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61. 发明公开

KR1020130010946A 간암 암 줄기세포 특성에 기초한 간암의 신규 바이오마커 및 그의 용도 审中-实审
标题翻译：基于肝癌干细胞特征的肝癌新生物标志物及其用途
公开(公告)号：KR1020130010946A
公开(公告)日：2013-01-30
申请号：KR1020110071749
申请日：2011-07-20
申请人： 연세대학교 산학협력단
发明人： 송시영 , 박수빈 , 김선아
IPC分类号： G01N33/574 , G01N33/68 , G01N33/15
CPC分类号： G01N33/574 , G01N33/00 , G01N33/15 , G01N33/68
摘要： PURPOSE: A method for screening a material which prevents or treats liver cancer using a molecular marker for cancer stem cells and liver cancer is provided to accurately diagnosing liver cancer or cancer. CONSTITUTION: A kit for diagnosing liver cancer or analyzing liver cancer prognosis contains a binder which specifically binds to a protein of sequence number 1, 3, or 5 or a probe or a primer which specifically binds to a polynucleotide of sequence number 2, 4, or 6. A kit is a kit for immunoassay. A method for screening a material which prevents or treats liver cancer comprises a step of contacting a sample with a cell or a tissue containing the protein or polynucleotide; and a step of measuring expression level of the protein or polynucleotide.
摘要翻译：目的：提供一种筛选使用癌症干细胞和肝癌分子标志物预防或治疗肝癌的材料的方法，以准确诊断肝癌或癌症。构成：用于诊断肝癌或分析肝癌预后的试剂盒含有特异性结合序列号1,3或5的蛋白质的结合剂，或特异性结合序列号2,4和5的多核苷酸的探针或引物，或6.试剂盒是用于免疫测定的试剂盒。用于筛选预防或治疗肝癌的材料的方法包括使样品与含有所述蛋白质或多核苷酸的细胞或组织接触的步骤; 以及测量蛋白质或多核苷酸的表达水平的步骤。

62. 发明公开

KR1020130010831A 담도암 암 줄기세포 특성에 기초한 담도암 신규 바이오마커 및 그의 용도 有权
标题翻译：基于双侧牵引癌的胆管癌的新生物标志物干细胞特征及其用途
公开(公告)号：KR1020130010831A
公开(公告)日：2013-01-29
申请号：KR1020120071292
申请日：2012-06-29
申请人： 연세대학교 산학협력단
发明人： 송시영 , 박수빈 , 김선아 , 박정엽
IPC分类号： C07K16/18 , G01N33/15 , G01N33/68 , G01N33/574
摘要： PURPOSE: A method for screening a material which prevents or treats biliary tract cancer using a novel molecular marker is provided to screen a therapeutic agent candidate which is specific to biliary tract cancer stem cells or cancer stem cells. CONSTITUTION: A method for screening a material which prevents or treats biliary cancer comprises: a step of contacting a sample with a cell or a tissue containing a protein of sequence number 1 or 3 or a polynucleotide of sequence number 2 or 4; and a step of measuring expression level of the protein or polynucleotide. The protein exists on the cell surface, viral surface, or in an isolated form. A kit for detecting biliary cancer stem cells contains a primer or a probe which specifically binds to the protein or polynucleotide. [Reference numerals] (AA) Expressing TAGLN2 at normal biliary epithalial tissue and biliary cancer tissue
摘要翻译：目的：提供一种用于筛选使用新型分子标记物预防或治疗胆道癌的材料的方法，以筛选对胆道癌干细胞或癌干细胞特异性的治疗剂候选物。构成：用于筛选预防或治疗胆汁癌的材料的方法包括：将样品与含有序列号1或3的蛋白质的细胞或组织或序列号2或4的多核苷酸接触的步骤; 以及测量蛋白质或多核苷酸的表达水平的步骤。蛋白质存在于细胞表面，病毒表面或分离形式。用于检测胆道癌干细胞的试剂盒含有特异性结合蛋白质或多核苷酸的引物或探针。（AA）在正常胆道骨髓组织和胆道癌组织中表达TAGLN2

63. 发明公开

KR1020130007974A 위암 암 줄기세포 특성에 기초한 위암의 치료용 타겟 有权
标题翻译：基于胃癌干细胞的胃癌新疗法目标
公开(公告)号：KR1020130007974A
公开(公告)日：2013-01-21
申请号：KR1020120071293
申请日：2012-06-29
申请人： 연세대학교 산학협력단
发明人： 송시영 , 박수빈 , 김선아
IPC分类号： G01N33/15 , G01N33/68 , G01N33/53 , C12Q1/68
CPC分类号： G01N33/15 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/5023 , G01N33/5302 , G01N33/5308 , G01N33/6893 , G01N2800/06
摘要： PURPOSE: A method for screening a material which prevents or treat gastric cancer using a novel molecular marker for gastric cancer stem cells and gastric cancer is provided to screen the gastric cancer stem cells and a therapeutic agent candidate and to accurately diagnose gastric cancer or cancer. CONSTITUTION: A method for screening a material for preventing or treating gastric cancer contains: a step of contacting a sample to a cell or a tissue; and a step of measuring expression level of a protein of sequence number 1, 3, 5, 7, or 9 or a polynucleotide of sequence number 2, 4, 6, 8, or 10 and determining the sample as the material for preventing or treating gastric cancer. The protein exists on the cell surface or virus surface, or in an isolated form.
摘要翻译：目的：提供一种筛选用于胃癌干细胞和胃癌的新型分子标记物来预防或治疗胃癌的材料的方法，用于筛选胃癌干细胞和治疗剂候选物并准确诊断胃癌或癌症。构成：筛选用于预防或治疗胃癌的材料的方法包括：使样品与细胞或组织接触的步骤; 以及测量序列号1,3,5,7或9的蛋白质的表达水平或序列号为2,4,6,8或10的多核苷酸的表达水平的步骤，并确定样品作为预防或治疗的材料胃癌。蛋白质存在于细胞表面或病毒表面，或以分离形式存在。

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