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81. 发明公开

KR1020110088197A 나팔꽃 캘러스 추출물을 함유하는 피부 외용제 조성물 有权
标题翻译：用于皮肤外部应用的组合物，包括药物提取物NALL CALLUS
公开(公告)号：KR1020110088197A
公开(公告)日：2011-08-03
申请号：KR1020100007989
申请日：2010-01-28
申请人： 주식회사 바이오에프디엔씨
发明人： 정대현 , 모상현 , 황현식 , 이정훈 , 김수정 , 김형식 , 서효현 , 배연자 , 임창일 , 정애진 , 박미영 , 김상미 , 조문진 , 성지연 , 이승준
IPC分类号： A61K36/39 , A61P17/00
摘要： PURPOSE: An external use skin composition containing Pharbitis nil callus extract is provided to activate skin cells by cell proliferation and to ensure antioxidation and anti-inflammation. CONSTITUTION: An external use skin composition for improving skin condition contains 0.1-10 weight% of Pharbitis nil callus extract as an active ingredient. The Pharbitis nil callus extract is the callus itself, Pharbitis nil callus powder, or extract thereof. The composition is a cosmetic composition or pharmaceutical composition. The composition contains cinnamaldehyde, capsaicin, EGCG, vanillin, or gallic acid.
摘要翻译：目的：提供含有愈伤组织愈伤组织提取物的外用皮肤组合物，通过细胞增殖活化皮肤细胞，并确保抗氧化和抗炎。构成：用于改善皮肤状况的外用皮肤组合物含有0.1-10重量％的作为活性成分的木瓜愈伤组织提取物。愈伤组织愈伤组织提取物是愈伤组织本身，没有愈伤组织的愈伤组织粉或其提取物。该组合物是化妆品组合物或药物组合物。该组合物含有肉桂醛，辣椒素，EGCG，香草醛或没食子酸。

82. 发明公开

KR1020110001830A 간엽줄기세포의 무혈청 배양액을 함유하는 피부주름 개선용 화장료 조성물 有权
标题翻译：化妆品组合物，用于包装骨髓干细胞无血清培养物溶液的皱纹
公开(公告)号：KR1020110001830A
公开(公告)日：2011-01-06
申请号：KR1020090059991
申请日：2009-06-30
申请人： 주식회사 바이오에프디엔씨 , 재단법인 인천경제산업정보테크노파크
发明人： 정대현 , 모상현 , 이정훈 , 김수정 , 김형식 , 서효현 , 임창일 , 이기범 , 노범석 , 박병희
IPC分类号： A61K8/98 , A61Q19/08
CPC分类号： A61K8/981 , A61K35/28 , A61K35/51 , A61Q19/08 , Y10S514/844
摘要： PURPOSE: A cosmetic composition containing serum-free culture medium of mesenchymal stem cells for anti-wrinkling is provided to ensure safety to the skin and antioxidation. CONSTITUTION: A cosmetic composition for improving anti-wrinkling contains serum-free culture medium of bone marrow or umbilical cord blood-derived mesenchymal stem cells. The medium contains 80-150 mM of glucose and 20-60 mM of glutamine. A serum-free culture medium of bone marrow or umbilical cord blood-derived mesenchymal stem cell is pretreated with UV-irradiated keratinocyte culture medium.
摘要翻译：目的：提供含有无血清培养基的间充质干细胞用于抗皱的化妆品组合物，以确保对皮肤的安全性和抗氧化作用。构成：用于改善抗皱的化妆品组合物含有骨髓或脐带血来源的间充质干细胞的无血清培养基。培养基含有80-150mM葡萄糖和20-60mM谷氨酰胺。用UV照射的角质形成细胞培养基预处理骨髓或脐带血源性间充质干细胞的无血清培养基。

83. 发明公开

KR1020100019632A 신규한 인간 베타 디펜신 유사 항균 펩타이드 및 이의 아토피 피부염 개선 소재로서의 활용 有权
标题翻译：新人类抗原防御素同源物及其作为抗真菌剂的用途
公开(公告)号：KR1020100019632A
公开(公告)日：2010-02-19
申请号：KR1020080078307
申请日：2008-08-11
申请人： 주식회사 바이오에프디엔씨
发明人： 김수정 , 정대현 , 모상현 , 이정훈 , 김형식 , 서효현
IPC分类号： C07K14/47 , C12N15/09 , A61K8/97
摘要： PURPOSE: A novel human beta defensin-like antibacterial peptide is provided to relieve dermatitis including atopic dermatitis and to ensure antibacterial activity. CONSTITUTION: A human beta defensin-like antibacterial peptide is denoted by amino acid of sequence number 1. A gene encoding the human beta defensin-like antibacterial peptide has a sequence of sequence number 2. An expression vector contains the gene encoding the peptide. The gene is derived from human keratinocytes. A cosmetic composition for treating atopic dermatitis contains 0.01-10 weight% of a human beta defensin-like antibacterial peptide. The cosmetic composition is used in the form of an emulsion, lotion, cream(oil-in-water, water-in-oil, multi-phase), solution, suspension(anhydrous and hydrous), anhydrous product(oil and glycol), gel, mask, pack, or powder.
摘要翻译：目的：提供一种新的人类β防御素样抗菌肽，以缓解皮炎，包括特应性皮炎，并确保抗菌活性。构成：人β-防御素样抗菌肽由序列号1的氨基酸表示。编码人β-防御素样抗菌肽的基因具有序列号2的序列。表达载体含有编码该肽的基因。该基因衍生自人角质形成细胞。用于治疗特应性皮炎的化妆品组合物含有0.01-10重量％的人β-防御素样抗菌肽。化妆品组合物以乳液，洗剂，霜剂（油包水，油包水，多相），溶液，悬浮液（无水和含水），无水产物（油和乙二醇）的形式使用，凝胶，面膜，包装或粉末。

84. 发明公开

KR1020100011176A 한방 복합 추출물을 이용한 탈모 방지 및 모발 생장 촉진용조성물 有权
标题翻译：自然和定向复合物具有抗毛发和头发生长刺激效应
公开(公告)号：KR1020100011176A
公开(公告)日：2010-02-03
申请号：KR1020080072287
申请日：2008-07-24
申请人： 주식회사 코스메카코리아 , 주식회사 바이오에프디엔씨 , 김형철
发明人： 박선기 , 차영권 , 엄태명 , 김형철 , 정대현 , 모상현 , 이정훈 , 김수정 , 김형식 , 서효현 , 배연자
IPC分类号： A61K8/97 , A61Q7/00
CPC分类号： A61K8/97 , A61K8/925 , A61K2800/59 , A61Q5/00 , A61Q7/00
摘要： PURPOSE: A composition for preventing hair loss and promote hair growth using medicinal herb extract is provided to ensure low irritation to the skin and promote hair growth. CONSTITUTION: A cosmetic composition for preventing hair loss and promoting hair growth contains 10-25 weight% of Chrysanthemum indicum L., 10-25 weight% of Carthamus tinctorius, 10-25 weight% of Calendula arvensis, 10-25 weight% of Lonicera japonica Thunberg, 10-25 weight% of Inula Britannica var. japonica., and 0.1-5 weight% of badger oil as active ingredient. The medicinal herb extract is contained in 0.001-5 weight% of dry or 0.001-50.00% of liquid phase. The medicinal herb extract is obtained by adding 1 to 15 times volume of extract solvent to Chrysanthemum indicum L., Carthamus tinctorius, Calendula arvensis, Lonicera japonica Thunberg, Inula Britannica var. japonica., and badger oil, heating at 80-100°C for 8 to 48 hours, extracting at 4-10°C for 3 to 20 days. The extraction solvent is water, ethanol, ethylacetate, glycerin, ethyleneglycol, butyleneglycol, propyleneglycol, hydrous ethano, hydrous glycerin, hydrous ethyleneglycol, hydrous butyleneglycol, or hydrous propyleneglycol. The composition is used in the form of shampoo, rinse, hair gel, hair tonic, hair lotion, soap, or hair pack.
摘要翻译：目的：提供使用药草提取物预防脱发和促进头发生长的组合物，以确保对皮肤的低刺激并促进毛发生长。构成：用于防止脱发和促进头发生长的化妆品组合物含有10-25重量％的菊花，10-25重量％的红花，10-25重量％的金盏花，10-25重量％的忍冬 j豆Thunberg，10-25重量％的Inula Britannica var。 j ica和0.1-5重量％的獾油作为活性成分。药草提取物含有0.001-5重量％的干燥液或0.001-50.00％的液相。通过向菊花，Carthamus tinctorius，金盏花，忍冬子，Thunberg，Inula Britannica变种中加入1〜15倍量的提取溶剂，得到药用草药提取物。粳稻和獾油，在80-100℃下加热8至48小时，在4-10℃下提取3至20天。提取溶剂为水，乙醇，乙酸乙酯，甘油，乙二醇，丁二醇，丙二醇，含水乙醇，含水甘油，含水乙二醇，含水丁二醇或含水丙二醇。该组合物以洗发剂，漂洗剂，发胶，头发补品，洗发剂，肥皂或头发包的形式使用。

85. 发明公开

KR1020100007654A 피부미백용 한방 화장료 조성물 有权
标题翻译：用于皮肤白化和皱纹护理的中国化妆品组合物及其制备方法
公开(公告)号：KR1020100007654A
公开(公告)日：2010-01-22
申请号：KR1020080068390
申请日：2008-07-11
申请人： 주식회사 바이오에프디엔씨
发明人： 모상현 , 정대현 , 이정훈 , 김수정 , 김형식 , 서효현 , 배연자 , 임창일 , 정애진 , 모지홍
IPC分类号： A61K8/97 , A61Q19/02 , A61Q19/00
CPC分类号： A61K8/97 , A61K2800/72 , A61Q19/02 , A61Q19/08
摘要： PURPOSE: An oriental medicinal herb cosmetic composition for improving skin whitening and anti-wrinkling is provided to ensure strong anti-oxidation without cytotoxicity. CONSTITUTION: An oriental medicinal herb cosmetic composition for improving skin whitening and anti-wrinkle contains 50-70 weight parts of Thuja orientalis extract, 20-40 weight parts of Zanthoxylum piperitum extract, and 5-15 weight parts of Polygonum Cuspidatum. A method for producing the composition for improving skin whitening and anti-wrinkle comprises: a step of heating Thuja orientalis and Zanthoxylum piperitum at 80-100°C for 4 to 8 hours; a step of heating the extract at 80-100°C and collecting the liquid; and a step of heating Polygonum Cuspidatum at 80-100°C to obtain hot water extract.
摘要翻译：目的：提供用于改善皮肤美白和抗皱的东方药草化妆品组合物，以确保强力的抗氧化，无细胞毒性。构成：用于改善皮肤美白和抗皱的东方药草化妆品组合物含有50-70重量份的东方蓟马提取物，20-40重量份的花椒酱提取物和5-15重量份的Poly草。一种用于生产用于改善皮肤美白和抗皱的组合物的方法包括：在80-100℃下加热东方蓟马和花椒素4至8小时的步骤; 在80-100℃下加热萃取液并收集液体的步骤; 并在80-100℃下加热枸杞子以获得热水提取物的步骤。

86. 发明授权

KR100820010B1 라벤더，베르가못，후리지아，페퍼민트，카모마일 및 로즈마리를 함유하는 피부 및 두피 보호용 항산화 허브 화장료 조성물 및 그 제조방법 有权
标题翻译：抗氧化剂草药组合物，其含有RAVENDOR，HORSEMINT，FREESIA，PEPPERMINT，用于保护皮肤和头发皮肤的护肤品和护肤品及其制备方法
公开(公告)号：KR100820010B1
公开(公告)日：2008-04-07
申请号：KR1020060099587
申请日：2006-10-13
申请人： 주식회사 바이오에프디엔씨 , 주식회사 나투젠
发明人： 정대현 , 모상현 , 이정훈 , 김수정 , 최선애 , 김현 , 박문정 , 손영기 , 이덕성 , 이건봉
IPC分类号： A61K8/97 , A61Q19/08
CPC分类号： A61K8/97 , A61K36/28 , A61K36/53 , A61K36/534 , A61K36/752 , A61K2236/331 , A61K2800/522 , A61Q19/08
摘要： An anti-oxidizing oriental herb cosmetic composition is provided to be adequate for being added to a cosmetic product for protecting skin and scalp due to no toxicity against keratinocyte, excellent chemical antioxidizing capability and oxidation inhibitory capacity of an enzyme and no succession of microorganisms even for a long storage time and be effective for soothing damaged skin due to excellent skin soothing effect on inflammation. A method for preparing an anti-oxidizing oriental herb cosmetic composition with skin and scalp protecting effect comprises the steps of: (a) extracting a mixture consisting of 10-20 parts by weight of lavender, 10-20 parts by weight of horsemint, 10-20 parts by weight of freesia, 10-20 parts by weight of peppermint, 10-20 parts by weight of chamomile and 10-20 parts by weight of rosemary with hot water; and (b) heating the hot water extract to generate vapor and cooling the vapor to obtain distillate.
摘要翻译：提供抗氧化东方草本化妆品组合物，以适于添加到用于保护皮肤和头皮的化妆品中，由于对角质形成细胞没有毒性，优异的化学抗氧化能力和酶的氧化抑制能力以及甚至对于长期保存时间，并有效舒缓受损皮肤，因为对炎症有良好的皮肤舒缓作用。一种制备具有皮肤和头皮保护作用的抗氧化东方草本化妆品组合物的方法包括以下步骤：（a）提取由10-20重量份薰衣草，10-20重量份的马匹，10 -20份重量的小苍兰，10-20份重的薄荷，10-20份重量的洋甘菊和10-20份重量的迷迭香与热水; 和（b）加热热水提取物以产生蒸气并冷却蒸气以获得馏出物。

87. 发明授权

KR100813781B1 아토피 피부염 개선능을 갖는 한방 조성물 및 그 제조방법 有权
标题翻译：具有提高特异度的能力的中文组合物及其制备方法
公开(公告)号：KR100813781B1
公开(公告)日：2008-03-13
申请号：KR1020060099583
申请日：2006-10-13
申请人： 주식회사 바이오에프디엔씨
发明人： 정대현 , 모상현 , 이정훈 , 김수정 , 최선애 , 김현
IPC分类号： A61K36/804 , A61K36/538 , A61K36/78 , A61P17/00
CPC分类号： A61K36/804 , A61K36/074 , A61K36/48 , A61K36/489 , A61K36/538 , A61K36/758 , A61K36/78 , A61K36/82 , A61K2236/331 , Y10S514/857
摘要： A traditional oriental medicine with atopic dermatitis improving capability is provided to show no toxicity on keratinocyte and strong antioxidative capability, do not have any succession of microorganism even for a long time storage so that the addition of an antiseptic for a cosmetic which is able to induce skin irritation when used for a long period of time is not needed and be effective for treating atopic dermatitis. A method for preparing a traditional oriental medicine with atopic dermatitis improving capability comprises the steps of: (a) mixing 4-6 parts by weight of Rehmannia glutinosa root, 4-6 parts by weight of Schizonepeta tenuifolia, 1-3 parts by weight of Panax notoginseng, 1-3 parts by weight of Polygonum fagopyrum seed, 1-3 parts by weight of Glycine soja seed, 4-6 parts by weight of Acanthopanax senticosus root, 5-7 parts by weight of Ulmus davidiana root, 3-5 parts by weight of Smilax glabra root, 4-6 parts by weight of Ginkgo biloba leaf, 4-6 parts by weight of Prunus armeniaca kernel, 4-6 parts by weight of Camellia sinensis leaf, 3-5 parts by weight of Sanguisorba officinalis root, 3-5 parts by weight of Phellodendron amurense bark, 4-6 parts by weight of Prunus mune fruit, 4-6 parts by weight of Zanthoxylum piperitum peel, 5-7 parts by weight of Pinus densiflora bark, 3-5 parts by weight of Portulaca oleracea, 3-5 parts by weight of Magnolia obovata bark, 5-7 parts by weight of Polygonum cuspidatum root, 1-3 parts by weight of Sophora angustifola root, 5-7 parts by weight of Ganoderma lucidum stem, 1-3 parts by weight of Carthamus tinctorius flower, 3-5 parts by weight of Bletilla striata root and 1-3 parts by weight of Rice(Oryza sativa) bran and extracting the mixture with hot water; and (b) cooling vapor generated by heating the hot water extract to obtain a distilled solution. The method further comprises a step of mixing 70-90 parts by weight of the traditional oriental composition prepared by the step(b) with 10-30 parts by weight of the hot water extract obtained from the step(a).
摘要翻译：提供具有特应性皮炎改善能力的传统东方药物，以显示对角质形成细胞无毒性和强抗氧化能力，即使长时间保存也不具有任何继代的微生物，因此添加能够诱导的化妆品的防腐剂皮肤刺激长时间使用不需要，对治疗特应性皮炎有效。一种用于制备具有特应性皮炎改善能力的传统东方药物的方法包括以下步骤：（a）将4-6份重的地黄枸杞子，4-6份重的荆芥，1-3份重量的三七，1-3重量份f草种子，1-3重量份甘氨酸大豆种子，4-6重量份刺五加，5-7重量份榆树根，3-5 重量百粒重的银杏叶粉，4-6份重量的银杏叶，4-6份重量的杏仁仁，4-6份重量的山茶花，3-5份重量的Sanguisorba officinalis 根，3-5重量份的黄柏树皮，4-6重量份的杏仁果，4-6重量份的花椒椒叶，5-7重量份的松属松树皮，3-5份，马齿苋（Portulaca oleracea），3-5重量份的木兰木皮，5-7重量份的P 枸杞根，1-3重量份苦参，5-7重量份灵芝，1-3重量份红花，3-5重量份白芷根和1- 3重量份米（水稻）麸皮，用热水萃取混合物; 和（b）冷却通过加热热水提取物产生的蒸气以获得蒸馏溶液。该方法还包括将70-90重量份由步骤（b）制备的传统东方组合物与10-30重量份由步骤（a）获得的热水提取物混合的步骤。

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