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71. 发明授权

KR1019910003972B1 2,4-디클로로-5-플루오로벤조산의 제조방법 无效
标题翻译：制备2,4-二氯-5-氟代苯甲酸的方法
公开(公告)号：KR1019910003972B1
公开(公告)日：1991-06-17
申请号：KR1019880015380
申请日：1988-11-22
申请人： 씨제이 주식회사
发明人： 이광혁 , 박인협 , 박성용
IPC分类号： C07C63/10
摘要： A process for preparing 2,4-dichloro-5-fluorobenzoic acid of formula (I) comprises reacting 2,4-dichlorofluorobenzene with chloroacetylchloride in the presence of an acylating catalyst and an organic solvent at 35-120 deg.C to obtain 2,4- dichloro-5-fluoro-phenacylchloride of formula (II) with NaOCl at 30- 100 deg.C, and acidifying the obtd. cpd. with HCl or H2SO4. Pref. the acylating catalyst is selected from aluminum trichloride, aluminum tribromide or iron trichloride.
摘要翻译：制备式（I）的2,4-二氯-5-氟苯甲酸的方法包括在酰化催化剂和有机溶剂存在下，在35-120℃下使2,4-二氯氟苯与氯乙酰氯反应，得到2，式（II）的4-二氯-5-氟 - 苯甲酰氯与NaOCl在30-100℃反应，并酸化。 CPD。用HCl或H2SO4。县。酰化催化剂选自三氯化铝，三溴化铝或三氯化铁。

72. 发明公开

KR1019910006209A 2혹은 3-니트로 벤즈 알데히드의 제조 방법 无效
标题翻译： 2或3-硝基苯甲醛
公开(公告)号：KR1019910006209A
公开(公告)日：1991-04-27
申请号：KR1019890013975
申请日：1989-09-28
申请人： 씨제이 주식회사
发明人： 이광혁 , 박인협 , 이정교
IPC分类号： C07C201/12
摘要： 내용 없음

73. 发明授权

KR100473967B1 캐테콜 카르복실아미드 유도체 및 그를 함유한 약제학적 조성물 失效
标题翻译：儿茶酚羧基酰胺衍生物和含有它们的药物组合物
公开(公告)号：KR100473967B1
公开(公告)日：2005-03-07
申请号：KR1019990018882
申请日：1999-05-25
申请人： 씨제이 주식회사
发明人： 이정근 , 장명식 , 서병철 , 이광혁 , 이윤하 , 김영지 , 방원영
IPC分类号： C07D231/38
摘要： PURPOSE: Cathecol carboxylamide derivatives and a pharmaceutical composition containing the same compounds are provided, which compounds inhibit activity of phosphodiesterase IV so as to maintain the concentration of cyclic adenosine 3', 5'-monophosphate, and inhibit bronchial spasm and inflammation, so that the compounds are useful for treatment of asthma. CONSTITUTION: The cathecol carboxylamide derivatives represented by formula (I) or pharmaceutically acceptable salts thereof are provided, wherein R1 is C1-C7 alkyl or C3-C7 cycloalkane; X, Y and Z are (1) X = CH, Y = CH, Z = S, (2) X = N, Y = CH, Z = NR2, or (3) X = NR2, Y = N, Z = CH; R2 is C1-C6 alkyl; and W is O; and the cathecol carboxylamide derivative is 3-(3-cyclopentyloxy- 4-methoxyphenylcarboxylamino)- 1H-4- pyrazolecarboxylamide, 4-(3-cyclopentyloxy- 4-methoxyphenylcarboxylamido)- 1N-imidazol-5-carboxylamide, or 4-(3-cyclopentyloxy- 4-methoxyphenylcarboxylamido)-2 -diopencarboxylamide. A composition for prevention and treatment of asthma comprises the cathecol carboxylamide derivatives of formula (I) or pharmaceutically acceptable salts thereof.

74. 发明公开

KR1020040011753A 암로디핀의 유기산염 失效
标题翻译：有机酸亚麻酸盐
公开(公告)号：KR1020040011753A
公开(公告)日：2004-02-11
申请号：KR1020020044858
申请日：2002-07-30
申请人： 씨제이 주식회사
发明人： 조성환 , 윤용식 , 정윤택 , 박충실 , 이혁구 , 이광혁 , 정은주 , 김영훈 , 진해탁 , 천준희 , 이성학 , 정성학 , 임동권 , 연규정 , 김윤철 , 박경미 , 강현석
IPC分类号： C07D211/90
CPC分类号： C07D211/90
摘要： PURPOSE: Novel organic acid salt of amlodipine is provided which is excellent in physico-chemical properties. And its manufacture method and a pharmaceutical composition containing it are provided. CONSTITUTION: Amlodipine ethanesulfonic acid salt is represented by the formula(2) and has crystallized form. It is manufactured by reaction of amlodipine and ethanesulfonic acid in an inert solvent. A pharmaceutical composition contains a therapeutically effective amount of amlodipine ethanesulfonic acid salt and a pharmaceutically acceptable diluent or carrier.
摘要翻译：目的：提供氨氯地平的新型有机酸盐，物理化学性质优良。并提供其制造方法和含有它的药物组合物。构成：氨氯地平乙磺酸盐由式（2）表示，并具有结晶形式。它是通过氨氯地平和乙磺酸在惰性溶剂中的反应来制备的。药物组合物含有治疗有效量的氨氯地平乙磺酸盐和药学上可接受的稀释剂或载体。

75. 发明授权

KR100403143B1 1-브로모에틸 아세테이트의 제조방법 失效
标题翻译： 1-브로모에틸아세테이트의제조방법
公开(公告)号：KR100403143B1
公开(公告)日：2003-10-30
申请号：KR1020000076486
申请日：2000-12-14
申请人： 씨제이 주식회사
发明人： 이광혁 , 조성환 , 윤용식 , 최광도
IPC分类号： C07C67/44
摘要： PURPOSE: Provided is a method for preparing high purity 1-bromoethyl acetate of the formula by simple refining process using industrially available material. CONSTITUTION: The method comprises reacting acetyl bromide and para-aldehyde. The para-aldehyde is used in equivalent of 0.8-1.5. The reaction temperature is 30-50 deg.C. The reaction effects in the presence of zinc chloride catalyst. The method further comprises the steps of washing the reactants with water to remove unreacted acetyl bromide and HBr, and distilling the reactants under reduced pressure to isolate a pure 1-bromoethyl acetate of the formula.
摘要翻译：目的：提供一种通过使用工业上可获得的材料的简单精制方法来制备高纯度的下式的乙酸1-溴乙基酯的方法。组成：该方法包括使乙酰溴和对甲醛反应。对甲醛的使用量相当于0.8-1.5。反应温度为30-50℃。在氯化锌催化剂存在下的反应效果。该方法还包括以下步骤：用水洗涤反应物以除去未反应的乙酰溴和HBr，并在减压下蒸馏反应物以分离下式的纯1-溴乙基乙酸酯。

76. 发明授权

KR100377289B1 신규피리돈카르복실산유도체의중간체합성에관한새로운광학분할방법 失效
公开(公告)号：KR100377289B1
公开(公告)日：2003-08-09
申请号：KR1019950029142
申请日：1995-09-06
申请人： 씨제이 주식회사
发明人： 황호성 , 송석범 , 이재욱 , 김진완 , 이광혁
IPC分类号： C07D209/02
摘要： PURPOSE: Provided is a novel method of optical resolution for the synthesis of an intermediate of a novel pyridinecarboxylic acid derivative which has excellent antibacterial activity and used for medicaments and therapeutics for animals and fishes. CONSTITUTION: A method for manufacturing optical isomer of the formula(I) is characterized by reacting a compound of the formula(II) with 0.5-5.0 equivalent weight of an optical resolution agent(X) at -20 to 100 deg.C for 0.5-10 hours in the solvent selected from water, methanol, ethanol, isopropanol, n-butanol, isobutanol and t-butanol.

77. 发明公开

KR1020020049678A 7-아미노세팔로스포라닌산의 결정화 방법 失效
标题翻译：用于结晶7-氨基戊酸的方法
公开(公告)号：KR1020020049678A
公开(公告)日：2002-06-26
申请号：KR1020000078894
申请日：2000-12-20
申请人： 씨제이 주식회사
发明人： 이광혁 , 김진완 , 고동현 , 최광도
IPC分类号： C07D501/12
摘要： PURPOSE: Provided is a method for crystallizing 7-aminocephalosporanic acid(7-ACA) by adding acid having the mean value of each pKa of amino groups and carboxyl group to increase dissolving rate and filtration time. CONSTITUTION: The crystallizing method of 7-ACA is characterized by adding acid having 4-5 pKa, wherein in the acid is selected from the group consisting of acetic acid or formic acid. Therefore, 7-ACA having regular crystal size is manufactured in high yield.
摘要翻译：目的：提供通过加入具有氨基和羧基的每个pKa的平均值的酸来增加7-氨基头孢烷酸（7-ACA）的方法，以提高溶解速率和过滤时间。构成：7-ACA的结晶方法的特征在于加入具有4-5pKa的酸，其中酸选自乙酸或甲酸。因此，以高产率制造具有规则晶体尺寸的7-ACA。

78. 发明授权

KR100307211B1 옥사졸리디논유도체,이의제조방법및그를함유한항균제조성물 失效
标题翻译：恶唑烷酮衍生物，其制备方法和含有它们的抗微生物组合物
公开(公告)号：KR100307211B1
公开(公告)日：2001-11-30
申请号：KR1019970020523
申请日：1997-05-24
申请人： 씨제이 주식회사
发明人： 윤여흥 , 김학성 , 이광호 , 이광혁 , 강진아 , 이윤하
IPC分类号： C07D413/10 , C07D413/14
摘要： PURPOSE: Provided are an oxazolidinone derivative having stronger antibacterial effect on gram positive bacteria than vancomycin, its salt and hydrate, its manufacturing method, and an antibacterial composition containing it as an active ingredient. CONSTITUTION: The novel oxazolidinone derivative is represented by the formula(1) as described in the description. It is manufactured by the steps of: reacting a compound of the formula(17) with a compound of the formula(2) to obtain a compound of the formula(3); reducing the compound of the formula(3) to obtain a compound f the formula(4); reacting the compound of the formula(4) with (R)-(-)-glycidyl butylate to produce a compound of the formula(5); carrying out mesylation of the compound of the formula(5) to produce a compound of the formula(7); and aminating and acylating the compound of the formula(7) to obtain a compound of the formula(1).

79. 发明公开

KR1020010036703A 캐테콜 히드라존 유도체를 함유한 제초제 조성물 无效
标题翻译：含有CATHECOL HYDRAZONE DERIVATIVES的除草组合物
公开(公告)号：KR1020010036703A
公开(公告)日：2001-05-07
申请号：KR1019990043818
申请日：1999-10-11
申请人： 씨제이 주식회사
发明人： 윤용식 , 장명식 , 서병철 , 김종훈 , 이광혁 , 김의경 , 신재규 , 이정근
IPC分类号： A01N37/34
CPC分类号： A01N33/26
摘要： PURPOSE: A herbicidal composition comprising an effective amount of cathecol hydrazone derivatives to remove weeds and carriers generally used in the field of agricultural chemicals is provided, which exhibits excellent herbicidal activity and in particular selectively acts on Graminae. CONSTITUTION: This composition is characterized in that it contains an effective amount of a compound of formula(1) to control weeds, and carriers generally used in the field of agricultural chemicals. In formula, R1 is C1-7 alkyl or C3-7 cycloalkyl; R2 is -H, -OH, -C1 to 5 alkyl or -CH2CH2C(=O)NH2; R3 or R4 are each independently i)-H, ii)C1-7 alkyl, iii)-C(=X)-R5, iv)substituted 2-, 3- or 4- pyridyl or phenyl or v)a ring compound directly connected to C3-4 containing O, S or N; X is O, S or N-R5; R5 is i)-C1-7 alkyl, ii)-NHR6 or iii)substituted 2-, 3- or 4- pyridyl, pyrimidyl or phenyl; and R6 is -H, -OH, -C1-5 alkoxy, -C1-5 alkyl, pyridyl or phenyl.
摘要翻译：目的：提供一种除草组合物，其包含有效量的用于去除农药领域中常用的杂草和载体的维管腙衍生物，其显示出优异的除草活性，特别是选择性地作用于禾本科植物。构成：该组合物的特征在于其含有有效量的用于控制杂草的式（1）化合物和通常用于农药领域的载体。在式中，R 1是C 1-7烷基或C 3-7环烷基; R 2是-H，-OH，-C 1至5烷基或-CH 2 CH 2 C（= O）NH 2; R 3或R 4各自独立地为i）-H，ii）C 1-7烷基，iii）-C（= X）-R 5，iv）直接取代的2-，3-或4-吡啶基或苯基或v）环化合物连接到含有O，S或N的C3-4; X是O，S或N-R5; R5是i）-C1-7烷基，ii）-NHR6或iii）取代的2-，3-或4-吡啶基，嘧啶基或苯基; R6是-H，-OH，-C1-5烷氧基，-C1-5烷基，吡啶基或苯基。

80. 发明公开

KR1020010036702A 캐테콜 히드라존 유도체를 함유한 살충제 조성물 无效
标题翻译：含有CATHECOL HYDRAZONE DERIVATIVES的杀虫剂组合物
公开(公告)号：KR1020010036702A
公开(公告)日：2001-05-07
申请号：KR1019990043817
申请日：1999-10-11
申请人： 씨제이 주식회사
发明人： 윤용식 , 장명식 , 서병철 , 김종훈 , 이광혁 , 김의경 , 신재규 , 이정근
IPC分类号： A01N37/34
CPC分类号： A01N33/26
摘要： PURPOSE: An insecticidal composition comprising an effective amount of novel cathecol hydrazone derivatives, pharmaceutically acceptable salts and carriers generally used in the field of agricultural chemicals is provided, which exhibits excellent insecticidal activity. CONSTITUTION: This composition is characterized in that it contains an effective amount of a compound of formula(1) to control insects, pharmaceutically acceptable salts and carriers generally used in the field of agricultural chemicals. In formula, R1 is C1-7 alkyl or C3-7 cycloalkyl; R2 is -H, -OH, -C1 to 5 alkyl or -CH2CH2C(=O)NH2; R3 or R4 are each independently i)-H, ii)C1-7 alkyl, iii)-C(=X)-R5, iv)substituted 2-, 3- or 4- pyridyl or phenyl or v)a ring compound directly connected to C3-4 containing O, S or N; X is O, S or N-R5; R5 is i)-C1-7 alkyl, ii)-NHR6 or iii)substituted 2-, 3- or 4- pyridyl, pyrimidyl or phenyl; and R6 is -H, -OH, -C1-5 alkoxy, -C1-5 alkyl, pyridyl or phenyl.
摘要翻译：目的：提供一种杀虫剂组合物，其具有优异的杀虫活性，该杀虫组合物包含通常用于农药领域的有效量的新型导管腙衍生物，药学上可接受的盐和载体。构成：该组合物的特征在于其含有有效量的式（1）化合物以控制农药领域通常使用的昆虫，药学上可接受的盐和载体。在式中，R 1是C 1-7烷基或C 3-7环烷基; R 2是-H，-OH，-C 1至5烷基或-CH 2 CH 2 C（= O）NH 2; R 3或R 4各自独立地为i）-H，ii）C 1-7烷基，iii）-C（= X）-R 5，iv）直接取代的2-，3-或4-吡啶基或苯基或v）环化合物连接到含有O，S或N的C3-4; X是O，S或N-R5; R5是i）-C1-7烷基，ii）-NHR6或iii）取代的2-，3-或4-吡啶基，嘧啶基或苯基; R6是-H，-OH，-C1-5烷氧基，-C1-5烷基，吡啶基或苯基。

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