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    • 1. 发明公开
    • 당 사슬 조성 분석 방법
    • Suger链组成分析方法
    • KR1020150044053A
    • 2015-04-24
    • KR1020130122424
    • 2013-10-15
    • 한국표준과학연구원
    • 정지선임정혁김숙경박상열
    • C12Q1/54C12Q1/00G01N33/15G01N30/00
    • G01N30/96G01N30/64G01N2030/009
    • 본발명은당 사슬(sugar chain)의조성을분석하는방법에관한것으로, 구체적으로당 사슬을포함하는시료를음이온교환크로마토그래피(high-performance anion-exchange chromatography: HPAEC)를이용하여이동상이칼럼을통과하는중에이동상저장소에불활성기체주입하면서단당류및 시알산을분리하고, 칼럼후시액(post-column reagent, PCR)을첨가하여검출간섭피크를억제하여분리된시료를펄스식전기화학검출기(pulsed amperometric detector: PAD)로검출하여분석한결과, 본발명의사슬조성의분석하기위한 HPAEC 분석을위한장치는높은선택성, 높은감도및 우수한분석재현성으로단당류및 시알산의동시분석이가능할뿐 아니라, 시간을절약하고간편하도록하므로, 상기분석장치는시료내 당사슬의단당류및 시알산의동시분석에유용하게사용될수 있다.
    • 本发明涉及糖链组成的分析方法,更具体地说,涉及一种包括以下步骤的方法:通过使用高效阴离子交换层析(HPAEC)在含有糖链的试剂中分离单糖和唾液酸,同时 当流动相通过柱时,将惰性气体注入流动相储存器中; 通过添加柱后试剂(PCR)抑制检测干扰峰; 并用脉冲电流检测器(PAD)检测分析分离的试剂。 用于链组成分析的HPAEC装置具有高选择性的性质和灵敏度以及优异的分析重现性,能够同时分析单糖和唾液酸,并且方便地节省时间。 因此,该装置可以有效地用于同时分析试剂中的糖链和唾液酸。
    • 3. 发明公开
    • 유전 감지 방법 및 시스템
    • 电介质感测方法与系统
    • KR1020090033166A
    • 2009-04-01
    • KR1020087024056
    • 2007-03-16
    • 디라니, 알-아민수가누마, 요시노리
    • 디라니,알-아민수가누마,요시노리
    • G01N27/22G01N27/447G01N30/64
    • G01N30/64G01N27/3278G01N2030/645
    • Sensing device and method for detecting presence and concentration of generic target analytes of interest The device and method are based on detecting changes in effective dielectric induced by the target analytes of interest Applications of the invention include, but are not restricted to, detecting and characterizing the presence of chemical and biological target analytes of interest as well as detecting and characterizing target analytes of interest from a separation apparatus. In one embodiment of the invention, the device comprises at least two electrodes in a rigid architecture such as a solid surface, where the electrodes have sizes and Inter-electrode spacings that are on the order of sizes of target analytes of interest to improve sensitivity of the device Changes in effective dielectric and, therefore, capacitance induced by a presence of the target analytes of interest are measured electronically The changes are used to detect the presence of the target analytes of interest and to characterize their presence.
    • 用于检测感兴趣的通用目标分析物的存在和浓度的感测装置和方法装置和方法基于检测由目标分析物感兴趣的有效介电介质的变化。本发明的应用包括但不限于检测和表征 存在感兴趣的化学和生物目标分析物,以及从分离设备检测和表征感兴趣的目标分析物。 在本发明的一个实施例中,该装置包括至少两个刚性结构中的电极,例如固体表面,其中电极具有尺寸和电极间距,其大小等于感兴趣的目标分析物的尺寸,以提高敏感度 该装置电子测量有效电介质的变化,因此感兴趣的目标分析物的存在引起的电容。这些变化用于检测感兴趣的目标分析物的存在并表征其存在。