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1. 发明公开

KR1020040075795A 신경보호 활성을 갖는 치자에서 분리한 제니포사이드을포함하는 조성물 无效
标题翻译：具有分离于花椰菜种子的神经保护活性的组合物
公开(公告)号：KR1020040075795A
公开(公告)日：2004-08-30
申请号：KR1020040044755
申请日：2004-06-16
申请人： 주식회사 풀무원 , (주) 바이탈랩 , 풀무원건강생활 주식회사
发明人： 손동욱 , 강정일 , 김현수 , 이상현
IPC分类号： A61K36/744 , A61P25/28 , A61P9/10
CPC分类号： A61K36/744 , A23V2200/322 , A61K2236/331 , A61K2236/333
摘要： PURPOSE: A pharmaceutical composition including Gardenia jasminoides Ellis extract and a geniposide compound useful in treatment of disease caused by neuronal cell damage in the brain of mammals is provided. It is excellent in neuroprotective activity and thus can be effectively used in prevention and treatment of nervous system disorders such as cerebral apoplexy, dementia or the like. CONSTITUTION: The pharmaceutical and health supplementary composition for protection of brain cells and prevention and treatment of cerebral apoplexy contains an effective concentration of a Gardenia jasminoides Ellis extract and a geniposide compound of formula 1 as an effective ingredient. The Gardenia jasminoides Ellis extract is extracted in water, butyl alcohol or its mixed solvent. For an example, a suitable amount of Gardenia jasminoides Ellis extract is mixed with 3.0mg sodium metabisulfite, 0.8mg methylparaben, 0.1mg propylparaben and a suitable amount of sterilized distilled water and then sterilized to give injectable formulations.
摘要翻译：目的：提供一种药物组合物，包括栀子栀子提取物和可用于治疗由哺乳动物脑中的神经元细胞损伤引起的疾病的栀子苷化合物。神经保护活性优异，因此可以有效地用于脑卒中，痴呆等神经系统疾病的预防和治疗。构成：用于保护脑细胞和预防和治疗脑中风的药物和健康补充组合物含有栀子栀子提取物和式1的栀子苷化合物的有效浓度作为有效成分。栀子栀子提取物在水，丁醇或其混合溶剂中萃取。例如，将适量的栀子栀子提取物与3.0mg焦亚硫酸钠，0.8mg对羟基苯甲酸甲酯，0.1mg对羟基苯甲酸丙酯和适量的无菌蒸馏水混合，然后灭菌，得到可注射制剂。

2. 发明公开

KR1020040004764A 간독성에 대한 보호 활성을 갖는 가시오가피 추출물 또는이로부터 부탄올로 분획한 분획층과 부탄올분획층에서분리한 시린진과시린가레시놀-디-오-베타-굴루코피라노사이드을 함유하는항산화작용과 간독성 보호 활성을 갖는 조성물 无效
标题翻译：具有抗氧化和抗肝炎药物作用的组合物，其含有ACANTHOPANAX SENTICOSUS，其丁酸酯及其与SYRINGIN和SYRINGARESINOL-DI-O-BET-D-GLUCOPYRANOSIDE的萃取物的萃取物
公开(公告)号：KR1020040004764A
公开(公告)日：2004-01-14
申请号：KR1020030061603
申请日：2003-09-03
申请人： 주식회사 풀무원 , 풀무원건강생활 주식회사
发明人： 손동욱 , 류지영 , 강정일 , 김현수 , 이상현
IPC分类号： A61K36/254 , A61P1/16 , A61P39/06
CPC分类号： A61K36/254 , A23L33/105 , A23V2002/00 , A23V2250/21 , A61K31/7034 , Y10S514/894
摘要： PURPOSE: Provided is a hepatotoxic-resistant composition which contains an extract of Acanthopanax senticosus or derivatives thereof, such as syringin and syringaresinol-di-O-beta-D-glucopyranoside compounds, and is effectively used to prevent and treat liver diseases and to make energy boosting. CONSTITUTION: An extract of Acanthopanax senticosus is obtained by using water, lower alcohol, a nonpolar solvent, or butyl alcohol. A hepatotoxic-resistant composition contains 0.0001-50% of syringin and syringaresinol-di-O-beta-D-glucopyranoside compounds derived from the butanol fractions of the Acanthopanax senticosus extract, and represented by the formula (I), wherein R1 is OCH3, R2 is O-Glc, R3 is OCH3, and R4 is CH2OH, and formula (II), wherein R1 is OCH3, R2 is O-Glc, R3 is OCH3, R4 is OCH3, R5 is O-Glc, and R6 is OCH3, respectively.
摘要翻译：目的：提供含有刺五加提取物或其衍生物，如丁香精和丁香胺 - 二-O-β-D-吡喃葡萄糖苷化合物的肝毒性组合物，有效用于预防和治疗肝脏疾病，并使能量提升。构成：使用水，低级醇，非极性溶剂或丁醇得到刺五加提取物。一种耐肝毒性组合物含有0.0001-50％的来自刺五加提取物的丁醇级分的丁香腈和丁香腈 - 二-O-β-D-吡喃葡萄糖苷化合物，由式（I）表示，其中R1是OCH3， R2是O-Glc，R3是OCH3，R4是CH2OH，式（Ⅱ）其中R1是OCH3，R2是O-Glc，R3是OCH3，R4是OCH3，R5是O-Glc，R6是OCH3 ，分别。

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