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1. 发明公开

KR1020130067950A 체중 감소효과를 가지는 당질이 제거된 갈근 추출물을 유효성분으로 하는 비만 예방 및 개선용 건강 식품 조성물 无效
标题翻译：包含PUERARIA LOBATA提取物的中和组合物，用于减少肥胖
公开(公告)号：KR1020130067950A
公开(公告)日：2013-06-25
申请号：KR1020110135015
申请日：2011-12-15
申请人： 주식회사 진생사이언스
发明人： 김복득 , 신윤상 , 유동열 , 박만기 , 이양범 , 김성용 , 박용성 , 박인순 , 이용재 , 이진균
IPC分类号： A23L33/00 , A61K36/488 , A61P3/04
CPC分类号： A23L33/105 , A23L5/20 , A23L19/10 , A23V2002/00 , A23V2200/332 , A23V2250/21 , A61K36/488
摘要： PURPOSE: A health food composition is provided to offer an excellent inhibitory effect against adiposity resulted by a weight loss measurement test using an estrogen deficiency obesity induced animal model, and an influence test to associated gene expression. CONSTITUTION: Health functional food for adiposity prevention and treatment contains Puerariae Radix extraction fraction water in which glucoside is removed as an active ingredient. The Puerariae Radix extraction fraction water is manufactured as follows: a solvent is added to washed, dried, and sliced Puerariae Radix for 1-200 times the amount of total weight of a sample(w/w), and the Puerariae Radix is extracted for 2 hours to 1 week at10-150 deg. C; water and an ethanol mixed solvent are added in the extract, precipitates are removed, and filtrate is obtained; the filtrate is centrifugated and protein precipitation is removed; and the filtrate is dried and condensed. The solvent is purified water, alcohol, low grade alcohol with 1-4 carbons, or a mixture thereof. The extraction is enfleurage extraction, hot water extraction, ultrasonic wave extraction, reflux extraction, etc.
摘要翻译：目的：提供保健食品组合物，以通过使用雌激素缺乏症肥胖诱导的动物模型进行的体重减轻测量测试以及对相关基因表达的影响测试，为肥胖提供优异的抑制作用。构成：用于预防和治疗肥胖症的健康功能食品含有将葡萄糖苷作为活性成分除去的葛根提取级分水。葛根提取级分水如下制造：将溶剂加入洗涤，干燥，切片的葛根中，加入样品总重量（w / w）1-200倍，葛根提取葛根 2〜1周，10〜150度。 C; 在萃取液中加入水和乙醇混合溶剂，除去沉淀，得到滤液; 将滤液离心，除去蛋白质沉淀; 将滤液干燥并浓缩。溶剂是纯化水，醇，具有1-4个碳的低级醇或其混合物。提取物是灌肠提取，热水提取，超声波提取，回流提取等。

2. 发明公开

KR1020130067948A 당질이 제거된 갈근 추출물을 유효성분으로 함유하는 비만 예방 및 치료용 약학 조성물 无效
标题翻译：包含PUERARIA LOBATA提取物的药物组合物，用于预防和治疗肥胖
公开(公告)号：KR1020130067948A
公开(公告)日：2013-06-25
申请号：KR1020110135013
申请日：2011-12-15
申请人： 주식회사 진생사이언스
发明人： 김복득 , 신윤상 , 유동열 , 박만기 , 이양범 , 김성용 , 박용성 , 박인순 , 이용재 , 이진균
IPC分类号： A61K36/488 , A61P3/04 , A61P3/00
CPC分类号： A61K36/488 , A61K2236/33 , A61K2236/39 , Y10S514/909
摘要： PURPOSE: A Pueraria lobata extract is provided to suppress obesity by measuring body weight reduction and testing influence on gene expression, and to be used for a pharmaceutical composition for preventing and treating obesity. CONSTITUTION: A pharmaceutical composition for preventing and treating obesity contains a carbohydrate-removed fraction of Pueraria lobata extract as an active ingredient. A method for preparing the fraction comprises: a step of washing, drying, and slicing Pueraria lobata, and adding 1-200 times weight(w/w) of water including purified water, spirit, C1-C4 alcohol, or a mixture thereof to Pueraria lobata extract; a step of extracting at 10-150 deg. C for 12 hours to 1 week by macerating, hot water extraction, sonication, and reflux to obtain an extract; a step of adding a mixture of water and ethanol and removing precipitates to obtain a liquid; a step of centrifuging the liquid and removing protein precipitates to collect remaining liquid; and a step of concentrating and drying the remaining liquid.
摘要翻译：目的：提供葛根提取物，通过测量体重减轻和测试对基因表达的影响来抑制肥胖症，并用于预防和治疗肥胖症的药物组合物。构成：用于预防和治疗肥胖症的药物组合物含有作为活性成分的葛根提取物的去除碳水化合物的部分。制备级分的方法包括：洗涤，干燥和切片葛根的步骤，并加入1-200倍重量（w / w）的水，包括纯净水，精油，C1-C4醇或其混合物，葛根提取物; 在10-150度下提取的步骤。通过浸渍，热水提取，超声处理和回流12小时至1周，得到提取物; 加入水和乙醇的混合物并除去沉淀物以获得液体的步骤; 离心液体并除去蛋白质沉淀物以收集剩余液体的步骤; 以及浓缩和干燥剩余液体的步骤。

3. 发明公开

KR1020130059860A 육계 추출물을 유효성분으로 하는 골형성 증가 효과를 가지는 식품첨가물 无效
标题翻译：食品添加剂包括中华IA IA THE THE THE ME TH TH TH TH TH TH TH TH TH TH TH TH TH TH TH TH TH TH TH TH TH TH
公开(公告)号：KR1020130059860A
公开(公告)日：2013-06-07
申请号：KR1020110126069
申请日：2011-11-29
申请人： 주식회사 진생사이언스
发明人： 김복득 , 유동열 , 김성용 , 박용성 , 박인순 , 이용재 , 이진균
IPC分类号： A23L1/30 , A61K36/54 , A61P19/10
CPC分类号： A23L33/105 , A23V2002/00 , A23V2200/306 , A23V2250/21 , A23V2300/14 , A61K36/54
摘要： PURPOSE: Food additive including cinnamon extract is provided to increase division potential of bone cell separated and cultivated from skull of a rat, and increase activity of alkali phosphatase and amount of collagen synthetic. CONSTITUTION: Food additive for promoting growth, preventing and improving osteoporosis comprises crude extract of cinnamon, polar solvent soluble extract or nonpolar solvent soluble extract as active ingredient. Crude extract is soluble to solvent selected from water including purified water, low-grade alcohol of carbon number one to four or the mixture of these. Polar solvent soluble extract is soluble to solvent selected from water, methanol, ethanol, butanol or mixed solvent of these. Nonpolar solvent extract is an extract soluble from solvent selected from hexane, chloroform, and ethyl acetate. Food additive includes 0.1 to 50% weight of cinnamon extract.
摘要翻译：目的：提供包括肉桂提取物在内的食品添加剂，以增加从大鼠头骨分离培养的骨细胞的分裂潜力，增加碱性磷酸酶的活性和胶原合成量。构成：用于促进生长，预防和改善骨质疏松症的食品添加剂包括肉桂粗提物，极性溶剂可溶性提取物或非极性溶剂可溶性提取物作为活性成分。粗提取物可溶于选自包括纯化水，碳数为1至4的低级醇或这些混合物的水的溶剂。极溶剂可溶性提取物可溶于选自水，甲醇，乙醇，丁醇或其混合溶剂的溶剂。非极性溶剂提取物是可溶于选自己烷，氯仿和乙酸乙酯的溶剂的提取物。食品添加剂含0.1〜50％肉桂提取物。

4. 发明公开

KR1020130071216A 항골다공증 활성을 나타내는 ＳＫＧ 추출물을 함유하는 식품첨가물 无效
标题翻译：食品添加剂包括提供抗骨质疏松症的SKG提取物
公开(公告)号：KR1020130071216A
公开(公告)日：2013-06-28
申请号：KR1020110138596
申请日：2011-12-20
申请人： 주식회사 진생사이언스
发明人： 김복득 , 황귀서 , 박정일 , 김진희 , 유동열
IPC分类号： A23L1/30 , A23L33/00 , A61P19/00
CPC分类号： A23L33/105 , A23L19/00 , A23V2002/00 , A23V2200/306 , A23V2250/21 , A23V2300/14
摘要： PURPOSE: A food additive is provided to reduce bone diseases including a osteoporosis through suppressing osteoclast differentiation and suppressing activity of osteoclast including suppressing expression of TRAP of oasteoclas and suppressing of expression of MMP-9 and Cathepsin K. CONSTITUTION: A food additive for a metabolic bone disease improvement and prevention is an extract from complex crude drug are contained as an active ingredient. A complex herb medicine includesrehmanniae Radix Preparata, houttuynia cordata, eucommia ulmoides, achyranthes, angelica gigas, chinese matrimony vine, hoelen, paeonia japonica, cinnamomi Cortex spissus, asiasari Radix, angelicae dahuricae Radix, aconiti Tuber, glycyrrhizae radix and ginger at a combination (w/w) ratio of 1~10;1~10:1~10:1~10:1~10:1~10:1~10:1~10:1~10: 1~10:1~10:1~10:1~10: 1~10. The extract is available in a solvent selected from water including purified water, a lower alcohol, and their mixed solvent of a carbon number 1 to 4. The metabolic bone disease is osteoporosis, Paget disease, periodontal disease, metastatic cancer, or rheumatoid arthritis.
摘要翻译：目的：提供一种食品添加剂，用于通过抑制破骨细胞分化和抑制破骨细胞活性，减少骨质疏松症，包括抑制破骨细胞的TRAP表达和抑制MMP-9和组织蛋白酶K的表达，从而减少骨质疏松症。构成：用于代谢的食品添加剂作为活性成分含有来自复合生药的骨疾病的改善和预防。复方草药包括地黄根，杜鹃花，杜仲，当归，中国枸杞，ho elen，芍药，肉桂，皮栎，白芷，当归，栀子，甘草，姜， w / w）比例为1〜10; 1〜10：1〜10：1〜10：1〜10：1〜10：1〜10：1〜10：1〜10：1〜10：1〜10： 1〜10：1〜10：1〜10。提取物可以在选自包括纯化水，低级醇和其中1至4碳数的混合溶剂的水中的溶剂中获得。代谢性骨病是骨质疏松症，佩吉特病，牙周病，转移性癌症或类风湿性关节炎。

5. 发明公开

KR1020130059859A 골형성 증가 효과를 가지는 육계 추출물을 유효성분으로 하는 건강식품 조성물 无效
标题翻译：健康食品包括中华白喉药物的提取物，用于预防和治疗骨质疏松症或促进体液生长
公开(公告)号：KR1020130059859A
公开(公告)日：2013-06-07
申请号：KR1020110126068
申请日：2011-11-29
申请人： 주식회사 진생사이언스
发明人： 김복득 , 유동열 , 김성용 , 박용성 , 박인순 , 이용재 , 이진균
IPC分类号： A23L1/30 , A61K36/54 , A61P19/10
CPC分类号： A23L33/105 , A23V2002/00 , A23V2200/306 , A23V2250/21 , A23V2300/14 , A61K36/54
摘要： PURPOSE: Health food composition including cinnamon extract is provided to increase division potential of bone cell separated and cultivated from skull of a rat, and increase activity of alkali phosphatase and amount of collagen synthetic. CONSTITUTION: Health food composition comprises crude extract of Cinnamon, soluble extract of polar solvent or nonpolar solvent extract as active ingredient. Crude extract is soluble to solvent selected from water including purified water, low-grade alcohol of carbon number one to four or the mixture of these. Polar solvent soluble extract is soluble to solvent selected from water, methanol, ethanol, butanol or mixed solvent of these. Nonpolar solvent extract is an extract soluble from solvent selected from hexane, chloroform, and ethyl acetate.
摘要翻译：目的：提供包括肉桂提取物在内的保健食品组合，以增加从大鼠头骨分离培养的骨细胞的分裂潜力，增加碱性磷酸酶的活性和胶原合成量。构成：健康食品组合物包括肉桂粗提物，极性溶剂的可溶性提取物或非极性溶剂提取物作为活性成分。粗提取物可溶于选自包括纯化水，碳数为1至4的低级醇或这些混合物的水的溶剂。极溶剂可溶性提取物可溶于选自水，甲醇，乙醇，丁醇或其混合溶剂的溶剂。非极性溶剂提取物是可溶于选自己烷，氯仿和乙酸乙酯的溶剂的提取物。

6. 发明公开

KR1020130067949A 갈근 추출물 중 당질이 제거된 유효성분을 함유하는 체중 감소효과를 가지는 식품첨가물 无效
标题翻译：包含PUERARIA LOBATA萃取物的食品添加剂用于减少身体重量
公开(公告)号：KR1020130067949A
公开(公告)日：2013-06-25
申请号：KR1020110135014
申请日：2011-12-15
申请人： 주식회사 진생사이언스
发明人： 김복득 , 신윤상 , 유동열 , 박만기 , 이양범 , 김성용 , 박용성 , 박인순 , 이용재 , 이진균
IPC分类号： A23L1/30 , A23L5/20 , A61K36/488 , A61P3/04
CPC分类号： A23L33/105 , A23L5/20 , A23V2002/00 , A23V2200/332 , A61K36/488
摘要： PURPOSE: A food additive is provided to offer an excellent inhibitory effect against adiposity resulted by a weight loss experiment and influence test to associated gene expression. CONSTITUTION: A solvent is added to washed, dried, and sliced Puerariae Radix for 1-200 times the amount of the total weight of a sample(w/w), and the Puerariae Radix is extracted for 2 hours to 1 week at 10-150 deg. C. Water and an ethanol mixed solvent are added into the extract, and precipitates are removed to obtain filtrate. The filtrate is centrifugated and protein precipitates are removed. The filtrate is dried, and condensed. The food additive contains Puerariae Radix extraction fraction water, in which glucoside is removed, as an active ingredient. The solvent is purified water, alcohol, low grade alcohol with 1-4 carbons, or a mixture thereof. The extraction comprises enfleurage extraction, hot water extraction, ultrasonic wave extraction, reflux extraction, etc.
摘要翻译：目的：提供食品添加剂，通过减肥实验和对相关基因表达的影响测试，为肥胖提供优异的抑制作用。构成：将溶剂加入洗涤，干燥和切片的葛根中，加入样品总重量（w / w）的1-200倍，并将葛根提取10小时至1周， 150度 C.将水和乙醇混合溶剂加入萃取液中，除去沉淀物，得到滤液。将滤液离心，除去蛋白沉淀。将滤液干燥并浓缩。食品添加剂含有作为活性成分的葡萄糖苷被除去的葛根提取级分水。溶剂是纯化水，醇，具有1-4个碳的低级醇或其混合物。提取物包括灌浆提取，热水提取，超声波提取，回流提取等。

7. 发明公开

KR1020130060585A 밀리타리스동충하초 추출물을 유효성분으로 함유하는 골다공증 억제 효과를 가지는 약학 조성물 无效
标题翻译：包含肌肉提取物的药物组合物显示骨质疏松症的抑制作用
公开(公告)号：KR1020130060585A
公开(公告)日：2013-06-10
申请号：KR1020110126720
申请日：2011-11-30
申请人： 주식회사 진생사이언스
发明人： 김복득 , 김진희 , 이혜진 , 유동열
IPC分类号： A61K36/068 , A61K36/066 , A61P19/10 , A61P19/00
摘要： PURPOSE: A Cordyceps militaris extract is provided to suppress osteoclast differentiation and expression of genes such as TRAP, JNK, and AKT1 which are factors related to osteoclast differentiation and proliferation, and to be used as a pharmaceutical composition for suppressing osteoporosis. CONSTITUTION: A pharmaceutical composition for preventing and treating metabolic bone diseases contains a Cordyceps militaris extract as an active ingredient. The metabolic bone diseases are osteoporosis, Paget's disease, periodontal disease, metastatic cancer, or rheumatoid arthritis. The extract is prepared from a fruit body of Cordyceps militaris. The extract contains 0.1-99 wt% of a crude drug extract.
摘要翻译：目的：提供冬虫夏草提取物，以抑制与破骨细胞分化和增殖相关的因素的TRAP，JNK和AKT1等基因的破骨细胞分化和表达，并用作抑制骨质疏松症的药物组合物。构成：用于预防和治疗代谢性骨疾病的药物组合物含有冬虫夏草提取物作为活性成分。代谢性骨病是骨质疏松症，佩吉特氏病，牙周病，转移性癌症或类风湿性关节炎。提取物由冬虫夏草的果实制成。提取物含有0.1-99重量％的生物药物提取物。

8. 发明公开

KR1020130059858A 육계 추출물을 유효성분으로 함유하는 발육 성장 촉진용 또는 골다공증의 예방 및 치료용 약학 조성물 无效
标题翻译：包含中华绒螯蟹提取物的药物组合物，用于预防和治疗OSTEOPOSOSIS或促进体内生长
公开(公告)号：KR1020130059858A
公开(公告)日：2013-06-07
申请号：KR1020110126067
申请日：2011-11-29
申请人： 주식회사 진생사이언스
发明人： 김복득 , 유동열 , 김성용 , 박용성 , 박인순 , 이용재 , 이진균
IPC分类号： A61K36/54 , A61P19/10
CPC分类号： A61K36/54 , A61K2236/331 , A61K2236/333
摘要： PURPOSE: A composition containing a Cinnamomum cassia Blume extract for promoting growth or preventing and treating osteoporosis is provided to enhance osteogenesis. CONSTITUTION: A pharmaceutical composition for promoting growth or preventing and treating osteoporosis contains a crude extract, a polar solvent soluble extract, or a non-polar solvent soluble extract of Cinnamomum cassia Blume as an active ingredient. The crude extract is prepared using a solvent selected from the group consisting of water, C1-C4 alcohols, or a mixture thereof. The polar solvent soluble extract is dissolved in a solvent selected among water, methanol, ethanol, butanol, or a mixture thereof. The non-polar solvent soluble extract is dissolved in a solvent selected from hexane, chloroform, and ethyl acetate. The composition contains 0.1-50 wt% of the extract.
摘要翻译：目的：提供含有用于促进生长或预防和治疗骨质疏松症的肉桂肉桂提取物的组合物以增强成骨。构成：用于促进生长或预防和治疗骨质疏松症的药物组合物含有粗提物，极性溶剂可溶性提取物或肉桂肉桂的非极性溶剂可溶性提取物作为活性成分。使用选自水，C 1 -C 4醇或其混合物的溶剂制备粗提取物。极性溶剂可溶性提取物溶于选自水，甲醇，乙醇，丁醇或其混合物的溶剂中。将非极性溶剂可溶性提取物溶于选自己烷，氯仿和乙酸乙酯的溶剂中。组合物含有0.1-50重量％的提取物。

9. 发明公开

KR1020130060587A 골다공증 억제 효과를 가지는 밀리타리스동충하초 추출물을 유효성분으로 함유하는 식품첨가제 无效
标题翻译：食品添加剂包括提取骨质疏松症的抑制作用
公开(公告)号：KR1020130060587A
公开(公告)日：2013-06-10
申请号：KR1020110126722
申请日：2011-11-30
申请人： 주식회사 진생사이언스
发明人： 김복득 , 김진희 , 이혜진 , 유동열
IPC分类号： A23L1/30 , A61K36/066 , A61P19/00 , A23L2/52
CPC分类号： A23L33/10 , A23L2/52 , A23L31/15 , A23V2002/00 , A23V2200/306 , A23V2250/208 , A23V2300/14 , A61K36/068
摘要： PURPOSE: Food additives are provided to prevent or improve bone metabolism related diseases by containing a cordyceps militaris extract, which shows an osteoporosis suppressing effect, as an active component. CONSTITUTION: Food additives for the prevention or improvement of bone metabolism related diseases contain a cordyceps militaris extract, which shows an osteoporosis suppressing effect, as an activie component. The bone metabolism related diseases are osteoporosis, paget disease, periodontal disease, metastatic cance or rheumatoid arthritis. The food additives are candy type various foods, beverages, gums, teas, vitamin complexes or health supplement foods.
摘要翻译：目的：通过将含有骨质疏松症抑制作用的冬虫夏草提取物作为活性成分，提供食品添加剂以预防或改善骨代谢相关疾病。构成：用于预防或改善骨代谢相关疾病的食品添加剂含有作为活性组分的骨质疏松症抑制作用的冬虫夏草提取物。骨代谢相关疾病是骨质疏松症，佩吉特病，牙周病，转移性或类风湿性关节炎。食品添加剂是糖果类各种食品，饮料，牙龈，茶，维生素复合物或保健品。

10. 发明公开

KR1020130060586A 파골세포 분화를 억제하는 밀리타리스 동충하초 추출물을 유효성분으로 함유하는 건강기능식품 无效
标题翻译：健康功能食物包括提取骨质疏松症的抑制作用
公开(公告)号：KR1020130060586A
公开(公告)日：2013-06-10
申请号：KR1020110126721
申请日：2011-11-30
申请人： 주식회사 진생사이언스
发明人： 김복득 , 김진희 , 이혜진 , 유동열
IPC分类号： A23L1/30 , A61K36/066 , A61P19/00
CPC分类号： A23L33/10 , A23L31/15 , A23V2002/00 , A23V2200/306 , A23V2250/208 , A23V2300/14 , A61K36/068
摘要： PURPOSE: A health functional food with a cordyceps militaris extract is provided to have the suppressing effect of osteoclast differentiation and to have the suppressing effect of a gene expression such as TRAP, JNK, AKT1 which are relative factors of osteoclast differentiation or the actiovation of osteoclast. CONSTITUTION: A health functional food for the prevention and the improvement of osteoclast differentiation bone metabolism related disease contains a cordyceps militaris extract, which shows the suppressing effect of aosteoclast, as an active component. The health functional food has the cordyceps militaris extract with 0.01-99 weight %. The health functional food is in a powder type, tablet type, capsule type and liquid type dosage form.
摘要翻译：目的：提供一种具有冬虫夏草提取物的保健功能食品，具有破骨细胞分化的抑制作用，并具有基因表达的抑制作用，如作为破骨细胞分化或破骨细胞活化的相关因素的TRAP，JNK，AKT1等基因表达。构成：用于预防和改善破骨细胞分化骨代谢相关疾病的健康功能食品含有冬虫夏草提取物，其显示作为活性成分的成骨细胞的抑制作用。健康功能食品具有0.01-99重量％的冬虫夏草提取物。保健功能食品为粉末型，片剂型，胶囊型和液体型剂型。

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