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51. 发明公开

KR1020100075471A 트롬빈 유래 펩타이드를 포함하는 망막증 또는 녹내장 치료용 조성물 有权
标题翻译：用于治疗包含THROMBIN衍生肽的复发性或GLAUCOMA的组合物
公开(公告)号：KR1020100075471A
公开(公告)日：2010-07-02
申请号：KR1020107007106
申请日：2007-09-21
申请人： 아이진 주식회사
发明人： 장진욱 , 임형준 , 조양제 , 유원일 , 김두식 , 권오웅 , 고경철 , 김경설
IPC分类号： A61K38/10 , A61P27/06 , A61P27/02
CPC分类号： A61K38/4833
摘要： PURPOSE: A composition containing thrombine-derived peptide is provided reduce abnormal vessel and normal angiogenesis. CONSTITUTION: A composition for treating retinose or glaucoma contains a peptide having sequence number 6. The composition further contains a peptide of sequence number 3 having additional amino acid to N-terminal and C-terminal.
摘要翻译：目的：提供含有血栓素衍生肽的组合物可减少异常血管和正常血管生成。构成：用于治疗视网膜或青光眼的组合物含有具有序列号6的肽。该组合物还含有具有额外氨基酸至N-末端和C-末端的序列号3的肽。

52. 发明公开

KR1020080094922A 펩타이드를 유효성분으로 하는 혈관 관련 질환 치료제조성물 有权
标题翻译：用于治疗包含肽的血管相关疾病的药物组合物
公开(公告)号：KR1020080094922A
公开(公告)日：2008-10-27
申请号：KR1020087020099
申请日：2007-01-19
申请人： 아이진 주식회사
发明人： 김두식 , 조양제 , 유원일 , 권오웅 , 장진욱 , 임형준
IPC分类号： A61K38/32 , C07K14/435 , C07K7/14
CPC分类号： A61K38/06 , A61K38/17 , A61K38/4886 , C12N9/6489
摘要： A composition comprising a peptide is provided to treat vascular diseases by acting on abnormal angiogenesis through secretion of angiopoietins. A pharmaceutical composition for treating vascular-related diseases comprises a peptide having a sequence Xaa-Gly-Asp as an effective component, wherein the amino acid Xaa of the peptide is Arg or Lys, the peptide includes a sequence described as SEQ ID : NO. 1 or SEQ ID : NO. 2, or a sequence described as SEQ ID : NO. 4, or one peptide sequence selected from the group consisting of peptide sequences described as SEQ ID : NOs. 6 to 10, NO: 6 to SEQ ID NO: 10, and the vascular-related disease is edema and/or ischemia caused by blood leakage of blood vessel walls, damages of blood vessels or abnormal angiogenesis.
摘要翻译：提供了包含肽的组合物，通过血管生成素分泌作用于血管生成异常来治疗血管疾病。用于治疗血管相关疾病的药物组合物包含具有序列Xaa-Gly-Asp作为有效成分的肽，其中肽的氨基酸Xaa为Arg或Lys，肽包含SEQ ID NO： 1或SEQ ID：NO。 2，或如SEQ ID NO： 4或选自由SEQ ID NO：所示的肽序列组成的组中的一个肽序列。 6〜10，NO：6〜SEQ ID NO：10，血管相关疾病是由血管壁血渗，血管损伤或异常血管发生引起的水肿和/或缺血。

53. 发明授权

KR100794288B1 인간 인테그린 결합 단백질 또는 펩타이드를 유효성분으로하는 안질환 치료제 有权
标题翻译：用于治疗眼病的含有人整联蛋白结合蛋白或肽的治疗剂
公开(公告)号：KR100794288B1
公开(公告)日：2008-01-11
申请号：KR1020030050397
申请日：2003-07-23
申请人： 아이진 주식회사
发明人： 이성호 , 이겸정 , 유원일 , 조양제
IPC分类号： A61K38/16
摘要： 본 발명은 재조합된 디스인테그린계열 단백질 삭사트린(saxatilin) 및 이와 유사한 서열을 가진 인간 인테그린 결합 단백질을 유효성분으로 하는 안질환 치료제에 관한 것이다. 본 발명에서 서술한 바와 같이 삭사트린을 유효성분으로 함유하고 또한 그 투여농도에 따른 다른 효능을 이용하여 비정상적인 신생혈관 관련 안질환 치료제로 유용하게 사용될 수 있다.

54. 发明公开

KR1020070115336A 당뇨 망막증 진단 키트 有权
标题翻译：用于诊断糖尿病的药盒
公开(公告)号：KR1020070115336A
公开(公告)日：2007-12-06
申请号：KR1020060049597
申请日：2006-06-01
申请人： 아이진 주식회사
发明人： 조양제 , 권수미 , 권오웅 , 김혜리 , 이지연
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/683 , C12Q1/6844 , G01N33/5308
摘要： A kit for diagnosing diabetic retinopathy is provided to improve rapidness and convenience of diagnosis by using genotypes of vascular endothelial growth factor(VEGF) and VEGF receptor 1(VEGFR1), so that retinopathy caused by diabetes is diagnosed at an early stage and diabetic complications are anticipated. A kit for diagnosing diabetic retinopathy comprises (a) a primer for PCR(polymerase chain reaction) amplification of VEGF and VEGFR1 genes, and (b) at least one restriction enzyme selected from Nsp I(nitro stack protein I), Bsr I(blasticidin resistance), N1a III and Hsp92(heat shock protein 92) II and has the nucleotide sequence selected from SEQ ID NO:1 to SEQ NO: 30. A method for diagnosis of diabetic retinopathy comprises the steps of: collecting a tissue or fluid sample from a patient; extracting DNA from the sample; amplifying the extracted DNA by using the primer through PCR; treating the PCR product with the restriction enzymes; subjecting the enzyme-treated product to electrophoresis; and analyzing the DNA pattern of electrophoresed gel.
摘要翻译：提供诊断糖尿病性视网膜病变的工具，通过使用血管内皮生长因子（VEGF）和VEGF受体1（VEGFR1）的基因型，提高诊断的快速性和便利性，从而早期诊断糖尿病引起的视网膜病变，糖尿病并发症预料。用于诊断糖尿病性视网膜病变的试剂盒包括（a）用于VEGF和VEGFR1基因的PCR（聚合酶链式反应）扩增的引物，和（b）至少一种选自Nsp I（硝基叠加蛋白I），Bsr I（杀稻瘟菌素抗性），N1a III和Hsp92（热休克蛋白92）II，并且具有选自SEQ ID NO：1至SEQ ID NO：30的核苷酸序列。诊断糖尿病性视网膜病变的方法包括以下步骤：收集组织或液体样品来自病人从样品中提取DNA; 通过PCR引物扩增提取的DNA; 用限制酶处理PCR产物; 对酶处理产物进行电泳; 并分析电泳凝胶的DNA图谱。

55. 发明公开

KR1020060117387A 올리고뉴클레오타이드 및 비독성 다당체를 포함하는면역보조제 有权
标题翻译：包括寡核苷酸和非毒性LPS的ADJUVANT
公开(公告)号：KR1020060117387A
公开(公告)日：2006-11-17
申请号：KR1020050038771
申请日：2005-05-10
申请人： 아이진 주식회사 , 이나경
发明人： 이나경 , 안보영 , 유원일 , 조양제
IPC分类号： A61K31/7088
CPC分类号： A61K39/39 , A61K31/7088 , A61K2039/55561 , A61K2039/55572
摘要： An immunoadjuvant comprising oligonucleotide and non-toxic lipopolysaccharide(LPS) is provided to improve safety, efficiency and specificity in induction of immune responses compared to using single of oligodeoxynucleotide immunoadjuvant by using bacteria-derived LPS. The immunoadjuvant composition comprises (a) oligodeoxynucleotide(ODN) and (b) non-toxic lipopolysaccharide(LPS) isolated from bacteria, wherein the oligodeoxynucleotide has more than 20 mer and optionally contains CG motif; the cytosine base of the oligodeoxynucleotide is optionally methylated; the oligodeoxynucleotide comprises the nucleotide sequence of SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO:3; the non-toxic polymer derived from lipopolysaccharide(LPS) has molecular weight of 2000 to 10000 dalton; the bacterium is Escherichia coli or Mycobacterium; and the immunoadjuvant composition is used as adjuvant of HBV(hepatitis B virus) vaccine.
摘要翻译：提供包含寡核苷酸和无毒性脂多糖（LPS）的免疫佐剂以提高与使用细菌来源的LPS使用单个寡脱氧核苷酸免疫佐剂相比，在诱导免疫应答方面的安全性，效率和特异性。免疫佐剂组合物包含（a）寡脱氧核苷酸（ODN）和（b）从细菌中分离的无毒性脂多糖（LPS），其中所述寡脱氧核苷酸具有多于20个聚体并且任选地包含CG基序; 寡脱氧核苷酸的胞嘧啶碱基任选被甲基化; 寡脱氧核苷酸包含SEQ ID NO：1，SEQ ID NO：2或SEQ ID NO：3的核苷酸序列; 衍生自脂多糖（LPS）的无毒性聚合物的分子量为2000〜10000道尔顿; 该细菌是大肠杆菌或分枝杆菌; 免疫佐剂组合物用作HBV（乙型肝炎病毒）疫苗的佐剂。

56. 发明公开

KR1020060044620A 망막혈관질환 진단용 단백질 및 그 분석방법 有权
标题翻译：用于分析视网膜血管病变的蛋白质及其分析方法
公开(公告)号：KR1020060044620A
公开(公告)日：2006-05-16
申请号：KR1020050024041
申请日：2005-03-23
申请人： 아이진 주식회사
发明人： 조양제 , 안보영 , 유원일 , 권오웅
IPC分类号： G01N33/68 , G01N33/48
CPC分类号： G01N33/6893 , C12Q1/527 , G01N33/564 , G01N2800/164
摘要： 본 발명은 망막혈관질환 진단용 단백질 및 그의 절편, 이를 포함하는 망막혈관질환 진단용 키트, 이를 코딩하는 유전자 및 이를 이용하여 망막혈관질환으로 생성된 항체를 분석하는 방법에 관한 것이다. 본 발명의 망막혈관질환 진단용 단백질, 이를 포함하는 키트 및 이를 이용한 분석방법을 사용하여 망막혈관질환을 간단하고 빠르게 진단할 수 있다.

57. 发明公开

KR1020050011350A 인간 인테그린 결합 단백질 또는 펩타이드를 유효성분으로하는 안질환 치료제 有权
标题翻译：含有重组蛋白质，SAXATILIN和人体蛋白质结合蛋白作为活性成分的眼科手术的治疗方法
公开(公告)号：KR1020050011350A
公开(公告)日：2005-01-29
申请号：KR1020030050397
申请日：2003-07-23
申请人： 아이진 주식회사
发明人： 이성호 , 이겸정 , 유원일 , 조양제
IPC分类号： A61K38/16
CPC分类号： A61K38/1703 , Y10S514/912
摘要： PURPOSE: Provided is a therapeutic for ophthalmopathy which containing recombinant disintegrin protein, saxatilin and human integrin binding protein which has a similar sequence to the saxatilin, as active ingredient. Therefore, it is useful for treatment of ophthalmopathy associated with abnormal angiogenesis. CONSTITUTION: The therapeutic for treatment of angiogenesis related ophthalmopathy is characterized by containing, as an active ingredient, human integrin binding proteins which has a protein sequence of saxatilin represented by the SEQ ID NO: 1 or a similar sequence thereto. Its effective amount is 100ng-1mg/100kg of body weight.
摘要翻译：目的：提供含有与萨克西汀相似的重组解整蛋白，萨克西汀和人整联蛋白结合蛋白作为活性成分的治疗性眼病。因此，它可用于治疗与异常血管发生相关的眼病。构成：用于治疗血管生成相关性眼病的治疗剂的特征在于含有作为活性成分的人整联蛋白结合蛋白，其具有由SEQ ID NO：1表示的萨克西汀蛋白序列或其类似序列。其有效量为100ng-1mg / 100kg体重。

58. 发明公开

KR1020040006404A 당뇨망막증 진단용 단백질 有权
标题翻译：用于诊断糖尿病性肾病的蛋白质
公开(公告)号：KR1020040006404A
公开(公告)日：2004-01-24
申请号：KR1020020040679
申请日：2002-07-12
申请人： 아이진 주식회사
发明人： 유원일 , 이성호 , 박건우 , 김성수 , 조양제 , 안보영 , 권오웅
IPC分类号： C07K14/775
CPC分类号： G01N33/6893 , C07K14/775 , G01N33/581
摘要： PURPOSE: A protein for diagnosing diabetic retinopathy is provided, thereby easily and accurately detecting apolipoprotein J protein of which amount is decreased in a patient suffering from diabetic retinopathy. CONSTITUTION: An apolipoprotein J protein having the amino acid sequence of SEQ ID NO: 1 useful for diagnosis of diabetic retinopathy or peptide fragments thereof are provided, wherein the peptide fragments comprise a peptide having the amino acid sequence of SEQ ID NO: 2. An antibody binding to the protein of SEQ ID NO: 1 or the peptide fragment thereof is provided. A kit for the diagnosis of diabetic retinopathy comprises the antibody against the protein of SEQ ID NO: 1, wherein the kit further comprises an antigen which is labeled with apolipoprotein J protein by using peroxidase, alkalinephosphatase or biotin.
摘要翻译：目的：提供用于诊断糖尿病性视网膜病变的蛋白质，从而容易且准确地检测患有糖尿病性视网膜病变的患者的载脂蛋白J蛋白的量减少。提供了具有可用于诊断糖尿病性视网膜病变的氨基酸序列的载脂蛋白J蛋白或其肽片段，其中所述肽片段包含具有SEQ ID NO：2的氨基酸序列的肽。提供了与SEQ ID NO：1的蛋白质或其肽片段结合的抗体。用于诊断糖尿病性视网膜病变的试剂盒包括针对SEQ ID NO：1的蛋白质的抗体，其中所述试剂盒还包含通过使用过氧化物酶，碱性磷酸酶或生物素用载脂蛋白J蛋白标记的抗原。

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