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1. 发明公开

US20240093196A1 MODIFICATIONS OF MAMMALIAN CELLS USING ARTIFICIAL MICRO-RNA TO ALTER THEIR PROPERTIES AND THE COMPOSITIONS OF THEIR PRODUCTS 审中-公开
公开(公告)号：US20240093196A1
公开(公告)日：2024-03-21
申请号：US18522923
申请日：2023-11-29
申请人： DNA TWOPOINTO INC.
发明人： Jeremy MINSHULL , Maggie LEE
IPC分类号： C12N15/113 , C12N9/12 , C12N15/86 , C12N15/90
CPC分类号： C12N15/113 , C12N9/1241 , C12N9/1247 , C12N15/1137 , C12N15/86 , C12N15/90 , C12N2310/141 , C12N2310/3519 , C12N2310/51 , C12N2310/531 , C12N2800/90 , C12Y207/07006 , C12Y603/01002
摘要： The present invention provides methods and compositions for stable genetic modification of cultured mammalian cells. The genetic modifications can be used to produce cultured mammalian cells for therapeutic or diagnostic purposes.

2. 发明授权

US11845936B2 Modifications of mammalian cells using artificial micro-RNA to alter their properties and the compositions of their products 有权
公开(公告)号：US11845936B2
公开(公告)日：2023-12-19
申请号：US17519546
申请日：2021-11-04
申请人： DNA TWOPOINTO INC.
发明人： Jeremy Minshull , Maggie Lee
IPC分类号： C12N15/113 , C12N9/12 , C12N15/90 , C12N15/86
CPC分类号： C12N15/113 , C12N9/1241 , C12N9/1247 , C12N15/1137 , C12N15/86 , C12N15/90 , C12N2310/141 , C12N2310/3519 , C12N2310/51 , C12N2310/531 , C12N2800/90 , C12Y207/07006 , C12Y603/01002
摘要： The present invention provides methods and compositions for stable genetic modification of cultured mammalian cells. The genetic modifications can be used to produce cultured mammalian cells for therapeutic or diagnostic purposes.

3. 发明授权

US11713468B2 DNA vectors and elements for sustained gene expression in eukaryotic cells 有权
公开(公告)号：US11713468B2
公开(公告)日：2023-08-01
申请号：US16635886
申请日：2018-08-02
申请人： DNA TWOPOINTO INC.
发明人： Jeremy Minshull , Maggie Lee
IPC分类号： C07H21/04 , C12N15/00 , C12N15/63 , C12N15/86 , A01K67/00
CPC分类号： C12N15/86 , C12N2750/14143 , C12N2820/60 , C12N2830/15 , C12N2830/48 , C12N2830/50
摘要： The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel elements that further improve expression. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.

4. 发明申请

US20200318107A1 TRANSPOSITION OF NUCLEIC ACIDS INTO EUKARYOTIC GENOMES WITH A TRANSPOSASE FROM HELIOTHIS 审中-公开
公开(公告)号：US20200318107A1
公开(公告)日：2020-10-08
申请号：US16842707
申请日：2020-04-07
申请人： DNA TWOPOINTO INC.
发明人： Jeremy Minshull , Sridhar Govindarajan , Maggie Lee
IPC分类号： C12N15/11 , C12N5/071 , C12N9/12
摘要： The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.

5. 发明申请

US20110059860A1 SYSTEMS AND METHODS FOR BIOPOLYMER ENGINEERING 审中-公开
标题翻译：生物聚合物工程系统与方法
公开(公告)号：US20110059860A1
公开(公告)日：2011-03-10
申请号：US12238227
申请日：2008-09-25
申请人： Claes Gustafsson , Sridhar Govindarajan , Jeremy Minshull
发明人： Claes Gustafsson , Sridhar Govindarajan , Jeremy Minshull
IPC分类号： C40B30/00 , C40B30/06 , C40B30/08 , G06F19/00 , G06G7/58
CPC分类号： G16B20/00
摘要： Methods, computer systems, and computer program products for biopolymer engineering. A variant set for a biopolymer of interest is constructed by identifying, using a plurality of rules, a plurality of positions in the biopolymer of interest and, for each respective position in the plurality of positions, substitutions for the respective position. The plurality of positions and the substitutions for each respective position in the plurality of positions collectively define a biopolymer sequence space. A variant set comprising a plurality of variants of the biopolymer of interest is selected. A property of all or a portion of the variants in the variant set is measured. A sequence-activity relationship is modeled between (i) one or more substitutions at one or more positions of the biopolymer of interest represented by the variant set and (ii) the property measured for all or the portion of the variants in the variant set. The variant set is redefined to comprise variants that include substitutions in the plurality of positions that are selected based on a function of the sequence-activity relationship.
摘要翻译：方法，计算机系统和生物聚合物工程的计算机程序产品。通过使用多个规则来识别感兴趣的生物聚合物中的多个位置，并且对于多个位置中的每个相应位置，通过识别相应位置的替代来构建用于感兴趣的生物聚合物的变体。多个位置中的各个位置的多个位置和替换共同限定生物聚合物序列空间。选择包含感兴趣的生物聚合物的多个变体的变体组。测量变体集中全部或部分变体的属性。在（i）由变体组表示的感兴趣的生物聚合物的一个或多个位置处的一个或多个取代和（ii）针对变体组中的全部或部分变体测量的特性的序列活性关系进行建模。变体集被重新定义为包括在基于序列活动关系的函数选择的多个位置中的替换的变体。

6. 发明授权

US07805252B2 Systems and methods for designing and ordering polynucleotides 有权
标题翻译：用于设计和排序多核苷酸的系统和方法
公开(公告)号：US07805252B2
公开(公告)日：2010-09-28
申请号：US11207151
申请日：2005-08-16
申请人： Claes Gustafsson , Sridhar Govindarajan , Jon E. Ness , Alan Marco Villalobos , Jeremy Minshull
发明人： Claes Gustafsson , Sridhar Govindarajan , Jon E. Ness , Alan Marco Villalobos , Jeremy Minshull
IPC分类号： G06F7/00
CPC分类号： G06F19/26 , G06F19/18 , G06F19/20
摘要： Computer systems, computer program products and methods for designing oligonucleotides are provided. A set of sequence elements is defined. Each sequence element represents an amino acid sequence segment or a nucleic acid sequence segment. The set of sequence elements collectively represent a design nucleic acid sequence. The set of sequence elements are displayed as a plurality icons in a linear or a near linear arrangement such that each respective icon in the plurality of icons uniquely represents a corresponding sequence element in the set of sequence elements. In this representation, neighboring icons in the plurality of icons represent neighboring sequence elements in the set of sequence elements. Each respective icon in the plurality of icons depicts a directional property for the corresponding sequence element in the set of sequence elements. An oligonucleotide selection module is used to identify oligonucleotides in the design nucleic acid sequence.
摘要翻译：提供计算机系统，计算机程序产品和设计寡核苷酸的方法。定义了一组序列元素。每个序列元件代表氨基酸序列片段或核酸序列片段。序列元件的集合统称为设计核酸序列。序列元素的集合被显示为线性或近似线性布置的多个图标，使得多个图标中的每个相应图标唯一地表示序列元素集合中的相应序列元素。在该表示中，多个图标中的相邻图标表示该组序列元素中的相邻序列元素。多个图标中的每个相应的图标描绘了序列元素集合中相应的序列元素的方向属性。寡核苷酸选择模块用于鉴定设计核酸序列中的寡核苷酸。

7. 发明申请

US20100100331A1 SYSTEMS AND METHODS FOR BIOPOLYMER ENGINEERING 有权
标题翻译：生物聚合物工程系统与方法
公开(公告)号：US20100100331A1
公开(公告)日：2010-04-22
申请号：US12238216
申请日：2008-09-25
申请人： Claes Gustafsson , Sridhar Govindarajan , Jeremy Stephen Minshull
发明人： Claes Gustafsson , Sridhar Govindarajan , Jeremy Stephen Minshull
IPC分类号： G06F19/00 , G06G7/48 , G06G7/58
CPC分类号： G06F19/18
摘要： Methods, computer systems, and computer program products for biopolymer engineering. A variant set for a biopolymer of interest is constructed by identifying, using a plurality of rules, a plurality of positions in the biopolymer of interest and, for each respective position in the plurality of positions, substitutions for the respective position. The plurality of positions and the substitutions for each respective position in the plurality of positions collectively define a biopolymer sequence space. A variant set comprising a plurality of variants of the biopolymer of interest is selected. A property of all or a portion of the variants in the variant set is measured. A sequence-activity relationship is modeled between (i) one or more substitutions at one or more positions of the biopolymer of interest represented by the variant set and (ii) the property measured for all or the portion of the variants in the variant set. The variant set is redefined to comprise variants that include substitutions in the plurality of positions that are selected based on a function of the sequence-activity relationship.
摘要翻译：方法，计算机系统和生物聚合物工程的计算机程序产品。通过使用多个规则来识别感兴趣的生物聚合物中的多个位置，并且对于多个位置中的每个相应位置，通过识别相应位置的替代来构建用于感兴趣的生物聚合物的变体。多个位置中的各个位置的多个位置和替换共同限定生物聚合物序列空间。选择包含感兴趣的生物聚合物的多个变体的变体组。测量变体集中全部或部分变体的属性。在（i）由变体组表示的感兴趣的生物聚合物的一个或多个位置处的一个或多个取代和（ii）针对变体组中的全部或部分变体测量的特性的序列活性关系进行建模。变体集被重新定义为包括在基于序列活动关系的函数选择的多个位置中的替换的变体。

8. 发明申请

US20060136184A1 Systems and methods for antibody engineering 有权
标题翻译：抗体工程的系统和方法
公开(公告)号：US20060136184A1
公开(公告)日：2006-06-22
申请号：US10566953
申请日：2004-07-30
申请人： Claes Gustafsson , Sridhar Govindarajan , Jeremy Minshull
发明人： Claes Gustafsson , Sridhar Govindarajan , Jeremy Minshull
IPC分类号： G06G7/48 , G06G7/58
CPC分类号： G06F19/18
摘要： Methods, computer systems, and computer program products for biopolymer engineering. A variant set for a biopolymer of interest is constructed by identifying, using a plurality of rules, a plurality of positions in the biopolymer of interest and, for each respective position in the plurality of positions, substitutions for the respective position. The plurality of positions and the substitutions for each respective position in the plurality of positions collectively define a biopolymer sequence space. A variant set comprising a plurality of variants of the biopolymer of interest is selected. A property of all or a position of the variants in the variant set is measured. A sequence-activity relationship is modeled between (i) one or more substitutions at one or more positions of the biopolymer of interest represented by the variant set and (ii) the property measured for all or the portion of the variants in the variant set. The variant set is redefined to comprise variants that include substitutions in the plurality of positions that are selected based on a function of the sequence-activity relationship.
摘要翻译：方法，计算机系统和生物聚合物工程的计算机程序产品。通过使用多个规则来识别感兴趣的生物聚合物中的多个位置，并且对于多个位置中的每个相应位置，通过识别相应位置的替代来构建用于感兴趣的生物聚合物的变体。多个位置中的各个位置的多个位置和替换共同限定生物聚合物序列空间。选择包含感兴趣的生物聚合物的多个变体的变体组。测量变体集中变体的全部或位置的属性。在（i）由变体组表示的感兴趣生物聚合物的一个或多个位置处的一个或多个取代和（ii）针对变体组中的全部或部分变体测量的性质之间建立序列活性关系。变体集被重新定义为包括在基于序列活动关系的函数选择的多个位置中的替换的变体。

9. 发明授权

US12054702B2 DNA vectors, transposons and transposases for eukaryotic genome modification 有权
公开(公告)号：US12054702B2
公开(公告)日：2024-08-06
申请号：US17150878
申请日：2021-01-15
申请人： DNA TWOPOINTO INC.
发明人： Jeremy Minshull , Mark Welch , Sridhar Govindrajan , Maggie Lee , Kate Caves , Jon Ness
IPC分类号： C12N9/00 , A61K8/66 , A61K47/42 , C07K14/435 , C12N1/16 , C12N1/18 , C12N9/12 , C12N15/10 , C12N15/52 , C12N15/62 , C12N15/63 , C12N15/81 , C12N15/85 , C12N15/90 , C12N15/67 , C12R1/84 , C12R1/865
CPC分类号： C12N1/165 , C12N1/185 , C12N9/12 , C12N9/1241 , C12N15/1082 , C12N15/52 , C12N15/625 , C12N15/63 , C12N15/81 , C12N15/815 , C12N15/85 , C12N15/8509 , C12N15/90 , C12Y207/00 , C12Y207/07 , C07K2319/09 , C12N15/67 , C12N2800/90 , C12N2830/007 , C12N2830/40 , C12N2830/42 , C12N2840/203 , C12R2001/84 , C12R2001/865
摘要： The present invention provides polynucleotide vectors for high expression of heterologous genes. Some vectors further comprise novel transposons and transposases that further improve expression. Further disclosed are vectors that can be used in a gene transfer system for stably introducing nucleic acids into the DNA of a cell. The gene transfer systems can be used in methods, for example, gene expression, bioprocessing, gene therapy, insertional mutagenesis, or gene discovery.

10. 发明申请

US20220307056A1 TETRACYCLINE-INDUCIBLE EXPRESSION SYSTEMS 有权
公开(公告)号：US20220307056A1
公开(公告)日：2022-09-29
申请号：US17700405
申请日：2022-03-21
申请人： DNA TWOPOINTO INC.
发明人： Jeremy Minshull
IPC分类号： C12N15/86 , C12N5/071 , C12N15/85 , A01K67/027
摘要： The invention provides inducible promoter systems and their components incorporating components of a tetracycline operon. By coordinating expression of different transcriptional units in these systems as a result of selection of promoters and/or linking the units into the same DNA molecule, these systems can achieve higher levels of expression of coding segments of interest, increased differential levels of expression between on- and off-states, and/or greater responsiveness to inducing agents than conventional systems.

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