16/24 , A61P25/28 , A61K2039/505 , C07K2317/565 , C07K2317/76
摘要： Provided herein are methods for promoting axonal regeneration of sensory neurons and functional recovery of neurons following peripheral nerve injury in a subject experiencing aging-dependent nerve regenerative decline, the method comprising administering to a subject in need thereof an effective amount of an isolated binding molecule which specifically binds to CXCL13.

9. 发明公开

US20230149658A1 CONTROL METHOD FOR MEDICAL VENTILATORS 审中-公开
公开(公告)号：US20230149658A1
公开(公告)日：2023-05-18
申请号：US17917413
申请日：2021-04-08
申请人： Imperial College Innovations Limited
发明人： Joseph van Batenburg-Sherwood , Jakob Mathiszig-Lee , Michael Madekurozwa
IPC分类号： A61M16/20 , A61M16/00
CPC分类号： A61M16/205 , A61M16/024 , A61M2016/0042 , A61M2230/46
摘要： A method of controlling exhalation in a ventilation system for providing Positive Expiratory End Pressure, PEEP, ventilation to a lung is disclosed, the method comprising: determining a lung resistance based on conditions of the system detected during an exhalation; and causing the system to inhibit system exhalation to cause and maintain a target system pressure based on the determined lung resistance and a pressure condition in the system.

10. 发明申请

US20230068371A1 CANCER 有权
公开(公告)号：US20230068371A1
公开(公告)日：2023-03-02
申请号：US17793374
申请日：2021-01-18
申请人： Imperial College Innovations Limited
发明人： George Hanna
IPC分类号： G01N33/574 , G01N33/497
摘要： The invention relates to biomarkers, and to novel biological markers for diagnosing cancer. In particular, the invention relates to the use of these compounds as diagnostic and prognostic markers in assays for detecting cancer, such as oesophagogastric cancer, and corresponding methods of detection. The invention also relates to methods of determining the efficacy of treating these diseases with a therapeutic agent. The assays are qualitative and/or quantitative, and are adaptable to large-scale screening and clinical trials.

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