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51. 发明公开

KR1020100036361A 프로스타글란딘 유도체 및 모노 치환, 하전된 베타-사이클로덱스트린의 복합체 无效
标题翻译：前列腺素衍生物和单核苷酸复合物，充电的β-环糊精
公开(公告)号：KR1020100036361A
公开(公告)日：2010-04-07
申请号：KR1020107002891
申请日：2008-07-03
申请人： 오프탈모파르마 에이쥐 , 바이오사이덱스 에스에이에스
发明人： 벨크서엘무스타파 , 세나티엠포이브 , 가츠랜달 , 튀르팽프레드릭
IPC分类号： A61K31/557 , A61K47/48 , C08B37/16 , A61P27/06
CPC分类号： C08B37/0015 , A61K9/0048 , A61K47/6951 , B82Y5/00 , C07C405/00 , A61K31/557 , A61K47/50 , C08B37/0012
摘要： The present invention relates to water-soluble, non-covalent complexes of a group of prostaglandin derivatives including latanoprost and monosubstituted, charged β-cyclodextrins, as well as uses of these complexes in therapeutic compositions that are administered topically for treating intraocular hypertension and glaucoma.
摘要翻译：本发明涉及一组前列腺素衍生物（包括拉坦前列素和单取代的β-环糊精）的水溶性非共价复合物，以及这些复合物在局部用于治疗眼内高血压和青光眼的治疗组合物中的用途。

52. 发明授权

KR100785913B1 경화된 β-사이클로덱스트린 중합체 분말과 그의 제조방법 失效
标题翻译：聚合β-环糊精粉及其制备方法
公开(公告)号：KR100785913B1
公开(公告)日：2007-12-17
申请号：KR1020060119300
申请日：2006-11-29
申请人： 한국과학기술연구원
发明人： 최만호 , 김동현 , 정봉철 , 문주연
IPC分类号： C08L5/16 , C08J5/12
CPC分类号： C08F251/00 , C08B37/0012 , C08L5/16 , C08L51/02 , G01N33/548 , G01N33/743 , G01N2600/00 , C08L2666/02
摘要： A cured beta-cyclodextrin polymer powder, its preparation method, and a filler for a solid phase extraction containing the cured beta-cyclodextrin polymer powder are provided to extract a steroid hormone present in a living body sample simply and effectively by using the cured beta-cyclodextrin polymer powder. A cured beta-cyclodextrin polymer powder comprises a beta-cyclodextrin polymer prepared by the reaction of a beta-cyclodextrin monomer and epichlorohydrin; and a metal ion which is coated on the surface of the beta-cyclodextrin polymer. Preferably the metal ion is selected from Ca and Na. The cured beta-cyclodextrin polymer powder is prepared by dissolving beta-cyclodextrin in an alkaline aqueous solution and adding epichlorohydrin to it to prepare a beta-cyclodextrin polymer of gel state; dipping the polymer in a metal salt aqueous solution to coat the polymer with a metal ion, thereby preparing a cured beta-cyclodextrin polymer; and washing, drying and pulverizing the obtained polymer.
摘要翻译：提供固化的β-环糊精聚合物粉末，其制备方法和用于固相β-环糊精聚合物粉末的固相提取填料，通过使用固化的β-环糊精聚合物粉末提取活体样品中存在的类固醇激素，环糊精聚合物粉末。固化的β-环糊精聚合物粉末包含通过β-环糊精单体和表氯醇反应制备的β-环糊精聚合物; 以及涂覆在β-环糊精聚合物表面上的金属离子。优选地，金属离子选自Ca和Na。固化的β-环糊精聚合物粉末通过将β-环糊精溶解在碱性水溶液中并加入表氯醇来制备凝胶状态的β-环糊精聚合物来制备; 将聚合物浸渍在金属盐水溶液中以用金属离子涂覆聚合物，从而制备固化的β-环糊精聚合物; 并洗涤，干燥和粉碎所得聚合物。

53. 发明公开

KR1020070060098A 세포 박리제 및 세포 시트 박리 방법 失效
标题翻译： CYTODETACHING代理和拆卸细胞片的方法
公开(公告)号：KR1020070060098A
公开(公告)日：2007-06-12
申请号：KR1020077007144
申请日：2005-09-09
申请人： 고쿠리츠켄큐카이하츠호진 카가쿠기쥬츠신코키코 , 가부시키가이샤 재팬 티슈 엔지니어링 , 고쿠리츠다이가쿠호진 호쿠리쿠 센단 가가쿠 기쥬츠 다이가쿠인 다이가쿠
发明人： 타차본야카트완펜 , 가토마사카즈 , 오오야도오루 , 유이노부히코
IPC分类号： C12M1/26 , C12M1/00 , C12N1/02 , C12N5/07
CPC分类号： C12N1/02 , C08B37/0012 , C08B37/0015 , C12M33/00
摘要： A cell sheet detaching agent comprising an aminated polyrotaxane. The polyrotaxane constituting the skeleton of this cytodetaching agent has such a structure that multiple cyclic molecules are arranged so as to have a linear molecule pass therethrough, the linear molecule at both ends thereof having bulky caps bonded thereto so as to prevent dropping of the cyclic molecules therefrom. The aminated polyrotaxane contained in the cytodetaching agent is a compound resulting from replacement of at least some of hydroxyls of the cyclodextrin skeleton contained in the polyrotaxane by an amino-having substituent. By the use of this cell sheet detaching agent, cultured cells adhering to a container surface can be detached without causing any cell damaging and without the need to conduct temperature control.
摘要翻译：一种包含胺化聚轮烷的细胞片分离剂。构成该细胞增敏剂骨架的聚轮烷具有使多个环状分子排列成线性分子通过的结构，其两端的直链状分子具有与其结合的庞大的帽，以防止环状分子的滴落由此。包含在细胞悬液中的胺化聚轮烷是由具有氨基取代基的聚轮烷中所含的环糊精骨架的至少一部分的羟基置换而成的化合物。通过使用这种细胞片分离剂，可以分离附着在容器表面上的培养细胞，而不会引起任何细胞破坏并且不需要进行温度控制。

54. 发明公开

KR1020060029145A 사이클로덱스트린 또는 사이클로덱스트린 유도체의 수성액체 조성물 및 당해 조성물을 이용하는 공정 无效
标题翻译：环糊精或环糊精衍生物的水性液体组合物和使用该组合物的方法
公开(公告)号：KR1020060029145A
公开(公告)日：2006-04-04
申请号：KR1020057024979
申请日：2004-06-18
申请人： 시바 홀딩 인크 , 훈츠만 텍스틸레 에펙츠 (게르마니) 게엠베하
发明人： 쿨케토르슈텐 , 나즐발터
IPC分类号： D06M15/03 , C08B37/00 , C08K5/00 , D06M13/00
CPC分类号： C08B37/0012 , C08K5/159 , C08L5/16 , D06M13/005 , D06M15/03
摘要： An aqueous liquid composition comprising a cyclodextrin or a cyclodextrine derivative, at least one emulsifier and a resin finishing or crosslinking agent is excellent in storage stability and useful in a finishing process for the treatment of suitable substrates, such as fibre materials.
摘要翻译：包含环糊精或环糊精衍生物的水性液体组合物，至少一种乳化剂和树脂整理剂或交联剂具有优异的储存稳定性，并且可用于处理合适的基材如纤维材料的精加工工艺中。

55. 发明公开

KR1020050082383A 기공형성용 템플레이트로 유용한 사이클로덱스트린유도체와 이를 이용하여 제조된 저유전체 有权
标题翻译：作为成型模板的环糊精衍生物和使用其制备的低介电材料
公开(公告)号：KR1020050082383A
公开(公告)日：2005-08-23
申请号：KR1020040010827
申请日：2004-02-18
申请人： 학교법인 서강대학교
发明人： 이희우 , 윤도영 , 차국헌 , 이진규 , 문봉진 , 민성규 , 박세정 , 신재진
IPC分类号： H01B3/30
CPC分类号： C08B37/0015 , C08B37/0012 , C08G77/44 , C08L83/04 , C09D183/14 , H01B3/185 , H01L21/02126 , H01L21/02203 , H01L21/02214 , H01L21/02282 , H01L21/3122 , H01L21/31695 , C08L2666/26
摘要： 본 발명은 기공형성용 템플레이트로 유용한 사이클로덱스트린 유도체와, 상기한 사이클로덱스트린 유도체 자체를 졸-젤 반응하여 제조한 것으로 기계적 물성이 매우 우수하고 균일하게 분포된 나노기공을 함유한 저유전 매트릭스와, 상기한 사이클로덱스트린 유도체를 기공형성제로 사용하고 여기에 통상의 유기 혹은 무기 실리케이트 전구체를 박막화하여 제조한 것으로 균일하게 분포된 나노기공을 함유하고 있고 51% 정도의 높은 공극률과 1.6 정도의 낮은 유전율을 갖는 초저유전막에 관한 것이다.

56. 发明授权

KR100469699B1 치환된 시클로덱스트린을 함유하는 피부조직침투 향상 활성용 화장료 조성물 有权
标题翻译： 치환된시클로덱스트린을함유하는피부조직침투향상활성용화장료조성물
公开(公告)号：KR100469699B1
公开(公告)日：2005-02-02
申请号：KR1020000059859
申请日：2000-10-11
申请人： 바스프 뷰티 케어 솔루션즈 프랑스 에스에이에스
发明人： 페리어에릭 , 테리니콜라스 , 리발델핀 , 콜맨안토니
IPC分类号： C01G19/02 , C09D133/06 , C09D5/24 , B82B3/00
CPC分类号： C08B37/0012 , A61K8/738 , A61K9/0014 , A61K9/5161 , A61K47/40 , A61K2800/413 , A61Q1/06 , A61Q1/10 , A61Q5/02 , A61Q19/00 , A61Q19/10 , B82Y5/00
摘要： 본 발명은 히드록시알킬화되지 않은(non-hydroxyalkylated) 신규한 시클로덱스트린 유도체에 관한 것으로, 적어도 1개의 1차 알콜작용기(CH
2 OH)가 치환되고 상기 OH기 부분이 -O-CO-R 또는 -NR
1 R
2 의 구조식을 가지는 치환기로 치환되어 있는 시클로덱스트린에 관한 것이다. 여기서, R, R
1 및 R
2 는 독립적으로 선형 또는 고리형, 포화 또는 불포화, 히드록시 또는 히드록시되지 않은 알킬기를 나타내며, 상기 알킬기는 1∼30개의 탄소원자, 바람직하게는 1∼22개의 탄소원자, 더욱 바람직하게는 2∼22개의 탄소원자를 가진 지방사슬을 포함한다.
본 발명에 따른 시클로덱스트린은 화장품산업에서 특히 조직침투를 촉진시키기 위해 적어도 1개의 활성성분에 대한 벡터로서 사용되거나 또는 약학 조성물 특히 피부약제의 제조를 위한 벡터로서 사용된다.
摘要翻译：公开了其中至少一个伯醇官能（CH 2 OH）被取代，-OH部分被具有式-O-CO-R或-NR 1 R 2的取代基取代的非羟烷基化环糊精，其中：R，R 1和R 2独立地表示线性或环状的，饱和或不饱和的，含有1至30个碳原子，优选1至22个碳原子的羟基化或非羟基化烷基，更优选含有2至22个碳原子的脂肪链。这些环糊精用作至少一种活性成分的载体，尤其用于促进组织穿透，用于化妆品应用或用于生产药物组合物，特别是皮肤药物。

57. 发明公开

KR1020020085407A 수용성 사이클로덱스트린-풀로렌 복합체 및 그 제조방법 失效
标题翻译：水溶性环糊精 - 荧光复合物及其制造方法
公开(公告)号：KR1020020085407A
公开(公告)日：2002-11-16
申请号：KR1020010024909
申请日：2001-05-08
申请人： 광주과학기술원
发明人： 쿠르트에게클러 , 시엔머디
IPC分类号： C08B37/16
CPC分类号： C01B32/152 , C08B37/0012
摘要： PURPOSE: Provided are a water-soluble cyclodextrin-fluorene complex used in the biomedical field and a simple process for producing the water-soluble cyclodextrin-fluorene complex in a high yield. CONSTITUTION: The water-soluble cyclodextrin-fluorene complex is produced by the process comprising the steps of: preparing a cyclodextrin solution by dissolving alpha-cyclodextrin or beta-cyclodextrin in water as a polar solvent and preparing a fluorene solution by dissolving fluorene in toluene as a non-polar solvent; reacting the fluorene solution and the cyclodextrin solution; removing the non-polar solvent from the reacted mixture and condensing; washing the condensed resultant and freeze drying.
摘要翻译：目的：提供生物医学领域中使用的水溶性环糊精 - 芴络合物和高产率生产水溶性环糊精 - 芴络合物的简单方法。构成：水溶性环糊精 - 芴络合物是通过以下方法制备的，其包括以下步骤：通过将α-环糊精或β-环糊精溶解在水中作为极性溶剂并通过将芴溶解在甲苯中制备芴溶液来制备环糊精溶液，非极性溶剂; 使芴溶液与环糊精溶液反应; 从反应混合物中除去非极性溶剂并冷凝; 洗涤冷凝物并冷冻干燥。

58. 发明公开

KR1020020072210A 직접 압축가능한 베타-싸이클로덱스트린의 제조방법 및이로써 얻어진 직접 압축가능한 베타-싸이클로덱스트린 无效
标题翻译：制备直接可压缩的β-环糊精和直接耐受的BETA-CYCLODEXTRIN的方法
公开(公告)号：KR1020020072210A
公开(公告)日：2002-09-14
申请号：KR1020020012150
申请日：2002-03-07
申请人： 로께뜨프레르
发明人： 리스호세 , 레페브르필리프
IPC分类号： C08B30/18
CPC分类号： C08B37/0012
摘要： PURPOSE: A process for preparing a beta-cyclodextrin possessing high compressibility and stable over time in order to use it as direct compression excipient-binder is provided, and a directly compressible beta-cyclodextrin thus obtained is provided. CONSTITUTION: The process for preparing beta-cyclodextrin which is of high compressibility and which is stable over time comprises a step of dehydrating hydrated beta-cyclodextrin to a water content of less than 6%, preferably less than 4% and more preferably still less than or equal to 2% by weight, followed by forced rehydration to a water content greater than 10%, preferably greater than 12% and more preferably still greater than or equal to 13% by weight, wherein the dehydration is carried out on a fluidized air bed dryer-granulator, the rehydration is carried out on a fluidized air bed granulator, and the rehydration is carried out by spraying water at a temperature of less than 60 deg.C, preferably less than 40 deg.C. Beta-cyclodextrin has a compressibility greater than 70 N expressed in a C test, wherein beta-cyclodextrin has a specific surface area according to the BET method greater than or equal to 1 m/g for a particle size fraction of between 100 and 160 micrometers, a mean particle diameter greater than 80 micrometers and an apparent mass density greater than or equal to 0.45 g/ml, and preferably greater than or equal to 0.50 g/ml, for a particle size fraction of between 100 and 315 micrometers, and beta-cyclodextrin exhibits a stability greater than six months at room temperature.
摘要翻译：目的：提供一种制备具有高压缩性和随时间稳定的β-环糊精以便将其用作直接压制赋形剂 - 粘合剂的方法，并且提供如此获得的直接可压缩的β-环糊精。构成：具有高可压缩性并且随时间稳定的β-环糊精的方法包括使水合β-环糊精脱水至含水量小于6％，优选小于4％，更优选仍低于或等于2重量％，然后强制再水合至大于10重量％，优选大于12重量％，更优选仍大于或等于13重量％的水含量，其中脱水在流化空气床式干燥机造粒机，在流化床床造粒机上进行再水化，再水合通过在低于60℃，优选小于40℃的温度下喷洒水进行。 β-环糊精在C试验中具有大于70N的压缩性，其中对于100至160微米的粒度分数，β-环糊精具有大于或等于1m / g的BET法的比表面积，平均粒径大于80微米，表观质量密度大于或等于0.45g / ml，优选大于或等于0.50g / ml，对于100至315微米的粒度分数，β 环糊精在室温下表现出稳定性大于6个月。

59. 发明公开

KR1020000057206A 사이클로덱스트린 중합체 분리재료 无效
标题翻译：环糊精聚合物分离材料
公开(公告)号：KR1020000057206A
公开(公告)日：2000-09-15
申请号：KR1019997004538
申请日：1997-11-21
申请人： 더 리전트 오브 더 유니버시티 오브 캘리포니아
发明人： 마민 , 리디콴
IPC分类号： B01D24/00
CPC分类号： C08B37/0012 , C08G18/6484
摘要： PURPOSE: Provided are cyclodextrin polymer materials and the use of such cyclodextrin polymer materials as separation materials for separation or removal of, e.g., organic contaminants from aqueous compositions. CONSTITUTION: A water insoluble polymeric composition which is a reaction product of a cyclodextrin monomer and a polyfunctional crosslinker from the group of polyisocyanates, dihalohydrocarbons, and dihaloacetylhydrocarbons is disclosed together with a process for removing a target organic compound from an aqueous composition including contacting the aqueous composition containing a target organic compound with a water insoluble cyclodextrin polymer which is the reaction product of a cyclodextrin monomer and a polyfunctional crosslinker from the group of polyisocyanates, dihalohydrocarbons, and dihaloacetylhydrocarbons for time sufficient to form a reaction product between the water insoluble cyclodextrin polymer and the target organic compound whereby the concentration of the target organic compound in the aqueous composition is reduced. Organic chromophores added to the water insoluble cyclodextrin polymers can provide organic nonlinear optical materials.
摘要翻译：目的：提供环糊精聚合物材料以及使用这种环糊精聚合物材料作为用于从水性组合物中分离或去除例如有机污染物的分离材料。公开了一种水不溶性聚合物组合物，其是环糊精单体和来自多异氰酸酯，二卤代烃和二卤代乙酰基烃的多官能交联剂的反应产物，以及从水性组合物中除去目标有机化合物的方法，包括使含水含有目标有机化合物的组合物与水不溶性环糊精聚合物，其是环糊精单体和来自多异氰酸酯，二卤代烃和二卤代乙酰基烃的多官能交联剂的反应产物，足以在水不溶性环糊精聚合物和目标有机化合物，其中水性组合物中的目标有机化合物的浓度降低。添加到水不溶性环糊精聚合物中的有机发色团可以提供有机非线性光学材料。

60. 发明公开

KR1020000029774A 생체내에서의산화질소수송용중합체 无效
标题翻译：聚合物在血液中输送氮氧化物
公开(公告)号：KR1020000029774A
公开(公告)日：2000-05-25
申请号：KR1019997000889
申请日：1997-07-28
申请人： 듀크 유니버시티
发明人： 스탬러,조나단,에스. , 툰,에릭,제이. , 스택,리차드,에스.
IPC分类号： C08B37/00
CPC分类号： B82Y5/00 , A61K47/6951 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/416 , A61L2300/42 , C08B37/0012 , C08L5/16
摘要： PURPOSE: Novel nitrated or nitrosylated polymers can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites. CONSTITUTION: Novel nitrated or nitrosylated polymers are derivatized with NOx. The polymer has at least one NOx group per 1200 atomic mass units (amu) of the polymer, preferably per 600 amu of the polymer, and even more preferably per 70 amu of the polymer. In a preferred embodiment, the polymer has pendant -S-NO and/or pendant -O-NO- groups, i.e. the polymer is S-nitrosylated and/or O-nitrosylated. In another embodiment, the polymer is prepared by reacting a polythiolated polysaccharide with a nitrosylating agent or a nitrating agent under conditions suitable for nitrosylating or nitrating free thiol groups.
摘要翻译：目的：新型硝化或亚硝基化聚合物可用于涂覆医疗器械以将体内一氧化氮输送至治疗部位。构成：新型硝化或亚硝基化聚合物用NOx衍生。聚合物每1200原子质量单位（amu），优选每600amu聚合物，甚至更优选每70atu聚合物具有至少一个NOx基团。在优选的实施方案中，聚合物具有-S-NO侧基和/或侧基-O-NO-基团，即聚合物是S-亚硝基化和/或O-亚硝基化的。在另一个实施方案中，聚合物是通过使多硫醇化多糖与亚硝酰化剂或硝化剂在适于亚硝化或硝化游离硫醇基团的条件下反应来制备的。

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