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    • 9. 发明公开
    • 표적 물질 검출용 키트 및 이를 이용한 표적 물질 검출 방법
    • 检测目标材料的试剂盒和方法
    • KR1020120128440A
    • 2012-11-27
    • KR1020110046389
    • 2011-05-17
    • 삼성전자주식회사포항공과대학교 산학협력단
    • 임규현박노경박종진허재현박준혁김성지
    • G01N33/53G01N33/68G01N33/483C12Q1/68
    • B82Y5/00C12Q1/6834G01N33/54346G01N33/587G01N33/483C12Q2525/197C12Q2563/131C12Q2563/155
    • PURPOSE: A kit for detecting a target material and a method for detecting the target material using the same are provided to quickly and simply amplify detection signal and to ensure efficiency. CONSTITUTION: A kit for detecting a target material comprises: a target material binding part containing a first molecule and a probe conjugated to the first molecule; and a target molecule detection unit containing a compound(110) with zwitterions and nanoparticles conjugated with a second molecule. The compound with zwitterions is amino acids, bicine, tricine, sulfamic acid, alkaloid, psilocybin, quinonoid, or betaine. The second molecule is linked through a linker(130). The linker contains a nanoparticle-binding site of an organic base including organic acid containing hydroxyl group, thiol groups or phenol groups or an organic base containing pyridine, methyl amine, imidazole, benzimidazole, histidine, phophagene base or hydroxide groups; or a nanoparticle non-binding site of organic molecules including carboxylic acid and azide group.
    • 目的:提供用于检测目标材料的试剂盒和使用其的目标材料的检测方法,以快速且简单地放大检测信号并确保效率。 构成:用于检测目标材料的试剂盒包括:含有第一分子的靶材料结合部分和与第一分子缀合的探针; 和含有具有两性离子的化合物(110)和与第二分子共轭的纳米颗粒的靶分子检测单元。 具有两性离子的化合物是氨基酸,二甘氨酸,三羟甲基氨基磺酸,氨基磺酸,生物碱,psilocybin,醌类或甜菜碱。 第二分子通过连接体(130)连接。 连接体包含有机碱的纳米粒子结合位点,包括含羟基,硫醇基或酚基的有机酸或含有吡啶,甲胺,咪唑,苯并咪唑,组氨酸,吡啶基或氢氧基的有机碱。 或包括羧酸和叠氮基的有机分子的纳米颗粒非结合位点。