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1. 发明公开

KR1020020008814A 알레르기성 질환 치료용 조성물 无效
标题翻译：过敏性疾病中的治疗组合物
公开(公告)号：KR1020020008814A
公开(公告)日：2002-01-31
申请号：KR1020010070534
申请日：2001-11-13
申请人： (주)쎌믹스
发明人： 김재홍 , 김익영
IPC分类号： A61K33/04
摘要： PURPOSE: A therapeutic composition in allergic diseases is provided, which composition can inhibit the activity of NF- B that is a transcription-regulating factor of inflammation-inducing gene, and is thus useful for the treatment of inflammation relating diseases. CONSTITUTION: The therapeutic composition in allergic diseases contains sodium selenite as an active ingredient, in which the allergic disease is selected from asthma, allergic splenitis, allergic conjunctivitis, atopic dermatitis, contact dermatitis and inflammatory enteritis; the effective amount of the composition is 0.1 to 1.25 mg per 1 kg of the weight of a mammal, more preferably 0.01 to 0.125 mg/kg and most preferably 0.001 to 0.0125 mg/kg a day. The composition may be administrated orally, rectally, topically, non-orally or optically.
摘要翻译：目的：提供过敏性疾病的治疗组合物，该组合物可以抑制作为炎性诱导基因的转录调节因子的NF-B的活性，因此可用于治疗炎症相关疾病。构成：过敏性疾病中的治疗组合物含有亚硒酸钠作为活性成分，其中过敏性疾病选自哮喘，过敏性脾炎，过敏性结膜炎，特应性皮炎，接触性皮炎和炎性肠炎; 组合物的有效量为每1kg哺乳动物为0.1〜1.25mg，更优选为0.01〜0.125mg / kg，最优选为0.001〜0.0125mg / kg。组合物可以口服，直肠，局部，非口服或光学给药。

2. 发明公开

KR1020020009532A 류코트리엔 합성 억제용 조성물 无效
标题翻译：用于抑制紫杉醇合成的组合物
公开(公告)号：KR1020020009532A
公开(公告)日：2002-02-01
申请号：KR1020010070533
申请日：2001-11-13
申请人： (주)쎌믹스
发明人： 김재홍
IPC分类号： A61K31/4439
摘要： PURPOSE: A pharmaceutical composition containing a therapeutically effective amount of imidazole compounds and pharmaceutically acceptable salts thereof is provided, which can prevent and treat diseases caused by leukotriene such as asthma, chronic bronchitis, allergy and allergic disease, arthritis or the like. CONSTITUTION: The composition contains 4-(4-fluorophenyl)-2-(4-methylsulfinyl)-5-(4-pyridyl)1H-imidazole as imidazole compounds of formula 1 and pharmaceutically acceptable salts and inhibits leukotriene synthesis in warm-blooded animals. The imidazole compound inhibits the movement of the nuclear membrane of lipoxygenase. The effective daily intake amount of the compounds of formula 1 is orally about 0.1 to 2.5mg/Kg weight of warm-blooded animals.
摘要翻译：目的：提供含有治疗有效量的咪唑化合物及其药学上可接受的盐的药物组合物，其可以预防和治疗由白细胞三烯如哮喘，慢性支气管炎，过敏和过敏性疾病，关节炎等引起的疾病。组成：该组合物含有作为式1咪唑化合物的4-（4-氟苯基）-2-（4-甲基亚磺酰基）-5-（4-吡啶基）1H-咪唑及其药学上可接受的盐，并在温血动物中抑制白三烯合成。咪唑化合物抑制脂氧合酶的核膜的运动。式1化合物的有效每日摄入量口服约为0.1至2.5mg / Kg重量的温血动物。

3. 发明授权

KR100626850B1 흑미추출물을 이용한 알레르기성 질환 예방 또는 치료용조성물 및 이들의 치료학적 용도 有权
标题翻译：使用黑米提取物预防或治疗过敏性疾病的组合物及其治疗用途
公开(公告)号：KR100626850B1
公开(公告)日：2006-09-21
申请号：KR1020040021843
申请日：2004-03-30
申请人： (주)쎌믹스
发明人： 김재홍
IPC分类号： A61K36/899 , A61P37/08
CPC分类号： A61K31/352 , A61K31/353 , A61K31/7048 , A61K36/88 , A61K36/899
摘要： 본 발명은 흑미추출물을 이용한 알레르기성 질환의 예방 또는 치료용 조성물 및 그 치료학적 용도에 관한 것이다. 보다 상세하게는 호산구의 조직 내 침착을 억제 하는 활성을 나타내는 페랄고니딘, 시아니딘 배당체 또는 이들을 함유하는 흑미추출물을 유효성분으로 함유하는 알레르기성 질환 예방 또는 치료용 조성물 및 이들의 치료학적 용도에 관한 것이다. 본 발명의 페랄고니딘, 시아니딘 배당체 또는 이들을 함유하는 흑미추출물은 호산구의 조직내 침착과 이로 인한 알레르기성 염증반응을 억제하므로, 알레르기성 비염, 알레르기성 결막염, 천식, 만성폐쇄성폐질환, 아토피성 피부염, 알레르기성 설사 등과 같이 조직 내 염증과 호산구 침착을 동반하는 알레르기성 질환을 예방 또는 치료하는데 유용하게 사용될 수 있다.
페랄고니딘, 시아니딘 배당체, 흑미추출물, 염증, 호산구, 알레르기성 질환

4. 发明公开

KR1020040086790A 흑미추출물을 이용한 알레르기성 질환 예방 또는 치료용조성물 및 이들의 치료학적 용도 有权
标题翻译：使用黑麦提取物及其治疗方法预防或治疗过敏症的组合物
公开(公告)号：KR1020040086790A
公开(公告)日：2004-10-12
申请号：KR1020040021843
申请日：2004-03-30
申请人： (주)쎌믹스
发明人： 김재홍
IPC分类号： A61K36/899 , A61P37/08
CPC分类号： A61K31/352 , A61K31/353 , A61K31/7048 , A61K36/88 , A61K36/899
摘要： PURPOSE: Provided are a composition for preventing or treating allergic diseases using black rice extract as active ingredient and its therapeutic use. The black rice extract inhibits eosinophil involvement causing allergic inflammatory reaction, and is thus useful for the prevention and treatment of allergic diseases. CONSTITUTION: The extract of black rice is characterized by containing 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-1-benzopyrylium chloride of the formula(1) or cyanidin-3-o-beta-glucopyranoside of the formula(2). The composition for preventing or treating allergic diseases contains, as active ingredient, 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-1-benzopyrylium chloride of the formula(1), its pharmaceutically effective salt or diploid, or cyanidin-3-O-beta-glucopyranoside of the formula(2) or its pharmaceutically effective salt.
摘要翻译：目的：提供使用黑米提取物作为有效成分及其治疗用途的用于预防或治疗过敏性疾病的组合物。黑米提取物抑制嗜酸性粒细胞参与引起过敏性炎症反应，因此可用于预防和治疗过敏性疾病。构成：黑米提取物的特征在于含有式（1）的3,5,7-三羟基-2-（4-羟基苯基）-1-苯并吡喃氯化物或式（1）的花青素-3-o-β-吡喃葡萄糖苷（2）。用于预防或治疗过敏性疾病的组合物含有式（1）的3,5,7-三羟基-2-（4-羟基苯基）-1-苯并吡喃氯化物作为活性成分，其药学上有效的盐或二倍体或花青素 -3-O-β-吡喃葡萄糖苷或其药学上有效的盐。

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