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41. 发明授权

KR100482695B1 베타-카르볼린 유도체 또는 그를 함유한 고련피 추출물을유효성분으로 하는 피부 미백용 조성물 有权
标题翻译：含有美洲楝树或β-咔啉生物碱提取物的皮肤美白组合物
公开(公告)号：KR100482695B1
公开(公告)日：2005-04-13
申请号：KR1020020026122
申请日：2002-05-13
申请人： 주식회사 아모레퍼시픽그룹
发明人： 최현정 , 황재성 , 신현정 , 이병곤
IPC分类号： A61K8/49 , A61K8/97 , A61Q19/02
摘要： 본 발명은 피부 미백용 조성물에 관한 것으로서, 본 발명에 의한 조성물은 베타-카르볼린 유도체를 함유한 고련피 추출물 또는 하기 화학식 1로 표시되는 베타-카르볼린 유도체를 유효 성분으로 포함하는 것을 특징으로 한다. 본 발명에 의한 피부 미백용 조성물을 이용하면, 베타-카르볼린 유도체의 효능으로 인해 부작용 없이 멜라민 생성을 효과적으로 억제할 수 있다.
[화학식 1]

42. 发明公开

KR1020050028565A 질경이 추출물을 함유하는 피부 외용제 조성물 有权
标题翻译：含有植物亚麻籽亚麻提取物的皮肤外用施用组合物
公开(公告)号：KR1020050028565A
公开(公告)日：2005-03-23
申请号：KR1020030064906
申请日：2003-09-18
申请人： 주식회사 아모레퍼시픽그룹
发明人： 김수남 , 이소희 , 최규호 , 이병곤 , 장이섭
IPC分类号： A61K8/99 , A61Q19/08
CPC分类号： A61K8/97 , A61K9/0014 , A61K36/68 , A61Q19/08 , Y10S514/886
摘要： A composition for skin external application comprising an extract of Plantago asiatica Linne is provided, which composition controls micro-inflammation on the skin and thickness of the skin, maintains elasticity and health of the skin, and increases biosynthesis of collagen, elastin and glycosaminoglycan in the dermal skin to enhances wrinkles and recover elasticity. The composition for skin external application comprises 0.001 to 10 wt.%, preferably 0.01 to 5 wt.% of the extract of Plantago asiatica Linne, wherein the Plantago asiatica Linne extract is obtained from the seeds or the total of Plantago asiatica Linne; the composition is useful for skin inflammation control, skin hydration, skin cell growth stimulation, elasticity enhancement and wrinkle enhancement; the composition is administered orally or nonorally; the composition has a formulation selected from ointment, cream, injection, powder, granule and tablet; and the dosage of the composition is 0.001 to 100 mg/kg per day.
摘要翻译：提供了一种用于皮肤外用的组合物，其包含山茶皂甙提取物，其组合物控制皮肤上的微量炎症和皮肤厚度，保持皮肤的弹性和健康，并增加胶原蛋白，弹性蛋白和糖胺聚糖的生物合成真皮皮肤，增强皱纹，恢复弹性。用于皮肤外用的组合物包括山茶皂甙提取物的0.001至10重量％，优选0.01至5重量％，其中来自种子或车前草的总皂甙获得的车前草亚麻提取物; 该组合物可用于皮肤炎症控制，皮肤水合，皮肤细胞生长刺激，弹性增强和皱纹增强; 组合物口服或非口服给药; 该组合物具有选自软膏，霜剂，注射剂，粉剂，颗粒剂和片剂的制剂; 组合物的剂量为0.001〜100mg / kg /日。

43. 发明授权

KR100476069B1 １，２－디티올티온 유도체를 함유하는 발모촉진용 또는탈모방지용 조성물 失效
标题翻译：含有1,2-二硫硫醇衍生物的脱毛组合物或防止脱毛的组合物
公开(公告)号：KR100476069B1
公开(公告)日：2005-03-10
申请号：KR1020030008765
申请日：2003-02-12
申请人： 주식회사 아모레퍼시픽그룹
发明人： 이창훈 , 김광미 , 김승훈 , 남개원 , 이정오 , 박원석 , 이병곤
IPC分类号： A61K8/49 , A61K8/46 , A61Q7/00
摘要： 본 발명은 1,2-디티올티온 유도체(1,2-dithiolthione derivate)를 함유하는 발모촉진용 또는 탈모방지용 조성물에 관한 것으로, 보다 구체적으로는 1,2-디티올티온 유도체, 특히 3H-1,2-디티올-3-티온(3H-1,2-dithiole-3-thione), 4-메틸-5-(2-피라지닐)-1,2-디티올-3-티온(4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione)[이하, 올티프라즈(oltipraz)라 함], 5-(p-메톡시페닐)-3H-1,2-디티올-3-티온(5-(p-Methoxyphenyl)-3H-1,2-dithiole-3-thione)[이하 설파렘(sulfarlem)이라 함] 등의 화합물이 종래 알려져 있던 기능 이외에 모낭 세포를 활성화하는 기능이 있음을 이용하여, 이러한 1,2-디티올티온 유도체를 함유함으로써 발모촉진 또는 탈모방지 목적을 달성할 수 있는 피부 외용제 제형의 조성물 또는 경구 복용제 제형의 조성물에 관한 것이다.

44. 发明授权

KR100435855B1 손바닥선인장 추출물을 함유하는 피부 외용제 조성물 有权
标题翻译： 손바닥선인장추출물을함유유하는피부외용제조성물
公开(公告)号：KR100435855B1
公开(公告)日：2004-06-12
申请号：KR1020010056572
申请日：2001-09-13
申请人： 주식회사 아모레퍼시픽그룹
发明人： 손의동 , 남개원 , 박원석 , 김수정 , 이창훈 , 이병곤
IPC分类号： A61K8/97 , A61Q19/00
摘要： PURPOSE: An external agent composition for application to the skin containing an extract of Opuntia ficus-indica var. Saboten Makino is provided which increases moisturization, softness and stiffness of the skin and enhances the skin barrier and thus reduces generation of fine wrinkles caused by dry skin while preventing and treating dermatoxerasia. CONSTITUTION: The skin preparation composition for external use contains 0.0001 to 60% by weight of an extract of Opuntia ficus-indica var. Saboten Makino. The extract is obtained by mixing stems or fruits of Opuntia ficus-indica with one or more solvents selected from group consisting of water, ethanol, methanol, hexane, ethylacetate or butanol, fractioning and concentrating under reduced pressure.
摘要翻译：用途：用于含有仙人掌变种仙人掌提取物的皮肤外用剂组合物。 Saboten Makino提供增加皮肤的保湿性，柔软性和硬挺度，并且增强皮肤屏障并因此减少由干性皮肤引起的细皱纹的产生，同时预防和治疗皮肤病。组成：用于外用的皮肤制剂组合物含有0.0001至60重量％的仙人掌变种仙人掌提取物。 Saboten牧野。提取物通过将仙人掌果的茎或果实与选自水，乙醇，甲醇，己烷，乙酸乙酯或丁醇的一种或多种溶剂混合，在减压下分馏和浓缩而获得。

45. 发明公开

KR1020040017678A 피부 감작 및 자극을 완화하는 피부 외용제 조성물 有权
标题翻译：用于消除皮肤刺激和敏感度引起的皮肤不良反应的皮肤组合物
公开(公告)号：KR1020040017678A
公开(公告)日：2004-02-27
申请号：KR1020020050099
申请日：2002-08-23
申请人： 주식회사 아모레퍼시픽그룹
发明人： 김광미 , 김승훈 , 남개원 , 김지현 , 이종찬 , 박원석 , 이창훈 , 이병곤 , 안수미
IPC分类号： A61K8/55 , A61Q19/00
摘要： PURPOSE: Provided is a dermatologic composition for relieving skin adverse reaction induced by skin irritant and sensitizer. It contains only fructose-1,6-diphosphate or together with glucocorticoid to inhibit histamine release and provide anti-oxidation effect on skin cells. CONSTITUTION: A dermatologic composition for relieving skin adverse reaction induced by skin irritant and sensitizer is characterized by containing fructose-1,6-diphosphate or its salt in the amount of 0.00001-10 wt.%. It further contains glucocorticoid.
摘要翻译：目的：提供一种用于缓解由皮肤刺激和敏化剂引起的皮肤不良反应的皮肤病学组合物。它只含有果糖-1,6-二磷酸盐或与糖皮质激素一起抑制组胺释放并对皮肤细胞提供抗氧化作用。构成：用于缓解皮肤刺激性和敏化剂引起的皮肤不良反应的皮肤病学组合物的特征在于含有0.00001-10重量％的果糖-1,6-二磷酸盐或其盐。它还含有糖皮质激素。

46. 发明授权

KR100406124B1 자외선에 의해 증가하는 프로스타글란딘을 억제하는성분과 멜라닌 합성을 억제하는 성분을 동시에 함유하는미백 화장료 조성물 有权
标题翻译：用户可以通过使用自定义功能来实现自定义功能，从而实现最佳性能。화료백백백백백백백백백백백백백백백백백백
公开(公告)号：KR100406124B1
公开(公告)日：2003-11-15
申请号：KR1020010016889
申请日：2001-03-30
申请人： 주식회사 아모레퍼시픽그룹
发明人： 노민수 , 김수현 , 황재성 , 최현정 , 이영하 , 오택진 , 이병곤
IPC分类号： A61K8/49 , A61K8/60 , A61K8/97 , A61Q19/02
摘要： PURPOSE: A skin whitening cosmetic composition exhibiting an excellent whitening effect despite the reduction of the amount of a tyrosinase inhibiting material used to reduce skin irritation is provided which prevents skin pigmentation such as ephelides and sun burn while simultaneously increasing melanin synthesis inhibiting effect by inhibiting prostaglandin increased by ultraviolet rays. CONSTITUTION: The skin whitening cosmetic composition contains 0.0001 to 10% by weight of one or more selected from a kojic acid or derivatives thereof, arbutin, a Broussonetia Kazinoki Sieb. extract and ascorbyl 3-aminopropylphosphate and 0.00001 to 30% by weight of one or more of a leaf or fruit extract of Rubus coreanum, a leaf or fruit extract of Rubus idaeus, a stalk extract of Vitis vinifera and a leaf extract of Cola nitida.
摘要翻译：目的：提供了尽管减少了用于减少皮肤刺激的酪氨酸酶抑制物质的量，但仍显示出优异的增白效果的皮肤增白化妆品组合物，其防止皮肤色素沉着如腮红和晒伤，同时通过抑制前列腺素增加黑色素合成抑制作用紫外线增加。组成：增白化妆品组合物含有0.0001-10重量％的一种或多种选自曲酸或其衍生物，熊果苷，Broussonetia Kazinoki Sieb。提取物和抗坏血酸3-氨基丙基磷酸酯以及0.00001至30重量％的一种或多种红松天竺葵的叶或果实提取物，悬钩子属的叶或果实提取物，葡萄的茎提取物和可乐叶提取物。

47. 发明授权

KR100383366B1 신규한 페닐환 유도체, 그의 제조방법 및 이를 포함하는약학 조성물 및 화장료 조성물 失效
标题翻译： 신규한페닐환유도체，그의제조방법및이를포함하는약학조성물및화장료조성물
公开(公告)号：KR100383366B1
公开(公告)日：2003-05-12
申请号：KR1020000078491
申请日：2000-12-19
申请人： 김선여 , 최상윤 , 석경호 , 김상희 , 김호철 , 주식회사 아모레퍼시픽그룹
发明人： 김선여 , 김상희 , 최상윤 , 김호철 , 석경호 , 황재성 , 이병곤
IPC分类号： C07C15/52
摘要： PURPOSE: Provided are novel phenyl ring derivatives which has tyrosinase inhibiting and lightening effects, a production method thereof, and pharmaceutical and cosmetic composition containing the same. CONSTITUTION: The phenyl ring derivatives have a chemical structure represented by the formula I, in which R1, R2 and R3 are independently hydrogen, halogen or C1-4 alkoxy, X is a carbon atom or nitrogen atom, M is (i) 2-pyridyl, 3-pyridyl or 4-pyridyl, substituted with R4, (ii) 2-puryl or 3-puryl, substituted with R4, (iii) a phenyl ring represented by the formula I-1, in which R4 is a hydrogen, halogen, hydroxy or C1-4 alkoxy group, R5, R6, R7, R8 and R9 are a hydrogen or C1-4 alkoxy group, provided that R1 to R9 may be substituted.
摘要翻译：目的：提供具有酪氨酸酶抑制和淡化作用的新型苯环衍生物及其生产方法，以及含有其的药物和化妆品组合物。构成：苯环衍生物具有由式I表示的化学结构，其中R1，R2和R3独立地为氢，卤素或C1-4烷氧基，X为碳原子或氮原子，M为（i）2- （ii）被R4取代的2-嘌呤基或3-嘌呤基，（iii）由式I-1表示的苯基环，其中R4是氢，（ii）被R4取代的吡啶基，3-吡啶基或4-吡啶基，卤素，羟基或C 1-4烷氧基，R 5，R 6，R 7，R 8和R 9是氢或C 1-4烷氧基，条件是R 1至R 9可以被取代。

48. 发明公开

KR1020030026062A 3,4,5-트리메톡시 페닐아세트산, 3,4,5-트리메톡시 신남산또는 3,4,5-트리메톡시 히드로 신남산의 에스테르화합물 및 이를 함유하는 미백 화장료조성물 有权
标题翻译： 3,4,5-三甲氧基苯甲酸酯，3,4,5-三甲氧基酸或3,4,5-三甲氧基酰胺酸的酯化合物，其制备方法和白色化妆品组合物
公开(公告)号：KR1020030026062A
公开(公告)日：2003-03-31
申请号：KR1020010059048
申请日：2001-09-24
申请人： 주식회사 아모레퍼시픽그룹
发明人： 노호식 , 황재성 , 최현정 , 신현정 , 김배환 , 이은영 , 이병곤 , 김덕희
IPC分类号： C07C69/708
CPC分类号： A61Q19/02 , A61K8/37 , C07C69/734
摘要： PURPOSE: An ester compound of 3,4,5-trimethoxyphenylacetic acid, 3,4,5-trimethoxycinnamic acid or 3,4,5-trimethoxyhydrocinnamic acid, their preparation method and a whitening cosmetics composition containing the compound are provided, which ester compound inhibits the generation of melanin and shows no toxicity or irritation to the skin. CONSTITUTION: The ester compound is represented by the formula, wherein R1 is -CH2-, -CH=CH- or -CH2-CH2-; and R2 is a thymyl group or a carvacryl group. The ester compound is prepared by dehydrating a starting material (3,4,5-trimethoxyphenylacetic acid, 3,4,5-trimethoxycinnamic acid or 3,4,5-trimethoxyhydrocinnamic acid) with thymol or carvacrol in the presence of an acid. Also the ester compound is prepared by halogenating the starting material; and reacting the halogenated compound with thymol or carvacrol in the presence of a base. Also the ester compound is prepared by converting the starting material into an acid anhydride form; and reacting the obtained acid anhydride with thymol or carvacrol. Also the ester compound is prepared by reacting the starting material with 1,3-dicyclohexylcarbodimide to obtain an active ester; and reacting the active ester with thymol or carvacrol in the presence of a base.
摘要翻译：目的：提供3,4,5-三甲氧基苯乙酸，3,4,5-三甲氧基肉桂酸或3,4,5-三甲氧基氢化肉桂酸的酯化合物，其制备方法和含有该化合物的美白化妆品组合物，该酯化合物抑制黑色素的产生，并且对皮肤没有毒性或刺激性。构成：酯化合物由下式表示，其中R 1是-CH 2 - ， - CH = CH-或-CH 2 -CH 2 - ; R2是胸腺基或carvacryl基。酯化合物通过在酸存在下使起始原料（3,4,5-三甲氧基苯基乙酸，3,4,5-三甲氧基肉桂酸或3,4,5-三甲氧基氢化肉桂酸）与百里酚或香芹酚脱水而制备。酯化合物也可通过卤化原料制备; 并在碱的存在下使卤代化合物与百里香酚或香芹酚反应。酯化合物也可以通过将原料转化为酸酐形式来制备; 并将得到的酸酐与百里香酚或香芹酚反应。酯化合物也可以通过使起始原料与1,3-二环己基碳二亚胺进行反应制得，得到活性酯; 并在碱的存在下使活性酯与百里香酚或香芹酚反应。

49. 发明公开

KR1020030023398A 손바닥선인장 추출물을 함유하는 피부 외용제 조성물 有权
标题翻译：包含OPENTIA FICUS-INDICA萃取物外用的皮肤制剂
公开(公告)号：KR1020030023398A
公开(公告)日：2003-03-19
申请号：KR1020010056572
申请日：2001-09-13
申请人： 주식회사 아모레퍼시픽그룹
发明人： 손의동 , 남개원 , 박원석 , 김수정 , 이창훈 , 이병곤
IPC分类号： A61K8/97 , A61Q19/00
CPC分类号： A61K8/97 , A61K2800/84 , A61Q19/007 , Y10S514/861
摘要： PURPOSE: An external agent composition for application to the skin containing an extract of Opuntia ficus-indica var. Saboten Makino is provided which increases moisturization, softness and stiffness of the skin and enhances the skin barrier and thus reduces generation of fine wrinkles caused by dry skin while preventing and treating dermatoxerasia. CONSTITUTION: The skin preparation composition for external use contains 0.0001 to 60% by weight of an extract of Opuntia ficus-indica var. Saboten Makino. The extract is obtained by mixing stems or fruits of Opuntia ficus-indica with one or more solvents selected from group consisting of water, ethanol, methanol, hexane, ethylacetate or butanol, fractioning and concentrating under reduced pressure.
摘要翻译：目的：一种用于皮肤的外用剂组合物，含有仙人掌提取物。提供Saboten Makino，其增加皮肤的保湿性，柔软性和刚度，并增强皮肤屏障，从而减少由干性皮肤引起的细小皱纹的产生，同时预防和治疗皮肤病。构成：外用皮肤制剂组合物含有0.0001〜60重量％的榕a an提取物。 Saboten Makino。通过将榕果芸香的茎或果实与选自水，乙醇，甲醇，己烷，乙酸乙酯或丁醇的一种或多种溶剂混合，在减压下分馏和浓缩，得到提取物。

50. 发明公开

KR1020030013738A 멜라닌 생성 조절제로서 디리놀릴시스타민을 함유하는피부 미백용 조성물 失效
标题翻译：含有N，N-二烯基甲酰胺作为造血剂调节剂的皮肤白化组合物
公开(公告)号：KR1020030013738A
公开(公告)日：2003-02-15
申请号：KR1020010047912
申请日：2001-08-09
申请人： 주식회사 아모레퍼시픽그룹
发明人： 최현정 , 황재성 , 신현정 , 노호식 , 김덕희 , 이병곤
IPC分类号： A61K8/46 , A61Q19/02
CPC分类号： A61K8/46 , A61Q19/00 , A61Q19/02
摘要： PURPOSE: Provided is a skin whitening composition containing as active ingredient N,N'-dilinoleylcystamine of the formula(I) as a melanogenesis modulator to inhibit the production of melanin and consequently to have skin whitening effect. CONSTITUTION: The skin whitening composition characteristically contains as active ingredient N,N'-dilinoleylcystamine of the formula(I) as a melanogenesis modulator in an amount of 0.00001-10 wt.% based on total weight of the composition. The N,N'-dilinoleylcystamine is excellent in the inhibition of the production of melanin, therefore the composition is useful as a skin whitening agent.
摘要翻译：目的：提供含有作为黑色素生成调节剂的式（I）的活性成分N，N'-二亚油酰基胱胺的皮肤美白组合物，以抑制黑色素的产生，从而具有皮肤美白效果。构成：皮肤美白组合物特征在于，作为黑色素发生调节剂的式（I）的N，N'-二亚油酰基胱胺作为组合物的总重量为0.00001-10重量％。 N，N'-二亚油酰基胱胺在抑制黑色素的生成方面是优异的，因此该组合物可用作皮肤增白剂。

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