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    • 1. 发明公开
    • 공역 리놀레인산 유도체 및 그의 합성방법
    • 共轭亚油酸(CLA)的衍生物及其制备方法
    • KR1020000022882A
    • 2000-04-25
    • KR1019990037151
    • 1999-09-02
    • 하영래김정옥
    • 하영래김정옥박구부김석종박숙자김정곤
    • C11C3/00
    • C11C3/025C11C1/08C11C3/06
    • PURPOSE: The derivatives of conjugated linoleic acid(CLA) and a manufacturing method thereof are provided, which can be easily added to food or oil and fat, and enhance a function of linoleic acid. CONSTITUTION: A conjugated linoleic acid(CLA) is produced by alkaline isomerization of linoleum acid. And the derivatives of CLA which improve the functions of CLA, are produced by adding a functional group to carboxy terminus of CLA. To generate the neutral lipid derivatives of CLA, triglyceride added to CLA is synthesized, or some fatty acid included in neutral lipids, such as cottonseed oil, corn oil, fish oil or lard is substituted for CLA by transesterification using a chemical method or an enzymatic method. Triglyceride derivative of CLA can be generated by chemical, enzymatic or biological method. Glycolipid derivatives of CLA can be generated in the form of ascorbic acid derivative, D-glucose derivative, and cyclodextrin micro capsule. Phospholipid derivatives of CLA are phospholipid of which fatty acid is substituted for CLA.
    • 目的:提供共轭亚油酸(CLA)的衍生物及其制造方法,其可以容易地添加到食品或油脂中,并增强亚油酸的功能。 构成:通过亚油酸的碱性异构化生产共轭亚油酸(CLA)。 并且通过向CLA的羧基末端加入官能团来制备改善CLA功能的CLA的衍生物。 为了产生CLA的中性脂质衍生物,合成添加到CLA中的甘油三酯,或者通过使用化学方法或酶的酯交换取代包括在中性脂质中的一些脂肪酸,例如棉籽油,玉米油,鱼油或猪油 方法。 CLA的甘油三酸酯衍生物可以通过化学,酶学或生物学方法产生。 CLA的糖脂衍生物可以以抗坏血酸衍生物,D-葡萄糖衍生物和环糊精微胶囊的形式产生。 CLA的磷脂衍生物是脂肪酸代替CLA的磷脂。
    • 7. 发明公开
    • 공역 리놀레인산 유도체 및 그의 합성방법
    • 联合亚油酸衍生物及其制备方法
    • KR1020020022743A
    • 2002-03-27
    • KR1020020008540
    • 2002-02-18
    • 하영래김정옥
    • 하영래김정옥박구부김석종박숙자김정곤
    • C11C3/00
    • C11C3/04
    • PURPOSE: A phospholipid derivative of conjugated linoleic acid and its preparation method are provided, to improve the compatibility of conjugated linoleic acid with food by modifying the terminal carboxyl group with phospholipid, thereby improving the solubility and reducing the toxicity due to the carboxyl group. CONSTITUTION: The conjugated linoleic acid derivative is such that some part of the fatty acid bonded to phospholipid is substituted with conjugated linoleic acid. The method comprises the steps of mixing 5 parts by weight of conjugated linoleic acid-methyl ester and 5 parts by weight of lecithin and stirring the mixture at a room temperature for 1-3 hours; adding sodium methoxide or lipozyme to the mixture at 60 deg.C and stirring the mixture; and washing the mixture with hot water to remove the sodium salt of conjugated linoleic acid and separating the product by distillation.
    • 目的:提供共轭亚油酸的磷脂衍生物及其制备方法,通过用磷脂改性末端羧基,提高共轭亚油酸与食品的相溶性,提高溶解性,降低由于羧基引起的毒性。 构成:共轭亚油酸衍生物使得与磷脂结合的部分脂肪酸被共轭亚油酸取代。 该方法包括将5重量份共轭亚油酸甲酯与5重量份卵磷脂混合并在室温下搅拌1-3小时的步骤; 在60℃下向混合物中加入甲醇钠或脂酶,并搅拌该混合物; 并用热水洗涤该混合物以除去共轭亚油酸的钠盐,并通过蒸馏分离产物。
    • 8. 发明公开
    • 공역 리놀레인산 유도체 및 그의 합성방법
    • 共轭亚油酸的衍生物及其合成方法
    • KR1020020019509A
    • 2002-03-12
    • KR1020020008539
    • 2002-02-18
    • 하영래김정옥
    • 하영래김정옥박구부김석종박숙자김정곤
    • C11C3/00
    • C11C3/04
    • PURPOSE: Provided are derivatives of conjugated linoleic acid(CLA), such as triglyceride derivatives, ascorbic acid derivatives, D-glucose derivatives, cyclodextrin microcapsules, phospholipid derivatives, which have higher functionality and can be used for food additives. CONSTITUTION: The cyclodextrin microcapsules of CLA are synthesized by a process comprising the steps of: dissolving 1.4pts.wt. of the CLA in 40pts.wt. of ethanol and adding 10-40pts.wt. of distilled water and 1-4pts.wt. of cyclodextrin and stirring and reacting at 60-80deg.C for 1-10 minutes; cooling the resultant till the temperature of 4-20deg.C for 0.5-5 hours and then removing the solvent by a vacuum refrigeration drying or a spray drying.
    • 目的:提供具有更高官能度并可用于食品添加剂的共轭亚油酸(CLA)衍生物,如甘油三酯衍生物,抗坏血酸衍生物,D-葡萄糖衍生物,环糊精微胶囊,磷脂衍生物。 构成:CLA的环糊精微胶囊通过包括以下步骤的方法合成:溶解1.4pts.wt。 的CLA在40pts.wt。 的乙醇并加入10-40pts.wt。 的蒸馏水和1-4pts.wt。 的环糊精并搅拌并在60-80℃下反应1-10分钟; 将所得物冷却至4-20℃的温度0.5-5小时,然后通过真空冷冻干燥或喷雾干燥除去溶剂。
    • 10. 发明公开
    • 공역 리놀레인산 유도체 및 그의 합성방법
    • 联合亚油酸衍生物及其制备方法
    • KR1020020022742A
    • 2002-03-27
    • KR1020020008536
    • 2002-02-18
    • 하영래김정옥
    • 하영래김정옥박구부김석종박숙자김정곤
    • C11C3/00
    • C11C3/00C11C3/04
    • PURPOSE: A neutral fat derivative of conjugated linoleic acid and its preparation method are provided, to improve the compatibility of conjugated linoleic acid with food by modifying the terminal carboxyl group, thereby improving the solubility and reducing the toxicity due to the carboxyl group. CONSTITUTION: The conjugated linoleic acid derivative is such that some part of the fatty acid bonded to animal or vegetable fats is substituted with conjugated linoleic acid. The method comprises the steps of mixing conjugated linoleic acid-methyl ester and animal or vegetable fats in the ratio of 2:1 to 6:1 by weight, adding sodium methoxide (1-2 times mol based on the amount of fats) to the solution, and reacting the mixture at 90 deg.C for 1-10 hours under the reduced pressure; and washing the mixture with water, removing water and separating the product by silica gel column chromatography. Also the method comprises the steps of mixing conjugated methyl linoleate and animal or vegetable fats in the ratio of 1:1 to 6:1 by weight, adding lipozyme (10 wt% based on the amount of fats) and an organic solvent (200 wt% based on the total amount) to the solution, and reacting the mixture at 40-70 deg.C for 24 hours; and extracting fats with hexane and separating the product.
    • 目的:提供共轭亚油酸的中性脂肪衍生物及其制备方法,通过改性末端羧基提高共轭亚油酸与食品的相容性,从而提高溶解性,降低由于羧基引起的毒性。 构成:共轭亚油酸衍生物使得与动植物脂肪结合的部分脂肪酸被共轭亚油酸取代。 该方法包括将共轭亚油酸 - 甲酯与动物或植物脂肪按重量比为2:1至6:1混合的步骤,将甲醇钠(基于脂肪的1-2倍摩尔)加入到 溶液,并在90℃下将混合物在减压下反应1-10小时; 并用水洗涤混合物,除去水并通过硅胶柱色谱分离产物。 此外,该方法包括以1:1至6:1的比例混合轭合的亚油酸亚油酸酯和动物或植物脂肪的步骤,加入脂酶(基于脂肪的10重量%)和有机溶剂(200重量% 基于总量的%),并将混合物在40-70℃下反应24小时; 并用己烷萃取脂肪并分离产物。