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    • 61. 发明公开
    • 항암제에 의해 유발되는 간 독성 및 신장 독성에 대한 억제활성을 갖는 복숭아 추출물을 유효성분으로 함유하는 약학조성물
    • 药物组合物,包含预防由抗癌药物引起的肝细胞毒性和抗生素毒素的麻黄素提取物
    • KR1020070110689A
    • 2007-11-20
    • KR1020060043478
    • 2006-05-15
    • 연세대학교 산학협력단
    • 정원윤이창기박광균황재관이상국
    • A61K36/736A61P1/16
    • A61K36/736A23V2200/308A61K2236/331A61K2236/333
    • A pharmaceutical composition comprising the extract of Prunus persica L.(peach) for inhibiting hepatotoxicity and nephrotoxicity induced by an anticancer agent is provided to inhibit growth of cancer cells and increase anticancer effects with reducing side effects of cisplatin such as toxicity when the composition and cisplatin is simultaneously administered. A pharmaceutical composition for inhibiting hepatotoxicity and nephrotoxicity induced by an anticancer agent comprises 0.01-99 wt.%, preferably 0.02-50 wt.% of the extract of Prunus persica L. which is prepared by extracting Prunus persica L. with a solvent selected from water, C1-C4 lower alcohol or a mixed solvent thereof, wherein the Prunus persica L. is white peach or yellow peach; the daily dosage of Prunus persica L. extract is 0.0001-100 mg/kg, preferably 0.001-10 mg/kg; and the composition is formulated as tablet, pill, powder, granule, capsule, suspension, solution, emulsion or syrup.
    • 提供包含用于抑制肝脏毒性的李子(桃)提取物和由抗癌剂引起的肾毒性的药物组合物,以抑制癌细胞的生长并增加抗癌作用,同时降低顺铂的副作用,例如当组合物和顺铂 同时给药。 用于抑制由抗癌剂诱导的肝毒性和肾毒性的药物组合物包含0.01-99重量%,优选0.02-50重量%的白芍提取物,其通过用选自以下的溶剂萃取柿子酱制备: 水,C1-C4低级醇或其混合溶剂,其中白芍是白桃或黄桃; 柿子提取物的日剂量为0.0001-100mg / kg,优选为0.001-10mg / kg; 并且组合物配制成片剂,丸剂,粉剂,颗粒剂,胶囊剂,悬浮液,溶液剂,乳剂或糖浆剂。