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1. 发明授权

KR100500760B1 염산 프로피베린의 제조방법 有权
标题翻译：丙酸炔丙酯的制备方法
公开(公告)号：KR100500760B1
公开(公告)日：2005-07-14
申请号：KR1020030050111
申请日：2003-07-22
申请人： 동방에프티엘 주식회사
发明人： 박찬신 , 이정권 , 최선희
IPC分类号： C07D211/44
摘要： 본 발명은 벤질릭산으로부터 On-프로필벤질릭산을 제조하는 단계; 및 상기 On-프로필벤질릭산을 4-히드록시-1-메칠피페리딘과 반응하여 프로피베린을 제조하고 염산을 사용하여 염산프로피베린을 제조하는 단계로 이루어진 염산프로피베린 제조방법에 관한 것이다.

2. 外观设计

KR3001713720000S 失效
公开(公告)号：KR3001713720000S
公开(公告)日：1996-01-08
申请号：KR3019940019634
申请日：1994-09-09
申请人： 동방에프티엘 주식회사
设计人： 송한영

3. 发明授权

KR100411599B1 5-치환된 인돌 유도체의 제조방법 有权
标题翻译： 5-치환된인돌유도체의제조방법
公开(公告)号：KR100411599B1
公开(公告)日：2003-12-18
申请号：KR1020010065508
申请日：2001-10-23
申请人： 동방에프티엘 주식회사
发明人： 김영배 , 이정권 , 최선희 , 강문석
IPC分类号： C07D209/14
摘要： PURPOSE: A process for preparing 5-substituted indol derivative is provided, thereby the 5-substituted indol derivative can be prepared in higher yield because a process for preparing an intermediate, ethyl 5-substituted indol-2-carboxylic acid is not required. CONSTITUTION: A process for preparing 5-substituted indol derivative comprises the steps of: treating p-substituted aniline derivative of formula(II) with sodium nitrate and hydrochloric acid to prepare p-substituted azoate chloride; reacting the p-substituted azoate chloride with ethyl alpha-methyl acetoacetate to prepare azoester; treating the azoester with hydrochloric acid and methanol to prepare ethyl pyruvate p-substituted phenylhydrazone; reacting the pyruvate p-substituted phenylhydrazone with polyphosphoric acid in toluene to prepare 5-substituted indol-2-carboxylate; and reacting the ethyl 5-substituted indol-2-carboxylate with a mixture of sulfuric acid and acetic acid or hydrogen bromide, wherein R is methyl, bromo, cyano, carboxy and methoxy.
摘要翻译：目的：提供一种制备5-取代的吲哚衍生物的方法，因此可以以较高的收率制备5-取代的吲哚衍生物，因为不需要制备中间体5-取代的吲哚-2-羧酸的方法。构成：制备5-取代的吲哚衍生物的方法包括以下步骤：用硝酸钠和盐酸处理式（II）的对位取代的苯胺衍生物以制备对取代的偶氮酸氯化物; 使对位取代的偶氮酸氯与乙基α-甲基乙酰乙酸酯反应制备偶氮酯; 用盐酸和甲醇处理该偶氮酯以制备丙酮酸乙酯对取代的苯腙; 使丙酮酸对位取代的苯腙与多磷酸在甲苯中反应以制备5-取代的吲哚-2-羧酸酯; 使5-取代的吲哚-2-羧酸乙酯与硫酸和乙酸或溴化氢的混合物反应，其中R是甲基，溴，氰基，羧基和甲氧基。

4. 发明公开

KR1020030033504A 구굴스테론의 제조방법 有权
标题翻译：生产防腐剂的方法
公开(公告)号：KR1020030033504A
公开(公告)日：2003-05-01
申请号：KR1020010065507
申请日：2001-10-23
申请人： 동방에프티엘 주식회사
发明人： 김영배 , 이정권 , 최선희 , 강문석
IPC分类号： C07J13/00
CPC分类号： C07J13/007 , A61K31/56
摘要： PURPOSE: Provided are Z- and E-type guggulsterone, which inhibits subcutaneous fat and has anti-fatness and cholesterol inhibiting activities and are produced from 16-dihydro pregnaron acetate. CONSTITUTION: The Z- and E-type guggulsterone(formula 2a and 2b) having the ratio of 80:20 are produced by a process comprising the steps of: reducing the 16-dihydro pregnaron acetate in an organic solvent by Red-Aldrich to prepare 5,16-pregnadiene-3beta-20 diol, wherein the organic solvent is toluene, xylene, cumene, or methyl ethyl ketone; oxidizing the 5,16-pregnadiene-3beta-20 diol by p-toluene sulfonic acid to prepare a mixture of 5,17(20)-trans pregnadiene-3beta, 16beta and 3beta, 16alpha diacetate; dissolving the mixture of 5,17(20)-trans pregnadiene-3beta, 16beta and 3beta, 16alpha diacetate in methanol solution in which potassium hydroxide is dissolved and refluxing to obtain 5,17(20)-trans pregnadiene-3beta, 16beta and 3beta, 16alpha diol; oxidizing the 5,17(20)-trans pregnadiene-3beta, 16beta and 3beta, 16alpha diol by NiO in the presence of a hydrogen acceptor mixture of cyclopentanone and acetone.
摘要翻译：目的：提供Z型和E型古格斯酮，其抑制皮下脂肪并具有抗脂肪和胆固醇抑制活性，并由16-二氢孕烯乙酸酯制备。构成：通过包括以下步骤的方法产生具有80:20比例的Z型和E型格格酮（式2a和2b），该方法包括：通过Red-Aldrich在有机溶剂中还原16-二氢孕烯乙酸酯以制备 5,16-孕二烯-3β-20二醇，其中有机溶剂是甲苯，二甲苯，异丙基苯或甲基乙基酮; 通过对甲苯磺酸氧化5,16-孕二烯-3β-20二醇以制备5,17（20） - 反式孕二烯-3β，16beta和3β，16α二乙酸酯的混合物; 将5,17（20） - 反式孕二烯-3βeta，16beta和3β，16α二乙酸酯的混合物溶解在其中溶解氢氧化钾并回流的甲醇溶液中，得到5,17（20） - 反式孕二烯-3βeta，16beta和3β ，16α二醇; 在环戊酮和丙酮的氢受体混合物存在下，通过NiO氧化5,17（20） - 反式孕二烯-3β，16beta和3β，16α二醇。

5. 发明授权

KR100513162B1 길경 유동 엑스 추출물의 제조 방법 有权
标题翻译：来自桔梗的提取物的制备方法A.DC
公开(公告)号：KR100513162B1
公开(公告)日：2005-09-07
申请号：KR1020010076224
申请日：2001-12-04
申请人： 동방에프티엘 주식회사
发明人： 김창희 , 이정권 , 김정현
IPC分类号： A61K36/346 , A61P3/10
摘要： 본 발명은 건조 길경을 세라믹으로 제작된 가열건조기내에서 질소가스를 사용하여 분무하면서 110∼130℃에서 가열 처리한 후 에탄올 중에서 초고주파 처리하여 제균여과기로 여과하여 고함량의 조사포닌이 함유된 길경 추출물의 제조방법에 관한 것이다.

6. 发明公开

KR1020050011139A 프로필벤질릭산 에스터로부터 염산 프로피베린의 제조방법 有权
标题翻译：用于制备作为中间体的O-N-丙氧基酸的丙酸氯丙酯的方法
公开(公告)号：KR1020050011139A
公开(公告)日：2005-01-29
申请号：KR1020030050112
申请日：2003-07-22
申请人： 동방에프티엘 주식회사
发明人： 박찬신 , 이정권 , 최선희
IPC分类号： C07D211/44
摘要： PURPOSE: A process for preparing propiverine hydrochloride from O-n-propylbenzylic acid is provided, thereby easily preparing propiverine hydrochloride which has improved anti-choline and calcium-antagonizing activity and is useful for prevention and treatment of various urination disorders of domestic animals using O-n-propylbenzylic acid as an intermediate. CONSTITUTION: The process for preparing propiverine hydrochloride from O-n-propylbenzylic acid comprises the steps of: reacting O-n-propylbenzylic acid ester with 4-hydroxy-1-methylpiperidine to prepare propiverine; and crystallizing the propiverine with hydrochloric acid gas, wherein the O-n-propylbenzylic acid ester is prepared by reacting benzylic acid with one or more alcohols selected from methanol, ethanol, n-propanol and isopropanol to prepare benzylic acid ester, sequentially adding tetrahydrofuran, triphenylphosphine and 1-propanol into the benzylic acid ester under nitrogen condition, adding 40% diethylazodicarboxylate into the mixed solution, adding benzylic acid ester in tetrahydrofuran into the mixed solution and reacting them.
摘要翻译：目的：提供从丙基苄基酸制备盐酸丙酸的方法，从而容易地制备具有改善的抗胆碱和钙拮抗活性的丙酸炔丙酯，并且可用于预防和治疗使用基于丙基苄基的家畜的各种排尿障碍酸作为中间体。构成：从O-正丙基苄基酸制备盐酸丙酸的方法包括以下步骤：使O-正丙基苄基酯与4-羟基-1-甲基哌啶反应制备丙酸; 并用盐酸气体结晶丙酰胺，其中通过苄基酸与选自甲醇，乙醇，正丙醇和异丙醇的一种或多种醇反应制备苄酸酯，依次加入四氢呋喃，三苯基膦和在氮气条件下将1-丙醇加入苄酸酯中，加入40％二乙基偶氮二羧酸二乙酯于混合溶液中，将苄酸酯在四氢呋喃中加入到混合溶液中并使其反应。

7. 发明公开

KR1020050011138A 염산 프로피베린의 제조방법 有权
标题翻译：使用O-N-丙烯酸作为中间体制备丙酸盐酸盐的方法
公开(公告)号：KR1020050011138A
公开(公告)日：2005-01-29
申请号：KR1020030050111
申请日：2003-07-22
申请人： 동방에프티엘 주식회사
发明人： 박찬신 , 이정권 , 최선희
IPC分类号： C07D211/44
摘要： PURPOSE: A process for preparing propiverine hydrochloride is provided, thereby easily preparing propiverine hydrochloride which has improved anti-choline and calcium-antagonizing activity and is useful for prevention and treatment of various urination disorders of domestic animals using O-n-propylbenzylic acid as an intermediate. CONSTITUTION: The process for preparing propiverine hydrochloride comprises the steps of: preparing O-n-propylbenzylic acid from benzylic acid by oxidizing benzylic acid with phosphate pentachloride and reacting the oxidized benzyl with 1-propanol, or by reacting benzylic acid with propylchloride; reacting the O-n-propylbenzylic acid with 4-hydroxy-1-methylpiperidine to prepare propiverine; and adding hydrochloric acid into propiverine to prepare propiverine hydrochloride.
摘要翻译：目的：提供一种制备盐酸丙酸的方法，从而易于制备具有改善的抗胆碱和钙拮抗活性的盐酸丙酸盐，并且可用于使用O-正丙基苄基酸作为中间体预防和治疗家畜的各种排尿障碍。构成：盐酸丙酸盐的制备方法包括以下步骤：通过用五氯化磷与苄基酸氧化苄基酸，并将氧化的苄基与1-丙醇反应，或通过苄基酸与丙基氯反应，由苄酸制备O-正丙基苄基酸; 使O-正丙基苄基酸与4-羟基-1-甲基哌啶反应以制备丙酸; 并加入盐酸以制备盐酸丙酸。

8. 发明授权

KR100510788B1 프로필벤질릭산 에스터로부터 염산 프로피베린의 제조방법 有权
标题翻译：由O-正丙基苄基酸制备盐酸丙酸的方法
公开(公告)号：KR100510788B1
公开(公告)日：2005-08-26
申请号：KR1020030050112
申请日：2003-07-22
申请人： 동방에프티엘 주식회사
发明人： 박찬신 , 이정권 , 최선희
IPC分类号： C07D211/44
摘要： 본 발명은 벤질릭산으로부터 제조한 On-프로필벤질릭산 에스터를 4-히드록시-1-메칠피페리딘과 반응시켜 프로피베린를 제조한 다음 염산가스로 결정화하여 염산프로피베린을 제조하는 염산프로피베린의 제조방법이다.

9. 发明公开

KR1020040043971A 자연산 상황버섯, 녹차, 정향, 영실 추출물의 추출방법 및그 혼합 추출물을 사용한 미백 화장품의 제조 방법 无效
标题翻译：方法提取枸杞子，绿茶，青蒿素和玫瑰果冻以及含有提取物的皮肤白化化妆品
公开(公告)号：KR1020040043971A
公开(公告)日：2004-05-27
申请号：KR1020020072451
申请日：2002-11-20
申请人： 동방에프티엘 주식회사
发明人： 김창희 , 이학수
IPC分类号： A61K8/97 , A61Q19/02
CPC分类号： A61K8/9706 , A61K8/97 , A61K2800/59 , A61K2800/782 , A61Q19/02
摘要： PURPOSE: Provided are a method for extracting Phellinus linteus, green tea, Caryophilli flos and Rosae fructus and skin whitening cosmetics comprising the extracts which inhibit the generation of melanin on the skin, ameliorate a discoloration on the face and freckles, and have anti-aging effect. CONSTITUTION: A skin whitening cosmetics composition is characterized by containing the extract consisting of 5 parts by weight of Phellinus linteus extract, 1 parts by weight of green tea extract, 1 parts by weight of Caryophilli flos, and 1 parts by weight of Rosae fructus.
摘要翻译：目的：提供一种提取番茄，绿茶，Caryophilli flos和Rosana fructus以及皮肤美白化妆品的方法，其包含抑制皮肤上黑色素产生的提取物，改善面部和雀斑上的变色，并具有抗老化影响。构成：皮肤美白化妆品组合物的特征在于含有由5重量份的桑黄提取物，1重量份的绿茶提取物，1重量份的Caryophilli flos和1重量份的Rosae fructus组成的提取物。

10. 发明公开

KR1020030033505A 5-치환된 인돌 유도체의 제조방법 有权
标题翻译：制备5代中性衍生物的方法
公开(公告)号：KR1020030033505A
公开(公告)日：2003-05-01
申请号：KR1020010065508
申请日：2001-10-23
申请人： 동방에프티엘 주식회사
发明人： 김영배 , 이정권 , 최선희 , 강문석
IPC分类号： C07D209/14
摘要： PURPOSE: A process for preparing 5-substituted indol derivative is provided, thereby the 5-substituted indol derivative can be prepared in higher yield because a process for preparing an intermediate, ethyl 5-substituted indol-2-carboxylic acid is not required. CONSTITUTION: A process for preparing 5-substituted indol derivative comprises the steps of: treating p-substituted aniline derivative of formula(II) with sodium nitrate and hydrochloric acid to prepare p-substituted azoate chloride; reacting the p-substituted azoate chloride with ethyl alpha-methyl acetoacetate to prepare azoester; treating the azoester with hydrochloric acid and methanol to prepare ethyl pyruvate p-substituted phenylhydrazone; reacting the pyruvate p-substituted phenylhydrazone with polyphosphoric acid in toluene to prepare 5-substituted indol-2-carboxylate; and reacting the ethyl 5-substituted indol-2-carboxylate with a mixture of sulfuric acid and acetic acid or hydrogen bromide, wherein R is methyl, bromo, cyano, carboxy and methoxy.
摘要翻译：目的：提供5-取代的吲哚衍生物的制备方法，因为5-取代的吲哚衍生物可以以更高的收率制备，因为不需要制备中间体5-取代的吲哚-2-羧酸乙酯的方法。构成：制备5-取代的吲哚衍生物的方法包括以下步骤：用硝酸钠和盐酸处理式（II）的对取代苯胺衍生物以制备对取代的偶氮氯化物; 使对取代的偶氮氯化物与乙酰乙酸乙酯乙酯反应，制备亚硒酯; 用盐酸和甲醇处理亚硒酸盐，制备丙酮酸乙酯取代苯腙; 使丙酮酸对取代苯腙与多磷酸在甲苯中反应制备5-取代的吲哚-2-羧酸酯; 并使5-取代的吲哚-2-羧酸乙酯与硫酸和乙酸或溴化氢的混合物反应，其中R是甲基，溴，氰基，羧基和甲氧基。

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