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1. 发明公开

KR1020080059280A 녹내장의 원발성 및 ２차 형태의 치료 방법 无效
标题翻译：用于处理GLAUCOMA的主要和次要形式的方法
公开(公告)号：KR1020080059280A
公开(公告)日：2008-06-26
申请号：KR1020087010658
申请日：2006-10-13
申请人： 알콘, 인코퍼레이티드
发明人： 로빈알란엘. , 위너알란엘. , 마쉬데이비드알렌
IPC分类号： A61K31/542 , A61K31/5575 , A61K9/08 , A61P27/06
CPC分类号： A61K9/0051 , A61K9/0048 , A61K9/10 , A61K9/5005 , A61K31/542 , A61K31/5575 , A61K31/57 , A61K31/573
摘要： Methods and compositions for controlling ocular hypertension associated with (i) primary open angle glaucoma (POAG), (ii) other forms of glaucoma, or (iii) glucocorticoid therapy are disclosed. The methods involve administration of angiostatic agents and other IOP-lowering agents via local injections in the anterior segment of the eye. The most preferred IOP-lowering agents are angiostatic steroids, particularly anecortave acetate, and the most preferred route of administration is an anterior juxtascleral injection or implant. The invention is based in part on the discovery that anterior juxtascleral injections of anecortave acetate are capable of controlling intraocular pressure for sustained periods of from one to several months or more. This result is believed to be attributable to facilitation of access of the anecortave acetate to the trabecular meshwork via the anterior juxtascleral route of administration. This route of administration is also believed to be advantageous for other types of IOP-lowering agents, particularly molecules that cannot readily penetrate the cornea due to size or other physical properties.
摘要翻译：公开了用于控制与（i）原发性开角型青光眼（POAG），（ii）其他形式的青光眼或（iii）糖皮质激素治疗）相关的高眼压症的方法和组合物。该方法包括通过局部注射在眼前段施用血管抑制剂和其它降低IOP的药剂。最优选的降低IOP的药物是血管抑制类固醇，特别是醋酸醋酸酯，并且最优选的给药途径是前交联注射或植入物。本发明部分基于以下发现：醋酸前列腺素的前交联注射能够在一至几个月或更长时间内控制眼内压。据认为，这一结果可归因于通过前交替施用途径来促进醋酸阿那替托通入小梁网。也认为这种给药途径对于其它类型的降低IOP的药剂是有利的，特别是由于大小或其它物理性质而不能容易地渗入角膜的分子。

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