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    • 8. 发明公开
    • 유전자 전달 효율이 향상된 신규의 합성 펩타이드 및 이를 이용한 유전자 전달방법
    • 提高基因交付效率的新型合成肽和使用它们递送基因的方法
    • KR1020120115850A
    • 2012-10-19
    • KR1020110033419
    • 2011-04-11
    • 압타바이오 주식회사
    • 이수진강현구도경오
    • C07K14/155A61K47/42A61K9/127A61K48/00
    • C07K14/005A61K47/6455A61K48/00C07K7/08C07K2319/09C12N15/87
    • PURPOSE: A novel synthetic peptide in which gene transfer efficiency is improved and a gene transfer method using the same are provided to enhance gene delivery ability to cells or inside the organs, thereby being used for a gene transfer. CONSTITUTION: A novel synthetic peptide in which gene transfer efficiency is improved includes comprises the amino acid sequence of the sequence number 1(SEQ ID NO:1) or 2 originated from Tat or NLS (nuclear localization sequence) of HIV(human immunodeficiency virus). The gene transmission peptide is represented by chemical formula 1 or chemical formula 2 (Ya-Xb-Cys-Cys-Xc-Yd). In the chemical formula 1 and 2, X indicates amino acid sequence of the sequence number 1 and Y indicates the amino acid sequence of the sequence number 2. The gene transfer peptide is expressed as the amino acid sequence selected from the sequence number 3-10. In the gene transfer complex, genes to be transferred to the peptide are combined. The gene is DNA or RNA. The composite additionally includes cation liposome.
    • 目的:提供基因转移效率提高的新型合成肽,并提供使用其的基因转移方法,以增强细胞或器官内部的基因传递能力,从而用于基因转移。 构成:改进基因转移效率的新型合成肽包括来源于HIV(人类免疫缺陷病毒)的Tat或NLS(核定位序列)的序列号1(SEQ ID NO:1)或2的氨基酸序列, 。 基因传递肽由化学式1或化学式2(Ya-Xb-Cys-Cys-Xc-Yd)表示。 在化学式1和2中,X表示序列号1的氨基酸序列,Y表示序列号2的氨基酸序列。基因转移肽以选自序列号3-10的氨基酸序列表示 。 在基因转移复合物中,将要转移到肽的基因合并。 该基因是DNA或RNA。 该复合物还包括阳离子脂质体。