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    • 59. 发明公开
    • 새싹보리 추출물 및 이로부터 분리된 폴리코사놀계 화합물을 포함하는 대사성 질환 예방 및 치료용 약학 조성물
    • 从包括与其分离的POLICOSANOL化合物和治疗药物组合物的BARLEY SPROUT和代谢疾病预防提取物
    • KR1020130051181A
    • 2013-05-20
    • KR1020110116385
    • 2011-11-09
    • 대한민국(농촌진흥청장)
    • 서우덕장기창한상익김상열오성환나지은최경진이기환송유천강항원
    • A61K36/8998A61P3/10A61P3/00
    • PURPOSE: An extract with high content of barley sprout-derived policosanol, and a method for preparing the same are provided to produce health functional food and a functional cosmetic product for treating cholesterol, arteriosclerosis, and diabetes with antibacterial property, thrombolysis, and skin vitality. CONSTITUTION: A pharmaceutical composition for preventing and treating cholesterol, arteriosclerosis, or diabetes contains a barley sprout extract as an active ingredient, and activates phosphorylation of AMPK(Adenosine monophosphate kinase). The pharmaceutical composition contains a compound selected among compound denoted by chemical formulas 1-9. A method for preparing the compounds denoted by the chemical formulas comprises: a step of freeze-drying barley sprouts and pulverizing; a step of extracting the barley sprouts with C1-C4 alcohol or n-hexane; a step of adding water and suspending; a step of adding an organic solvent, and obtaining each fraction; and a step of eluting the fraction on a silicagel column.
    • 目的:提供大麦芽衍生的二十烷醇含量高的提取物及其制备方法,以制备健康功能食品和用于治疗胆固醇,动脉硬化和糖尿病的功能性化妆品,具有抗菌性,溶栓作用和皮肤活力 。 构成:用于预防和治疗胆固醇,动脉硬化或糖尿病的药物组合物含有大麦芽提取物作为活性成分,并激活AMPK(腺苷单磷酸激酶)的磷酸化。 该药物组合物含有选自化学式1-9表示的化合物的化合物。 由化学式表示的化合物的制备方法包括:冷冻干燥大麦芽和粉碎的步骤; 用C1-C4醇或正己烷萃取大麦芽的步骤; 加水和暂停的一个步骤; 加入有机溶剂,得到各部分的工序; 以及在硅胶柱上洗脱级分的步骤。