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    • 80. 发明公开
    • 코돈 최적화된 IL―15를 사용하는 백신 및 면역치료제, 및 그의 사용 방법
    • 使用优化的IL-15的疫苗和免疫球蛋白及其使用方法
    • KR1020080094044A
    • 2008-10-22
    • KR1020087019727
    • 2007-01-12
    • 더 트러스티스 오브 더 유니버시티 오브 펜실바니아
    • 웨이너,데이비드,비.쿠츨러,미쉘
    • C07K14/54C12Q1/68
    • C07K14/5443A61K2039/55522Y02A50/394C12N15/11
    • Nucleic acid molecules that encode IL-15 or fragments thereof, which express protein at a higher level than nucleic acid molecules with native coding sequences for IL-15 are disclosed. Nucleic acid molecules with additional modifications such as the absence of coding sequences for IL-15 signal sequences and/or the absence of IL-15 untranslated sequences and/or inclusion of non-IL-15 signal sequences are also disclosed. Vectors, including plasmids and viral vectors, comprising such nucleic acid molecules; and to host cells comprising such nucleic acid molecules are disclosed as well as methods of using such nucleic acid molecules alone or in combination with nucleic acid sequences encoding immunogens which are part of the nucleic acid molecules and/or part of a different nucleic acid molecule. Recombinant vaccines and live attenuated pathogens encoding fusion proteins, and methods of using the same, are disclosed.
    • 公开了编码IL-15或其片段的核酸分子,其表达比具有IL-15的天然编码序列的核酸分子更高水平的蛋白质。 还公开了具有附加修饰的核酸分子,例如不存在IL-15信号序列的编码序列和/或不存在IL-15非翻译序列和/或包含非IL-15信号序列。 包括这种核酸分子的载体,包括质粒和病毒载体; 以及包含这种核酸分子的宿主细胞以及使用这些核酸分子单独或与编码作为核酸分子和/或不同核酸分子的一部分的免疫原的核酸序列组合的方法。 公开了重组疫苗和编码融合蛋白的活减毒病原体及其使用方法。