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1. 发明公开

KR1020080043194A 향상된 염소화 수크로스의 제조 방법 无效
标题翻译：改进生产氯化蔗糖的方法
公开(公告)号：KR1020080043194A
公开(公告)日：2008-05-16
申请号：KR1020067019138
申请日：2004-05-20
申请人： 브이.비. 메디케어 프리베이트 엘티디.
发明人： 라트남,라케쉬 , 쿨카니,쉬리칸트 , 오로라,수니트
IPC分类号： C07H5/02 , C07H3/00 , C07H1/06
CPC分类号： C07H1/06 , C07H5/02 , Y10T428/2982
摘要： Present invention relates to disclosure of application of some innovative techniques useful for substantially improving process efficiency of production of chlorinated sucrose including their intermediates and derivatives. Application of mild methods of drying has been made for recovery of chlorinated sucrose or their intermediates and derivatives, in substantially pure form or with other solid chemical impurities, obtained at various stages in the process of production of chlorinated sucrose. Mild methods of drying included agitated thin film drying, spray drying, freeze drying and super critical extraction. Use of alkoxides has been introduced for deacylation instead of alkali hydroxides or alkaline earth hydroxides. Deacylation has been shown to be effective both, either before or after drying of the reaction mixture. Extraction and purification of desired products i.e. of chlorinated sucrose or its intermediates or derivatives, from dried solid mixtures could be achieved by using appropriate extraction method, including but not limited to solvent extraction and super critical extraction. Further purification of such extracts can be done by crystallization or direct drying under mild conditions.
摘要翻译：本发明涉及一些创新技术的应用的公开，这些创新技术可用于显着提高包括其中间体和衍生物在内的氯化蔗糖生产的工艺效率。在氯代蔗糖生产过程中的不同阶段获得的氯代蔗糖或其中间体和衍生物的应用是以基本上纯的形式或其他固体化学杂质进行的。温和的干燥方法包括搅拌薄膜干燥，喷雾干燥，冷冻干燥和超临界萃取。已经引入了使用烷氧化物来代替碱金属氢氧化物或碱土金属氢氧化物脱醇。在反应混合物干燥之前或之后，已经显示脱酰基化有效。从干燥的固体混合物中提取和纯化所需产物即氯化蔗糖或其中间体或衍生物可以通过使用适当的提取方法来实现，包括但不限于溶剂萃取和超临界萃取。这种提取物的进一步纯化可以通过在温和条件下结晶或直接干燥来进行。

2. 发明公开

KR1020080052639A 전세포 생체촉매반응에 의한 수크로스-6-아세테이트제조방법 无效
标题翻译：通过全细胞生物分解制备蔗糖-6-乙酸酯的方法
公开(公告)号：KR1020080052639A
公开(公告)日：2008-06-11
申请号：KR1020087008004
申请日：2006-09-21
申请人： 브이.비. 메디케어 프리베이트 엘티디.
发明人： 라트남,라케쉬 , 오로라,선디프 , 숩라마니얌,피
IPC分类号： C12P19/12 , C07H1/00
CPC分类号： C07H1/00 , C12P19/18 , C12P19/44
摘要： A process is described which uses whole cell preparations, immobilized or without immobilization, of a microorganism, includingAureobasidium pullulans, capable of forming enzymes of the group of fructosyltransferases, for catalyzing a reaction between sucrose and 6-0-protected glucose for formation of 6-0-protected sucrose, an intermediate in synthesis of trichlorogaiactosucrose. 6-0-protected Sucrose is separated from high molecular weight by-products of the reaction having molecular weight of 500 daltons and more by reverse osmosis, and further purified by column chromatography.
摘要翻译：描述了一种使用能够形成果糖基转移酶基团的酶的微生物的全细胞制备（固定化或不固定）的方法，其包括能产生蔗糖基团转移酶的酶的微生物，用于催化蔗糖与6-0保护的葡萄糖之间的反应以形成6- 0保护的蔗糖，三氯蔗糖蔗糖的合成中间体。通过反渗透将6-0保护的蔗糖与分子量为500道尔顿的反应的高分子量副产物分离，并通过柱色谱进一步纯化。

3. 发明公开

KR1020080056187A 염소화 당 유도체의 효소 촉매적 탈아실화 처리 방법 无效
标题翻译：酶催化脱乙酰化糖衍生物的脱乙酰化
公开(公告)号：KR1020080056187A
公开(公告)日：2008-06-20
申请号：KR1020087008005
申请日：2006-09-21
申请人： 브이.비. 메디케어 프리베이트 엘티디.
发明人： 라트남,라케쉬 , 오로라,선디프 , 라리,아르빈드,엠. , 숩라마니얌,피. , 페트카르,마니시바르드하라 , 코티야,아르차나아비나시
IPC分类号： C07H3/04 , C07H5/02 , C07H1/06
CPC分类号： C07H1/06 , C07H3/04 , C07H5/02
摘要： A process of production of trichlorogalactosucrose is described in which deacylation of sucrose-6-ester is achieved by subjecting the reaction mixture after chlorination, neutralization and adjustment of pH to 6.5 to 7 to deacylation by using a lipase or a protease, in a free or in an immobilized form.
摘要翻译：描述了三氯半乳糖蔗糖的生产方法，其中蔗糖-6-酯的脱酰化通过在氯化，中和和pH调节至6.5至7之间使反应混合物通过使用脂肪酶或蛋白酶以游离或以固定形式。

4. 发明公开

KR1020080002766A 주석을 매개로 한 슈크로스-6-에스테르의 위치선택적 합성 无效
标题翻译：季铵盐的介导的选择性合成
公开(公告)号：KR1020080002766A
公开(公告)日：2008-01-04
申请号：KR1020077021482
申请日：2006-02-20
申请人： 브이.비. 메디케어 프리베이트 엘티디.
发明人： 라트남,라케쉬 , 모피주딘,모하메드 , 오로라,선디프
IPC分类号： C08B31/00 , C08B31/02
CPC分类号： C07H1/00 , C07H13/00
摘要： A method is disclosed for regioselective synthesis of sucrose-6-acetate via formation of a novel sucrose-tin adduct using sucrose and DBTO. The novel tin adduct can be represented by a formula (6-O-sucrose)-O-Snbutyl. sub.2-O-(6-O-sucrose) or as 1,3.(di O-sucrose) dibutyl stannylene. The adduct is acylated to yield sucrose-6-acetate or sucrose-6-benzoate as major product.
摘要翻译：公开了通过使用蔗糖和DBTO形成新的蔗糖 - 锡加合物来区域选择性合成蔗糖-6-乙酸酯的方法。新型锡加合物可由式（6-O-蔗糖）-O-锡丁基代表。亚-O-O-（6-O-蔗糖）或1,3（二O-蔗糖）二丁基亚锡。将加合物酰化生成蔗糖-6-乙酸酯或蔗糖-6-苯甲酸酯作为主要产物。

5. 发明公开

KR1020090007556A 염소화 시약의 제조 공정 및 염소화 당의 제조에 있어 그의용도 无效
标题翻译：生产氯仿试剂的过程及其在制备氯化糖中的应用
公开(公告)号：KR1020090007556A
公开(公告)日：2009-01-19
申请号：KR1020087022691
申请日：2007-02-28
申请人： 브이.비. 메디케어 프리베이트 엘티디.
发明人： 라트남,라케쉬 , 오로라,선디프 , 모피주딘,모하메드
IPC分类号： C07H1/00 , C07H13/02 , C07H15/00 , C07H5/02
CPC分类号： C07H1/00 , C07H5/02 , C07H13/02 , C07H15/00
摘要： Preparation of chlorinating reagent or chlorination reaction itself for use in a reaction such as production of high intensity sweetener trichlorogalactosucrose (TGS) from partially protected sucrose comprising reaction of dimethylformamide (DMF) with thionyl chloride or another sulphur containing inorganic acid chlorides including sulphuryl chloride is faced with a problem of prolific release of gaseous by-products, that at times may lead to violent explosion also. This problem is solved by innovative addition of solid powder inert to the constituents of the chlorination reaction mixture to the reaction, or by adding DMF to acid chloride solution in that order. The invention also leads to use of isolated solid Vilsmeier reagent being used for chlorination in a solvent other than DMF making it possible to avoid altogether problems arising from use of DMF which include irrecoverable loss in alkaline as well as acid conditions, interference in crystallization of TGS and the like.
摘要翻译：制备氯化试剂或氯化反应本身用于反应，例如从部分保护的蔗糖生产高强度甜味剂三氯半乳蔗糖（TGS），包括二甲基甲酰胺（DMF）与亚硫酰氯或另一种含硫的无机酰氯（包括磺酰氯）的反应存在气态副产物多产释放的问题，有时也可能导致剧烈的爆炸。通过将氯化反应混合物的成分惰性的固体粉末添加到反应中，或者通过向该酰氯溶液中依次加入DMF来解决这个问题。本发明还导致使用分离的固体维尔斯迈尔试剂用于在DMF以外的溶剂中进行氯化，使得可以避免使用DMF引起的一切问题，其包括在碱性和酸性条件下不可恢复的损失，TGS的结晶干扰等等。

6. 发明公开

KR1020080043342A 소수성 친화 크로마토그래피에 따른 염소화 당 제조방법 无效
标题翻译：基于亲水性亲和色谱法生产氯化蔗糖的方法
公开(公告)号：KR1020080043342A
公开(公告)日：2008-05-16
申请号：KR1020087005898
申请日：2006-08-29
申请人： 브이.비. 메디케어 프리베이트 엘티디.
发明人： 라트남,라케쉬 , 오로라,선디프 , 케일,산디프,바스카 , 라리,아르빈드,말리나트
IPC分类号： C07H1/06 , C07H5/02
CPC分类号： C07H1/06 , C07H5/02
摘要： This invention relates to a process for selective capture, isolation and purification of chlorinated sucrose compounds, including chlorinated sucrose, their precursors and derivatives, including trichlorogalactosucrose (TGS), directly from chlorinated reaction mixture by column chromatography on adsorbents and under conditions which result in specific and selective affinity towards one or more of chlorinated sucrose compound. The process also integrates de-esterification of chlorinated sucrose esters adsorbed on the adsorbent while they are being treated with desorbent. The process also provides a novel approach to concentration and crystallization of TGS. The chlorinated sucrose derivatives, including TGS, thus isolated are substantially free from most impurities, salts and organic solvents. The process has high recovery of more than 95% in terms of desired chlorinated sucrose derivatives including TGS.
摘要翻译：本发明涉及一种选择性捕获，分离和纯化氯化蔗糖化合物的方法，包括氯化蔗糖，其前体和衍生物，包括三氯半乳糖（TGS），直接由氯化反应混合物通过柱色谱法在吸附剂上和在导致特异性以及对一种或多种氯化蔗糖化合物的选择性亲和力。该方法还将吸附在吸附剂上的氯化蔗糖酯的脱酯化同时用解吸剂进行处理。该方法还提供了TGS的浓缩和结晶的新方法。由此分离的氯化蔗糖衍生物，包括TGS基本上不含大多数杂质，盐和有机溶剂。该方法在所需的氯代蔗糖衍生物（包括TGS）方面具有高于95％的高回收率。

7. 发明公开

KR1020080007347A 오염화인과 디엠에프로부터 부산물로서 옥시염화인의 생성및 빌스마이어-헥크 시약으로의 변환에 의한 염소화 반응에사용되는 옥시염화인의 용도 无效
标题翻译：从磷酸二氢钾和DMF中产生磷酰氯作为副产物，并通过转换成VILSMEIER-HAACK试剂用于氯化反应
公开(公告)号：KR1020080007347A
公开(公告)日：2008-01-18
申请号：KR1020077025559
申请日：2006-04-28
申请人： 브이.비. 메디케어 프리베이트 엘티디.
发明人： 라트남,라케쉬 , 선디프,오로라 , 모피주딘,모하메드
IPC分类号： C07C251/30
CPC分类号： C01B25/10 , C07B39/00 , C07C249/02 , C07F9/1403 , C07H1/00 , C07H5/02 , C07H13/04 , C07H13/08 , C07C251/04
摘要： A process is described wherein after formation of first crop of Vilsmeier-Haack reagent by reacting Phosphorus Pentachloride with N,N-dimethylformamide to form a first crop of Vilsmeier reagent as insoluble crystals, a by-product of this reaction, the Phosphorus Oxy-Chloride, reacts with N,N-dimethylformamide to give a second crop of Vilsmeier reagent. This second crop of Vilsmeier reagent is soluble in DIV1F. This process makes it possible to double the yield of chlorinated substrate, such as sucrose-6-acetate or sucrose-6-benzoate, from the same quantity of Phosphorus Pentachloride.
摘要翻译：描述了一种方法，其中在通过使五氯化磷与N，N-二甲基甲酰胺反应形成第一批Vilsmeier-Haack试剂后，形成第一批Vilsmeier试剂作为不溶性晶体，该反应的副产物是氧氯化磷与N，N-二甲基甲酰胺反应，得到第二批Vilsmeier试剂。第二批Vilsmeier试剂可溶于DIV1F。该方法可以使来自相同量的五氯化磷的氯化底物如蔗糖-6-乙酸酯或蔗糖-6-苯甲酸酯的产率增加一倍。

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