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    • 2. 发明公开
    • MIC-1 유전자의 억제제를 함유하는 위암 치료제, 위암진단방법 및 진단킷트
    • 含有MIC-1基因抑制剂的胃癌的治疗剂,诊断STOMC癌和诊断试剂盒的方法
    • KR1020040079266A
    • 2004-09-14
    • KR1020030014352
    • 2003-03-07
    • 한국생명공학연구원
    • 최인표양영이정형김근영신선미윤석란
    • A61K39/395
    • A61K48/00A61K39/39558C12Q1/6837C12Q1/6886G01N33/57446G01N33/58G01N33/6893
    • PURPOSE: An agent for treatment of stomach cancer containing an inhibitor of an MIC-1 gene involved in the invasion and metastasis of cancer cells is provided. The diagnosis of stomach cancer is achieved by measuring the activity of the MIC-1 gene or its protein. A diagnostic kit containing the gene complementary to the MIC-1 gene is used for the diagnosis of stomach cancer. CONSTITUTION: The agent for treatment of stomach cancer contains an inhibitor of an MIC-1 gene selected from a material inhibiting the transcription of the MIC-1 gene, a material inhibiting the translation of transcribed MIC-1 mRNA and a material inhibiting the function of an MIC-1 protein. The inhibitor inhibits the metastasis of stomach cancer. A diagnostic kit for the diagnosis of stomach cancer containing the gene sequence complementary to the MIC-1 gene comprises: micro chips containing complementary genes for the MIC-1 gene; a vessel receiving a primer which binds with MIC-1 mRNA; buffer and amplification enzyme for PCR amplification; and nucleotides.
    • 目的:提供一种治疗包含参与癌细胞侵袭转移的MIC-1基因的抑制剂的胃癌的药剂。 通过测量MIC-1基因或其蛋白质的活性来实现胃癌的诊断。 含有与MIC-1基因互补的基因的诊断试剂盒用于诊断胃癌。 构成:胃癌治疗剂含有选自抑制MIC-1基因的转录的材料的MIC-1基因的抑制剂,抑制转录的MIC-1 mRNA的翻译的材料和抑制转录的功能的材料 MIC-1蛋白。 该抑制剂抑制胃癌的转移。 用于诊断含有与MIC-1基因互补的基因序列的胃癌的诊断试剂盒包括:含有MIC-1基因互补基因的微型切片; 接受与MIC-1mRNA结合的引物的容器; 用于PCR扩增的缓冲液和扩增酶; 和核苷酸。