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1. 发明公开

KR1020120023500A 벨벳애플 추출물을 유효성분으로 함유하는 염증성 질환, 알레르기 질환 또는 천식의 예방 및 치료용 약학적 조성물 有权
标题翻译：用于预防和治疗炎症性疾病的药物组合物，包含双酚A的提取物的过敏性疾病或哮喘A.DC。作为活跃成分
公开(公告)号：KR1020120023500A
公开(公告)日：2012-03-13
申请号：KR1020110018950
申请日：2011-03-03
申请人： 한국생명공학연구원
发明人： 안경섭 , 권옥경 , 오세량 , 김정희 , 이형규 , 박지원 , 장하영 , 정혁 , 이미영 , 손화영 , 이경열
IPC分类号： A61K36/44 , A61P29/00 , A61P37/08
CPC分类号： A61K36/44
摘要： PURPOSE: A pharmaceutical composition containing Diospyros discolor extract for preventing and treating inflammatory and allergic diseases or asthma is provided to suppress iNOS and COX-2 expression. CONSTITUTION: A pharmaceutical composition for preventing and treating inflammatory or allergic diseases or asthma contains Diospyros discolor extract as an active ingredient. The extract is isolated using water, low alcohol of C1-C2, or a mixture thereof. An external use formulation for preventing and treating inflammatory or allergic diseases or asthma contains the Diospyros discolor extract as an active ingredient. A method for preparing or treating inflammatory or allergic diseases comprises a step of administering pharmaceutically active amount of the Diospyros discolor extract to an individual.
摘要翻译：目的：提供含有用于预防和治疗炎性和过敏性疾病或哮喘的Diospyros变色提取物的药物组合物，以抑制iNOS和COX-2的表达。构成：用于预防和治疗炎性或过敏性疾病或哮喘的药物组合物含有作为活性成分的柿子色素提取物。使用水，C1-C2的低级醇或其混合物分离提取物。用于预防和治疗炎性或过敏性疾病或哮喘的外用制剂含有作为活性成分的柿子色素提取物。一种制备或治疗炎性或过敏性疾病的方法包括向个体施用药物活性量的二孢子虫色素提取物的步骤。

2. 发明公开

KR1020120094258A 데카스퍼뮴 프루티코숨 추출물을 함유하는 염증성 질환 또는 천식의 예방 및 치료용 약학적 조성물 有权
标题翻译：包含用于预防或治疗炎症和哮喘的十二指肠溃疡提取物的药物组合物
公开(公告)号：KR1020120094258A
公开(公告)日：2012-08-24
申请号：KR1020110013640
申请日：2011-02-16
申请人： 한국생명공학연구원
发明人： 오세량 , 안경섭 , 권옥경 , 이형규 , 이중구 , 정혁 , 이미영 , 손화영 , 이경열
IPC分类号： A61K36/61 , A61P11/06 , A61P29/00
CPC分类号： A61K36/61
摘要： PURPOSE: A pharmaceutical composition for prevention and treatment of inflammation disease containing decaspermum fruticosum extracts or asthma are provided to prevent increase of eosinocyte of bronchoalveolar lavage fluid and secretion of eotaxin and immunoglobulin of the bronchoalveolar lavage fluid and blood. CONSTITUTION: A pharmaceutical composition for prevention and treatment of inflammation disease contains decaspermum fruticosum extracts as an active ingredient. The extract is extracted using water, alcohol or a mixture thereof as a solvent. The alcohol is C1-C2 low grade alcohol. The low grade alcohol is ethanol or methanol. A manufacturing method of the decaspermum fruticosum extracts comprises the following steps: adding an extracting solvent to the decaspermum fruticosum in order to extract; filtering the extracts; vacuum concentrating the filtered extracts; and freeze-drying the condensed products. A pharmaceutical composition for prevention and treatment of asthma contains the decaspermum fruticosum extracts as an active ingredient. A health supplement for prevention and treatment of inflammation disease contains decaspermum fruticosum extracts as an active ingredient. A health supplement for prevention and treatment of asthma contains the decaspermum fruticosum extracts as an active ingredient.
摘要翻译：目的：提供一种预防和治疗含有十六指肠溃疡提取物或哮喘的炎症疾病的药物组合物，以防止支气管肺泡灌洗液的嗜酸性粒细胞增多和支气管肺泡灌洗液和血液中嗜酸性粒细胞趋化因子和免疫球蛋白的分泌。构成：用于预防和治疗炎症疾病的药物组合物含有十字花精萃取物作为活性成分。使用水，醇或其混合物作为溶剂提取提取物。酒精是C1-C2低级酒精。低级酒精是乙醇或甲醇。赤藓糖提取物的制备方法包括以下步骤：将提取溶剂加入到十字花精油中以提取; 过滤提取物; 真空浓缩过滤的提取物; 并冷冻干燥冷凝产品。用于预防和治疗哮喘的药物组合物含有作为活性成分的十字花精油提取物。用于预防和治疗炎症疾病的健康补充剂含有十字花精油提取物作为活性成分。用于预防和治疗哮喘的健康补充剂包含十字花精油提取物作为活性成分。

3. 发明授权

KR101389383B1 벨벳애플 추출물을 유효성분으로 함유하는 염증성 질환, 알레르기 질환 또는 천식의 예방 및 치료용 약학적 조성물 有权
标题翻译：用于预防和治疗炎性疾病，过敏性疾病或哮喘的药物组合物，其包含Diospyros blancoi A.DC的提取物。作为活性成分
公开(公告)号：KR101389383B1
公开(公告)日：2014-04-25
申请号：KR1020110018950
申请日：2011-03-03
申请人： 한국생명공학연구원
发明人： 안경섭 , 권옥경 , 오세량 , 김정희 , 이형규 , 박지원 , 장하영 , 정혁 , 이미영 , 손화영 , 이경열
IPC分类号： A61K36/44 , A61P29/00 , A61P37/08
CPC分类号： A61K36/44
摘要： 본 발명은 벨벳애플(
Diospyros

blancoi A. DC.) 추출물을 유효성분으로 함유하는 염증성 질환, 알레르기 질환 또는 천식의 예방 및 치료를 위한 약학적 조성물에 관한 것으로, 더욱 구체적으로는 벨벳애플 추출물은 염증 유발에 의해 급격히 증가한 NO 및 PGE
2 의 생성을 억제하고, 이는 NF-kB의 핵으로 전이를 저해함으로써 iNOS 및 COX-2 발현을 억제하며, TNF-α와 IL-1β 및 IL-4와 IL-13의 양을 현저하게 감소시키는 효과를 가지며 또한, 마우스 대식세포 난백알부민(ovalbumin)-유도 천식 동물모델에서 기관지 폐포세척액의 호산구의 증가를 억제하고, 페포세척액 및 혈액의 면역글로불린의 분비와 케모카인의 분비를 억제하는 활성을 가지므로 염증성 질환, 알레르기 질환 또는 천식의 예방 및 치료용 조성물의 유효성분으로 유용하게 사용될 수 있다.

4. 发明授权

KR101188211B1 데카스퍼뮴 프루티코숨 추출물을 함유하는 염증성 질환 또는 천식의 예방 및 치료용 약학적 조성물 有权
标题翻译：一种药物组合物，其包含用于预防或治疗炎症和哮喘的十字花Decispermum fruticosum的提取物
公开(公告)号：KR101188211B1
公开(公告)日：2012-10-08
申请号：KR1020110013640
申请日：2011-02-16
申请人： 한국생명공학연구원
发明人： 오세량 , 안경섭 , 권옥경 , 이형규 , 이중구 , 정혁 , 이미영 , 손화영 , 이경열
IPC分类号： A61K36/61 , A61P11/06 , A61P29/00
CPC分类号： A61K36/61
摘要： The present invention relates to a pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma comprising the extract of Decaspermum fruticosum as an active ingredient. The extract of Decaspermum fruticosum of the present invention inhibited the increase of eosinophils in bronchoalveolar lavage fluid of the ovalbumin-induced asthma animal model, had the activity of inhibiting the secretions of immunoglobulin and chemokine (Eotaxin) in bronchoalveolar lavage fluid and blood, and inhibited the secretions of NO and TNF-alpha in macrophages. Therefore, the extract of Decaspermum fruticosum of the present invention can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma, and of a health functional food for the prevention and improvement of inflammatory disease or asthma.

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