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51. 发明公开

KR1020100056521A 치료제로서의 ＣＧＲＰ无效
标题翻译： CGRP作为治疗药物
公开(公告)号：KR1020100056521A
公开(公告)日：2010-05-27
申请号：KR1020107005652
申请日：2008-09-09
申请人： 몬도바이오테크 래보래토리즈 아게
发明人： 베펙도리안 , 카발리파비오 , 카발리베라 , 바허게랄트
IPC分类号： A61K38/22 , A61K38/16 , A61P35/00 , A61P37/00
CPC分类号： A61K38/22 , A23L33/18 , A23L33/40 , A23V2002/00 , Y02A50/385 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , A23V2200/308 , A23V2200/318 , A23V2200/322 , A23V2200/324 , A23V2200/326 , A23V2250/55
摘要： The present invention is directed to the use of the peptide compound Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Se r-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NHas a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Se r-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NHoptionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
摘要翻译：本发明涉及肽化合物Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Se -Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NHas是用于预防和/ ，自身免疫性疾病，纤维化疾病，炎症性疾病，神经变性疾病，感染性疾病，肺部疾病，心脏和血管疾病以及代谢疾病。此外，本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Thr-Cys-Val-Thr-His- Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Se-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys -Ala-Phe-NH选择性地与至少一种药学上可接受的载体，冷冻保护剂，冻干保护剂，赋形剂和/或稀释剂一起使用。

52. 发明公开

KR1020100056510A 치료제로서의 유로딜라틴의 용도 无效
标题翻译：用作治疗药物的URODILATIN
公开(公告)号：KR1020100056510A
公开(公告)日：2010-05-27
申请号：KR1020107005597
申请日：2008-09-09
申请人： 몬도바이오테크 래보래토리즈 아게
发明人： 베펙도리안 , 카발리파비오 , 카발리베라 , 바허게랄트
IPC分类号： A61K38/22 , A61K38/16 , A61P35/00 , A61P31/04
CPC分类号： A61K38/12 , A61K38/09 , C07K14/58 , Y02A50/385 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423
摘要： The present invention is directed to the use of the peptide compound Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-ll e-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-ll e-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
摘要翻译：本发明涉及肽化合物Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-11e -Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH作为预防和/或治疗癌症，自身免疫疾病，纤维化疾病，炎性疾病，神经变性疾病，传染病，肺部疾病，心血管疾病和代谢疾病。此外，本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Leu-Arg-Arg-Ser-Ser- Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-11e-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH 至少一种药学上可接受的载体，冷冻保护剂，冻干保护剂，赋形剂和/或稀释剂。

53. 发明公开

KR1020100063716A 치료제로서 사용하기 위한 아스트레신 및 베타-엔도르핀 无效
标题翻译：用于治疗药物的阿斯特星和BET-ENDORPHIN
公开(公告)号：KR1020100063716A
公开(公告)日：2010-06-11
申请号：KR1020107005636
申请日：2008-09-09
申请人： 몬도바이오테크 래보래토리즈 아게
发明人： 베펙도리안 , 카발리파비오 , 카발리베라 , 바허게랄트
IPC分类号： A61K38/16 , A61K38/08 , A61P35/00 , A61P3/00
CPC分类号： A61K38/08 , A61K38/1825 , Y02A50/385 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/422 , Y02A50/423
摘要： The present invention is directed to the use of the peptide compound D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cycloC-Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-lle-lle-NHas a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-Glu-Ala-His-Lys)-Asn-Arg-Lys-Leu-Nle-GIu-IIe-IIe-NHoptionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
摘要翻译：本发明涉及肽化合物D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln- 环C-Glu-Ala-His-Lys）-Asn-Arg-Lys-Leu-Nle-Glu-Ile-lle-NHas是用于预防和/或治疗癌症，自身免疫疾病，纤维化疾病，炎性疾病，神经变性疾病，传染病，肺部疾病，心脏和血管疾病以及代谢疾病。此外，本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有肽D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu- Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo（-Glu-Ala-His-Lys）-Asn-Arg-Lys-Leu-Nle-Glu-IIe-IIe-NH 至少一种药学上可接受的载体，冷冻保护剂，冻干保护剂，赋形剂和/或稀释剂。

54. 发明公开

KR1020100061484A 항혈관형성제로서의 칼시토닌의 용도 无效
标题翻译：卡马西汀作为抗血管生成剂的使用
公开(公告)号：KR1020100061484A
公开(公告)日：2010-06-07
申请号：KR1020107005642
申请日：2008-09-09
申请人： 몬도바이오테크 래보래토리즈 아게
发明人： 베펙도리안 , 카발리파비오 , 카발리베라 , 바허게랄트
IPC分类号： A61K38/23 , A61K38/16 , A61P3/00 , A61P9/00
CPC分类号： A61K38/23 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/397 , Y02A50/402 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/422 , Y02A50/423 , Y02A50/469
摘要： The present invention is directed to the use of the peptide compound Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Ph e-His-Thr-Phe-Pro-Gln-Thr-Ala-lle-Gly-Val-Gly-Ala-Pro-Nhas a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Ph e-His-Thr-Phe-Pro-Gln-Thr-Ala-lle-Gly-Val-GIy-AIa-Pro-NHoptionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
摘要翻译：本发明涉及肽化合物Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Ph e -His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-Nnas是用于预防和/或治疗癌症，自身免疫疾病，纤维化疾病，炎性疾病，神经变性疾病，传染病，肺部疾病，心脏和血管疾病以及代谢疾病。此外，本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有肽Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Asn-Leu-Gly- Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Ph e-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH- 一种药学上可接受的载体，低温保护剂，冻干保护剂，赋形剂和/或稀释剂。

55. 发明公开

KR1020100061480A 치료제로서의 글루카곤（１－２９） 단독 또는 뉴로펩티드 Ｗ３０과의 배합물의 용도 无效
标题翻译：使用GLUCAGON（1-29）单独或与神经病毒W30组合作为治疗剂
公开(公告)号：KR1020100061480A
公开(公告)日：2010-06-07
申请号：KR1020107005603
申请日：2008-09-09
申请人： 몬도바이오테크 래보래토리즈 아게
发明人： 베펙도리안 , 카발리파비오 , 카발리베라 , 바허게랄트
IPC分类号： A61K38/26 , A61K38/17 , A61P3/00 , A61P25/28
CPC分类号： A61K38/17 , A61K38/08 , A61K38/26 , Y02A50/385 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , A61K2300/00
摘要： The present invention is directed to the use of the peptide compound His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Va l-Gln-Trp-Leu-Met-Asn-Thr-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-As n-Thr-OH optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
摘要翻译：本发明涉及肽化合物His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala- Gln-Asp-Phe-Va1-Gln-Trp-Leu-Met-Asn-Thr-OH作为预防和/或治疗癌症，自身免疫疾病，纤维化疾病，炎性疾病，神经变性疾病，感染性疾病，肺疾病，心血管疾病和代谢疾病。此外，本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr- Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-As n-Thr-OH任选与至少一种药学上可接受的载体，冷冻保护剂，冻干保护剂，赋形剂和/或稀释剂。

56. 发明公开

KR1020100061478A 치료제로서의 세크레틴 및 임의의 유로딜라틴의 용도 无效
标题翻译：使用分泌物和作为治疗药物的选择性尿毒症
公开(公告)号：KR1020100061478A
公开(公告)日：2010-06-07
申请号：KR1020107005596
申请日：2008-09-09
申请人： 몬도바이오테크 래보래토리즈 아게
发明人： 베펙도리안 , 카발리파비오 , 카발리베라 , 바허게랄트
IPC分类号： A61K38/22 , A61P31/20 , A61P35/00 , A61P25/28
CPC分类号： A61K38/2242 , A23L33/18 , A23L33/40 , A23V2002/00 , A61K38/2235 , Y02A50/385 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , A61K2300/00 , A23V2200/308 , A23V2200/318 , A23V2200/322 , A23V2200/324 , A23V2200/326 , A23V2250/55
摘要： The present invention is directed to the use of the peptide compound His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Glu-Gly-Ala-Arg-Le u-Gln-Arg-Leu-Leu-Gln-GIy-LeU-VaI-NHas a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Glu-Gly-Ala-Arg-Le u-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NHoptionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
摘要翻译：本发明涉及肽化合物His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Glu-Gly-Ala-Arg-Le u -Gln-Arg-Leu-Leu-Gln-Gly-LeU-Val-NHA是用于预防和/或治疗癌症，自身免疫疾病，纤维化疾病，炎性疾病，神经变性疾病，传染病，肺部疾病，心脏的治疗剂和血管疾病和代谢疾病。此外，本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu- Ser-Arg-Leu-Arg-Glu-Gly-Ala-Arg-Le-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH选择性地连同至少一种药学上可接受的载体，冷冻保护剂，冻干保护剂，赋形剂和/或稀释剂。

57. 发明公开

KR1020100059866A Ｂ－타입 나트륨이뇨 펩티드 및 인간 성장 호르몬 １－４３의 치료적 용도 无效
标题翻译： B型神经肽和人生长激素1-43的治疗用途
公开(公告)号：KR1020100059866A
公开(公告)日：2010-06-04
申请号：KR1020107005667
申请日：2008-09-09
申请人： 몬도바이오테크 래보래토리즈 아게
发明人： 베펙도리안 , 카발리파비오 , 카발리베라 , 바허게랄트
IPC分类号： A61K38/16 , A61K38/27 , A61P3/00 , A61P9/00
CPC分类号： A61K38/12 , A23L33/18 , A23L33/40 , A23V2002/00 , A61K38/22 , Y02A50/385 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , A61K2300/00 , A23V2200/308 , A23V2200/318 , A23V2200/322 , A23V2200/324 , A23V2200/326 , A23V2250/55
摘要： The present invention is directed to the use of the peptide compound Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-lle-Se r-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-lle-Se r-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
摘要翻译：本发明涉及肽化合物Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Se Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His作为预防和/或治疗癌症，自身免疫疾病，纤维化疾病，炎性疾病，神经变性疾病，传染病，肺部疾病，心血管疾病和代谢疾病。此外，本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys- Phe-Gly-Arg-Lys-Met-Asp-Arg-Lys-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His任选与至少一个药学上可接受的载体，冷冻保护剂，冻干保护剂，赋形剂和/或稀释剂。

58. 发明公开

KR1020100059863A 치료제로서의 펩티드 티모신 베타 ４ 단독 또는 세크로핀 Ａ와의 배합물의 용도 无效
标题翻译：使用肽甲硫氨酸β4单独或与CECROPIN A组合作为治疗剂
公开(公告)号：KR1020100059863A
公开(公告)日：2010-06-04
申请号：KR1020107005651
申请日：2008-09-09
申请人： 몬도바이오테크 래보래토리즈 아게
发明人： 베펙도리안 , 카발리파비오 , 카발리베라 , 바허게랄트
IPC分类号： A61K38/17 , A61K38/22 , A61P35/00 , A61P31/00
CPC分类号： A61K38/08 , A61K38/1825 , Y02A50/385 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/422 , Y02A50/423
摘要： The present invention is directed to the use of the peptide compound Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-lle-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-T hr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-lle-Glu-Gln-Glu-Lys-Gln-A la-Gly-Glu-Ser-OH or its combination with the peptide Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Glu-Lys-Val-Gly-Gln-Asn-Ile-Arg-Asp-Gly-Il e-Ile-Lys-Ala-Gly-Pro-Ala-Val-Ala-Val-Val-Gly-Gln-Ala-Thr-Gln-Ile-Ala-Lys as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-lle-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-T hr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-lle-Glu-Gln-Glu-Lys-Gln-A la-Gly-Glu-Ser-OH or its combination optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
摘要翻译：本发明涉及肽化合物Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys- Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Lle-Glu-Gln-Glu-Lys-Gln-A 1a-Gly-Glu- Ser-OH或其与肽Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Glu-Lys-Val-Gly-Gln-Asn-Ile-Arg-Asp-Gly-IIe- Lys-Ala-Gly-Pro-Ala-Val-Ala-Val-Val-Gly-Gln-Ala-Thr-Gln-Ile-Ala-Lys作为预防和/或治疗癌症，自身免疫疾病，纤维化疾病，炎性疾病，神经变性疾病，传染病，肺部疾病，心脏和血管疾病以及代谢疾病。此外，本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile- Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr- -Glu-Gln-Glu-Lys-Gln-A 1a-Gly-Glu-Ser-OH或其组合，任选与至少一种药学上可接受的载体，冷冻保护剂，冻干保护剂，赋形剂和/或稀释剂一起。

59. 发明公开

KR1020100059861A 치료제로서의 스트레스코핀－관련 펩티드의 용도 无效
标题翻译：作为治疗药物的抗应激蛋白相关肽的使用
公开(公告)号：KR1020100059861A
公开(公告)日：2010-06-04
申请号：KR1020107005638
申请日：2008-09-09
申请人： 몬도바이오테크 래보래토리즈 아게
发明人： 베펙도리안 , 카발리파비오 , 카발리베라 , 바허게랄트
IPC分类号： A61K38/16 , A61P35/00 , A61P37/00 , A61P3/00
CPC分类号： A61K38/22 , A23L33/18 , A23L33/40 , A23V2002/00 , A61K38/26 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/397 , Y02A50/401 , Y02A50/402 , Y02A50/406 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/422 , Y02A50/423 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , A61K2300/00 , A23V2200/308 , A23V2200/318 , A23V2200/322 , A23V2200/324 , A23V2200/326 , A23V2250/55
摘要： The present invention is directed to the use of the peptide compound His-Pro-Gly-Ser-Arg-lle-Val-Leu-Ser-Leu-Asp-Val-Pro-lle-Gly-Leu-Leu-Gln-ll e-Leu-Leu-Glu-Gln-Ala-Arg-Ala-Arg-Ala-Ala-Arg-Glu-Gln-Ala-Thr-Thr-Asn-Ala-Arg-lle-Lu-Ala-Arg-Val-NH2 as atherapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases,fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide His-Pro-Gly-Ser-Arg-lle-Val-Leu-Ser-Leu-Asp-Val-Pro-lle-Gly-Leu-Leu-Gln-ll e-Leu-Leu-Glu-Gln-Ala-Arg-Ala-Arg-Ala-Ala-Arg-Glu-Gln-Ala-Thr-Thr-Asn-Ala-Arg-lle-Leu-Ala-Arg-Val-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
摘要翻译：本发明涉及肽化合物His-Pro-Gly-Ser-Arg-Lle-Val-Leu-Ser-Leu-Asp-Val-Pro-Lys-Gly-Leu-Leu-Gln-11e -Leu-LEU-GLU-GLN-ALA-Arg-Ala-Arg-Ala-ALA-精氨酸，谷氨酸，谷氨酰胺-ALA-THR-THR-ASN-丙氨酸 - 精氨酸 - LLE-鲁-ALA-精氨酸-VAL-NH2 作为预防和/或治疗癌症，自身免疫性疾病，纤维化疾病，炎性疾病，神经变性疾病，感染性疾病，肺部疾病，心脏和血管疾病和代谢疾病的治疗剂。此外，本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有His-Pro-Gly-Ser-Arg-Lele-Val-Leu-Ser-Leu- Asp-Val-Pro-Lle-Gly-Leu-Leu-Gln-11e-Leu-Leu-Glu-Gln-Ala-Arg-Ala-Arg-Ala-Ala-Arg-Glu-Gln-Ala-Thr-Thr -Asn-Ala-Arg-Leu-Leu-Ala-Arg-Val-NH 2任选与至少一种药学上可接受的载体，冷冻保护剂，冻干保护剂，赋形剂和/或稀释剂一起。

60. 发明公开

KR1020100059860A ＨＢＶ 감염 치료시 치료제로서의 ＮＦ―카파Ｂ 저해제 ＳＮ５０ 및 임의의 안지오텐신 Ⅲ의 용도 无效
标题翻译：使用NF-KAPPAB抑制剂SN50和可溶性血管紧张素II作为治疗乙肝感染的治疗药物
公开(公告)号：KR1020100059860A
公开(公告)日：2010-06-04
申请号：KR1020107005624
申请日：2008-09-09
申请人： 몬도바이오테크 래보래토리즈 아게
发明人： 베펙도리안 , 카발리파비오 , 카발리베라 , 바허게랄트
IPC分类号： A61K38/16 , A61K38/08 , A61P31/20 , A61P3/00
CPC分类号： A61K38/12 , Y02A50/385 , Y02A50/402 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/422 , Y02A50/423 , A61K2300/00
摘要： The present invention is directed to the use of the peptide compound AIa-AIa-VaI-AIa-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Ly s-Leu-Met-Pro-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquide buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
摘要翻译：本发明涉及肽化合物AIa-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg- Lys-Arg-Gln-Ly s-Leu-Met-Pro-OH作为预防和/或治疗癌症，自身免疫性疾病，纤维化疾病，炎性疾病，神经变性疾病，传染病，肺部疾病，心脏和/ 血管疾病和代谢疾病。此外，本发明涉及优选形式为冻干物或液体缓冲溶液或人造母乳制剂或含有Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu- Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH任选与至少一种药学上可接受的载体，冷冻保护剂，溶血保护剂，赋形剂和/ 或稀释剂。

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