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51. 发明公开

KR1020130070707A ＤＳ 복합생약추출물을 유효성분으로 함유하는 피부 미백용 화장료 조성물 无效
标题翻译：化妆品组合物包含含有皮肤白细胞活性的DS的提取物
公开(公告)号：KR1020130070707A
公开(公告)日：2013-06-28
申请号：KR1020110137848
申请日：2011-12-20
申请人： 주식회사 진생사이언스
发明人： 김복득 , 박만기 , 이양범 , 김성용 , 박용성 , 박인순 , 이용재 , 이진균
IPC分类号： A61K8/97 , A61Q19/02 , A61Q19/00
CPC分类号： A61K8/97 , A61K36/00 , A61K36/232 , A61K36/233 , A61K2236/33 , A61Q19/00 , A61Q19/02 , A61Q19/10 , Y10S514/844 , Y10S514/846
摘要： PURPOSE: A composition containing a complex crude drug extract of DS as an active ingredient is provided to suppress melanogenesis, tyrosinase activity, expression of TRP-1 and TRP-2 tyrosinase, and PKC-beta and MITF genes, and to be used as a composition for skin whitening and anti-wrinkling. CONSTITUTION: A cosmetic composition for skin whitening contains 0.1-50 wt% of a crude drug extract of Angelicae gigantis radix, Bupleurum falcatum, Paeoniae radix alba, Atractylodis Rhizoma alba, Poria cocos wolf, Moutan cortex radicis, Gardeniae fructus, Glycyrrhizae radix, Menthae herba, and Zingiberis rhizoma recens in a weight ratio of 1-5:1-5:1-5:1-5:1-5:1-5:1-5:1-5:1-5:1-5, as an active ingredient. The extract is prepared using water, C1-4 alcohols, or a mixture thereof.
摘要翻译：目的：提供含有DS复合生物药物提取物作为活性成分的组合物，用于抑制黑色素生成，酪氨酸酶活性，TRP-1和TRP-2酪氨酸酶表达，PKC-β和MITF基因的表达，并用作用于皮肤美白和抗皱的组合物。构成：用于皮肤美白的化妆品组合物含有0.1-50重量％的当归甘草，柴胡，白芍，白术，茯苓，茯苓，栀子，甘草草药和姜黄，重量比为1-5：1-5：1-5：1-5：1-5：1-5：1-5：1-5：1-5：1-5：1-5 ，作为活性成分。提取物是使用水，C 1-4醇或其混合物制备的。

52. 发明公开

KR1020130059962A 항골다공증 활성을 나타내는 일엽추 추출물을 함유하는 식품첨가물 无效
标题翻译：食品添加剂包括提取抗胰蛋白酶的SECURINEGA SUFFRUCTICOSA
公开(公告)号：KR1020130059962A
公开(公告)日：2013-06-07
申请号：KR1020110126228
申请日：2011-11-29
申请人： 주식회사 진생사이언스
发明人： 김복득 , 박만기 , 이양범 , 김성용 , 박용성 , 박인순 , 이용재 , 이진균
IPC分类号： A23L1/30 , A61K36/47 , A61P19/10
CPC分类号： A23L33/105 , A23V2002/00 , A23V2200/306 , A23V2250/21 , A23V2300/14 , A61K36/47
摘要： PURPOSE: Food additive having securinega suffruticosa extract as active ingredient is provided to suppress osteoclast, prevent and improve bone metabolic disease. CONSTITUTION: Food additive for preventing and improving bone metabolic disease comprises securinega suffruticosa extract as active ingredient. Food additive is added to food by being dipped, sprayed, and mixed. Food additive is added in a range of 0.01 through about 20 parts by weight about 100 weight unit of composition. Bone metabolic disease is osteoporosis, Paget disease, periodontal disease, metastatic cancer or rheumatoid arthritis.
摘要翻译：目的：提供具有securinega suffruticosa提取物作为活性成分的食品添加剂，用于抑制破骨细胞，预防和改善骨代谢疾病。构成：用于预防和改善骨代谢疾病的食品添加剂，其中包括作为活性成分的安氏苏木精提取物。通过浸渍，喷雾和混合将食品添加剂添加到食物中。食品添加剂的添加量为0.01至约20重量份，约100重量份的组合物。骨代谢疾病是骨质疏松症，佩吉特病，牙周病，转移性癌症或类风湿性关节炎。

53. 发明公开

KR1020130059773A 피부 주름 개선효과를 가지는 가공 인삼 추출물을 유효성분으로 함유하는 건강기능성식품 无效
标题翻译：包含加热PANAX GINSENG SHINSING SHINING皮肤抗皱活性提取物的中和组合物
公开(公告)号：KR1020130059773A
公开(公告)日：2013-06-07
申请号：KR1020110125927
申请日：2011-11-29
申请人： 주식회사 진생사이언스
发明人： 김복득 , 박만기 , 이양범 , 김성용 , 박용성 , 박인순 , 이용재 , 이진균
IPC分类号： A23L1/30 , A61K36/258 , A61P17/00 , A23L19/00
CPC分类号： A23L33/105 , A23V2002/00 , A23V2200/318 , A23V2250/2124 , A23V2300/14 , A61K36/258
摘要： PURPOSE: A health functional food is provided to improve skin wrinkling by controlling factors related to formation and decomposition of collagen. CONSTITUTION: Health functional food comprises processed extract of Panax species plant as an active ingredient that let sum of contents of ginsenoside Rg3, Rg5 higher than sum of content of ginsenoside Rb1, Rb2, Rc, and Rd. Processed Panax genus ginseng extract is manufactured as follows. Panax species plant is sliced and put in an autoclave to be heated at 70 °C to 150 °C, under 2 to 30 atmospheric pressure for 1 to 24 hours. Heated material is 1 or 20 times weight ratio(w/w) of water of sample weight, or low grade alcohol of C1 to C4 or mixture of these using cold extraction, hot water extraction, ultrasonic wave extraction, reflux cooling extraction, or heating extraction to be extracted. Extract is filtered, concentrated under reduced pressure, and dried. Health functional food is powder, granule, refinement, capsule or drink.
摘要翻译：目的：通过控制与胶原蛋白形成和分解相关的因素，提供健康功能性食品来改善皮肤皱纹。构成：健康功能食品包括人参植物的加工提取物作为活性成分，使人参皂苷Rg3，Rg5的含量总和高于人参皂苷Rb1，Rb2，Rc和Rd含量的总和。加工的人参提取物如下制造。将Panax种植物切片并置于高压釜中，在70℃至150℃，2至30大气压下加热1至24小时。加热材料是样品重量的水的1或20倍（w / w），或C1至C4的低级酒精或其混合物使用冷萃取，热水萃取，超声波萃取，回流冷却萃取或加热提取提取。将提取物过滤，减压浓缩并干燥。健康功能食品是粉末，颗粒，精制，胶囊或饮料。

54. 发明公开

KR1020130059660A 피부노화를 억제하는 가공인삼 추출물을 유효성분으로 함유하는 건강 기능성식품 无效
标题翻译：包含加热PANAX金山萃取物的中和组合物显示皮肤抗衰老活性
公开(公告)号：KR1020130059660A
公开(公告)日：2013-06-07
申请号：KR1020110125740
申请日：2011-11-29
申请人： 주식회사 진생사이언스
发明人： 김복득 , 박만기 , 이양범 , 김성용 , 박용성 , 박인순 , 이용재 , 이진균
IPC分类号： A23L1/30 , A61K36/258 , A61P17/00 , A23L2/38
CPC分类号： A23L33/105 , A23L2/52 , A23V2002/00 , A23V2200/318 , A23V2250/2124 , A23V2300/14 , A61K36/258
摘要： PURPOSE: Health promoting food which contains processed ginseng extract as an active ingredient is provided to prevent and improve skin aging disease. CONSTITUTION: Health promoting food comprises processed Panax species plant extract as an active ingredient that increases medicinal properties to higher sum of ginsenoside Rg3, Rk1, and Rg5 than sum of ginsenoside Rb1, Rb2, Rc, and Rd. Panax speices plant is a plant that artificially manufactured Panax ginseng, Panax quinquefolia, Panax notoginseng, Panax vietnamensis, Panax japonicas, Panax elegatior, Panax wangianus, Panax bipinnatifidus, and Panax pseudoginseng. Panax species plant is processed ginseng which let rate of ginsenoside (Rg3+Rg5) / (Rc+Rd+Rb1+Rb2) to be more than 1.0 by heating ginseng 120 to 180°C for 0.5 to 20 hours to increase medicinal properties. Health functional food is powder, granule, refinement, capsule or drink.
摘要翻译：目的：提供含有人参提取物作为活性成分的健康促进食品，以预防和改善皮肤老化病。构成：健康促进食品包括加工的人参植物提取物作为活性成分，其比人参皂甙Rb1，Rb2，Rc和Rd的总和增加药物性质，使人参皂苷Rg3，Rk1和Rg5的总和高于人参皂甙Rg3，Rk1和Rg5。人参是一种人参制造人参，三七，三七，三七，Panax japonicas，Panax elegatior，Panax wangianus，Panax bipinnatifidus和Panax pseudginseng的植物。人参加工人参，其中将人参120至180℃加热0.5至20小时以使人参皂甙（Rg3 + Rg5）/（Rc + Rd + Rb1 + Rb2）的比例大于1.0，以提高药用性能。健康功能食品是粉末，颗粒，精制，胶囊或饮料。

55. 发明公开

KR1020130059560A 별갑 추출물을 유효성분으로 함유하는 골다공증 억제 효과를 가지는 건강 식품 조성물 无效
标题翻译：包含AMYDA SINENSIS提取物的抑制作用的中性组合物
公开(公告)号：KR1020130059560A
公开(公告)日：2013-06-07
申请号：KR1020110125596
申请日：2011-11-29
申请人： 주식회사 진생사이언스
发明人： 김복득 , 한충희 , 박만기 , 이양범 , 이용재 , 이진균
IPC分类号： A23L1/30 , A61K35/56 , A61P19/10
CPC分类号： A23L33/10 , A23V2002/00 , A23V2200/306 , A23V2250/204 , A23V2300/14 , A61K35/586
摘要： PURPOSE: A neutraceutical composition is provided to relieve bone diseases of an older people and bone diseases caused by menopause of women. CONSTITUTION: A neutraceutical composition for reducing and preventing osseous metabolic diseases contains an Amyda sinensis extract as an active ingredient. The osseous metabolic diseases include osteoporosis, Paget disease, periodontal disease, metastatic cancer, or rheumatoid arthritis.
摘要翻译：目的：提供一种减少老年人骨骼疾病和妇女更年期引起的骨骼疾病的营养成分。构成：用于减少和预防骨代谢疾病的营养药物组合物含有Amyda sinensis提取物作为活性成分。骨代谢疾病包括骨质疏松症，佩吉特病，牙周病，转移性癌症或类风湿性关节炎。

56. 发明公开

KR1020130059531A 항골다공증 활성을 나타내는 토사자 추출물을 함유하는 약학 조성물 无效
标题翻译：包含CUSCUTA JAPONICA提取物的药物组合物显示抗肿瘤活性
公开(公告)号：KR1020130059531A
公开(公告)日：2013-06-07
申请号：KR1020110125559
申请日：2011-11-29
申请人： 주식회사 진생사이언스
发明人： 김복득 , 박만기 , 이양범 , 김성용 , 박용성 , 박인순 , 이용재 , 이진균
IPC分类号： A61K36/43 , A61P19/10
摘要： PURPOSE: A Cuscuta japonica Chois. extract is provided to suppress osteoclast differentiation(suppression of TRAP(+) multinucleate cell generation), and expression of genes such as cathepsin K, TNFalpha, and IL-6, and to be used as a pharmaceutical composition for suppressing osteoporosis. CONSTITUTION: A pharmaceutical composition for preventing and treating metabolic bone diseases contains a Cuscuta japonica Chois. extract as an active ingredient. The metabolic bone diseases are osteoporosis, Paget's disease, periodontal disease, metastatic cancer, or rheumatoid arthritis. The extract contains 0.01-99wt% of a crude drug extract.
摘要翻译：目的：Cuscuta japonica Chois。提供提供物以抑制破骨细胞分化（抑制TRAP（+）多核细胞产生）和基因如组织蛋白酶K，TNFα和IL-6的表达，并用作抑制骨质疏松症的药物组合物。构成：用于预防和治疗代谢性骨疾病的药物组合物含有猕猴桃。提取物作为活性成分。代谢性骨病是骨质疏松症，佩吉特氏病，牙周病，转移性癌症或类风湿性关节炎。提取物含有0.01-99重量％的生药提取物。

57. 发明公开

KR1020130058790A 형개 추출물을 유효성분으로 함유하는 발육 성장 촉진용 또는 골다공증의 예방 및 치료용 약학 조성물 无效
标题翻译：包含枸杞子提取物的药物组合物日本预防和治疗骨质疏松症或促进体内生长
公开(公告)号：KR1020130058790A
公开(公告)日：2013-06-05
申请号：KR1020110124720
申请日：2011-11-28
申请人： 주식회사 진생사이언스
发明人： 김복득 , 이주엽 , 박만기 , 이양범 , 이용재 , 이진균
IPC分类号： A61K36/538 , A61P19/10
CPC分类号： A61K36/538 , A23V2200/30 , A61K2236/331 , A61K2236/333
摘要： PURPOSE: A composition containing a Schizonepeta tenuifolia var. japonica extract for promoting growth or preventing and treating osteoporosis is provided to excellently increase osteoporosis and to be used as a pharmaceutical composition for promoting growth or preventing and treating osteoporosis. CONSTITUTION: A pharmaceutical composition for promoting growth and preventing and treating osteoporosis contains 0.1-50 wt% of a Schizonepeta tenuifolia var. japonica extract as an active ingredient. The extract is a crude extract, a polar solvent-soluble extract, or a non-polar solvent-soluble extract of Schizonepeta tenuifolia var. japonica. The crude extract is prepared by extracting with water including purified water, C1-C4 alcohol, or a mixture thereof. The polar solvent-soluble extract is prepared using water, methanol, ethanol, butanol, or a mixture thereof. The non-polar solvent-soluble extract is prepared using hexane, chloroform, or ethyl acetate.
摘要翻译：目的：含有Schizonepeta tenuifolia var。提供用于促进生长或预防和治疗骨质疏松症的粳稻提取物以优异地增加骨质疏松症并用作促进生长或预防和治疗骨质疏松症的药物组合物。构成：用于促进生长和预防和治疗骨质疏松症的药物组合物含有0.1-50wt％的Schizonepeta tenuifolia var。粳稻提取物作为活性成分。提取物是粗提物，极性溶剂可溶性提取物或Schizonepeta tenuifolia var的非极性溶剂可溶性提取物。粳稻。通过用包括纯化水，C1-C4醇或其混合物的水提取制备粗提物。使用水，甲醇，乙醇，丁醇或其混合物制备极性溶剂可溶性提取物。使用己烷，氯仿或乙酸乙酯制备非极性溶剂可溶性提取物。

58. 发明授权

KR101141971B1 진세노사이드를 함유하는 마그네슘-뉴클레오티드-작동성 금속 이온통로 또는 세포내 칼슘고갈에 의해 작동되는 칼슘통로 활성화 건강기능식품 조성물 有权
标题翻译：健康功能食品组合物包含人参皂苷化合物刺激镁核苷酸调节的金属离子通道或电容钙入口
公开(公告)号：KR101141971B1
公开(公告)日：2012-05-24
申请号：KR1020100085943
申请日：2010-09-02
申请人： 주식회사 진생사이언스
发明人： 정성권 , 양현옥 , 박정일 , 이승기 , 김복득 , 이양범 , 이용재 , 이진균 , 임선희 , 김성향 , 임향수
IPC分类号： A23L33/00 , A23L1/30 , A23L2/38 , A61K31/704
摘要： 본 발명은 이온통로를 활성화시키는 진세노사이드 함유 조성물에 관한 것으로, 상세하게는 인삼의 진세노사이드가 MagNum 이온통로 또는 CCE 이온통로를 활성화시킴으로써, 세포 내의 칼슘농도를 효과적으로 증가시켜, 칼슘 농도 저하로 기인되는 질환의 예방 및 치료에 사용가능한 의약품 및 건강기능식품에 관한 것이다.

59. 发明公开

KR1020110017062A 진세노사이드를 유효성분으로 함유하는 혈전성 질환의 예방 및 치료용 조성물 无效
标题翻译：包含茚三酮的组合物，用于预防和治疗血栓性疾病
公开(公告)号：KR1020110017062A
公开(公告)日：2011-02-21
申请号：KR1020090074549
申请日：2009-08-13
申请人： 주식회사 진생사이언스
发明人： 김복득 , 이진균 , 김성향 , 임향수 , 이용재 , 임선희
IPC分类号： A61K31/7034 , A61P7/02 , A23L1/30 , A61P9/10
CPC分类号： A61K31/704 , A23L29/035 , A23V2200/326 , A23V2200/3262 , A61K9/0095 , A61K9/14 , A61K9/20 , A61K9/48 , Y10S514/824
摘要： PURPOSE: A composition containing dammarane compound for preventing and treating thrombotic diseases is provided to suppress aggregation of platelet. CONSTITUTION: A pharmaceutical composition for preventing and treating thrombotic diseases contains ginsenoside Rg6, ginsenoside F4, ginsenoside Rk3, or ginsenoside Rh4 as an active ingredient. A health food for preventing and treating thrombotic diseases contains ginsenoside Rg6, ginsenoside F4, ginsenoside Rk3, or ginsenoside Rh4 as an active ingredient. The health food is powder, granule, tablet, capsule, or beverage.
摘要翻译：目的：提供含有用于预防和治疗血栓性疾病的抗坏血酸化合物的组合物，以抑制血小板聚集。构成：用于预防和治疗血栓性疾病的药物组合物含有人参皂甙Rg6，人参皂甙F4，人参皂甙Rk3或人参皂甙Rh4作为活性成分。用于预防和治疗血栓性疾病的保健食品含有人参皂苷Rg6，人参皂甙F4，人参皂甙Rk3或人参皂甙Rh4作为活性成分。保健食品是粉末，颗粒，片剂，胶囊或饮料。

60. 发明公开

KR1020050018226A 진세노사이드를 함유하는 마그네슘-뉴클레오티드-작동성금속 이온통로 또는 세포내 칼슘고갈에 의해 작동되는칼슘통로 활성화 조성물 无效
标题翻译：包含茚三酮化合物的组合物刺激镁核调节的金属离子通道或电容性钙进入与低钙浓度相关的预防和治疗疾病
公开(公告)号：KR1020050018226A
公开(公告)日：2005-02-23
申请号：KR1020030056556
申请日：2003-08-14
申请人： 주식회사 진생사이언스
发明人： 정성권 , 양현옥 , 박정일 , 이승기 , 김복득 , 이양범 , 이용재 , 이진균 , 임선희 , 김성향 , 임향수
IPC分类号： A61K31/704
CPC分类号： A61K31/704 , A23L2/38 , A23L33/105 , A23V2002/00 , A23V2200/322 , A23V2250/2124 , A61K36/258
摘要： PURPOSE: Provided is a composition comprising a ginsenoside compound stimulating magnesium- nucleotide-regulated metal ion channel or capacitative calcium entry. The ginsenoside compound stimulates MagNum ion channel or CCE ion channel and thus increases calcium concentration effectively. Therefore, the composition prevents and treats diseases associated with low calcium concentration. CONSTITUTION: The ginsenoside compound includes, ginsenoside Rk1, Rg2, Rg3 or the mixture thereof, and increases MagNum ion channel or CCE ion channel. Therefore, the pharmaceutical composition containing the ginsenoside compound is used for prevention and treatment of diseases associated with low calcium concentration.
摘要翻译：目的：提供一种组合物，其包含刺激镁核苷酸调节的金属离子通道或电容钙入口的人参皂苷化合物。人参皂苷化合物可刺激MagNum离子通道或CCE离子通道，从而有效提高钙浓度。因此，该组合物预防和治疗与低钙浓度相关的疾病。构成：人参皂苷化合物包括人参皂苷Rk1，Rg2，Rg3或其混合物，并增加MagNum离子通道或CCE离子通道。因此，含有人参皂苷化合物的药物组合物用于预防和治疗与低钙浓度相关的疾病。

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