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1. 发明授权

KR100456607B1 트랜스-9,트랜스-11 ＣＬＡ 및 트랜스-10,트랜스-12ＣＬＡ의 제조방법 失效
标题翻译： 트랜스-9，트랜스-11 CLA및트랜스-10，트랜스-12CLA의제조방
公开(公告)号：KR100456607B1
公开(公告)日：2004-11-10
申请号：KR1020010016798
申请日：2001-03-30
申请人： 김정옥
发明人： 하영래 , 김정옥 , 김석종 , 박숙자 , 김영림
IPC分类号： C07C51/42
摘要： PURPOSE: Provided is a method for producing trans-9, trans-11 CLA(conjugated linoleic acid) and trans-10, trans-12 CLA, which are pure, from chemically synthesized CLA. CONSTITUTION: The method comprises the steps of (i) synthesizing cis-9, trans-11 CLA and trans-10,cis-12 CLA from linolenic acid, and isolating pure cis-9, trans-11 CLA and trans-10,cis-12 CLA; (ii) methylating the pure cis-9, trans-11 CLA and trans-10,cis-12 CLA to form trans-9,trans-11 CLA and trans-10,trans-12 CLA, respectively; and (iii) isolating pure trans-9, trans-11 CLA and trans-10,trans-12 CLA. The methylation is effected by heating the pure cis-9,trans-11 CLA and trans-10,cis-12 CLA in the presence of acid catalyst.
摘要翻译：目的：提供一种由化学合成的CLA制备纯的反式-9，反式-11CLA（共轭亚油酸）和反式-10，反式-12CLA的方法。组成：该方法包括以下步骤：（i）从亚麻酸合成顺-9，反-11CLA和反-10，顺-12CLA，并分离纯顺-9，反-11CLA和反-10，顺式 -12 CLA; （ii）分别使纯顺式-9，反式-11CLA和反式-10，顺式-12CLA甲基化以分别形成反式-9，反式-11CLA和反式-10，反式-12CLA; 和（iii）分离纯的反式-9，反式-11CLA和反式-10，反式-12CLA。甲基化通过在酸催化剂存在下加热纯顺式-9，反式-11CLA和反式-10，顺式-12CLA来实现。

2. 发明公开

KR1020020076716A 트랜스-9,트랜스-11 ＣＬＡ 및 트랜스-10,트랜스-12ＣＬＡ의 제조방법 失效
标题翻译：用于生产TRANS-9，TRANS-11 CLA和TRANS-10，TRANS-12 CLA的方法
公开(公告)号：KR1020020076716A
公开(公告)日：2002-10-11
申请号：KR1020010016798
申请日：2001-03-30
申请人： 김정옥
发明人： 하영래 , 김정옥 , 김석종 , 박숙자 , 김영림
IPC分类号： C07C51/42
摘要： PURPOSE: Provided is a method for producing trans-9, trans-11 CLA(conjugated linoleic acid) and trans-10, trans-12 CLA, which are pure, from chemically synthesized CLA. CONSTITUTION: The method comprises the steps of (i) synthesizing cis-9, trans-11 CLA and trans-10,cis-12 CLA from linolenic acid, and isolating pure cis-9, trans-11 CLA and trans-10,cis-12 CLA; (ii) methylating the pure cis-9, trans-11 CLA and trans-10,cis-12 CLA to form trans-9,trans-11 CLA and trans-10,trans-12 CLA, respectively; and (iii) isolating pure trans-9, trans-11 CLA and trans-10,trans-12 CLA. The methylation is effected by heating the pure cis-9,trans-11 CLA and trans-10,cis-12 CLA in the presence of acid catalyst.
摘要翻译：目的：提供从化学合成的CLA生产纯的反式9，反式-11Rα（共轭亚油酸）和反式-10反式-12 CLA的方法。方法：该方法包括以下步骤：（i）从亚麻酸合成顺式-9，反式-11Rα和反式-10，顺式-12RAC，并分离纯的顺式-9，反式-11Rα和反式-10，顺式 -12 CLA （ii）分别将纯的顺式-9，反式-11Rα和反式-10顺式-12 CLA甲基化形成反式-9，反式-11 CLA和反式-10，反式-12 CLA; 和（iii）分离纯的反式-9，反式-11 CLA和反式-10，反式-12 CLA。通过在酸催化剂的存在下加热纯的顺式-9，反式-11 CLA和反式-10，顺式-12 CLA来进行甲基化。

3. 发明公开

KR1020020071998A 버섯 균사체 배양물 또는 버섯 자실체의 추출물을포함하는 숙취 해소용 조성물 无效
标题翻译：用于减少含有麦芽糖和果汁提取物的香菇的组合物
公开(公告)号：KR1020020071998A
公开(公告)日：2002-09-14
申请号：KR1020010011931
申请日：2001-03-08
申请人： 김정옥
发明人： 김정옥 , 하영래 , 박철우
IPC分类号： A61K36/07 , A61P25/32
摘要： PURPOSE: A composition containing a fruit body extract of a mushroom or a liquid or solid culture extract of mushroom mycelium is provided which has an effect on reducing drunkenness as well as reducing an alcoholic concentration in blood after drinking and can be used in a beverage, food and medicine. CONSTITUTION: The composition having preventing effects for drunken sickness and hangover contains a fruit body extract of a mushroom or a liquid or solid culture extract of mushroom mycelium, wherein the mush room is one selected from Pleurotus ostreatus, Agaricus Blazei, Pleurotus eryngii, Tricholoma matsutake, Flammulina velutipes, Phellinus linteus, Lentinus edodes, Paecilomyces japonica, Cordyceps militaris, Hericium erinaceum, Coprinus comatus, Grifola frondosa, Morchella esculenta, Coriolus versicolor, Ganoderma lucidum, Pholiota nameko and Agaricus bisporus.
摘要翻译：目的：提供一种含有蘑菇的水果体提取物或蘑菇菌丝体的液体或固体培养物提取物的组合物，其具有减轻饮酒并降低饮酒后血液中酒精浓度的作用，并且可用于饮料，食物和药物。构成：具有防止醉酒和宿醉的作用的组合物含有蘑菇或蘑菇菌丝体的液体或固体培养物提取物的果实体提取物，其中所述蘑菇是选自侧耳菇，姬松茸，白头翁，Tricholoma matsutake ，金黄色葡萄球菌（Flammulina velutipes），桑黄，香菇，香茅，冬虫夏草，黑麦草，鬼臼草，紫草，灵芝，茯苓和双孢蘑菇。

4. 发明公开

KR1020010098171A 고순도 ＣＬＡ 이성체 분리 방법 失效
标题翻译：高纯CLA异构体的分离方法
公开(公告)号：KR1020010098171A
公开(公告)日：2001-11-08
申请号：KR1020000022905
申请日：2000-04-28
申请人： 김정옥
发明人： 하영래 , 김정옥 , 김석종 , 박숙자 , 윤정한
IPC分类号： C07C51/42
摘要： 본 발명은 씨엘에이(Conjugated linoleic acid, 이하 'CLA'라 함)에 포함된 CLA 이성체의 분리방법에 관한 것으로, CLA를 메틸화시킨 후 이를 분별침전시켜 이성체를 분리하는 방법에 있어서, CLA-Me을 유기용매에 용해시킨 후, 이 용액을 cis-9,trans-11 CLA-Me의 어는점과 trans-10,cis-12 CLA-Me의 어는점 사이의 적어도 두 곳의 온도를 선정하여 각각의 온도에서 1회 이상 분별침전 과정을 수행하는 것을 포함하여 이루어져, 간단하면서도 저렴하게 고순도의 cis-9,trans-11 CLA와 trans-10,cis-12 CLA 이성체를 분리 대량 생산할 수 있는 방법에 관한 것이다.

5. 发明公开

KR1020000022882A 공역 리놀레인산 유도체 및 그의 합성방법 失效
标题翻译：共轭亚油酸（CLA）的衍生物及其制备方法
公开(公告)号：KR1020000022882A
公开(公告)日：2000-04-25
申请号：KR1019990037151
申请日：1999-09-02
申请人： 하영래 , 김정옥
发明人： 하영래 , 김정옥 , 박구부 , 김석종 , 박숙자 , 김정곤
IPC分类号： C11C3/00
CPC分类号： C11C3/025 , C11C1/08 , C11C3/06
摘要： PURPOSE: The derivatives of conjugated linoleic acid(CLA) and a manufacturing method thereof are provided, which can be easily added to food or oil and fat, and enhance a function of linoleic acid. CONSTITUTION: A conjugated linoleic acid(CLA) is produced by alkaline isomerization of linoleum acid. And the derivatives of CLA which improve the functions of CLA, are produced by adding a functional group to carboxy terminus of CLA. To generate the neutral lipid derivatives of CLA, triglyceride added to CLA is synthesized, or some fatty acid included in neutral lipids, such as cottonseed oil, corn oil, fish oil or lard is substituted for CLA by transesterification using a chemical method or an enzymatic method. Triglyceride derivative of CLA can be generated by chemical, enzymatic or biological method. Glycolipid derivatives of CLA can be generated in the form of ascorbic acid derivative, D-glucose derivative, and cyclodextrin micro capsule. Phospholipid derivatives of CLA are phospholipid of which fatty acid is substituted for CLA.
摘要翻译：目的：提供共轭亚油酸（CLA）的衍生物及其制造方法，其可以容易地添加到食品或油脂中，并增强亚油酸的功能。构成：通过亚油酸的碱性异构化生产共轭亚油酸（CLA）。并且通过向CLA的羧基末端加入官能团来制备改善CLA功能的CLA的衍生物。为了产生CLA的中性脂质衍生物，合成添加到CLA中的甘油三酯，或者通过使用化学方法或酶的酯交换取代包括在中性脂质中的一些脂肪酸，例如棉籽油，玉米油，鱼油或猪油方法。 CLA的甘油三酸酯衍生物可以通过化学，酶学或生物学方法产生。 CLA的糖脂衍生物可以以抗坏血酸衍生物，D-葡萄糖衍生物和环糊精微胶囊的形式产生。 CLA的磷脂衍生物是脂肪酸代替CLA的磷脂。

6. 发明公开

KR1020040062814A 혈당강하효과를 지닌 버섯균사체추출물 제조 방법 无效
标题翻译：用于制备具有血液葡萄糖水平降低活性的葡萄酒的液体液体培养方法
公开(公告)号：KR1020040062814A
公开(公告)日：2004-07-09
申请号：KR1020030000345
申请日：2003-01-03
申请人： 김정옥
发明人： 김정옥 , 하영래 , 김정인 , 김영숙 , 김미숙
IPC分类号： C12P1/00
摘要： PURPOSE: A method for preparing submerged liquid culture of mushroom mycelia having blood glucose level lowering activity is provided, which submerged liquid culture of mushroom mycelia inhibits the activity of α-glucosidase and prevents and treats diabetes. CONSTITUTION: The method for preparing submerged liquid culture of mushroom mycelia having blood glucose level lowering activity comprises the steps of: treating grains such as soybean meals with protease and cellulase and adding saccharides such as sugar and inorganic salts such as magnesium sulfate or potassium phosphate into the enzyme treated grains to prepare a medium for mushroom mycelia; and inoculating mushroom mycelia into the medium and culturing it with stirring or aeration, wherein the mushroom mycelium is selected from Agaricus blazei, Pleurotus ostreatus, Tricholoma matsutake, Flammulina velutipes, Phellinus linteus, Lentinus edodes and Cordyceps militaris.
摘要翻译：目的：提供一种具有血糖降低活性的蘑菇菌丝体浸没式液体培养方法，将蘑菇菌丝体的液体培养液浸没，抑制α-葡萄糖苷酶的活性，预防和治疗糖尿病。构成：制备具有血糖降低活性的蘑菇菌丝体的浸没液体培养方法包括以下步骤：用蛋白酶和纤维素酶处理大豆粉等谷物，并将糖和无机盐如硫酸镁或磷酸钾加入到酶处理颗粒以制备用于蘑菇菌丝体的培养基; 将蘑菇菌丝体接种到培养基中并在搅拌或通气下进行培养，其中蘑菇菌丝体选自姬松茸（Agaricus blazei），侧耳菇（Pleurotus ostreatus），马铃薯Tricholoma matsutake，Flammulina velutipes，Phellinus linteus，香菇和Cordyceps militaris。

7. 发明公开

KR1020030082859A 느타리 버섯 균사체 배양물로부터 육고기향의 생산 방법 失效
标题翻译：通过培养含有CYSTEINE和RIBOSE的液体中的PLEUROTUS OSTREATUS MYCELIUM生产肉粉
公开(公告)号：KR1020030082859A
公开(公告)日：2003-10-23
申请号：KR1020020021362
申请日：2002-04-18
申请人： 김정옥
发明人： 하영래 , 김정옥 , 김영림
IPC分类号： A23L1/231
摘要： PURPOSE: Provided is a method of producing a meat flavor by culturing Pleurotus ostreatus mycelium in a liquid medium containing cysteine and ribose under the optimum culture condition, thereby mass producing the meat flavor at low cost. CONSTITUTION: Pleurotus ostreatus mycelium is inoculated into a liquid medium containing 1% by weight of cysteine and 2% by weight of ribose for 7 days at a pH of 5.5 at 25deg.C. The liquid medium is prepared by distilling 10%(w/v) of soy bean meal, 2.7%(w/v) of yellow sugar, 0.5%(w/v) of KH2PO4%(w/v) and 0.5%(w/v) of MgSO4.7H2O in distilled water and followed by sterilization. The culture of the Pleurotus ostreatus mycelium produces 2-furancarboxamide as a precursor of a meat flavor, the heating of the culture solution produces 2-formyl-5-methylthiophene and dimethylformyl-thiophene as a meat flavor component.
摘要翻译：目的：提供一种通过在最佳培养条件下在含有半胱氨酸和核糖的液体培养基中培养侧耳菇菌丝体来生产肉香味的方法，从而以低成本大量生产肉味。构成：在25℃的pH5.5下，将侧耳菇菌丝体接种到含有1重量％半胱氨酸和2重量％核糖的液体培养基中7天。液体培养基是通过将10％（w / v）的大豆粉，2.7％（w / v）的黄糖，0.5％（w / v）的KH 2 PO 4％（w / v）和0.5％（w / v）MgSO 4·7H 2 O在蒸馏水中，然后灭菌。侧耳菌菌丝体的培养物产生2-呋喃甲酰胺作为肉类风味的前体，培养液的加热产生2-甲酰基-5-甲基噻吩和二甲基甲酰基噻吩作为肉香味成分。

8. 发明授权

KR100350431B1 공역 리놀레인산 유도체 및 그의 합성방법 失效
公开(公告)号：KR100350431B1
公开(公告)日：2002-08-29
申请号：KR1020020008540
申请日：2002-02-18
申请人： 하영래 , 김정옥
发明人： 하영래 , 김정옥 , 박구부 , 김석종 , 박숙자 , 김정곤
IPC分类号： C11C3/00
摘要： 본 발명은 고기능성 물질인 공역 리놀레인산(conjugated linoleic acid, CLA)의 유도체 및 그의 합성 방법에 관한 것으로, 본 발명에 따른 CLA의 트리글리세리드 유도체, 아스코르브산 유도체, D-글루코스 유도체, 시클로덱스트린 미세캡슐, 인지질 유도체 및 CLA 함유 동, 식물성 유지들은 CLA 자체의 기능성에 부가된 관능기의 기능성이 결합되어 더욱 기능성이 높은 물질을 제공할 수 있을 뿐 아니라, CLA 말단의 카르복실기에서 오는 독성을 줄이게 되므로, 식품 첨가제로서의 CLA의 효용성을 높일 수 있다.

9. 发明公开

KR1020020022742A 공역 리놀레인산 유도체 및 그의 합성방법 失效
标题翻译：联合亚油酸衍生物及其制备方法
公开(公告)号：KR1020020022742A
公开(公告)日：2002-03-27
申请号：KR1020020008536
申请日：2002-02-18
申请人： 하영래 , 김정옥
发明人： 하영래 , 김정옥 , 박구부 , 김석종 , 박숙자 , 김정곤
IPC分类号： C11C3/00
CPC分类号： C11C3/00 , C11C3/04
摘要： PURPOSE: A neutral fat derivative of conjugated linoleic acid and its preparation method are provided, to improve the compatibility of conjugated linoleic acid with food by modifying the terminal carboxyl group, thereby improving the solubility and reducing the toxicity due to the carboxyl group. CONSTITUTION: The conjugated linoleic acid derivative is such that some part of the fatty acid bonded to animal or vegetable fats is substituted with conjugated linoleic acid. The method comprises the steps of mixing conjugated linoleic acid-methyl ester and animal or vegetable fats in the ratio of 2:1 to 6:1 by weight, adding sodium methoxide (1-2 times mol based on the amount of fats) to the solution, and reacting the mixture at 90 deg.C for 1-10 hours under the reduced pressure; and washing the mixture with water, removing water and separating the product by silica gel column chromatography. Also the method comprises the steps of mixing conjugated methyl linoleate and animal or vegetable fats in the ratio of 1:1 to 6:1 by weight, adding lipozyme (10 wt% based on the amount of fats) and an organic solvent (200 wt% based on the total amount) to the solution, and reacting the mixture at 40-70 deg.C for 24 hours; and extracting fats with hexane and separating the product.
摘要翻译：目的：提供共轭亚油酸的中性脂肪衍生物及其制备方法，通过改性末端羧基提高共轭亚油酸与食品的相容性，从而提高溶解性，降低由于羧基引起的毒性。构成：共轭亚油酸衍生物使得与动植物脂肪结合的部分脂肪酸被共轭亚油酸取代。该方法包括将共轭亚油酸 - 甲酯与动物或植物脂肪按重量比为2:1至6:1混合的步骤，将甲醇钠（基于脂肪的1-2倍摩尔）加入到溶液，并在90℃下将混合物在减压下反应1-10小时; 并用水洗涤混合物，除去水并通过硅胶柱色谱分离产物。此外，该方法包括以1：1至6：1的比例混合轭合的亚油酸亚油酸酯和动物或植物脂肪的步骤，加入脂酶（基于脂肪的10重量％）和有机溶剂（200重量％基于总量的％），并将混合物在40-70℃下反应24小时; 并用己烷萃取脂肪并分离产物。

10. 发明公开

KR1020020019508A 공역 리놀레인산 유도체 및 그의 합성방법 失效
标题翻译：共轭亚油酸的衍生物及其合成方法
公开(公告)号：KR1020020019508A
公开(公告)日：2002-03-12
申请号：KR1020020008538
申请日：2002-02-18
申请人： 하영래 , 김정옥
发明人： 하영래 , 김정옥 , 박구부 , 김석종 , 박숙자 , 김정곤
IPC分类号： C11C3/00
CPC分类号： C11C3/04
摘要： PURPOSE: Provided are derivatives of conjugated linoleic acid(CLA), such as triglyceride derivatives, ascorbic acid derivatives, D-glucose derivatives, cyclodextrin microcapsule, phospholipid derivatives, which have higher functionality and can be used for food additives. CONSTITUTION: The D-glucose derivatives of CLA are synthesized by a process comprising the steps of: concentrating 220pts.wt. of 1,2-isopropylidine-D-glucofuranose and 20pts.wt. of dried pyridine until the volume is half and then adding 372pts.wt. of CLA-chloride and reacting at an ordinary temperature for 6 hours; extracting the reacted mixture by using ethyl ether and chloroform and then concentrating and removing the pyridine by an azeotropic distillation and separating the residue by using a mixture solvent comprising hexane and ethylacetate in the volume ratio of 2:1; adding 10.7pts.wt. of 70% acetic acid to the separated 1,2-isopropylidine-D-glucofuranose-CLA and then stirring at 60-80deg.C for 60-90 hours.
摘要翻译：目的：提供共轭亚油酸（CLA）的衍生物，如甘油三酯衍生物，抗坏血酸衍生物，D-葡萄糖衍生物，环糊精微胶囊，磷脂衍生物，其功能性较高，可用于食品添加剂。构成：CLA的D-葡萄糖衍生物通过包括以下步骤的方法合成：浓缩220pts.wt。的1,2-异丙基-D-葡萄糖呋喃糖和20pts.wt。的干燥吡啶直到体积为一半，然后加入372pts.wt。的氯化钯，并在常温下反应6小时; 通过乙醚和氯仿萃取反应的混合物，然后通过共沸蒸馏浓缩和除去吡啶，并使用体积比为2:1的己烷和乙酸乙酯的混合溶剂分离残余物; 加10.7pts.wt. 的70％乙酸加入到分离的1,2-异丙基-D-葡萄糖 - 呋喃葡萄糖中，然后在60-80℃下搅拌60-90小时。

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