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    • 3. 发明公开
    • 자초 추출물을 유효성분으로 함유하는 급성 췌장염의 전이로 인한 폐의 침투성 염증을 예방 또는 개선하기 위한 조성물
    • 包含用于治疗或预防急性胰腺炎的LITHOSPERMI RADIX提取物的药物
    • KR1020150047173A
    • 2015-05-04
    • KR1020130126897
    • 2013-10-24
    • 원광대학교산학협력단
    • 최선복박성주배기상조일주송호준
    • A61K36/30A61P1/18
    • A61K36/30A23L33/105A23V2002/00A23V2200/324
    • 본발명은자초추출물을유효성분으로함유하는급성췌장염의예방, 개선또는치료하기위한조성물에관한것으로, 구체적으로는췌장조직및 샘꽈리세포에서의급성췌장염발병을저해하는효능을보유하는것을특징으로하는급성췌장염의예방, 개선또는치료를위한조성물에관한것이다. 본발명에따른조성물은췌장조직에서의부종및 염증, 췌장조직에서의혈청아밀라제, 리파제및 트립신의활성, 췌장조직에서의전염증성사이토카인및 전염증성사이토카인 mRNA의발현과, 췌장조직에서의 MPO 침윤을저해시키는효능및 췌장중량/체중의비율(P.W/B.W)을감소시키는효능을보유하고있다. 또한, 본발명에따른조성물은샘꽈리세포에서의전염증성사이토카인및 전염증성사이토카인 mRNA의발현과, 샘꽈리세포에서의 MAPKs 통로의활성, 샘꽈리세포에서의 HMGB1 단백질의발현을저해시키는효능및, 샘꽈리세포에서의세포독성이없으며, 추가적으로폐 조직의부종및 염증정도와, 폐조직의 MPO 침윤을저해시키는효능을보유하고있다.
    • 本发明涉及一种用于预防,缓解或治疗包含紫草提取物作为活性成分的急性胰腺炎的组合物,更具体地说,涉及一种抑制胰腺组织中急性胰腺炎的产生和用于预防, 缓解或治疗急性胰腺炎。 根据本发明,该组合物具有抑制胰腺组织中的水肿和炎症,胰腺组织中血清淀粉酶,脂肪酶和胰蛋白酶活化,促炎细胞因子,胰腺组织中促炎细胞因子mRNA表达和胰腺组织中MPO渗透的作用 ,并减少胰腺重量与体重的比例(PW / BW)。 此外,根据本发明,组合物对腺泡细胞中抑制促炎细胞因子,促炎细胞因子mRNA的表达,腺泡细胞中MAPKs途径的激活以及HMGB1在腺泡细胞中的表达具有抑制作用,无毒性 腺泡细胞,并且抑制肺组织中的水肿,炎症水平和MPO渗透。
    • 4. 发明公开
    • 지치 추출물을 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물
    • 用于预防或治疗包含硅藻土硫酸盐提取物的癌症的药物组合物
    • KR1020140098057A
    • 2014-08-07
    • KR1020147009396
    • 2012-08-10
    • 부산대학교 산학협력단
    • 최영환박세진시타라만라자세커박순영박다정김윤한
    • A61K36/30A61P35/00
    • A61K36/30A61K31/352
    • The present invention relates to a pharmaceutical composition including a Lithospermum erythrorhizon extract as an active ingredient for preventing or treating cancer. More specifically, the present invention relates to a pharmaceutical composition containing a Lithospermum erythrorhizon extract, a hexane extract of Lithospermum erythrorhizon, or a shikonin-based compound as an active ingredient for preventing or treating cancer. The Lithospermum erythrorhizon extract and the shikonin-based compound isolated from the extract according to the present invention have effects in controlling the proliferation of cancer cells including colon carcinoma, melanoma, gastric cancer, liver cancer, sarcomatosis, and breast cancer, controlling cell cycles, and promoting the expression of cell death factors so as to have excellent anti-cancer activities compared to existing anti-cancer agents. Naturally derived components therein do not have side effects and are in vivo stable. Accordingly, the Lithospermum erythrorhizon hexane extract and the shikonin-based compound isolated from the extract can be practically used in producing an anti-cancer agent for preventing and treating several kinds of cancer.
    • 本发明涉及一种药物组合物,其包含紫草素红景天提取物作为预防或治疗癌症的有效成分。 更具体地说,本发明涉及含有紫草红精提取物,赤霉素的己烷提取物或紫草素类化合物作为预防或治疗癌症的活性成分的药物组合物。 从本发明提取物中分离出的紫草素提取物和紫草素类化合物具有控制癌细胞增殖的作用,包括结肠癌,黑素瘤,胃癌,肝癌,肉瘤瘤和乳腺癌,控制细胞周期, 促进细胞死亡因子的表达,与现有的抗癌药相比具有优异的抗癌活性。 其中天然衍生的成分不具有副作用并且在体内稳定。 因此,从提取物中分离出的紫草红己烷提取物和紫草素类化合物可以实际应用于制备预防和治疗多种癌症的抗癌剂。
    • 9. 发明公开
    • 초임계 추출법을 이용한 자초 추출물을 유효성분으로함유하는 피부노화방지용 및 피부주름개선용 화장료 조성물
    • 化妆品组合物,用于皮肤衰老保护和皱纹改善,包括使用超临界流体萃取物作为活性成分提取石蕊烯硫醚
    • KR1020090070455A
    • 2009-07-01
    • KR1020070138471
    • 2007-12-27
    • 주식회사 코리아나화장품
    • 서유미김지현이정노김성래이건국
    • A61K8/97A61Q19/08
    • A61K8/97A61K36/30A61K2236/37A61Q19/08Y10S514/844
    • A cosmetic composition containing a supercritical Lithospermum erythrorhizon extract is provided to have the effects of antioxidation, MMP-1(matrix metallo protein 1) synthesis inhibition, collagen synthesis enhancement, antiaging and antiwrinkle. A cosmetic composition for antiaging and antiwrinkle comprises 0.001-30.0 weight% of supercritical Lithospermum erythrorhizon extract as an active ingredient. The supercritical Lithospermum erythrorhizon extract is isolated by supercritical extraction using carbon dioxide at 35-100°C and the pressure of 100-500. A mixture fluid mixing with co-solvent is additionally used. The co-solvent is chloroform, ethanol, methanol, water, ethylacetate, butylacetate, hexane or diethylether. The composition is used in a form of solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, powder type foundation, emulsion type foundation, wax type foundation or spray.
    • 提供含有超临界紫草红提取物的化妆品组合物,具有抗氧化,MMP-1(基质金属蛋白1)合成抑制,胶原合成增强,抗衰老和抗皱纹的作用。 用于抗衰老和抗皱的化妆品组合物包含0.001-30.0重量%的超临界紫草提取物作为活性成分。 超临界紫苏提取物通过超临界萃取法分离,使用二氧化碳在35-100℃,压力为100-500。 另外使用与共溶剂混合的混合流体。 共溶剂为氯仿,乙醇,甲醇,水,乙酸乙酯,乙酸丁酯,己烷或乙醚。 该组合物以溶液,悬浮液,乳液,糊剂,凝胶,霜剂,洗剂,粉末,肥皂,含表面活性剂的清洁剂,粉末型粉底,乳液型粉底,蜡型粉底或喷雾剂的形式使用。