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    • 73. 发明公开
    • 선택적 세로토닌 재흡수 억제를 위한 조성물 및 그 제조 방법
    • 选择性丝氨酸重复抑制的组合物及其过程
    • KR1020090117736A
    • 2009-11-12
    • KR1020097016796
    • 2008-02-11
    • 인두스 바이오텍 프라이빗 리미티드
    • 바스카란순일비시와라만모한
    • A61K31/704A61K31/7024A61P25/24A61P3/04
    • A61K31/702A61K36/23
    • The present invention relates to a novelsynergistic pharmaceutical composition for serotonin reuptake inhibition, wherein thesaid composition comprises pentacyclic terpenoid glycosides, preferably asiaticoside and madecassoside optionally along with excipients. Also the present invention relates toexcipients; a process of preparation of novelsynergistic pharmaceutical composition for serotonin reuptake inhibition, wherein the process comprising steps of: (a) obtaining extract from the plant Centella asiatica; (b) treating the extract with the solvents to remove fatty substances, chlorophyll and other colorants; (c) purifying the extract through HPLC to obtain the eluted solvent; and (d) concentrating the eluted solvent to arrive at the composition. The invention also relates to thecomposition; and use of a composition comprising pentacyclic terpenoid glycosides, preferably asiaticoside and madecassoside optionally along with excipients to manufacture a medicament for serotonin reuptake inhibition in a subject in need thereof.
    • 本发明涉及一种用于5-羟色胺再摄取抑制的新颖的药物组合物,其中所述组合物包括五环萜糖苷,优选积雪草苷和十八烷基苷,任选地与赋形剂一起使用。 本发明还涉及清洁剂; 一种制备用于5-羟色胺再吸收抑制的新型药物组合物的方法,其中该方法包括以下步骤:(a)从植物积雪草获得提取物; (b)用溶剂处理提取物以除去脂肪物质,叶绿素等着色剂; (c)通过HPLC纯化萃取液得到洗脱溶剂; 和(d)浓缩洗脱的溶剂以得到组合物。 本发明还涉及组合物; 以及任选地与赋形剂一起使用包含五环萜糖苷,优选积雪草苷和十八烷基苷的组合物以制备有需要的受试者中的5-羟色胺再摄取抑制的药物。