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2. 发明公开

KR1020030062139A 구강점막 부착형 필름제제 有权
标题翻译：口腔胶囊
公开(公告)号：KR1020030062139A
公开(公告)日：2003-07-23
申请号：KR1020020002577
申请日：2002-01-16
申请人： 동화약품주식회사
发明人： 정용호 , 유제만 , 정재희 , 김유은 , 조종수 , 최후균 , 전명관 , 안재순 , 김태희
IPC分类号： A61K9/24
CPC分类号： A61K9/006 , A61K47/10 , A61K47/32 , A61K47/38
摘要： PURPOSE: A film applicable to the oral mucosa comprising two layers such as a protective layer and an adhesive layer which contain a drug is provided to effectively delivery the drug without changing the formulation. The film causes no foreign body sensation when applied to oral mucosa and has excellent convenience and efficiency in the preparation process. CONSTITUTION: An oral mucoadhesive film comprises: an adhesion layer containing 5 to 80% by weight of each of a polyacrylic acid-based polymer and a cellulose-based polymer, 5 to 70% by weight of poloxamer, 0.05 to 20% by weight of a drug absorbable through the oral mucosa and 0.1 to 10% by weight of a plasticizer; and a protective layer containing 5 to 50% by weight of a water-insoluble, water-impermeable polymer and 0.1 to 10% by weight of a plasticizer. The film has a thickness of 50 to 300 microns.
摘要翻译：目的：提供适用于包含两层如口服粘膜的保护层和含有药物的粘合剂层的膜，以有效地输送药物而不改变制剂。当应用于口腔粘膜时，该膜不引起异物感，并且在制备过程中具有极好的便利性和效率。构成：口腔粘膜粘附膜包括：含有5〜80重量％的聚丙烯酸类聚合物和纤维素系聚合物的粘合层，5〜70重量％的泊洛沙姆，0.05〜20重量％通过口腔粘膜吸收的药物和0.1〜10重量％的增塑剂; 和含有5〜50重量％水不溶性水不渗透性聚合物和0.1〜10重量％增塑剂的保护层。该膜具有50至300微米的厚度。

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