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1. 发明公开

KR1020040080083A ＰＭＴ 또는 Ｈ6Ｈ 유전자가 도입된 미치광이풀 모상근을이용한 트로판 알칼로이드 생산 방법 无效
标题翻译：可用于治疗NAUSEA和STOMACH DISORDER，由PMT或H6H基因产生的草甘膦的生产方法基因引入了SCOPOLIA PARVIFLORA NAK的毛发根文化
公开(公告)号：KR1020040080083A
公开(公告)日：2004-09-18
申请号：KR1020030014928
申请日：2003-03-10
申请人： 경상대학교산학협력단
发明人： 최명석 , 윤대진 , 박정동 , 이옥선 , 강영민 , 정희영
IPC分类号： C12P17/18
摘要： PURPOSE: A production method of tropane alkaloids by PMT or H6H genes introduced hairy root cultures of Scopolia parviflora Nak is provided, thereby improving production yield of tropane alkaloids which are useful for treatment of nausea and stomach disorder. CONSTITUTION: The production method of tropane alkaloids comprises the steps of: introducing PMT or H6H gene into Scopolia parviflora Nak; adding one or more microorganisms selected from Pseudomoanas aeruginosa, Staphylococcus aureus and Bacillus cereus into a medium to induce hairy root cultures of Scopolia parviflora Nak; and over-expressing the hairy root cultures of Scopolia parviflora Nak, wherein the PMT gene has the nucleotide sequence set forth in SEQ ID NO:1; the H6H gene has the nucleotide sequence set forth in SEQ ID NO:2; and the tropane alkaloid is hyoscyamine or scopolamine.
摘要翻译：目的：提供通过PMT或H6H基因的托烷生物碱的生产方法，引入了Scopolia parviflora Nak的毛根培养物，从而提高了可用于治疗恶心和胃功能障碍的托烷生物碱的产量。构成：托烷生物碱的生产方法包括：将PMT或H6H基因导入番荔枝Nak; 将一种或多种选自铜绿假单胞菌，金黄色葡萄球菌和蜡状芽孢杆菌的微生物添加到培养基中以诱导番茄兰花的根毛发根培养物; 过表达Scopolia parviflora Nak的毛根培养物，其中PMT基因具有SEQ ID NO：1所示的核苷酸序列; H6H基因具有SEQ ID NO：2所示的核苷酸序列; 托品生物碱是莨菪碱或东莨菪碱。

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