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    • 2. 发明公开
    • 이온성 액체 EMI-BF₄의 정제방법
    • 用于离子液体的净化方法EMI-BF_4
    • KR1020140013802A
    • 2014-02-05
    • KR1020120082351
    • 2012-07-27
    • 캡솔루션 주식회사
    • 이영환전경수양경철김형찬정경식이광제
    • C07F5/02C07D233/12B01D3/14
    • C07D233/12B01D3/14
    • The present invention relates to a purifying method for high purity ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate (EMI-BF4) comprising: a step of preparing synthesized EMI-BF4 (1-ethyl-3-methylimidazolium tetrafluoroborate); a step of removing precipitates existing in the synthesized EMI-BF4 by passing the synthesized EMI-BF4 through a glass filter; a step of performing primary vacuum distillation on the EMI-BF4 in which precipitates are removed; a step of mixing a distilled water mixture and the EMI-BF4 in a predetermined ratio and extracting ionic liquids with a liquid/liquid continuous extraction process by an extraction solvent; a step of drying the extracted ionic liquid by removing moisture; and a step of performing secondary vacuum distillation on the dried EMI-BF4. [Reference numerals] (AA) Filtration; (BB) Vacuum distillation (100mmHg ↓ 24hr, 10mmHg ↓ 24hr); (CC) Mixing with a distilled water in a predetermined ratio; (DD) Extracting for 48 hours by an extraction solvent (dichloromethane); (EE) Drying (MgSO_4 anhydrous) vacuum distillation (100mmHg ↓ 24hr, 1mmHg ↓ 48hr); (FF) High purity ionic liquid (Purified 1-ethyl-3-methylimidazolium tetrafluoroborate)
    • 本发明涉及一种高纯度离子液体1-乙基-3-甲基咪唑鎓四氟硼酸盐(EMI-BF4)的净化方法,包括:制备合成的EMI-BF4(1-乙基-3-甲基咪唑鎓四氟硼酸盐)的步骤; 通过将合成的EMI-BF 4通过玻璃过滤器去除合成的EMI-BF4中存在的沉淀物的步骤; 在去除了析出物的EMI-BF4上进行一次真空蒸馏的步骤; 以预定比例混合蒸馏水混合物和EMI-BF4并通过萃取溶剂用液/液连续萃取方法提取离子液体的步骤; 通过去除水分干燥所提取的离子液体的步骤; 以及在干燥的EMI-BF 4上进行二次真空蒸馏的步骤。 (标号)(AA)过滤; (BB)真空蒸馏(100mmHg↓24hr,10mmHg↓24hr); (CC)以预定比例与蒸馏水混合; (DD)通过萃取溶剂(二氯甲烷)萃取48小时; (EE)干燥(无水MgSO 4)减压蒸馏(100mmHg↓24hr,1mmHg↓48hr); (FF)高纯度离子液体(纯化的1-乙基-3-甲基咪唑鎓四氟硼酸盐)
    • 4. 发明公开
    • 4-이미다졸린 및 항우울제로서 이의 용도
    • 4-咪唑啉及其作为抗生素的用途
    • KR1020100029145A
    • 2010-03-15
    • KR1020107002417
    • 2008-06-24
    • 에프. 호프만-라 로슈 아게
    • 갈레이구이도그로에브케쯔빈덴카트린노르크로스로저스탈더헨리
    • C07D233/24C07D233/12A61K31/4174A61P25/24
    • C07D233/06C07D233/12C07D233/22C07D233/24
    • The present invention relates to compounds of formula (I) wherein Ris hydrogen, halogen or lower alkyl; Ris hydrogen or amino; X-Y is-(CH)-, N(R)-CH-,-O-CH-or-S-CH-; Ar is phenyl or naphthyl; n is 1 or 2; R is hydrogen or lower alkyl; and to their pharmaceutically active salts, with the exclusion of the racemic compound 4-benzyl-4,5-dihydro-lH-imidazole or its tautomer (CAS 131548-83-9). It has been found that the compounds of formula (I) have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The compounds may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
    • 本发明涉及式(I)的化合物,其中R 1为氢,卤素或低级烷基; Ris是氢或氨基; X-Y是 - (CH) - ,N(R)-CH - , - O-CH-或-S-CH-; Ar是苯基或萘基; n为1或2; R是氢或低级烷基; 和其药物活性盐,排除外消旋化合物4-苄基-4,5-二氢-1H-咪唑或其互变异构体(CAS 131548-83-9)。 已经发现式(I)化合物对微量胺相关受体(TAAR)具有良好的亲和力,特别是对于TAAR1。 这些化合物可用于治疗抑郁症,焦虑障碍,双相情感障碍,注意力缺陷多动障碍(ADHD),应激相关疾病,精神病性精神障碍如精神分裂症,神经系统疾病如帕金森病,神经变性疾病如阿尔茨海默病, 癫痫,偏头痛,高血压,药物滥用和代谢障碍如进食障碍,糖尿病,糖尿病并发症,肥胖症,血脂异常,能量消耗和同化障碍,体温平衡紊乱和失调,睡眠和昼夜节律紊乱以及心血管疾病 。