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51. 发明公开

KR1020120052911A 스트레스 측정을 위한 전기소자 기반 바이오 센서 및 그 측정방법 无效
标题翻译：用于测量应力的生物传感器及其方法
公开(公告)号：KR1020120052911A
公开(公告)日：2012-05-24
申请号：KR1020120028617
申请日：2012-03-21
申请人： 연세대학교 산학협력단
发明人： 정효일 , 이정현 , 이희조
IPC分类号： G01N33/74 , G01N33/53 , A61B5/00
摘要： PURPOSE: An electrical device-based biosensor is provided to read electric signal and to quickly and easily measure cortisol in sativa. CONSTITUTION: A sensor(10) for detecting cortisol comprise: an earth layer(30) formed of metal at the lower end; a dielectric layer(60) formed on the earth layer; and a masking layer(200) which is formed on the dielectric layer and has a microstrip transmission line and circular resonator.
摘要翻译：目的：提供基于电气设备的生物传感器来读取电信号，并快速，轻松地测量水中的皮质醇。构成：用于检测皮质醇的传感器（10）包括：在下端由金属形成的地层（30）; 形成在所述地层上的电介质层（60）以及形成在电介质层上并具有微带传输线和圆形谐振器的掩模层（200）。

52. 发明公开

KR1020120041870A 다중 형광 정도 이용 세포 분리 장치 및 전극구조와 다중 형광 정도 이용 세포 분리 방법 有权
标题翻译：荧光多孔电极激活细胞分离器及其电极结构及其方法
公开(公告)号：KR1020120041870A
公开(公告)日：2012-05-03
申请号：KR1020100103243
申请日：2010-10-22
申请人： 연세대학교 산학협력단
发明人： 정효일 , 문희성 , 김형준
IPC分类号： G01N33/52 , C12Q1/24 , G01N27/30
摘要： PURPOSE: A cell isolation apparatus using multiple fluorescence degrees is provided to measure the degree of fluorescence of proteins in gene modified cells. CONSTITUTION: A cell isolation apparatus using multiple fluorescence degrees comprises: a sample inlet(121) for injecting a sample containing microparticles; a fluid inlet(122) for injecting cis fluid for forming a channel in the sample; a plurality of outlets for discharging microparticles; a channel(125) in which the sample and fluid flow; a fluid flow control unit(120) containing a plurality of microelectrodes; an electronic control unit(140).
摘要翻译：目的：提供使用多个荧光度的细胞分离装置，以测量基因修饰细胞中蛋白质的荧光程度。构成：使用多个荧光度的细胞分离装置包括：用于注射含有微粒的样品的样品入口（121）流体入口（122），用于注射用于在样品中形成通道的顺式流体; 多个用于排出微粒的出口; 通道（125），其中样品和流体流动; 包含多个微电极的流体流量控制单元（120）电子控制单元（140）。

53. 发明公开

KR1020110135330A ＭＯＦＦ 채널을 이용한 표적 입자 분리 장치 및 분리 방법 审中-实审
标题翻译：使用多路流分流通道分离目标颗粒的装置和方法
公开(公告)号：KR1020110135330A
公开(公告)日：2011-12-16
申请号：KR1020110037353
申请日：2011-04-21
申请人： 삼성전자주식회사 , 연세대학교 산학협력단
发明人： 심태석 , 이정건 , 정효일 , 권기호
IPC分类号： G01N35/08 , G01N33/483 , G01N15/10
CPC分类号： G01N35/08 , G01N15/10 , G01N33/483 , G01N35/00
摘要： PURPOSE: Target particle separating apparatus and method using a multi-orifice flow fractionation(MOFF) channel are provided to improve the efficiency of separation with respect to target particles contained in a fluid sample. CONSTITUTION: An apparatus for separating target particles from a fluid sample includes three or more MOFF channels, a first separating part(400), and buffer introducing parts(20a, 20b). The MOFF channels include multi-orifice segments, inlets, and outlets(30). Contraction channels and extension channels, defined by a pre-determined dimension based on target particles, are repeatedly connected in the multi-orifice segments. The first separating part includes a first separating channel and a first branched channel. The first separating channel corresponds to the center part of the cross section of the outlet in a first MOFF channel(100).
摘要翻译：目的：提供使用多孔流量分馏（MOFF）通道的目标颗粒分离装置和方法，以提高流体样品中包含的靶颗粒的分离效率。构成：用于从流体样品分离目标颗粒的装置包括三个或更多个MOFF通道，第一分离部分（400）和缓冲引入部分（20a，20b）。 MOFF渠道包括多孔段，入口和出口（30）。通过基于目标颗粒的预定尺寸限定的收缩通道和延伸通道在多孔段中重复连接。第一分离部分包括第一分离通道和第一分支通道。第一分离通道对应于第一MOFF通道（100）中出口的横截面的中心部分。

54. 发明公开

KR1020110125510A 음용수 내 세균 검사를 위한 전처리 및 검침장치와 그 방법 有权
标题翻译：用预处理系统检测水中微生物的仪器及其方法
公开(公告)号：KR1020110125510A
公开(公告)日：2011-11-21
申请号：KR1020100045077
申请日：2010-05-13
申请人： 연세대학교 산학협력단
发明人： 정효일 , 문희성
IPC分类号： C12Q1/04 , C12Q1/66 , G01N33/52 , G01N33/18
CPC分类号： C12Q1/06 , C12Q1/26 , C12Y113/12007 , G01N1/4005 , G01N15/1436
摘要： PURPOSE: A pretreatment and test apparatus for detecting bacteria in drinking water is provided to quickly isolate and concentrate bacteria from a liquid phase. CONSTITUTION: A pretreatment and test apparatus for detecting bacteria comprises: a pretreatment part(100) which generated photoreaction of bacteria by inputting measuring samples and reaction samples and concentrating bacteria contained in the measuring sample; and a measuring unit(200) which measures luminescence by the photoreaction of the bacteria and detecting the amount of the bacteria in the sample .
摘要翻译：目的：提供一种用于检测饮用水中细菌的预处理和试验装置，用于从液相中快速分离和浓缩细菌。构成：用于检测细菌的预处理和测试装置包括：通过输入测量样品和反应样品以及浓缩测量样品中的细菌而产生细菌光反应的预处理部分（100）以及测量单元（200），其通过细菌的光反应来测量发光并检测样品中细菌的量。

55. 发明公开

KR1020110057341A 적혈구의 광열효과를 이용한 헤모글로빈 정량적 측정장치 및 방법 有权
标题翻译：使用红细胞光热效应定量测定血红蛋白的装置和方法
公开(公告)号：KR1020110057341A
公开(公告)日：2011-06-01
申请号：KR1020090113700
申请日：2009-11-24
申请人： 연세대학교 산학협력단
发明人： 정효일 , 곽봉섭 , 송석흥
IPC分类号： G01N33/72 , G01N33/49 , G01N21/71
摘要： PURPOSE: An apparatus for quantitative measurement of hemoglobin is provided to measure the photothermal effect of erythrocytes based on the concentration of hemoglobin. CONSTITUTION: An apparatus for quantitative measurement of hemoglobin comprises: a laser(10) for irradiating light to whole blood cells; a detection unit(20) for detecting the temperature of erythrocytes; and a measuring unit(30) for measuring the concentration of hemoglobin in erythrocytes using the detected temperature. The detection unit comprises a micro thermal sensor(22) for placing a whole blood sample; and a current-voltage system(24) for measuring a resistance value of the micro thermal sensor.
摘要翻译：目的：提供一种用于血红蛋白定量测定的仪器，用于测量血红蛋白浓度对红细胞的光热效应。构成：用于定量测定血红蛋白的装置包括：用于向全血细胞照射光的激光（10）用于检测红细胞的温度的检测单元（20）; 以及用于使用检测到的温度测量红细胞中的血红蛋白浓度的测量单元（30）。检测单元包括用于放置全血样本的微热传感器（22）以及用于测量微型热传感器的电阻值的电流 - 电压系统（24）。

56. 发明公开

KR1020110057331A 적혈구의 광열효과를 이용한 세포 내외부 헤모글로빈의 차이 측정방법 有权
标题翻译：使用光热效应检测内皮细胞/细胞外HEMOGLOBIN差异蛋白酶的方法
公开(公告)号：KR1020110057331A
公开(公告)日：2011-06-01
申请号：KR1020090113690
申请日：2009-11-24
申请人： 연세대학교 산학협력단
发明人： 정효일 , 곽봉섭 , 송석흥
IPC分类号： G01N33/72 , G01N33/49 , G01N21/71
CPC分类号： Y02A50/58
摘要： PURPOSE: A method for measuring the difference between intracellular and extracellular hemoglobin is provided to quickly and simply measure a hemoglobin difference. CONSTITUTION: A method for measuring the difference between intracellular and extracellular hemoglobin comprises: a step of irradiating light to a whole blood sample and detecting the temperature of erythrocytes(S34,S35); a step of comparing the detected temperature with a sample temperature; and a step of calculating the difference between the intracellular and extracellular hemoglobin(S36).
摘要翻译：目的：提供一种测量细胞内和细胞外血红蛋白差异的方法，以快速简便地测量血红蛋白差异。构成：测定细胞内和细胞外血红蛋白之间的差异的方法，包括：向全血样品照射光并检测红细胞的温度的步骤（S34，S35）; 将检测到的温度与样品温度进行比较的步骤; 以及计算细胞内和细胞外血红蛋白之间的差异的步骤（S36）。

57. 发明授权

KR100949311B1 미생물 농도 측정 센서 및 미생물 농도 측정 시스템 有权
标题翻译：用于测量微生物浓度的传感器
公开(公告)号：KR100949311B1
公开(公告)日：2010-03-23
申请号：KR1020080001592
申请日：2008-01-07
申请人： 연세대학교 산학협력단
发明人： 정효일 , 김영훈 , 이흥용 , 박재성
IPC分类号： G01N33/48 , G01N33/00 , G01N27/26 , G01N27/00
摘要： 본 발명은 미생물 농도 측정 센서에 관한 것으로, 보다 상세하게는 금을 증착시킨 실리콘 웨이퍼를 전극으로 사용하여 유체의 흐름이 지속적으로 있는 미생물 배양기에서도 누구나 손쉽게 미생물의 농도를 정확하게 측정할 수 있는 미생물 농도 측정 센서에 관한 것이다.
본 발명은 원통형이며 동심축으로 이루어진 내부관 및 외부관을 구비하여 이루어진 미생물 농도 측정 센서에 있어서, 상기 내부관은 서로 대칭되는 위치에 있는 내부관 구멍을 2개 구비하며, 상기 외부관은 서로 대칭되는 위치에 있는 외부관 구멍을 2개 구비하고, 상기 내부관에는 한쌍의 전극의 위와 아래가 각각 지지체에 고정된 상태로 내부관에 삽입되며, 상기 내부관 구멍과 상기 외부관 구멍은 상기 위의 지지체와 상기 아래 지지체 사이에 위치되어 지며, 상기 내부관을 상기 외부관에 대해 상대적 회전시킴으로써 상기 미생물 농도 측정 센서를 온(on) 또는 오프(off)시키도록 이루어진 것을 특징으로 한다.
미생물 농도, 센서, 전극, 외부관, 내부관, 임피던스

58. 发明公开

KR1020090120584A 생체유체의 반응 온도 측정 방법, 이를 이용한마이크로칼로리미터 및 마이크로칼로리미터의 제조방법 有权
标题翻译：测量生物流体的反应温度的方法，使用其的微量元素和制造微孔子的方法
公开(公告)号：KR1020090120584A
公开(公告)日：2009-11-25
申请号：KR1020080046467
申请日：2008-05-20
申请人： 연세대학교 산학협력단
发明人： 조형희 , 정효일 , 김범석 , 곽봉섭
IPC分类号： G01K7/02 , G01K7/00
CPC分类号： G01K13/02 , G01K3/08 , G01K7/02 , G01K2013/026
摘要： PURPOSE: A method of measuring reaction temperature of bio fluids, a micro calorimeter using the same, and a method of manufacturing the micro calorimeter are provided to promote the mixing of bio fluids for reaction without a separate temperature control system. CONSTITUTION: A method of manufacturing a micro calorimeter(100) comprises following steps. A protective layer and an insulating layer are formed on a substrate. A part of a lower surface of the substrate is etched. An adhesive layer is formed on the upper side of the substrate. A first wiring layer is formed on the upper side of the adhesive layer. A first wiring layer pattern is formed by etching the first wiring layer. A second wiring layer is formed on the upper side of the substrate. A thermopile(200) is made of first wiring layer patterns and second wiring layer patterns. A polymer pattern defines a first fluid path(110), a second fluid path(120), a third fluid path(130), a fourth fluid path(140), and a fifth fluid path(150).
摘要翻译：目的：提供一种测量生物流体的反应温度的方法，使用其的微量热计和微量热计的制造方法，以促进生物流体的混合，而不需要单独的温度控制系统。构成：制造微量热计（100）的方法包括以下步骤。在基板上形成保护层和绝缘层。蚀刻基板的下表面的一部分。在基板的上侧形成有粘接层。第一布线层形成在粘合剂层的上侧。通过蚀刻第一布线层形成第一布线层图案。第二布线层形成在基板的上侧。热电堆（200）由第一布线层图案和第二布线层图案构成。聚合物图案限定第一流体路径（110），第二流体路径（120），第三流体路径（130），第四流体路径（140）和第五流体路径（150）。

59. 发明公开

KR1020090118366A 기체 내 미세입자 검출 장치 및 이의 제작 방법 有权
标题翻译：用于检测气体中的微粒子的装置和用于制造装置的方法
公开(公告)号：KR1020090118366A
公开(公告)日：2009-11-18
申请号：KR1020080044107
申请日：2008-05-13
申请人： 삼성전자주식회사 , 연세대학교 산학협력단
发明人： 남윤우 , 정효일 , 이승재 , 문희성
IPC分类号： G01N27/02 , G01N27/12 , G01N27/14 , G01N27/26
CPC分类号： G01N1/2214 , G01N15/0656 , G01N2001/4033
摘要： PURPOSE: An apparatus for detecting minute particle within gases and a manufacturing method thereof are provided to detect minute particle within gaseous sample without a separate pump or a collector. CONSTITUTION: An apparatus for detecting minute particle within gases comprises an inlet port(10), an outlet port(20), a channel(30), a cooling layer(40), a collecting tank(45), a detection unit(50) and a heating unit(60). A gaseous sample including minute particles(100) flows into the inlet port. The sample flows out through the outlet port. The channel is formed between the inlet port and the outlet port. The cooling layer cools and condenses the sample flowing within the channel. The condensed sample is collected in the collecting tank. The detection unit detects the minute particle included in the sample. The detection unit comprises a dielectrophoresis impedance sensor.
摘要翻译：目的：提供一种用于检测气体中的微小颗粒的装置及其制造方法，用于在没有单独的泵或集电器的情况下检测气态样品中的微小颗粒。构成：用于检测气体中的微小颗粒的装置包括入口（10），出口（20），通道（30），冷却层（40），收集罐（45），检测单元）和加热单元（60）。包含微小颗粒（100）的气态样品流入入口。样品通过出口流出。通道形成在入口和出口之间。冷却层冷却并冷凝在通道内流动的样品。将浓缩的样品收集在收集罐中。检测单元检测样品中包含的微小颗粒。检测单元包括介电电泳阻抗传感器。

60. 发明公开

KR1020090083679A 자극체를 이용한 세포 배양기 및 세포 배양 방법 失效
标题翻译：使用微珠冲击的微流感细胞刺激装置
公开(公告)号：KR1020090083679A
公开(公告)日：2009-08-04
申请号：KR1020080009635
申请日：2008-01-30
申请人： 연세대학교 산학협력단
发明人： 정효일 , 김태진 , 이흥용
IPC分类号： C12M3/00 , C12M1/24 , C12M1/32
CPC分类号： C12M23/16 , C12M35/06
摘要： An apparatus and method for culturing a cell with a stimulator such as a micro-bead are provided to maximize proliferation rate by stimulating the cell physiologically and obtain the cell with a small amount of sample. An apparatus for culturing cells comprises an inlet port for injecting pure culture medium or medium containing cell or stimulator; a micro flow channel which passes the stimulator from the inlet port and culture cells; and a discharging port which discharges medium or stimulator from the micro flow channel. The apparatus further comprises a first inlet tube, second inlet tube and third inlet tube.
摘要翻译：提供了用刺激剂如微珠培养细胞的装置和方法，以通过在生理学上刺激细胞使细胞增殖最大化，并用少量样品获得细胞。培养细胞的装置包括用于注射纯培养基或含有细胞或刺激剂的培养基的入口; 将来自入口和培养细胞的刺激器通过的微流通道; 以及从微流路排出介质或刺激器的排出口。该装置还包括第一入口管，第二入口管和第三入口管。

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