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1. 发明公开

KR1020070010183A 치환된 아릴 아실티오우레아 및 관련 화합물； 바이러스복제 억제제 无效
标题翻译：取代的芳基乙二醇和相关化合物; VIRAL REPLICATION的抑制剂
公开(公告)号：KR1020070010183A
公开(公告)日：2007-01-22
申请号：KR1020067024219
申请日：2005-05-17
申请人： 아칠리온 파르마세우티칼스 인코포레이티드
发明人： 패드케애비네쉬 , 첸다웨이 , 데쉬팬드밀린드 , 뚜르카우프앤드류 , 왕시앙쥬 , 쉔이핑 , 리우큐이시앙 , 퀸제스 , 리쇼우밍 , 오칸다준코
IPC分类号： C07D285/06 , C07D401/12 , C07D239/28 , C07D277/68
CPC分类号： C07D295/15 , C07C335/26 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/64 , C07D211/78 , C07D213/56 , C07D213/82 , C07D215/54 , C07D231/14 , C07D233/54 , C07D233/64 , C07D233/90 , C07D237/24 , C07D239/28 , C07D241/24 , C07D241/44 , C07D249/06 , C07D253/07 , C07D261/18 , C07D263/34 , C07D263/58 , C07D265/30 , C07D271/12 , C07D277/56 , C07D277/68 , C07D285/06 , C07D307/68 , C07D307/84 , C07D307/85 , C07D309/38 , C07D311/58 , C07D333/38 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D419/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The invention provides compounds and pharmaceutically acceptable salts of Formula (I) wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula (I) described herein which possess potent antiviral activity. The invention particularly provides compounds of Formula (I) that are potent and/ or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compound of Formula (I), or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease. Methods of treatment include administering a compound of Formula (I) as a single active agent or administering a compound of Formula (I) in combination with on or more other therapeutic agent. ® KIPO & WIPO 2007
摘要翻译：本发明提供式（I）的化合物和药学上可接受的盐，其中变量A1，A2，R1，R2，V，W，X，Y和Z在本文中定义。某些本文所述的具有强抗病毒活性的式（I）化合物。本发明特别提供了作为丙型肝炎病毒复制的有效和/或选择性抑制剂的式（I）化合物。本发明还提供含有一种或多种式（I）化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。本发明还包括通过向这些患者施用一定量的有效减少疾病或病症的体征或症状的式I化合物来治疗患有某些感染性疾病的患者的方法。这些传染病包括病毒感染，特别是HCV感染。本发明特别包括治疗患有感染性疾病的人类患者的方法，还包括治疗其它动物（包括患有传染病的家畜和驯养的伴侣动物）的方法。治疗方法包括施用式（I）化合物作为单一活性剂或与一种或多种其它治疗剂组合施用式（I）化合物。 ®KIPO＆WIPO 2007

2. 发明公开

KR1020060121289A 아자벤조퓨란 치환된 티오우레아, 바이러스 복제의 억제제 无效
标题翻译：作为病毒复制的抑制剂的AZABENZOFURAN替代THI
公开(公告)号：KR1020060121289A
公开(公告)日：2006-11-28
申请号：KR1020067013660
申请日：2005-01-05
申请人： 아칠리온 파르마세우티칼스 인코포레이티드
发明人： 뚜르카우프앤드류 , 첸다웨이 , 패드케애비네쉬 , 리쇼우밍 , 데쉬팬드밀린드
IPC分类号： C07D491/04 , C07D471/04 , A61K31/4353
CPC分类号： A61K31/00 , A61K31/4355 , C07D491/04
摘要： The present invention provides compounds of Formula: (1), wherein the variables Ar, A1, A2, A 3, A4, R5, R6, R7, V, W, X, and Y are defined herein. Certain compounds of Formula (1) described herein possess potent antiviral activity. The invention also provides compounds of Formula (1) that are potent and/ or selective inhibitors of Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compounds of Formula (1), or a salt, solvate, or acylated prodrug of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents. The invention further comprises methods of treating patients suffering from certain infectious diseases by administering to such patients an amount of a compound of Formula (1) effective to reduce signs or symptoms of the disease. These infectious diseases include viral infections, particularly HCV infections. The invention is particularly includes methods of treating human patients suffering from an infectious disease, but also encompasses methods of treating other animals, including livestock and domesticated companion animals, suffering from an infectious disease. Methods of treatment include administering a compound of Formula (1) as a single active agent or administering a compound of Formula (1) in combination with on or more other therapeutic agent.
摘要翻译：本发明提供式（1）的化合物，其中变量Ar，A 1，A 2，A 3，A 4，R 5，R 6，R 7，V，W，X和Y在本文中定义。某些本文所述的式（1）化合物具有有效的抗病毒活性。本发明还提供了作为丙型肝炎病毒复制的有效和/或选择性抑制剂的式（1）化合物。本发明还提供了含有一种或多种式（1）化合物或这些化合物的盐，溶剂化物或酰化前药以及一种或多种药学上可接受的载体，赋形剂或稀释剂的药物组合物。本发明还包括通过向这些患者施用一定量的有效减少疾病体征或症状的式（1）化合物来治疗患有某些感染性疾病的患者的方法。这些传染病包括病毒感染，特别是HCV感染。本发明特别包括治疗患有感染性疾病的人类患者的方法，还包括治疗其它动物（包括患有传染病的家畜和驯养的伴侣动物）的方法。治疗方法包括施用作为单一活性剂的式（1）化合物或将式（1）的化合物与一种或多种其它治疗剂组合施用。

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