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1. 发明授权

KR100355482B1 큐맘브린 Ａ의 고혈압 치료제로서의 용도 失效
标题翻译： Cymbrene A作为高血压治疗剂的用途
公开(公告)号：KR100355482B1
公开(公告)日：2002-10-11
申请号：KR1020000006958
申请日：2000-02-15
申请人： 양민석 , 홍용근 , 박윤배 , 하태정 , 장대식 , 박기훈 , 남상해
发明人： 양민석 , 박윤배 , 남상해 , 장대식 , 하태정 , 홍용근 , 박기훈
IPC分类号： A61K36/28 , A61P9/12
摘要： 본 발명은 산국(Chrysantuemum boreale M.)으로부터 고혈압 치료제인 큐맘브린 A를 제조하는 방법 및 고혈압 치료제로서의 그의 용도에 관한 것이다.

2. 发明公开

KR1020010083448A 큐맘브린 Ａ의 고혈압 치료제로서의 용도 失效
标题翻译：用于治疗高血压的CAMAMBRIN的新型制剂
公开(公告)号：KR1020010083448A
公开(公告)日：2001-09-01
申请号：KR1020000006958
申请日：2000-02-15
申请人： 양민석 , 홍용근 , 박윤배 , 하태정 , 장대식 , 박기훈 , 남상해
发明人： 양민석 , 박윤배 , 남상해 , 장대식 , 하태정 , 홍용근 , 박기훈
IPC分类号： A61K36/28 , A61P9/12
摘要： PURPOSE: Provided is a novel preparation of cumambrin A which is prepared by extracting Chrysanthenum boreale M. And a pharmaceutical composition for the treatment of hypertension is also provided, which comprises the extracted cumambrin A as an active ingredient. CONSTITUTION: The preparation method of cumambrin A represented by the formula is characterized by extracting the petals or leaves of Chrysanthenum boreale M. with any solvent of 3 to 5 polar index, and if necessary, repeating at least a few times the extracting step. The solvent comprises preferably chloroform or ethyl acetate. The obtained extract may be purified by a conventional purification method of organic physiological active substances. The pharmaceutical composition comprising cumambrin A as an active ingredient can be formulated into various formulation types using conventional carriers. The formulation can be administered orally or parenterally, such as intravenous or intragastric injection. A dosage of the formulation ranges from 1 to 10 mg/kg body weight per a day. The pharmaceutical composition can be formulated into a form of tablet, syrup or solution for injection.
摘要翻译：目的：提供通过提取菊苣M制备的cumambrin A的新型制剂。还提供了用于治疗高血压的药物组合物，其包括提取的异丙肾上腺素A作为活性成分。构成：以下列化合物代表的番茄红素A的制备方法的特征在于用3至5种极性指数的任何溶剂提取菊花的花瓣或叶，如果需要，重复提取步骤的至少几次。溶剂优选为氯仿或乙酸乙酯。所得提取物可以通过常规的有机生理活性物质的纯化方法进行纯化。可以使用常规的载体将包含杂交布A作为活性成分的药物组合物配制成各种制剂类型。制剂可以口服或肠胃外给药，例如静脉内或胃内注射。制剂的剂量范围为每天1至10mg / kg体重。药物组合物可以配制成片剂，糖浆或注射溶液的形式。

3. 发明授权

KR100338479B1 암세포독성물질헤미스텝신B및그의분리방법 失效
标题翻译：癌细胞毒物hemistepine B及其分离方法
公开(公告)号：KR100338479B1
公开(公告)日：2002-07-18
申请号：KR1019980050781
申请日：1998-11-25
申请人： 박기훈 , 하태정 , 장대식 , 양민석
发明人： 양민석 , 장대식 , 하태정 , 박기훈
IPC分类号： C07D307/93
摘要： 지칭개 (
Hemistepta lyrata B.)로부터 신규 항암물질인 헤미스텝신 B (Hemistepsin B)가 분리되었다. 항암물질 헤미스텝신 B는 암세포 접착 저해 활성, 인체 암세포주인 UACC62 흑세포종 (melanoma), HCT15 결장암 (colon adenocarcinoma), UO-31 신장암 (renal carcinoma), PC-3 전립선암 (prostate adenocarcinoma) 및 A-549 폐암 (lung carcinoma) 세포주에 대한 세포 독성, 앤지오제네시스 저해 활성, 일산화질소의 방출 저해 활성이 있다.

4. 发明公开

KR1020000033768A 암세포독성물질헤미스텝신B및그의분리방법 失效
标题翻译： HEMISTEPSIN B及其分离方法
公开(公告)号：KR1020000033768A
公开(公告)日：2000-06-15
申请号：KR1019980050781
申请日：1998-11-25
申请人： 박기훈 , 하태정 , 장대식 , 양민석
发明人： 양민석 , 장대식 , 하태정 , 박기훈
IPC分类号： C07D307/93
摘要： PURPOSE: A novel anticancer substance, hemistepsin B, isolated from Hemistepta lyrat a B. is provided which has a cytotoxic effect on cell lines such as UACC62 melanoma, HCT15 colon adenocarcinoma, UO-31 renal carcinoma, PC-3 prostate adenocarcinoma and A-549 lung carcinoma, and anti abiogenesis activity and inhibition activity of NO production. CONSTITUTION: Hemistepsin B(formula (1)) is isolated from Hemistepta lyrat a B. by the following steps of: a) several times of extractions of dried and ground Hemistepta lyrat a B. with alcoholic solvent for about 24 hours; b) pressured condensation of filtered extract at about 40°C to obtain alcoholic solvent extract; c) several times of extractions and condensations with organic solvent such as chloroform after adding water into the condensed extract to suspend; d) silica-gel column chromatography of the extract by using the polarity of organic solvent to obtain the hemistepsin B. Column chromatography with different conditions can be carried out to purify the hemistepsin B if necessary.
摘要翻译：目的：提供从Hemistepta lyrat a B.分离的新型抗癌物质hemistepsin B，其对细胞系如UACC62黑素瘤，HCT15结肠腺癌，UO-31肾癌，PC-3前列腺腺癌和A- 549肺癌，抗生发活性和NO生成抑制活性。构成：Hemistepsin B（式（1））通过以下步骤从Hemistepta lyrat a B.B分离：a）几次提取干燥和研磨的Hemistepta，用乙醇溶剂与B.溶剂混合约24小时; b）在约40℃下过滤的提取物进行加压冷凝以得到醇溶剂提取物; c）将几份萃取液与有机溶剂如氯仿萃取并缩合后加入冷凝的萃取液中悬浮; d）通过使用有机溶剂的极性提取提取物的硅胶柱色谱法，得到hemistepsin B.如果需要，可以进行不同条件的柱色谱法纯化半溶蛋白B.

5. 发明公开

KR1020020074301A 컴퓨터 케이스 无效
标题翻译：电脑机箱
公开(公告)号：KR1020020074301A
公开(公告)日：2002-09-30
申请号：KR1020010014217
申请日：2001-03-20
申请人： 하태정 , 김기범 , 구자광
发明人： 하태정 , 구자광 , 김기범
IPC分类号： G06F1/00
摘要： PURPOSE: A computer case is provided to easily open a computer cover installed at a side of a computer main body by installing a sliding roll at a contact between the computer cover and the main body, and to prevent components within the main body from being stolen. CONSTITUTION: The case comprises a main body(4), a computer cover(2), a sliding roll(6), a knob(8) and a locking device(10). The main body(4) has one open side. The computer cover(2), installed at one open side of the main body, closes or opens the open side of the main body in a sliding operation. The sliding roll(6), installed at a contact between the main body and upper/lower parts of the computer cover, minimizes a friction force generated at the contact when the computer cover gets open or closed. The knob(8) is formed on a side of the computer cover(2). The locking device(10) is formed on a side of the main body(4) for preventing a CPU or a RAM from being stolen.
摘要翻译：目的：提供一种电脑机箱，通过在计算机机盖和主体之间的接触处安装滑动滑架，轻松打开安装在计算机主体一侧的电脑盖，并防止主体内的部件被盗。构成：壳体包括主体（4），计算机盖（2），滑动辊（6），旋钮（8）和锁定装置（10）。主体（4）具有一个开口侧。安装在主体的一个开口侧的计算机盖（2）在滑动操作中封闭或打开主体的开口侧。安装在主体与计算机盖的上/下部分之间的接触处的滑动辊（6）使计算机盖板打开或关闭时在接点处产生的摩擦力最小化。旋钮（8）形成在计算机盖（2）的一侧。锁定装置（10）形成在主体（4）的一侧，用于防止CPU或RAM被盗。

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