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1. 发明公开

KR1020100000203A 금나노입자를 이용한 표적지향형 항암약물전달체 无效
标题翻译：使用非专利药物的抗癌药物的目标递送系统
公开(公告)号：KR1020100000203A
公开(公告)日：2010-01-06
申请号：KR1020080059611
申请日：2008-06-24
申请人： 인하대학교 산학협력단
发明人： 김철희 , 박치영 , 김하나 , 박헌주 , 최은경
IPC分类号： A61K9/24 , A61K47/40 , B82Y5/00 , A61P35/00
CPC分类号： A61K47/60 , A61K31/122 , A61K31/352 , A61K33/00 , A61K47/61 , A61K47/6851 , B82Y5/00
摘要： PURPOSE: A targeted anti-cancer drug delivery system using gold nanoparticle is provided to prevent chemical modification and effectively deliver B-lapachone to cancer cells. CONSTITUTION: An anti-cancer drug delivery system contains: a gold nanoparticle, a polyethyleneglycol coated on the surface of gold nanoparticle, cyclodextrin for collecting drug, and an anti-epidermal growth factor receptor which is a targeted ligand of cancer cell. The polyethyleneglycol is thiolated polyethyleneglycol or methoxy-poly(ethyleneglycolsulfhydryl) which is activated with N-hydroxy succinimide. The cyclodextrin is per-6-thio-B-cyclodextrin. The delivery drug of anti-cancer drug deilivery system is B-lapachone. A method for preparing the anti-cancer drug delivery system using the gold nanoparticle comprises: a step of preparing gold nanoparticle solution; a step of adding the thiolated polyethyleleglycol or methoxy-poly(ethyleneglycolsulfhydryl), and per-6-thio-B-cyclodextrin to coat the gold nanoparticle; and a step of introducing anti-epidermal growth factor receptor on the gold nanoparticle to produce the anti-cancer drug delivery system.
摘要翻译：目的：提供使用金纳米颗粒的靶向抗癌药物递送系统，以防止化学修饰并有效地将B- lapachone递送至癌细胞。构成：抗癌药物递送系统包括：金纳米颗粒，涂覆在金纳米颗粒表面上的聚乙二醇，用于收集药物的环糊精和作为癌细胞靶向配体的抗表皮生长因子受体。聚乙二醇是用N-羟基琥珀酰亚胺活化的硫醇化聚乙二醇或甲氧基 - 聚（乙二醇硫醇）。环糊精是6-硫代-β-环糊精。抗癌药物治疗系统的运送药物是B-lapachone。制备使用金纳米颗粒的抗癌药物递送系统的方法包括：制备金纳米颗粒溶液的步骤; 加入硫醇化的聚乙二醇或甲氧基 - 聚（乙二醇硫酸酯）和每6-硫代-B-环糊精包衣金纳米颗粒的步骤; 以及在金纳米颗粒上引入抗表皮生长因子受体以产生抗癌药物递送系统的步骤。

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