专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

KR1020100079285A 크로토닉산 유도체의 제조방법 无效
标题翻译：一种制备CROTONIC酸衍生物的方法
公开(公告)号：KR1020100079285A
公开(公告)日：2010-07-08
申请号：KR1020080137714
申请日：2008-12-31
申请人： 코오롱생명과학 주식회사
发明人： 장원태 , 최윤환
IPC分类号： C07C229/30
摘要： PURPOSE: A producing method of a crotonic acid derivative is provided to reduce the content of an impurity, and to mass produce the crotonic acid derivative. CONSTITUTION: A producing method of a crotonic acid derivative comprises the following: forming a compound marked with chemical formula 7 by reacting a compound marked with chemical formula 6 under the presences of a base; and forming the crotonic acid derivative marked with chemical formula 1 by performing a hydrolysis with the compound marked with the chemical formula 7. In the chemical formulas, R2 is an alkyl group with the carbon number of 1~8. R is either an alkyl group with the carbon number of 1~5, or a phenyl group.
摘要翻译：目的：提供巴豆酸衍生物的制造方法以降低杂质含量，大量生产巴豆酸衍生物。构成：巴豆酸衍生物的制造方法包括以下步骤：通过在碱存在下使化学式6标记的化合物反应形成化学式7的化合物; 通过用化学式7标记的化合物进行水解，形成由化学式1表示的巴豆酸衍生物。在化学式中，R 2为碳数为1〜8的烷基。 R是碳数为1〜5的烷基或苯基。

2. 发明公开

KR1020120016053A 알킬아민 유도체의 제조방법 无效
标题翻译：制备烷基胺衍生物的方法
公开(公告)号：KR1020120016053A
公开(公告)日：2012-02-22
申请号：KR1020117024403
申请日：2010-05-14
申请人： 코오롱생명과학 주식회사
发明人： 최윤환 , 장원태
IPC分类号： C07C227/18 , C07C229/30 , C07C227/42
CPC分类号： C07C227/08 , C07C227/18 , C07C227/42 , C07C229/30
摘要： PURPOSE: A manufacturing method of alkylamine derivatives is provided to optimally reduce the generation of norcarnitine by using the acid of the hydrolysis of dialkylamino ester hydrochloride. CONSTITUTION: A manufacturing method of alkylamine derivatives comprises a step of manufacturing 4-dialkylamino crotonic acid by hydrolyze C1-4 alkyl 4-dialkylamino crotonic acid ester hydrochloride under the presence of acid. The C1-4 alkyl 4-dialkylamino crotonic acid ester hydrochloride is ethyl 4-dimethylamino crotonic acid ester hydrochloride. The acid is hydrochloric acid, sulfuric acid, benzene sulfonic acid, benzene sulfonic acid substituted by a methyl group, carboxylic acid, C1-3 alkyl carboxylic acid, phenyl carboxylic acid, phosphoric acid, bromic acid, or iodic acid.
摘要翻译：目的：提供烷基胺衍生物的制备方法，以通过使用二烷基氨基酯盐酸盐的水解酸来最佳地减少诺卡尼精的产生。构成：烷基胺衍生物的制造方法包括通过在酸存在下水解C 1-4烷基4-二烷基氨基巴豆酸酯盐酸盐来制备4-二烷基氨基巴豆酸的步骤。 C 1-4烷基4-二烷基氨基巴豆酸酯盐酸盐是4-二甲基氨基巴豆酸乙酯盐酸盐。酸是盐酸，硫酸，苯磺酸，被甲基取代的苯磺酸，羧酸，C 1-3烷基羧酸，苯基羧酸，磷酸，溴酸或碘酸。

3. 发明公开

KR1020130077458A 벤조디아제핀 유도체의 제조방법 无效
标题翻译：制备苯二酸衍生物的方法
公开(公告)号：KR1020130077458A
公开(公告)日：2013-07-09
申请号：KR1020110146178
申请日：2011-12-29
申请人： 코오롱생명과학 주식회사
发明人： 최윤환 , 신영균 , 장원태 , 최태근 , 박상후
IPC分类号： C07D243/14 , C07D243/26 , A61K31/5513 , A61P25/18
摘要： PURPOSE: A manufacturing method of the benzodiazepine derivative is provided to offer a simple production process and economic benefits not by using the expensive catalyst, and to safely mass-produce the high-yield of benzodiazepine derivative as there is not in danger of ignition or explosion. CONSTITUTION: A manufacturing method of the benzodiazepine derivative comprises the step of manufacturing the compound which is represented by the chemical formula 1 by the reduction reaction between a reducing agent and the compound represented by chemical formula 2. The above manufacturing method of the benzodiazepine derivative is performed by reacting the compound represented by chemical formula 2 with the reducing agent at a mol ratio of 1:0.5-1:10. The above reduction reaction occurs at 0 through 100°C. The above compound represented by chemical formula 2 is manufactured by cyclizing the compound represented by chemical formula 3 under the presence of base basic condition. The base is the one of the group comprised of sodium hydroxide and potassium hydroxide.
摘要翻译：目的：提供苯并二氮杂衍生物的制造方法，以提供简单的生产工艺和经济效益，而不是使用昂贵的催化剂，并且安全地大量生产高产量的苯并二氮杂衍生物，因为没有点燃或爆炸的危险。构成：苯并二氮杂衍生物的制造方法包括通过还原剂与化学式2所示的化合物的还原反应制造由化学式1表示的化合物的步骤。上述苯并二氮杂衍生物的制造方法为通过使化学式2表示的化合物与还原剂以摩尔比为1:0.5-1:10反应而进行。上述还原反应发生在0〜100℃。由化学式2表示的上述化合物通过在碱性碱性条件的存在下使由化学式3表示的化合物环化来制备。碱是由氢氧化钠和氢氧化钾组成的组中的一种。

4. 发明公开

KR1020120058314A 스타틴 화합물의 제조방법 및 이에 사용되는 중간체 화합물 无效
标题翻译：制备其化合物的方法及其使用的中间体化合物
公开(公告)号：KR1020120058314A
公开(公告)日：2012-06-07
申请号：KR1020100120032
申请日：2010-11-29
申请人： 코오롱생명과학 주식회사
发明人： 신영균 , 최윤환 , 장원태 , 최태근
IPC分类号： C07D215/14 , C07D405/06 , C07F9/50 , C07C309/79
CPC分类号： C07D215/14 , C07C309/79 , C07D405/06 , C07F9/50
摘要： PURPOSE: A method for preparing statin compounds and an intermediate compound are provided to ensure working stability and to easily remove reaction by-production. CONSTITUTION: A method for preparing statin compounds comprises: a step of reacting a starting material and sulfonyl compounds to prepare a first intermediate compound; a step of reacting the first intermediate compounds with phosphine compounds to prepare a second intermediate compound; and a step of reacting the second intermediate compounds with carbonyl compounds under the presence of base.
摘要翻译：目的：提供一种制备他汀类化合物和中间体化合物的方法，以确保工作稳定性，并易于除去反应副产物。构成：制备他汀类化合物的方法包括：使原料和磺酰化合物反应制备第一中间体化合物的步骤; 使第一中间体化合物与膦化合物反应以制备第二中间体化合物的步骤; 以及在碱存在下使第二中间体化合物与羰基化合物反应的步骤。

5. 发明公开

KR1020100079291A 6-디옥시글루코오스의 제조방법 无效
标题翻译：一种制备6-脱氧葡萄糖的方法
公开(公告)号：KR1020100079291A
公开(公告)日：2010-07-08
申请号：KR1020080137720
申请日：2008-12-31
申请人： 코오롱생명과학 주식회사
发明人： 장원태 , 최윤환
IPC分类号： C07H5/00 , C07H5/02 , C07H5/06
CPC分类号： C07H5/00 , A61K31/7004
摘要： PURPOSE: A method for preparing 6-dioxyglucose is provided to massively and safely produce 6-dioxyglucose of high yield and high purity without using dangerous industrial materials. CONSTITUTION: A method for preparing 6-dioxyglucose comprises: a step of performing tosylation or mesylation of a compound of chemical formula 5 under the presence of base to obtain a compound of chemical formula 4; a step of performing helogenation of a compound of chemical formula 4 to obtain a compound of chemical formula 3; a step of reducing the compound of chemical formula 3 to obtain a compound of chemical formula 2; and a step of deprotecting the compound of chemical formula 2 under the presence of acid catalyst to obtain a compound of chemical formula 1.
摘要翻译：目的：提供一种制备6-二羟基葡萄糖的方法，大量安全地生产高产率和高纯度的6-二羟基葡萄糖，而不使用危险的工业材料。构成：制备6-二羟基葡萄糖的方法包括：在碱的存在下进行化学式5的化合物的甲苯磺酰化或甲磺酰化以获得化学式4的化合物的步骤; 进行化学式4的化合物的均化以获得化学式3的化合物的步骤; 降低化学式3的化合物以获得化学式2的化合物的步骤; 以及在酸催化剂存在下使化学式2的化合物脱保护的步骤，得到化学式1的化合物。

6. 发明公开

KR1020130077451A 아미노벤질아민의 제조방법 无效
标题翻译：制备氨基苯胺的方法
公开(公告)号：KR1020130077451A
公开(公告)日：2013-07-09
申请号：KR1020110146169
申请日：2011-12-29
申请人： 코오롱생명과학 주식회사
发明人： 신영균 , 최윤환 , 장원태 , 김관희 , 최태근 , 박상후
IPC分类号： C07C209/66 , C07C211/49 , C07B31/00
摘要： PURPOSE: A producing method of aminobenzylamine is provided to simplify production processes, and to mass-produce aminobenzylamine with high yield by not using an expensive catalyst. CONSTITUTION: A producing method of aminobenzylamine comprises the following steps: producing a compound denoted by chemical formula 2 by the substitution reaction between a compound denoted by chemical formula 3 and metallic azide; and a producing a compound denoted by chemical formula 1 by the reduction reaction between a nitro group of the compound denoted by the chemical formula 2 with an azide group. In the chemical formula 1: R1 is an alkyl group, an aryl group, a cycloalkyl group, and a heteroaryl group; l is a fixed number selected from 0-4; and R2 is selected from hydrogen, an alkyl group, an aryl group, a cycloalkyl group, and a heteroaryl group.
摘要翻译：目的：提供氨基苄胺的生产方法以简化生产工艺，并通过不使用昂贵的催化剂以高产率大量生产氨基苄胺。构成：氨基苄胺的制造方法包括以下步骤：通过化学式3表示的化合物与金属叠氮化物之间的取代反应来制造由化学式2表示的化合物; 通过化学式2表示的化合物的硝基与叠氮基的还原反应来制造由化学式1表示的化合物。在化学式1中：R 1是烷基，芳基，环烷基和杂芳基; l是0-4的固定数; 并且R 2选自氢，烷基，芳基，环烷基和杂芳基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式