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    • 3. 发明公开
    • 노화-관련 장애 또는 질환의 진단 또는 치료를 위한 녹아웃된 p62 유전자를 포함하는 형질전환성 마우스 및 이를 이용한 노화 관련 장애 또는 질환에 대응하는 화합물의 스크리닝 방법
    • P62在老年相关疾病中的作用
    • KR1020050026389A
    • 2005-03-15
    • KR1020047018453
    • 2003-05-14
    • 신재균이한웅오구택
    • 신재균이한웅오구택
    • G01N33/68C12Q1/68
    • C12Q1/6883A01K2217/075C07K14/4702C07K2319/60C12Q2600/136C12Q2600/158G01N33/68
    • Role of p62 in aging-related disease is provided, which role of p62 includes development of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver, various tumors, increased male mortality, intracellular inclusion named sequestosome, and redox regulation. A method for screening a compound which inhibits manifestation of a p62 gene comprises the steps of: (a) contacting a compound with a sample containing p62 and ubiquitin; (b) determining the binding level of p62 and ubiquitin under conditions in which p62 specifically binds to ubiquitin; (c) determining the binding level of p62 and ubiquitin in the presence of the compound, and comparing it with the binding level of p62 and ubiquitin of steps (a) and (b), wherein the compound is decided as an inhibitor of p62 ubiquitin binding when the binding level is lower in step (c) than in step (b). A method for preventing binding between ubiquitin and p62 comprises the steps of: (a) preparing a recombinant viral or plasmid vector comprising a DNA sequence encoding a ubiquitin binding fragment of p62 polypeptide operatively linked to a promoter; and (b) administering the viral or plasmid vector to a patient in need thereof to induce binding between the ubiquitin-binding fragment of p62 and ubiquitin by the expression of the DNA sequence within a brain.
    • 提供p62在老龄化相关疾病中的作用,p62的作用包括发展肥胖,2型糖尿病,非酒精性脂肪肝,各种肿瘤,男性死亡率增加,细胞内包涵体命名为序列分析和氧化还原调节。 筛选抑制p62基因表达的化合物的方法包括以下步骤:(a)使化合物与含有p62和泛素的样品接触; (b)在p62与泛素特异性结合的条件下测定p62和泛素的结合水平; (c)确定化合物存在下p62和泛素的结合水平,并将其与步骤(a)和(b)的p62和泛素的结合水平进行比较,其中该化合物被确定为p62泛素的抑制剂 当步骤(c)中的结合水平低于步骤(b)时,结合。 防止泛素和p62之间的结合的方法包括以下步骤:(a)制备重组病毒或质粒载体,其包含编码与启动子有效连接的p62多肽的泛素结合片段的DNA序列; 和(b)向有需要的患者施用病毒或质粒载体以通过脑内的DNA序列的表达诱导p62的泛素结合片段与泛素之间的结合。
    • 5. 发明授权
    • 고밀도 화학섬유 직물의 제직방법 및 장치
    • 用于加工高密度合成纤维布的方法和装置
    • KR100734911B1
    • 2007-07-03
    • KR1020060090123
    • 2006-09-18
    • (주)세진안홍태신재균
    • 안홍태신재균
    • D03J1/06D03J1/00
    • D03J1/06D03D41/00D03D49/00D03J2700/02D06B15/00D06C7/00
    • A method and an apparatus for weaving high-density synthetic fiber cloth are provided to smoothly operate a weaving machine and obtain the high-density cloth, by changing the physical property of a chemical fiber yarn having heat sensitivity. A high-density synthetic fiber cloth is woven by heating a cloth fell(10) at which warp and weft are woven to form a texture. A heater(200) is installed adjacently to the cloth fell so as to heat the cloth fell. The cloth fell is heated at a temperature below and near the glass transition temperature. A controller keeps a heating temperature of the heater within a range of a predetermined temperature. The cloth fell is heated by using radiant heat, or applying hot air.
    • 提供一种用于编织高密度合成纤维布的方法和装置,以平滑地操作织造机,并通过改变具有热敏感性的化纤纱线的物理性质获得高密度布。 通过加热织物(10)编织高密度合成纤维布,经纱和纬纱被编织以形成纹理。 一个加热器(200)安装在布坠附近,以便加热布料。 在下降到接近玻璃化转变温度的温度下加热布料。 控制器将加热器的加热温度保持在预定温度的范围内。 通过使用辐射热或使用热空气来加热布料。
    • 7. 实用新型
    • 휴즈 홀더
    • KR2019960009337U
    • 1996-03-16
    • KR2019940022190
    • 1994-08-31
    • 신재균
    • 신재균
    • H01H85/00
    • 본고안은휴즈홀더에관한것으로, 상면중앙으로부터아랫쪽으로일정깊이의휴즈삽입홈이형성된절연성본체와, 상기휴즈삽입홈의상부와하부에고정설치되며각각전선과연결되는상하부접속단자와, 상기휴즈삽입홈의상방으로부터씌워지며내주연에는상부접속단자상면으로부터돌설된상기휴즈가이드보스와나사결합되는도전성의부싱이일체로형성되고, 다각형머리부의내주연상에는투시창이일체형으로끼워진절연성캡으로이루어지는휴즈홀더에있어서, 상기캡의다각형머리부내주연에끼워진투시창의소정위치와, 이와대응되는머리부내측면소정위치에, 내주연상의부싱위치까지도달되는소정직경의테스터봉끼움공을형성하여하므로써, 휴즈의단서여부를확인하고자하는경우에캡을직접분리하지않고도테스터를이용하여감전사고의위험을줄이면서비교적안전하게확인및 점검할수 있도록한 것이다.
    • 9. 发明公开
    • 비질과 물걸레 청소가 동시에 가능한 청소기
    • 具有刷和功能的清洁剂
    • KR1020010092962A
    • 2001-10-27
    • KR1020000015715
    • 2000-03-28
    • 신재균
    • 신재균
    • A47L11/00
    • A47L11/282A47L11/24A47L11/4069
    • PURPOSE: A cleaner is provided to improve convenience and time saving effect by enabling a cleaner to simultaneously sweep and wipe a place using a roller with a broom and a roller with a dustcloth. CONSTITUTION: A cleaner comprises: a cover with a handle and a penetrated hole for installation and separation of a dust bag; a drive motor(21) having a reduction unit(20); a drive gear(22); dustcloth rollers(23) having a driven gear(24) and a drive sprocket(27) below the drive gear; and a body having a drive unit connected with a brush roller(26) via a chain(28) and having a driven sprocket(29). The dustcloth rollers rotate at a specific speed, and so does the brush roller. The brush roller collects dust or wastes on the floor into a dust bag, and the dustcloth rollers wipe the floor. As brushing and wiping are performed simultaneously, convenience is improved and time is saved.
    • 目的:提供清洁剂,通过使用清洁剂同时扫掠并使用带扫帚的滚筒和带有抹布的滚筒擦拭地方,从而提高方便性和节省时间的效果。 构成:清洁器包括:具有手柄的盖和用于安装和分离除尘袋的穿透孔; 具有减速单元(20)的驱动马达(21); 驱动齿轮(22); 在驱动齿轮下方具有从动齿轮(24)和驱动链轮(27)的抹灰辊(23) 以及具有经由链条(28)与刷辊(26)连接并具有从动链轮(29)的驱动单元的主体。 抹布辊以特定的速度旋转,刷辊也是如此。 刷辊将地板上的灰尘或废物收集到防尘袋中,抹布辊擦拭地板。 随着刷洗和擦拭同时进行,便利性得到改善,节省了时间。