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1. 发明公开

KR1020120015158A 디플로르에토하이드록시카르마롤 화합물을 유효성분으로 함유하는 방사선 방호용 조성물 无效
标题翻译：包含DIPHLORETHOHYDROXYCARMALOL用于辐射防护的组合物
公开(公告)号：KR1020120015158A
公开(公告)日：2012-02-21
申请号：KR1020100077439
申请日：2010-08-11
申请人： 제주대학교 산학협력단 , 재단법인 제주테크노파크
发明人： 신태균 , 현진원 , 주홍구 , 지영흔 , 박재우 , 이남호 , 양원준 , 안미정 , 고려경 , 김기옥
IPC分类号： C07D319/24 , A61K36/03 , A61K31/357 , A61P35/00
摘要： PURPOSE: A radiation protective composition containing diphlorethohydroxycarmalol is provided to suppress cell apoptosis and to enhance hematogenesis and immunity. CONSTITUTION: A radiation protective composition contains DHPC(diphlorethohydroxycarmalol) of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The compound is derived from Ishigeaceae plants. The composition also contains Ishigeaceae plant extract as an active ingredient. The Ishigeaceae plant is Ishige okamurae. The extract is prepared using water, methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate, methylana chloride, n-hexane, acetic acid, formic acid, citric acid, or cyclo hexane.
摘要翻译：目的：提供一种含有双轴羟基卡马洛的辐射防护组合物，以抑制细胞凋亡，增强血液发生和免疫。构成：辐射防护组合物含有化学式1的DHPC（二
色柔和羟基卡马拉）或其药学上可接受的盐作为活性成分。该化合物衍生自石ae科植物。该组合物还含有菊科植物提取物作为活性成分。石斛科植物是Ishige okamurae。萃取液用水，甲醇，乙醇，丙醇，异丙醇，丁醇，丙酮，乙醚，苯，氯仿，乙酸乙酯，甲基丙烯酰氯，正己烷，乙酸，甲酸，柠檬酸或环己烷制备。

2. 发明授权

KR101007515B1 안페논이 함유된 더위지기 추출분획조성물 有权
标题翻译： AR IA IA I I I I ONE ONE ONE ONE ONE ONE ONE ONE ONE ONE ONE
公开(公告)号：KR101007515B1
公开(公告)日：2011-01-14
申请号：KR1020080062451
申请日：2008-06-30
申请人： 제주대학교 산학협력단
发明人： 현진원 , 정하숙 , 박재우 , 이남호 , 신태균 , 지영흔
IPC分类号： A61K36/282 , A61K31/7034
摘要： 본 발명은 안페논(Annphenone)이 함유된 더위지기 추출분획조성물에 관한 것이다.
본 발명의 안페논(Annphenone)이 함유된 더위지기 추출분획조성물은 더위지기(
Artemisia
iwayomogi )을 메탄올로 추출하고, 이 메탄올 추출물을 헥산과 물로 분배추출한 후, 분리된 물층에 극성이 다른 용매인 클로로포름과 에틸아세테이트, 부탄올을 넣고 순차적으로 분배추출하여 용매분획물을 제조한 후, 그 중 에틸아세테이트 분획물을 크로마토그래피를 이용하여 분획하고, 이 분획물을 헥산으로 정제하여 제조된다.
본 발명에 의해 항산화효과 및 세포보호효과를 갖는 안페논(Annphenone) 성분이 함유된 더위지기 추출분획조성물이 제공된다.
안페논, 더위지기, 항산화, 세포보호, 활성산소종, 아폽토시스

3. 发明授权

KR100791100B1 푸코이단을 유효성분으로 함유하는 방사선 방호용 조성물 有权
标题翻译：包含有效FUCOIDAN的辐射防护组合物
公开(公告)号：KR100791100B1
公开(公告)日：2008-01-04
申请号：KR1020070001206
申请日：2007-01-05
申请人： 제주대학교 산학협력단
发明人： 신태균 , 주홍구 , 지영흔 , 박재우 , 현진원 , 이남호 , 이지영 , 김미형
IPC分类号： A61K31/737
CPC分类号： A61K31/737 , A61K2121/00 , Y10S514/917
摘要： A radiation protective composition comprising fucoidan is provided to protect the radiation excellently, thereby preventing the decrease of circulatory leukocyte count and the death of bone marrow cells in accordance with the application of the radiation. A composition for protecting radiation comprises fucoidan which is prepared by dissolving fucoidan in phosphate buffer saline(PBS) as an effective ingredient, wherein the 1-10mg of fucoidan is dissolved in 1ml of the PBS.
摘要翻译：提供包含岩藻依聚糖的辐射防护组合物以保护辐射，从而根据辐射的应用防止循环白细胞计数减少和骨髓细胞死亡。用于保护辐射的组合物包括通过将岩藻依聚糖溶解在磷酸盐缓冲盐水（PBS）中作为有效成分制备的岩藻依聚糖，其中将1-10mg岩藻依聚糖溶解在1ml PBS中。

4. 发明公开

KR1020100124359A 수련 추출분획물에서 분리한 제라닌을 유효성분으로 함유하는 방사선 방호용 조성물 失效
标题翻译：辐射防护组合物包括吉非宁分离的NYMPHAEA TETRAGONA提取物
公开(公告)号：KR1020100124359A
公开(公告)日：2010-11-29
申请号：KR1020090043313
申请日：2009-05-19
申请人： 제주대학교 산학협력단
发明人： 지영흔 , 이남호 , 신태균 , 현진원 , 박재우 , 박은진 , 김민주
IPC分类号： A61K31/70 , A61K36/62 , A61P39/00 , A61P37/00
CPC分类号： A61K31/7048 , A61K36/62 , A61K2236/33 , A61K2236/55 , Y10S514/917
摘要： PURPOSE: A radiation radioprotective composition containing geraniin isolated from Nymphaea tetragona var. angusta extract fraction is provided to promote protection and recovery of hematopoietic system and to suppress oxidative cell damage. CONSTITUTION: A radiation radioprotective composition contains 0.001-10.0 weight% of geraniin as an active ingredient. The geraniin is isolated from Nymphaea tetragona var. angusta extract fraction. A method for isolating geraniin comprises: a step of preparing Nymphaea tetragona var. angusta in a powdery form and suspending with distilled water; a step of fractioning with hexane, ethyl acetoacetate, butanol, and water; a step of fractioning with methylene chloride, diethyl ether, ethyl acetate, and acetone; and a step of isolating geraniin by column chromatography.
摘要翻译：目的：从Nymphaea tetragona var。中分离出含有geraniin的辐射放射防护组合物。提供angusta提取物级分以促进造血系统的保护和恢复并抑制氧化细胞损伤。构成：辐射放射防护组合物含有0.001-10.0重量％的吉拉宁作为活性成分。 er in属从Nymphaea tetragona var。 angusta提取物级分。分离geraniin的方法包括：制备Nymphaea tetragona var。 angusta为粉状，用蒸馏水悬浮; 用己烷，乙酰乙酸乙酯，丁醇和水分级的步骤; 用二氯甲烷，乙醚，乙酸乙酯和丙酮分馏的步骤; 和通过柱色谱法分离geraniin的步骤。

5. 发明授权

KR100686251B1 감마선 방호용의 트리플로레톨-에이가 함유된 분획물과 그제조방법 有权
标题翻译： 감마선방호용의트리플로레톨 - 에이가함유된분획물과그제조방감
公开(公告)号：KR100686251B1
公开(公告)日：2007-02-26
申请号：KR1020050120427
申请日：2005-12-09
申请人： 제주대학교 산학협력단
发明人： 이남호 , 박재우 , 현진원
IPC分类号： A61K36/03 , A61K31/05 , A61P17/18
摘要： A fraction containing triphlorethol-A for radioprotection of a subject from gamma-ray and a preparation method thereof are provided to remove reactive oxygen species produced by irradiation of gamma-ray, protect plasma membrane lipid peroxidation and cell DNA damage induced by gamma-ray, and reduce apoptosis by gamma-ray. A composition for radioprotection of a subject from gamma-ray comprises the fraction of Ecklonia cava containing triphlorethol-A, wherein the fraction of Ecklonia cava containing triphlorethol-A is prepared by pulverizing the dried Ecklonia cava, dipping Ecklonia cava powder in 80% methanol at 20-25 deg.C for 2 days and filtering it to prepare methanol extract of Ecklonia cava, fractionating the methanol extract of Ecklonia cava with ethylacetate and water, extracting the ethylacetate fraction with diethylether to prepare the diethylether fraction, and adding chloroform and methanol into the diethylether fraction and subjecting the mixture to column chromatography.
摘要翻译：本发明提供含有用于伽马射线辐射防护的三氯苯甲醇-A的组分及其制备方法，以除去由γ射线照射产生的活性氧种类，保护由γ射线诱导的质膜脂质过氧化和细胞DNA损伤，并通过γ射线减少细胞凋亡。用于从γ射线辐射保护受试者的组合物包含含有三氯乙醇-A的Ecklonia cava级分，其中通过粉碎干燥的Ecklonia cava，将Ecklonia cava粉末浸入80％甲醇中制备含有三氯乙醇-A的级分Ecklonia cava 20-25℃2天，过滤后制备Ecklonia cava的甲醇提取物，乙酸乙酯和水分馏乙醇提取物，乙醚萃取乙酸乙酯部分，制备二乙醚部分，加入氯仿和甲醇二乙醚部分并将混合物进行柱色谱。

6. 发明授权

KR100791108B1 방사선 방호효과를 갖는 담팔수 분획농축물과 그 제조방법 失效
标题翻译：具有辐射防护效应的ELAEOCARPUS SYLVESTRIS分类及其制备方法
公开(公告)号：KR100791108B1
公开(公告)日：2008-01-03
申请号：KR1020060108652
申请日：2006-11-06
申请人： 제주대학교 산학협력단
发明人： 이남호 , 지영흔 , 박은진 , 백종석 , 박재우 , 신태균 , 현진원 , 주홍구
IPC分类号： A61K36/185
摘要： A method for preparing a fraction concentrate of Elaeocarpus sylvestris var. ellipticus is provided to be able to obtain the fraction which is able to inhibit the lymphocyte damage by the radioactive rays irradiation and the apoptosis of tissue cells. A method for preparing a fraction concentrate of Elaeocarpus sylvestris var. ellipticus comprises the steps of: (a) after drying branch of Elaeocarpus sylvestris var. ellipticus in the shade, finely cutting it to prepare Elaeocarpus sylvestris var. ellipticus finely cut materials; (b) after precipitating the prepared cut materials in 70% ethanol at a temperature of 20-25 deg.C for 20-24 hours, filtering it using a filtering device under reduced pressure to prepare an ethanol extract; (c) concentrating the ethanol extract under reduced pressure to prepare a concentrate solution; (d) after suspending the concentrate solution with distilled water and putting 0.5-2 liters of hexane in 1 liter of the suspension with agitation, separating a hexane layer using a separatory funnel to obtain the remaining water layer; (e) after putting 0.5-2 liters of ethylacetate in 1 liter of the water layer with agitation, separating an ethylacetate layer using a separatory funnel; (f) concentrating the ethylacetate layer under reduced pressure to prepare an ethylacetate concentrate solution; and (g) after mixing the ethylacetate concentrate solution with sellaite and charging a column with the mixture, obtaining an ethylacetate fraction using ethylacetate as a developing solvent and then concentrating the fraction to obtain the fraction concentrate of Elaeocarpus sylvestris var. ellipticus.
摘要翻译：一种制备Elaeocarpus sylvestris变种的级分浓缩物的方法提供椭圆体以能够获得能够通过放射线照射和组织细胞凋亡抑制淋巴细胞损伤的级分。一种制备Elaeocarpus sylvestris变种的级分浓缩物的方法椭圆形包括以下步骤：（a）干燥榆树的分枝后，椭圆形在阴凉处，精细切割，准备榆树。椭圆形细切材料; （b）在20-25℃的温度下将制备的切割材料在70％乙醇中沉淀20-24小时后，使用过滤装置在减压下过滤以制备乙醇提取物; （c）减压浓缩乙醇提取物以制备浓缩液; （d）用蒸馏水悬浮浓缩液后，在搅拌下将0.5-2升己烷置于1升悬浮液中，用分液漏斗分离己烷层，得到剩余的水层; （e）在搅拌下将0.5-2升乙酸乙酯置于1升水层中后，使用分液漏斗分离乙酸乙酯层; （f）减压浓缩乙酸乙酯层以制备乙酸乙酯浓缩液; 和（g）在将乙酸乙酯浓缩液与矾土混合并向混合物中加入柱子后，用乙酸乙酯作为展开溶剂获得乙酸乙酯部分，然后浓缩该级分以获得El the the the的级分浓缩物。 ellipticus。

7. 发明公开

KR1020130010604A 트리플로레톨-에이 화합물을 유효성분으로 포함하는 자외선에 의한 피부세포 손상 보호 및 치료용 조성물 无效
标题翻译：包含TRIPHLORETHOL-A的组合物用于保护和固化由超紫外线损伤的杀伤细胞
公开(公告)号：KR1020130010604A
公开(公告)日：2013-01-29
申请号：KR1020110071332
申请日：2011-07-19
申请人： 제주대학교 산학협력단
发明人： 현진원 , 이남호 , 박재우
IPC分类号： A61K31/05 , A61K31/045 , A61P17/00
摘要： PURPOSE: A triphlorethol-A compound which protects skin cells from UV ray is provided to suppress reactive oxygen species(ROS) generation and DNA damage due to UV ray and cell apoptosis and to enhance antioxidant enzyme(SOD, CAT) activity. CONSTITUTION: A composition for preventing and treating skin cell damage due to UV ray contains triphlorethol-A compound of chemical formula as an active ingredient. The compound is extracted from Ecklonia cava. The compound suppresses caspase-dependent pathway through mictochondria and prevents or suppresses skin cell apoptosis. A food composition for protecting skin cell damage due to UV ray contains the compound as an active ingredient. A cosmetic composition for protecting skin cell damage due to UV ray contains the compound as an active ingredient.
摘要翻译：目的：提供保护皮肤细胞免受紫外线影响的三叶醇A化合物，以抑制由于紫外线和细胞凋亡引起的活性氧（ROS）产生和DNA损伤，并增强抗氧化酶（SOD，CAT）活性。构成：用于预防和治疗由于紫外线引起的皮肤细胞损伤的组合物含有作为活性成分的化学式的三氟乙烯 - A化合物。该化合物从Ecklonia cava中提取。该化合物通过微型软骨细胞抑制胱天蛋白酶依赖性途径，并预防或抑制皮肤细胞凋亡。用于保护由于紫外线引起的皮肤细胞损伤的食品组合物含有作为活性成分的化合物。用于保护由于紫外线引起的皮肤细胞损伤的化妆品组合物含有作为活性成分的化合物。

8. 发明授权

KR101100126B1 수련 추출분획물에서 분리한 제라닌을 유효성분으로 함유하는 방사선 방호용 조성물 失效
标题翻译：辐射防护组合物包括吉非宁分离的NYMPHAEA TETRAGONA提取物
公开(公告)号：KR101100126B1
公开(公告)日：2011-12-29
申请号：KR1020090043313
申请日：2009-05-19
申请人： 제주대학교 산학협력단
发明人： 지영흔 , 이남호 , 신태균 , 현진원 , 박재우 , 박은진 , 김민주
IPC分类号： A61K31/70 , A61K36/62 , A61P39/00 , A61P37/00
摘要： 본 발명은 수련 추출분획물에서 분리한 제라닌을 유효성분으로 함유하는 방사선 방호용 조성물에 관한 것이다.
본 발명의 제라닌(Geraniin)은, 수련(
Nymphaea tetragona )을 분말형태로 제조한 후, 이를 알코올로 추출한 다음 증류수로 현탁시킨 후, 헥산(Hexane), 에틸아세테이트(Ethyl acetate), 부탄올(Butanol), 물(Water)로 용매분획한 다음, 이 용매분획물들 중 에틸아세테이트 분획물을 다시 메틸렌클로라이드(Methylene chloride), 디에틸에테르(Diethyl ether), 에틸아세테이트(Ethyl acetate), 아세톤(acetone)으로 용매분획한 후, 얻어진 디에틸에테르 분획물을 컬럼크로마토그래피로 분획하여 획득하는 것으로 구성된다.
본 발명에 의해, 수련 추출분획물에서 분리되어 뛰어난 방사선 방호효과를 갖는 제라닌(Geraniin)을 유효성분으로 함유하는 방사선 방호용 조성물이 제공된다.
수련, 추출물, 제라닌, 방사선, 방호효과

9. 发明公开

KR1020110132854A 시로미 추출물을 포함하는 방사선 방호용 조성물 无效
标题翻译：包含真空度的组合物。日本提取物防止辐射
公开(公告)号：KR1020110132854A
公开(公告)日：2011-12-09
申请号：KR1020100052424
申请日：2010-06-03
申请人： 제주대학교 산학협력단
发明人： 현진원 , 강경아 , 박재우
IPC分类号： A61K36/185 , A61P39/06
CPC分类号： A61K36/185 , C09K15/34 , Y10S514/917
摘要： PURPOSE: A composition containing Empetrum nigrum var. japonicum extract for radiation protection is provided to suppress ROS(reactive oxygen species) generation and recover antioxidative elements. CONSTITUTION: A composition for radiation protection contains Empetrum nigrum var. japonicum extract as an active ingredient. The Empetrum nigrum var. japonicum extract is prepared using water or organic solvent. The radiation is gamma-irradiation. The radiation protection is caused by promoting antioxidative activity of tissues or cells in the body. The radiation protection includes suppression of intracellular DNA damage, lipid peroxidation, or protein deformation.
摘要翻译：目的：含有Empetrum nigrum var。提供用于辐射防护的日本提取物以抑制ROS（活性氧）产生并回收抗氧化元素。构成：辐射防护用组合物含有Empetrum nigrum var。日本提取物作为活性成分。 Empetrum nigrum var。使用水或有机溶剂制备日本提取物。辐射是γ射线。辐射防护是通过促进身体组织或细胞的抗氧化活性引起的。辐射防护包括抑制细胞内DNA损伤，脂质过氧化或蛋白质变形。

10. 发明公开

KR1020100002528A 안페논이 함유된 더위지기 추출분획조성물 有权
标题翻译： AR IA IA I I I I ONE ONE ONE ONE ONE ONE ONE ONE ONE ONE ONE
公开(公告)号：KR1020100002528A
公开(公告)日：2010-01-07
申请号：KR1020080062451
申请日：2008-06-30
申请人： 제주대학교 산학협력단
发明人： 현진원 , 정하숙 , 박재우 , 이남호 , 신태균 , 지영흔
IPC分类号： A61K36/282 , A61K31/7034
CPC分类号： A61K36/282 , A23L29/035 , A61K8/602 , A61K8/97 , A61K31/7034 , A61K2236/33 , A61K2236/55
摘要： PURPOSE: An Artemisia iwayomogi extract fraction composition containing annphenone is provided to suppress ROS generation and enhance antioxidase activation. CONSTITUTION: A method for preparing Artemisia iwayomogi extract fraction composition comprises: a step of extracting the Artemisia iwayomogi with methanol and extracting with hexane and water; a step of fractioning with chloroform, ethylacetate, and butanol; a step of fractioning the ethylacetate fraction through chromatography; and a step of purifying the fraction with hexane to obtain the Artemisia iwayomogi extract fraction composition. A food additive, beverage composition, functional health food or cosmetic composition contains the Artemisia iwayomogi extract fraction composition.
摘要翻译：目的：提供含有苯乙酮的青蒿提取物组分，以抑制ROS的产生并增强抗氧化酶活性。构成：制备蒿木提取物组分的方法包括：用甲醇萃取青蒿素并用己烷和水萃取的步骤; 用氯仿，乙酸乙酯和丁醇分级的步骤; 通过色谱分离乙酸乙酯级分的步骤; 和用己烷纯化该级分以获得蒿木蒿提取物组分的步骤。食品添加剂，饮料组合物，功能保健食品或化妆品组合物含有蒿蒿提取物组分。

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