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41. 发明授权

KR100676298B1 고체분산체 및 그 제조방법 失效
标题翻译： 고체분산체및그제조방법
公开(公告)号：KR100676298B1
公开(公告)日：2007-01-30
申请号：KR1020050078006
申请日：2005-08-24
申请人： 씨제이 주식회사
发明人： 노현정 , 김택로 , 조청일 , 고동현 , 김태형 , 서혜란 , 조일환 , 김창주
IPC分类号： A61K31/4196
摘要： A solid dispersion is provided to show improved dissolution rate of a medicine, and improved stability of the dissolution rate according to passing of the storage time. The solid dispersion containing a compound represented by the formula(1) is prepared by dispersing a mixture consisting of a water-soluble polymer selected from the group consisting of poloxamer, polyethylene glycol, polyvinylpyrrolidone, copolymer of vinylpyrrolidone and vinyl acetate, and a mixture thereof, a surfactant having more than 10 of HLB, and the compound of the formula(1) in a strong disintegrating agent selected from the group consisting of crosscamellose sodium, sodium starch glycolate, crosspovidone, pre-gelatinized starch and a mixture thereof or a mixture consisting of the strong disintegrating agent and a pharmaceutically acceptable excipient. In the formula(1), R1 is C3-6 cycloalkyl, C3-6 cycloalkenyl, phenyl, C1-6 alkyl, C1-6 haloalky, C1-6 alkoxy, C1-6 haloalkoxy, phenyl substituted by at least one selected from the group consisting of halogen, amino, monoalkylamino, dialkylamino, nitro and cyano, styrenyl, C1-6 alkoxy styrenyl, and pyridyl, R2 is methyl or amino, and each A, B, C and D is independently C or N. Regarding the total weight of the dispersion, 0.1-10 wt.% of the water soluble polymer and 0.1-10 wt.% of the surfactant are contained.
摘要翻译：提供固体分散体以显示药物的溶解速率提高，并且随着储存时间的过去而改善溶解速率的稳定性。含有由式（1）表示的化合物的固体分散体通过将由选自泊洛沙姆，聚乙二醇，聚乙烯吡咯烷酮，乙烯基吡咯烷酮和乙酸乙烯酯的共聚物及其混合物的水溶性聚合物组成的混合物中，具有超过10的HLB的表面活性剂，和式（1）的在选自由crosscamellose钠，淀粉羟乙酸钠，交联聚维所组成的组中选择的强崩解剂的化合物中，预胶化淀粉和它们的混合物或混合物由强力崩解剂和药学上可接受的赋形剂组成。在式（1）中，R1是C3-6环烷基，C3-6环烯基，苯基，C1-6烷基，C1-6卤代烷基，C1-6烷氧基，C1-6卤代烷氧基，被选自选自卤素，氨基，单烷基氨基，二烷基氨基，硝基和氰基，苯乙烯，C 1-6烷氧基苯乙烯基和吡啶基的基团，R 2是甲基或氨基，且每个A，B，C和d独立地是C或N.关于总包含分散体的重量，0.1-10重量％的水溶性聚合物和0.1-10重量％的表面活性剂。

42. 发明公开

KR1020070010664A 근채류 또는 과채류의 가공 식품 제조 방법 有权
标题翻译：制备根蔬菜或水果蔬菜加工食品的方法
公开(公告)号：KR1020070010664A
公开(公告)日：2007-01-24
申请号：KR1020050065434
申请日：2005-07-19
申请人： 씨제이 주식회사
发明人： 동명곤 , 천희순 , 최준봉
IPC分类号： A23L1/212 , A23L1/214 , A23L1/218
CPC分类号： A23L19/105 , A23L19/09 , A23L19/10
摘要： Provided is a method for preparing a processed food which exhibits a substantially improved conveniences of package and circulation, and has a regular size and thus is easy to produce an industrial product, and can be produced irrespective of season. The method comprises the steps of (i) heating a vegetable selected from the group consisting of root and fruit vegetables and immersing the vegetable into sugar liquid, (ii) forming the immersed vegetable into paste, (iii) forming the paste into original forms of the vegetables, (iv) applying or coating a material containing vegetable having color similar to that of peel of original fruit, on surface of the formed product of the step(iii), and (v) drying the applied or coated product. The root vegetables are selected from the group consisting of sweet potato, potato, and carrot. The fruit vegetables are selected from the group consisting of pumpkin and red pepper. The heating step(i) comprises immersing the vegetable in water of 90-100 deg.C for 10-40 minutes.
摘要翻译：本发明提供了一种制备加工食品的方法，其显示出包装和循环的显着改进的便利性，并且具有规则的尺寸，因此易于生产工业产品，并且可以生产而不考虑季节。该方法包括以下步骤：（i）加热选自根和水果蔬菜的蔬菜并将植物浸入糖液中，（ii）将浸入的蔬菜形成糊状，（iii）将糊状物形成原始形式蔬菜，（iv）在步骤（iii）的形成产品的表面上涂覆或涂覆含有与原始果实的果皮类似的植物的材料的材料，和（v）干燥所施加的或涂覆的产品。根蔬菜选自甘薯，马铃薯和胡萝卜。水果蔬菜选自南瓜和红辣椒。加热步骤（i）包括将蔬菜浸入90-100℃的水中10-40分钟。

43. 发明授权

KR100671081B1 이노신을 생산하는 미생물 및 이를 이용한 이노신의 생산방법 有权
标题翻译：生产肌肉的微生物及其制备5'-肌苷酸的方法
公开(公告)号：KR100671081B1
公开(公告)日：2007-01-17
申请号：KR1020050115421
申请日：2005-11-30
申请人： 씨제이 주식회사
发明人： 박영훈 , 김형석 , 이진남 , 오윤석 , 최경오
IPC分类号： C12N1/20
摘要： A variant of Corynebacterium ammoniagenes CJTP-17 is provided to be able to produce the inosine with high concentration and high yield by direct fermentation, thereby capable of economically preparing an inosinic acid through enzyme transfer reaction of the inosine generated by the variant. The variant of Corynebacterium ammoniagenes CJTP-17 has the increased resistance against inosine and improved inosine producing capacity, and is deposited as a deposition number of KCCM-10699P. To produce the inosine, the variant is cultured and then the inosine is collected from the culture solution.
摘要翻译：提供产氨棒杆菌CJTP-17的一种变体，以能够通过直接发酵产生高浓度和高产量的肌苷酸，从而能够通过变体产生的肌苷的酶转移反应经济地制备肌苷酸。产氨棒杆菌CJTP-17的变体具有增加的抗肌苷抗性和肌苷生成能力的提高，并作为KCCM-10699P的保藏号进行沉积。为了产生肌苷，将变体培养，然后从培养液中收集肌苷。

44. 发明授权

KR100664653B1 ＸＭＰ를 ＧＭＰ로 전환시킬 수 있으면서도, ＧＭＰ의분해에 관련되는 유전자가 불활성화되어 있는 대장균변이주 및 그를 이용하는 방법 有权
标题翻译：能够将XMP转化为GMP并具有用于GMP降解的灭活基因的大肠杆菌菌株及其使用方法
公开(公告)号：KR100664653B1
公开(公告)日：2007-01-04
申请号：KR1020050005863
申请日：2005-01-21
申请人： 씨제이 주식회사
发明人： 박영훈 , 김형석 , 이진남 , 오기훈 , 김정환 , 오윤석 , 심재익 , 최경오
IPC分类号： C12N1/20
CPC分类号： C12N9/16 , C12N9/1077 , C12P19/32 , C12R1/19
摘要： 본 발명은 에스케리키아 종 (
Escherichia sp. ) GPU1114 (수탁번호 KCCM-10536)의 변이주로서,
deoD, aphA ,
appA 및
hprt 유전자가 각각 누적적으로 불활성화되어 있는 미생물 및 그를 이용하는 방법을 제공한다.
GMP, deoD, aphA, appA, hprt

45. 外观设计

KR3004343860000S 失效
公开(公告)号：KR3004343860000S
公开(公告)日：2006-12-19
申请号：KR3020060042351
申请日：2006-10-23
申请人： 씨제이 주식회사
设计人： 김시연

46. 外观设计

KR3004343850000S 失效
公开(公告)号：KR3004343850000S
公开(公告)日：2006-12-19
申请号：KR3020060042350
申请日：2006-10-23
申请人： 씨제이 주식회사
设计人： 김시연

47. 外观设计

KR3004343540001S 失效
公开(公告)号：KR3004343540001S
公开(公告)日：2006-12-18
申请号：KR3020060017724
申请日：2006-05-12
申请人： 씨제이 주식회사
设计人： 유원희

48. 发明公开

KR1020060129889A 사람 과립구 콜로니 형성인자 동종체 失效
标题翻译：人造粒组织刺激因子
公开(公告)号：KR1020060129889A
公开(公告)日：2006-12-18
申请号：KR1020050050608
申请日：2005-06-13
申请人： 씨제이 주식회사
发明人： 고형곤
IPC分类号： C07K14/535
CPC分类号： A61K38/193 , A61K47/60
摘要： Human granulocyte-colony stimulating factor isoforms are provided to increase half life of the human granulocyte-colony stimulating factor in a living body without decrease of its activity. The human granulocyte-colony stimulating factor isoforms are provided, wherein at least one amino acid is added before threonine(Thr) of the N-terminal region or after proline(Pro) of the C-terminal region of human granulocyte-colony stimulating factor represented by the amino acid sequence of SEQ ID NO:1; and at least one amino acids added is cysteine and at least one cysteine is coupled with polyethylene glycol. A pharmaceutical composition comprises the human granulocyte-colony stimulating factor isoforms and pharmaceutically acceptable carriers. Genes encoding the human granulocyte-colony stimulating factor isoform proteins are provided.
摘要翻译：提供人粒细胞集落刺激因子同种型以增加人体中人粒细胞集落刺激因子的半衰期，而不降低其活性。提供人粒细胞集落刺激因子同种型，其中在N末端区域的苏氨酸（Thr）之前或在人粒细胞集落刺激因子的C-末端区域的脯氨酸（Pro）之后加入至少一个氨基酸，通过SEQ ID NO：1的氨基酸序列; 并且加入的至少一个氨基酸是半胱氨酸，并且至少一个半胱氨酸与聚乙二醇偶联。药物组合物包含人粒细胞集落刺激因子同种型和药学上可接受的载体。提供编码人粒细胞集落刺激因子同种型蛋白质的基因。

49. 外观设计

KR3004335810000S 失效
公开(公告)号：KR3004335810000S
公开(公告)日：2006-12-13
申请号：KR3020060030655
申请日：2006-07-21
申请人： 씨제이 주식회사
设计人： 최보라

50. 外观设计

KR3004335790000S 失效
公开(公告)号：KR3004335790000S
公开(公告)日：2006-12-13
申请号：KR3020060030653
申请日：2006-07-21
申请人： 씨제이 주식회사
设计人： 최보라

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