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1. 发明授权

KR101558042B1 로티고틴을 함유한 경피흡수제제 有权
标题翻译：含罗替戈汀的经皮吸收制剂
公开(公告)号：KR101558042B1
公开(公告)日：2015-10-07
申请号：KR1020130079198
申请日：2013-07-05
申请人： 에스케이케미칼주식회사
发明人： 김혜민 , 황용연 , 윤원노 , 박여진 , 오준교 , 임종섭 , 김훈택
IPC分类号： A61K9/70 , A61K31/381
CPC分类号： A61K47/12 , A61K9/0014 , A61K9/7053 , A61K31/381 , A61K47/10 , A61K47/14 , A61K47/32
摘要： 본발명은로티고틴결정을방지하는방법에관한것으로, 더욱상세하게는로티고틴을지방알콜, 지방산, 지방산에스테르, 지방산아미드및 이의유도체로이루어진군에서선택된하나이상의결정방지제와혼합하는단계를포함하는로티고틴결정석출방지방법, 로티고틴및 결정방지제를포함하는경피흡수제제에관한것이다. 본발명의방법및 시스템은로티고틴의석출을방지하여, 장기보관안정성을증가시키므로로티고틴함유패치제등의제조에효과적으로적용할수 있다.
摘要翻译：本发明洛蒂涉及一种方法，用于防止罗替戈汀的晶体，更具体地，包括选自由以下组成的罗替戈汀是脂肪醇，脂肪酸，脂肪酸酯，脂肪酸酰胺和它们的衍生物组成的组中混合所选择的至少一个确定剂的步骤罗替戈汀结晶防止法，罗替戈汀和结晶抑制剂。本发明的方法和系统是为了防止罗替戈汀的沉淀，提高了长期的储存稳定性可以被应用于有效地含有罗替高汀的贴剂的制造。

2. 发明授权

KR101239150B1 도네페질-함유 경피흡수제제 및 그의 제조방법 有权
标题翻译：含有二苯并呋喃的透皮递送系统及其制备方法
公开(公告)号：KR101239150B1
公开(公告)日：2013-03-06
申请号：KR1020120020510
申请日：2012-02-28
申请人： 에스케이케미칼주식회사
发明人： 임종섭 , 황용연 , 윤원노 , 박여진 , 김혜민 , 오준교 , 김훈택 , 이봉용
IPC分类号： A61K9/70 , A61K31/445
CPC分类号： A61K9/7084 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K31/445
摘要： PURPOSE: A donepezil-containing transdermal formulation and a method for manufacturing the same are provided to prevent the excessive release of donepezil and to control the release thereof. CONSTITUTION: A donepezil-containing transdermal formulation contains a support layer, a drug-containing matrix layer, an adhesive layer, and an exfoliation layer. The drug-containing matrix layer contains a salt, polyvinyl pyrrolidone, and an acryl-based adhesive. The adhesive layer contains a silicon-based adhesive. The thickness of the adhesive layer is 50-150 um. [Reference numerals] (AA) Embodiment 3-1 5cm2; (BB) Embodiment 3-1 10cm2; (CC) Comparative embodiment 1
摘要翻译：目的：提供含多奈哌齐的透皮制剂及其制造方法，以防止多奈哌齐的过量释放并控制其释放。构成：含多奈哌齐的透皮制剂含有支持层，药物基质层，粘合剂层和剥离层。含药基质层含有盐，聚乙烯吡咯烷酮和丙烯酸类粘合剂。粘合剂层包含硅基粘合剂。粘合剂层的厚度为50-150μm。（标号）（AA）实施例3-1 5cm2; （BB）实施例3-1 10cm2; （CC）比较实施例1

3. 发明公开

KR1020110094858A 피부 자극이 감소한 톨테로딘의 경피 투여용 조성물 无效
标题翻译：具有低皮肤刺激用于转铁蛋白转运的组合物
公开(公告)号：KR1020110094858A
公开(公告)日：2011-08-24
申请号：KR1020100014551
申请日：2010-02-18
申请人： 에스케이케미칼주식회사
发明人： 황용연 , 최원재 , 김재선 , 박여진 , 오준교 , 이봉용 , 이해인 , 임종섭
IPC分类号： A61K9/70 , A61K47/44 , A61K31/137 , A61K31/167
CPC分类号： A61K31/137 , A61K9/7061 , A61K47/44 , A61K9/7023 , A61K31/167
摘要： PURPOSE: A tolterodine composition for transdermal administration is provided to relieve skin irritation and to be commercially used. CONSTITUTION: A tolterodine composition for transdermal administration contains essential oil for relieving skin irritation. Tolterodine is a free base form. The essential oil is contains 1-300 weight parts based on 100 weight parts of tolterodine. The essential oil is limonene, eugenol, geraniol, bisabolol, or eucalyptol. The composition additionally contains lidocaine or pharmaceutically acceptable salt thereof.
摘要翻译：目的：提供用于透皮给药的托特罗定组合物，以缓解皮肤刺激和商业用途。构成：用于透皮给药的托特罗定组合物含有用于缓解皮肤刺激的精油。托特罗定是一种游离碱形式。基于100重量份托特罗定，精油含有1-300重量份。精油是柠檬烯，丁子香酚，香叶醇，红没药醇或桉油醇。组合物另外含有利多卡因或其药学上可接受的盐。

4. 发明公开

KR1020130098902A 도네페질-함유 경피흡수제제 및 그의 제조방법 有权
标题翻译：含有二苯并呋喃的透皮递送系统及其制备方法
公开(公告)号：KR1020130098902A
公开(公告)日：2013-09-05
申请号：KR1020130010369
申请日：2013-01-30
申请人： 에스케이케미칼주식회사
发明人： 임종섭 , 황용연 , 윤원노 , 박여진 , 김혜민 , 오준교 , 김훈택 , 이봉용
IPC分类号： A61K9/70 , A61K31/445 , A61K47/22 , A61K47/02
CPC分类号： A61K9/7084 , A61K31/445 , A61K47/32 , A61K2121/00
摘要： PURPOSE: A transdermal formulation is provided to enable long-term release of donepezil in a constant rate and to prevent dose dumping. CONSTITUTION: A transdermal formulation comprises a support layer, a drug-containing matrix layer, an adhesion layer, and a release layer. The drug-containing matrix contains donepezil or a pharmaceutically acceptable salt thereof as an active ingredient, polyvinylpyrrolidone, and an acryl-based adhesive. The adhesion layer contains the acryl-based adhesive. A method for manufacturing the transdermal formulation comprises the steps of: dissolving the acryl-based adhesive in a solution containing donepezil or the pharmaceutical salt and polyvinylpyrrolidone; applying the prepared solution on a film and drying the applied solution to form a drug-containing matrix layer; and forming the adhesion layer containing the acryl-based adhesive on the drug-containing matrix layer. [Reference numerals] (AA) Example 3-1 5 cm2; (BB) Example 3-1 10 cm2; (CC) Comparative example 1
摘要翻译：目的：提供透皮制剂，以便能够以恒定的速率长期释放多奈哌齐，并防止剂量倾倒。构成：透皮制剂包括支持层，含药基质层，粘附层和释放层。含药基质含有多奈哌齐或其药学上可接受的盐作为活性成分，聚乙烯吡咯烷酮和丙烯酸类粘合剂。粘合层含有丙烯酸类粘合剂。用于制造透皮制剂的方法包括以下步骤：将丙烯酸类粘合剂溶解在含有多奈哌齐或药物盐和聚乙烯吡咯烷酮的溶液中; 将制备的溶液涂布在膜上并干燥所施加的溶液以形成含药基质层; 并在含药基质层上形成含有丙烯酸系粘合剂的粘合层。（附图标记）（AA）实施例3-1 5cm 2; （BB）实施例3-1 10cm 2; （CC）比较例1

5. 发明公开

KR1020120130073A 리바스티그민 함유 패취 审中-实审
标题翻译：补丁包括利凡斯的明
公开(公告)号：KR1020120130073A
公开(公告)日：2012-11-28
申请号：KR1020120053447
申请日：2012-05-21
申请人： 에스케이케미칼주식회사
发明人： 황용연 , 최원재 , 김재선 , 윤원노 , 박여진 , 오준교 , 임종섭
IPC分类号： A61K9/70 , A61F13/02 , A61L15/44 , A61K31/325
CPC分类号： A61K9/7084 , A61K31/27 , A61K47/02 , A61K47/14
摘要： PURPOSE: A rivastigmine containing patch is provided to enhance stability and to express optimal emission pattern. CONSTITUTION: A rivastigmine containing patch comprises rivastigmine free base, a copolymer including butyl methacrylate and methylmethacrylate; and drug adhesive layer manufactured by using adhesive, and double layer of skin adhesive layer which includes silicon gluing agent. As adhesive of the drug adhesive layer, 58-66 parts by weight of 2- ethylhexylacrylat, 28-36 parts by weight of random copolymer and a random copolymer of 4-8 parts by weight of acrylic acid are used. The DURO-TAK™ 87-235A (henkel corp) is used as the adhesive of the drug adhesive layer. The copolymer of the methylmethacrylate and butyl methacrylate is the random copolymer of the methylmethacrylate and butyl methacrylate, and has the weight-average molecular weight of 130,000-170,000 g/mol.
摘要翻译：目的：提供含有维生素B的贴片，以增强稳定性和表达最佳发射模式。构成：含有伐罗斯的明的贴剂包括利凡斯的明游离碱，包括甲基丙烯酸丁酯和甲基丙烯酸甲酯的共聚物; 和使用粘合剂制造的药物粘合剂层，以及包含硅胶粘剂的双层皮肤粘合剂层。作为药物粘合剂层的粘合剂，使用58-66重量份2-乙基己基丙烯酸酯，28-36重量份无规共聚物和4-8重量份丙烯酸的无规共聚物。 DURO-TAK＆贸易; 87-235A（henkel corp）用作药物粘合剂层的粘合剂。甲基丙烯酸甲酯和甲基丙烯酸丁酯的共聚物是甲基丙烯酸甲酯和甲基丙烯酸丁酯的无规共聚物，重均分子量为130,000-170,000g / mol。

6. 发明授权

KR101770675B1 도네페질-함유 경피흡수제제 및 그의 제조방법 有权
标题翻译：含多奈哌齐的透皮制剂及其制备方法
公开(公告)号：KR101770675B1
公开(公告)日：2017-08-23
申请号：KR1020130010369
申请日：2013-01-30
申请人： 에스케이케미칼주식회사
发明人： 임종섭 , 황용연 , 윤원노 , 박여진 , 김혜민 , 오준교 , 김훈택 , 이봉용
IPC分类号： A61K9/70 , A61K31/445 , A61K47/22 , A61K47/02
摘要： 본발명은도네페질을특정중합체를사용하여완전히용해시켜점착제와함께제제화한약물-함유매트릭스층및 점착층을갖는이중층구조의경피흡수제제(예를들어, 패치(patch) 형태의경피흡수제제) 및그의제조방법을제공한다. 본발명에따른경피흡수제제는제제내에서도네페질의석출을나타내지않으면서, 장시간동안균일한속도로도네페질을방출할수 있을뿐만아니라, 단일층구조의경피흡수제제에서발생하는방출과다(release dumping) 현상을방지할수 있다.
摘要翻译：本发明是多奈哌齐，通过使用特定的聚合物的药物配制与含粘合剂的基质层，和（经皮吸收制剂的即G.，补丁（补丁）形式），将具有粘合剂层的透皮制剂的双层结构的完全溶解及其制造方法。根据本发明的经皮吸收制剂，而不表现出NEPE查询甚至在制剂中析出，不仅可以以均匀的速率发射多奈哌齐对于长时间如，释放过在一单层结构现象的经皮吸收制剂中产生（释放倾倒）可以预防。

7. 发明公开

KR1020140006729A 로티고틴 함유 경피흡수제제 有权
标题翻译：包含ROTIGOTINE的透皮组合物
公开(公告)号：KR1020140006729A
公开(公告)日：2014-01-16
申请号：KR1020130079879
申请日：2013-07-08
申请人： 에스케이케미칼주식회사
发明人： 김혜민 , 황용연 , 윤원노 , 박여진 , 오준교 , 임종섭 , 김훈택
IPC分类号： A61K9/70 , A61K31/381
CPC分类号： A61K9/0014 , A61K9/7023 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K31/381 , A61K47/32
摘要： The present invention relates to a method for preparing a transdermal preparation comprising rotigotine as an active ingredient, and more particularly, to a method for preparing a transdermal preparation, comprising a step of mixing rotigotine and an ethylene-vinyl acetate adhesive at a weight ratio of 1:0.1 to 20. Further, the present invention relates to a transdermal preparation prepared by the method and a transdermal therapeutic system. The preparation and system of the present invention prevent the precipitation of rotigotine to improve the long-term storage stability and effectively release the rotigotine, and thus can be effectively applied in the preparation of rotigotine-containing patches. [Reference numerals] (AA) Sample 1; (BB) Sample 2; (CC) Sample 3; (DD) Sample 4
摘要翻译：本发明涉及一种制备包含罗替戈汀作为活性成分的透皮制剂的方法，更具体地说，涉及一种制备透皮制剂的方法，包括将罗替戈汀和乙烯 - 乙酸乙烯酯粘合剂以重量比 1：0.1〜20。此外，本发明涉及通过该方法制备的透皮制剂和透皮治疗系统。本发明的制剂和系统可防止罗替戈汀的沉淀，从而提高长期保存稳定性，有效释放罗替戈汀，可有效应用于含有罗替戈汀的贴剂。（附图标记）（AA）样品1; （BB）样品2; （CC）样品3; （DD）样品4

8. 发明公开

KR1020140006727A 로티고틴을 함유한 경피흡수제제 有权
标题翻译：包含ROTIGOTINE的透皮组合物
公开(公告)号：KR1020140006727A
公开(公告)日：2014-01-16
申请号：KR1020130079198
申请日：2013-07-05
申请人： 에스케이케미칼주식회사
发明人： 김혜민 , 황용연 , 윤원노 , 박여진 , 오준교 , 임종섭 , 김훈택
IPC分类号： A61K9/70 , A61K31/381
CPC分类号： A61K47/12 , A61K9/0014 , A61K9/7053 , A61K31/381 , A61K47/10 , A61K47/14 , A61K47/32
摘要： The present invention relates to a method for preventing the crystallization of rotigotine. Further, the present invention relates to a method for preventing the precipitation of rotigotine crystals, wherein the method comprises a step of mixing rotigotine with at least one selected from the group consisting of fatty alcohols, fatty acids, fatty acid esters, fatty acid amides, and derivatives thereof. Further, the present invention relates to a transdermal preparation comprising rotigotine and a crystallization inhibitor. The methods and systems of the present invention prevent the precipitation of rotigotine to improve the long-term storage stability, and thus can be effectively applied in the preparation of rotigotine-containing patches. [Reference numerals] (140) Controller; (150) Alarm generator; (AA) Low-concentration odor; (BB) High-concentration odor
摘要翻译：本发明涉及一种防止罗替戈汀结晶的方法。此外，本发明涉及一种防止罗替戈汀晶体沉淀的方法，其中该方法包括将罗替戈汀与选自脂肪醇，脂肪酸，脂肪酸酯，脂肪酸酰胺，及其衍生物。此外，本发明涉及包含罗替戈汀和结晶抑制剂的透皮制剂。本发明的方法和系统防止罗替戈汀的沉淀以改善长期储存稳定性，因此可有效地应用于制备含有罗替戈汀的贴剂。（附图标记）（140）控制器; （150）报警发生器; （AA）低浓度气味; （BB）高浓度气味

9. 发明公开

KR1020120126898A 리바스티그민 또는 이의 염을 함유하는 경피 투여 조성물 无效
标题翻译：包含利凡斯的明或其盐的透皮组合物
公开(公告)号：KR1020120126898A
公开(公告)日：2012-11-21
申请号：KR1020110045023
申请日：2011-05-13
申请人： 에스케이케미칼주식회사
发明人： 황용연 , 최원재 , 김재선 , 윤원노 , 박여진 , 오준교 , 임종섭
IPC分类号： A61K31/325 , A61K31/195 , A61K9/70
CPC分类号： A61K31/27 , A61K9/0014 , A61K31/192 , A61K2300/00
摘要： PURPOSE: A transdermal composition containing rivastigmine or salt thereof with improved storage stability is provided to enable long-term storage. CONSTITUTION: A composition with improved storage stability contains rivastigmine or pharmaceutically acceptable salt thereof and gentisic acid. The composition is a transdermal composition applied to the skin. The composition also applied to a patch. The composition is used for treating Alzheimer's disease type dementia or Parkinson's disease type dementia.
摘要翻译：目的：提供具有改善的储存稳定性的含有伐罗斯的明或其盐的透皮组合物，以便能够长期储存。构成：具有改善的储存稳定性的组合物包含利伐斯的明或其药学上可接受的盐和龙胆酸。该组合物是施用于皮肤的透皮组合物。该组合物也适用于贴剂。该组合物用于治疗阿尔茨海默病型痴呆或帕金森病型痴呆。

10. 发明授权

KR101746204B1 피부 투과가 개선된 톨테로딘의 경피 투여용 조성물 有权
标题翻译：具有改善的皮肤渗透性的托特罗定透皮给药组合物
公开(公告)号：KR101746204B1
公开(公告)日：2017-06-13
申请号：KR1020100014554
申请日：2010-02-18
申请人： 에스케이케미칼주식회사
发明人： 황용연 , 최원재 , 김재선 , 박여진 , 오준교 , 이봉용 , 이해인 , 임종섭
IPC分类号： A61K9/70 , A61K31/137 , A61K31/167
CPC分类号： A61K9/7061 , A61K31/137 , A61K31/167 , A61K2300/00
摘要： 본발명은톨테로딘을함유한경피투여조성물에관한것으로서, 피부투과를증진시키기위하여리도카인또는이의약학적으로허용가능한염을포함하는것을특징으로한다. 본발명에의한경피투여조성물은톨테로딘의피부투과를증진시켜톨테로딘경피제제의상업적이용을기대할수 있게되었다.
摘要翻译：本发明涉及含有托特罗定的透皮组合物，其特征在于它含有利多卡因或其药学上可接受的盐以促进皮肤渗透。根据本发明的经皮给药组合物可以促进托特罗定的皮肤渗透并预期托特罗定透皮制剂的商业应用。

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