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1. 发明授权

KR101104349B1 에소메프라졸 함유 약학 조성물 有权
标题翻译：含有艾美拉唑的药物组合物
公开(公告)号：KR101104349B1
公开(公告)日：2012-01-16
申请号：KR1020080090692
申请日：2008-09-16
申请人： 주식회사 씨티씨바이오
发明人： 이봉상 , 권도우 , 전홍렬 , 곽성신 , 문지윤 , 이동진
IPC分类号： A61K9/14 , A61K31/44 , A61K47/30
CPC分类号： A61K31/4439 , A61K9/1611 , A61K9/2009
摘要： 본 발명은 안정성이 개선되고, 제조가 간단한 에소메프라졸 유리염기 또는 이의 알칼리염 함유 약학 조성물을 제공한다.
에소메프라졸, 고체분산체, 폴리비닐피롤리돈, 비닐피롤리돈-비닐아세테이트 공중합체, 알칼리화제

2. 发明授权

KR101062907B1 올메사탄 실렉세틸을 포함하는 고혈압 치료용 약학 조성물 有权
公开(公告)号：KR101062907B1
公开(公告)日：2011-09-06
申请号：KR1020090099599
申请日：2009-10-20
申请人： 주식회사 씨티씨바이오
发明人： 오창현 , 김정훈 , 유승원 , 전홍렬 , 권도우 , 이봉상 , 김현일 , 조영진 , 문지윤 , 이동진
IPC分类号： C07D403/10 , C07D403/08 , A61K31/4178 , A61P9/12
摘要： 본 발명은 고혈압, 동맥경화 및 출혈성 심부전증의 치료 또는 예방에 유용한 신규 화합물 및 이들의 의약 용도에 관한 것이다.
올메사탄 실렉세틸, 고혈압

3. 发明公开

KR1020080007006A 용출편차가 감소한 염산파록세틴 서방정 无效
标题翻译：含有含有氯化氢的含氯化物的持续释放片具有降低的溶解度变化
公开(公告)号：KR1020080007006A
公开(公告)日：2008-01-17
申请号：KR1020060066456
申请日：2006-07-14
申请人： 주식회사 씨티씨바이오
发明人： 전홍렬 , 권도우 , 이봉상 , 박수준 , 문지윤 , 김현일
IPC分类号： A61K9/22 , A61K9/36
CPC分类号： A61K31/445 , A61K9/2054 , A61K9/2846 , A61K9/2866
摘要： A sustained-release tablet of paroxetine hydrochloride is provided to be mass-produced simply and economically without a special machine therefor, have a preferable elution speed, and show decreased elution variation. A sustained-release tablet of paroxetine hydrochloride comprises 7-21 wt.% of paroxetine hydrochloride; 1-10 wt.% of a first hydroxypropyl methylcellulose, wherein the methoxyl content is 28-30% and the hydroxypropoxyl content of 7-12%; 5-25 wt.% of a second hydroxypropylmethylcellulose, wherein the methoxyl content is 10-24% and the hydroxypropoxyl content is 4-12%; and 50-75 wt.% of a pharmaceutically acceptable excipient. The sustained-release tablet is characterized in that it is coated by a release-controlling polymer such as hydroxypropylmethylcellulose acetate succinate, ethylcellulose, ammonio methacrylate copolymer, methacrylic acid copolymer, and a methacrylic acid-acrylic acid ethyl ester copolymer.
摘要翻译：提供了帕罗西汀盐酸盐的缓释片剂，其生产简单且经济地不需要专门的机器，具有优选的洗脱速度，并且显示出降低的洗脱变化。盐酸帕罗西汀的缓释片含7-21重量％的盐酸帕罗西汀; 1-10重量％的第一羟丙基甲基纤维素，其中甲氧基含量为28-30％，羟丙氧基含量为7-12％; 5-25重量％的第二羟丙基甲基纤维素，其中甲氧基含量为10-24％，羟丙氧基含量为4-12％; 和50-75重量％的药学上可接受的赋形剂。缓释片剂的特征在于其由释放控制聚合物如乙酸琥珀酸羟丙基甲基纤维素，乙基纤维素，氨基甲基丙烯酸酯共聚物，甲基丙烯酸共聚物和甲基丙烯酸 - 丙烯酸乙酯共聚物包衣。

4. 发明公开

KR1020110045677A 올메사탄 유도체를 포함하는 고혈압 치료용 약학 조성물 有权
标题翻译：含有奥美沙坦衍生物的抗高血压药物组合物
公开(公告)号：KR1020110045677A
公开(公告)日：2011-05-04
申请号：KR1020090102347
申请日：2009-10-27
申请人： 주식회사 씨티씨바이오
发明人： 오창현 , 김정훈 , 유승원 , 전홍렬 , 권도우 , 이봉상 , 김현일 , 조영진 , 문지윤 , 이동진
IPC分类号： C07D403/10 , C07D403/08 , A61K31/4178 , A61P9/12
摘要： PURPOSE: A pharmaceutical composition containing olmesartan derivative for treating hypertension is provided to improve body absorption. CONSTITUTION: An olmesartan derivative is denoted by chemical formula 1. A pharmaceutical composition for preventing or treating hypertension or arteriosclerosis contains the olmesartan derivative of chemical formula 1 or pharmaceutically acceptable salt thereof. The compound has a hydrate or solvate form. The pharmaceutical composition is manufactured in the form of powders, granules, tablets, capsules, suppositories, solutions, suspensions, and emulsions.
摘要翻译：目的：提供含有治疗高血压的奥美沙坦衍生物的药物组合物，以改善身体吸收。构成：奥美沙坦衍生物由化学式1表示。用于预防或治疗高血压或动脉硬化的药物组合物含有化学式1的奥美沙坦衍生物或其药学上可接受的盐。该化合物具有水合物或溶剂化物形式。药物组合物以粉末，颗粒，片剂，胶囊，栓剂，溶液，悬浮液和乳液的形式制备。

5. 发明公开

KR1020090033000A 에소메프라졸 함유 약학 조성물 有权
标题翻译：含有异喹诺酮的药物组合物
公开(公告)号：KR1020090033000A
公开(公告)日：2009-04-01
申请号：KR1020080090692
申请日：2008-09-16
申请人： 주식회사 씨티씨바이오
发明人： 이봉상 , 권도우 , 전홍렬 , 곽성신 , 문지윤 , 이동진
IPC分类号： A61K9/14 , A61K31/44 , A61K47/30
CPC分类号： A61K31/4439 , A61K9/1611 , A61K9/2009
摘要： Provided is a pharmaceutical composition containing esomeprazole free base or alkaline salts thereof wherein the esomeprazole has improved stability for treating and preventing peptic ulcer and reflux oesophagitis as a proton pump inhibitor. A pharmaceutical composition containing esomeprazole includes solid-dispersion comprising esomeprazole free base or alkaline salts thereof, alkalizer, polyvinylpyrrolidone and vinylpyrrolidone-vinyl acetate copolymer. The alkalizer indicates MgO or Mg(OH)2. A method for producing the pharmaceutical composition containing esomeprazole consists of the following steps of: preparing a solution or suspension containing esomeprazole free base or alkaline salts thereof, magnesium oxide or magnesium hydroxide, polyvinylpyrrolidone, and vinylpyrrolidone-vinyl acetate copolymer; and drying the prepared solution or suspension.
摘要翻译：提供含有艾美拉唑游离碱或其碱式盐的药物组合物，其中艾美拉唑具有改善的稳定性，用于治疗和预防作为质子泵抑制剂的消化性溃疡和反流性食管炎。含有艾美拉唑的药物组合物包括含有埃索美拉唑游离碱或其碱式盐，碱化剂，聚乙烯吡咯烷酮和乙烯基吡咯烷酮 - 乙酸乙烯酯共聚物的固体分散体。碱化剂表示MgO或Mg（OH）2。制备含有艾美拉唑的药物组合物的方法包括以下步骤：制备含有艾美拉唑游离碱或其碱式盐，氧化镁或氢氧化镁，聚乙烯吡咯烷酮和乙烯基吡咯烷酮 - 乙酸乙烯酯共聚物的溶液或悬浮液; 并干燥制备的溶液或悬浮液。

6. 发明公开

KR1020110048677A 올메사탄 유도체를 포함하는 고혈압 치료용 약학 조성물 无效
标题翻译：含有OLMESARTAN衍生物的抗高血糖药物组合物
公开(公告)号：KR1020110048677A
公开(公告)日：2011-05-12
申请号：KR1020090105354
申请日：2009-11-03
申请人： 주식회사 씨티씨바이오
发明人： 오창현 , 김정훈 , 유승원 , 전홍렬 , 권도우 , 이봉상 , 김현일 , 조영진 , 문지윤 , 이동진
IPC分类号： C07D403/10 , A61K31/41 , A61K31/4178 , A61P9/12
摘要： PURPOSE: A pharmaceutical composition containing olmesartan derivative for treating hypertension is provided to improve body absorption. CONSTITUTION: An olmesartan derivative is denoted by chemical formula 1. A pharmaceutical composition for preventing or treating hypertension, hemorrhage cardiac failure, or arteriosclerosis contains the olmesartan derivative of chemical formula 1 or pharmaceutically acceptable salt thereof. A method for preparing the olmesartan derivative comprises: a step of preparing 4-(2-hydroxypropane-2-yl-2-propyl-1-(2'-(1-trityl-1H-tetrazole-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylic acid; and a step of synthesizing 1-(cyclohexanecarbonyloxy)ethyl-1-((2'-(1H-tetrazole-5-yl)biphenyl-4-yl)methyl)-4-(2-hydropropane-2-yl)-2-propyl-1H-imidazole-5-carboxyl ester.
摘要翻译：目的：提供含有治疗高血压的奥美沙坦衍生物的药物组合物，以改善身体吸收。组成：奥美沙坦衍生物由化学式1表示。用于预防或治疗高血压，出血性心脏衰竭或动脉硬化的药物组合物含有化学式1的奥美沙坦衍生物或其药学上可接受的盐。制备奥美沙坦衍生物的方法包括：制备4-（2-羟基丙烷-2-基-2-丙基-1-（2' - （1-三苯甲基-1H-四唑-5-基）联苯-4 - 基）甲基）-1H-咪唑-5-甲酸; 合成1-（环己烷羰氧基）乙基-1 - （（2' - （1H-四唑-5-基）联苯-4-基）甲基）-4-（2-氢丙烷-2-基）-2 - 丙基-1H-咪唑-5-羧酸酯。

7. 发明公开

KR1020110048676A 올메사탄 유도체를 포함하는 고혈압 치료용 약학 조성물 无效
标题翻译：含有OLMESARTAN衍生物的抗高血糖药物组合物
公开(公告)号：KR1020110048676A
公开(公告)日：2011-05-12
申请号：KR1020090105353
申请日：2009-11-03
申请人： 주식회사 씨티씨바이오
发明人： 오창현 , 김정훈 , 유승원 , 전홍렬 , 권도우 , 이봉상 , 김현일 , 조영진 , 문지윤 , 이동진
IPC分类号： C07D403/10 , A61K31/41 , A61K31/4178 , A61P9/12
摘要： PURPOSE: A novel compound which is useful in treating or preventing hypertension and arteriosclerosis is provided to ensure improved body absorption. CONSTITUTION: An olmesartan derivative is denoted by chemical formula 1. A pharmaceutical composition for preventing or treating hypertension or hemorrhage cardiac failure contains the olmesartan derivative of chemical formula 1 or pharmaceutically acceptable salt thereof. The pharmaceutical composition is solid or liquid formulation. The solid formulation is powder, granule, tablet, capsule, and suppository. The liquid formulation is water, propylene glycol solution, suspension, emulsion.
摘要翻译：目的：提供一种可用于治疗或预防高血压和动脉硬化的新型化合物，以确保改善身体吸收。构成：奥美沙坦衍生物由化学式1表示。用于预防或治疗高血压或出血性心脏衰竭的药物组合物含有化学式1的奥美沙坦衍生物或其药学上可接受的盐。药物组合物是固体或液体制剂。固体制剂为粉末，颗粒，片剂，胶囊和栓剂。液体制剂是水，丙二醇溶液，悬浮液，乳液。

8. 发明授权

KR101062908B1 올메사탄 유도체를 포함하는 고혈압 치료용 약학 조성물 有权
公开(公告)号：KR101062908B1
公开(公告)日：2011-09-06
申请号：KR1020090102347
申请日：2009-10-27
申请人： 주식회사 씨티씨바이오
发明人： 오창현 , 김정훈 , 유승원 , 전홍렬 , 권도우 , 이봉상 , 김현일 , 조영진 , 문지윤 , 이동진
IPC分类号： C07D403/10 , C07D403/08 , A61K31/4178 , A61P9/12
摘要： 본 발명은 고혈압, 동맥경화 및 출혈성 심부전증의 치료 또는 예방에 유용한 신규 화합물 및 이들의 의약 용도에 관한 것이다.
올메사탄 프로드럭, 고혈압

9. 发明公开

KR1020110042776A 올메사탄 실렉세틸을 포함하는 고혈압 치료용 약학 조성물 有权
标题翻译：含有OLMESARTAN CILEXETIL的抗高血压药物组合物
公开(公告)号：KR1020110042776A
公开(公告)日：2011-04-27
申请号：KR1020090099599
申请日：2009-10-20
申请人： 주식회사 씨티씨바이오
发明人： 오창현 , 김정훈 , 유승원 , 전홍렬 , 권도우 , 이봉상 , 김현일 , 조영진 , 문지윤 , 이동진
IPC分类号： C07D403/10 , C07D403/08 , A61K31/4178 , A61P9/12
摘要： PURPOSE: A novel compound is provided to prevent or treat hypertension, arteriosclerosis, and bleeding heart failure. CONSTITUTION: An olmesartan cilexetil is denoted chemical formula 1. A pharmaceutical composition for preventing or treating hypertension, breeding heart failure, or arteriosclerosis contains olmesartan cilexetil or pharmaceutically acceptable salt thereof. The pharmaceutical composition is solid or liquid formulation. The solid formulation is powder, granule, tablet, capsule, and suppository. The liquid formulation is water, and propylene glycol.
摘要翻译：目的：提供一种新型化合物，用于预防或治疗高血压，动脉硬化和心力衰竭。组合物：奥美沙坦cilexetil表示为化学式1.用于预防或治疗高血压，心脏衰竭或动脉硬化的药物组合物含有奥美沙坦cilexetil或其药学上可接受的盐。药物组合物是固体或液体制剂。固体制剂为粉末，颗粒，片剂，胶囊和栓剂。液体制剂是水和丙二醇。

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