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41. 发明授权

KR100522448B1 HIV 유사입자 및 그 용도 有权
标题翻译：艾滋病毒像颗粒和它的用途
公开(公告)号：KR100522448B1
公开(公告)日：2005-11-15
申请号：KR1020020001823
申请日：2002-01-08
申请人： 충남대학교산학협력단
发明人： 김철중 , 김은 , 신광순 , 김현수
IPC分类号： C12N15/86

42. 发明公开

KR1020030013585A 감염성을 갖는 ＨＣＶ 유사입자의 제조 有权
标题翻译：感染性HCV样颗粒的制备
公开(公告)号：KR1020030013585A
公开(公告)日：2003-02-15
申请号：KR1020010047663
申请日：2001-08-08
申请人： 충남대학교산학협력단
发明人： 김철중 , 신광순 , 김현수 , 서원덕 , 오윤이 , 임송
IPC分类号： C12N15/86
CPC分类号： C12N7/02 , C12N5/067 , C12N15/86 , C12N2770/24223 , C12N2770/24251 , C12N2770/36141
摘要： PURPOSE: Provided is a preparation of infectious HCV-like particles which are characteristically used as antigens for the detection HCV vaccine or HCV antibodies and for the inspection or examination of infection inhibiting drugs. CONSTITUTION: The preparation of infectious HCV-like particles is characterized by using a recombinant alphavirus expression vector(KCCM-10287) and a helper vector(KCCM-10286) which express HCV core, E1 and E2.
摘要翻译：目的：提供特征性地用作检测HCV疫苗或HCV抗体的抗原以及感染抑制药物的检查或检查的感染性HCV样颗粒的制剂。构成：感染性HCV样颗粒的制备的特征在于使用表达HCV核心，E1和E2的重组甲病毒表达载体（KCCM-10287）和辅助载体（KCCM-10286）。

43. 发明授权

KR100504322B1 암억제 단백질을 발현하는 알파바이러스계 발현 벡터,이의 제조 방법 및 용도 有权
标题翻译：基于ALPHAVIRUS的表达载体表达肿瘤抑制蛋白，其制备及其用途
公开(公告)号：KR100504322B1
公开(公告)日：2005-07-28
申请号：KR1020040060593
申请日：2004-07-30
申请人： 충남대학교산학협력단
发明人： 김철중 , 이승훈 , 홍석일 , 부하령 , 신광순 , 이종수
IPC分类号： A61K48/00 , C12N15/86

44. 发明授权

KR100457790B1 감염성을 갖는 ＨＣＶ 유사입자의 제조 有权
标题翻译： 감염성을갖갖는HCV유사입자의제조
公开(公告)号：KR100457790B1
公开(公告)日：2004-12-08
申请号：KR1020010047663
申请日：2001-08-08
申请人： 충남대학교산학협력단
发明人： 김철중 , 신광순 , 김현수 , 서원덕 , 오윤이 , 임송
IPC分类号： C12N15/86
摘要： PURPOSE: Provided is a preparation of infectious HCV-like particles which are characteristically used as antigens for the detection HCV vaccine or HCV antibodies and for the inspection or examination of infection inhibiting drugs. CONSTITUTION: The preparation of infectious HCV-like particles is characterized by using a recombinant alphavirus expression vector(KCCM-10287) and a helper vector(KCCM-10286) which express HCV core, E1 and E2.
摘要翻译：目的：提供一种感染性HCV样颗粒的制备物，其特征性地用作检测HCV疫苗或HCV抗体的抗原以及检测或检查感染抑制药物。构成：通过使用表达HCV核心，E1和E2的重组α病毒表达载体（KCCM-10287）和辅助载体（KCCM-10286）来表征感染性HCV样颗粒的制备。

45. 发明公开

KR1020020067833A 암억제 단백질을 발현하는 알파바이러스계 발현 벡터, 이의 제조 방법 및 용도 有权
标题翻译：表达抑癌基因蛋白的ALPHAVIRUS表达载体及其制备方法及其用途
公开(公告)号：KR1020020067833A
公开(公告)日：2002-08-24
申请号：KR1020010008201
申请日：2001-02-19
申请人： 충남대학교산학협력단
发明人： 김철중 , 이승훈 , 홍석일 , 부하령 , 신광순 , 이종수
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C07K14/4703 , C07K14/4746 , C12N5/0693
摘要： PURPOSE: An Alphavirus expression vector capable of expressing a cancer-inhibiting protein, its producing method and its use are provided, thereby effectively inhibiting and preventing the growth of a cancer cell. CONSTITUTION: The Alphavirus expression vector capable of expressing a cancer-inhibiting protein contains a first cancer-inhibiting gene which is operably linked under operation of a first subgenomic promoter, a second cancer-inhibiting gene which is operably linked under operation of a second subgenomic promoter, and a third cancer-inhibiting gene which is operably linked under operation of a third subgenomic promoter, in which the cancer-inhibiting gene is selected from pRb/p110 or its homologue p107 and p120, p53 protein, p21 protein, p21 protein(WAF-1), bak, BRCA1, BRCA2, PTEN, APC, DCC, NF-1, NF-2, WT-1, MEN-I, MEN-II, zac1, p73, VHL, FCC and MCC; and the Alphavirus is Sindbis virus or Semliki Forest virus(SFV).
摘要翻译：目的：提供能够表达癌抑制蛋白的甲病毒表达载体及其制备方法及其用途，从而有效抑制和预防癌细胞的生长。构成：能够表达癌症抑制蛋白的甲病毒载体表达载体含有第一癌抑制基因，其在第一亚基因组启动子的操作下可操作地连接，第二癌抑制基因在第二亚基因组启动子的操作下可操作地连接，以及第三癌抑制基因，其在第三亚基因组启动子的操作下可操作地连接，其中所述癌抑制基因选自pRb / p110或其同源物p107和p120，p53蛋白，p21蛋白，p21蛋白（WAF -1），bak，BRCA1，BRCA2，PTEN，APC，DCC，NF-1，NF-2，WT-1，MEN-1，MEN-II，zac1，p73，VHL，FCC和MCC; 甲病毒属于辛德毕斯病毒或辛格利奇森林病毒（SFV）。

46. 发明公开

KR1020020060100A HIV 유사입자 및 그 용도 有权
标题翻译：艾滋病毒样颗粒及其使用
公开(公告)号：KR1020020060100A
公开(公告)日：2002-07-16
申请号：KR1020020001823
申请日：2002-01-08
申请人： 충남대학교산학협력단
发明人： 김철중 , 김은 , 신광순 , 김현수
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N5/0686 , C12N2740/16023 , C12N2740/16051 , C12N2770/36141 , G01N33/536 , G01N33/56988 , G01N33/6854 , G01N2333/16
摘要： PURPOSE: Provided is HIV like particle which is composed of HIV-1 Gag, Env, Pol and/or Pro proteins expressed by an expression vector containing HIV-1 env, gag, pro, pol genes. The HIV like particle can be used as an antigen in a diagnosis kit of HIV infection and for HIV vaccine composition. CONSTITUTION: Alphavirus based expression vectors contain HIV-1 env, gag, pro and pol genes and they are as follows: pSFV/env-gag, pSFV/gag-env, pSFV/env-gag-pro, pSFV/env-gag-gagpro, pSFV/env-gag-gagΔpro, and pSFV/gagpol-env. The expression vectors further contains CTE(constitutive transport element) gene and they are as follows: pSFV/env-gag-gagpro-CTE, pSFV/env-gag-gagΔpro-CTE, pSFV/gagpol-env-MCTE, and pSF/gag-env-MCTE. HIV-like particle is manufactured by introducing one of the above vectors or its RNA transcript into an animal cell then expressing it.
摘要翻译：目的：提供由含有HIV-1 env，gag，pro，pol基因的表达载体表达的由HIV-1Gag，Env，Pol和/或Pro蛋白组成的HIV样颗粒。 HIV样颗粒可用作HIV感染和HIV疫苗组成的诊断试剂盒中的抗原。构成：基于甲病毒基因的表达载体含有HIV-1 env，gag，pro和pol基因，它们如下：pSFV / env-gag，pSFV / gag-env，pSFV / env-gag-pro，pSFV / env-gag- gagpro，pSFV / env-gag-gagΔpro和pSFV / gagpol-env。表达载体还含有CTE（组成型转运元件）基因，它们如下：pSFV / env-gag-gagpro-CTE，pSFV / env-gag-gagΔpro-CTE，pSFV / gagpol-env-MCTE和pSF / gag -env-MCTE。通过将上述载体之一或其RNA转录物引入动物细胞中然后进行表达来制备HIV样颗粒。

47. 发明授权

KR101919002B1 구제역 바이러스의 가용성 다가 항원단백질 및 이의 용도 有权
公开(公告)号：KR101919002B1
公开(公告)日：2018-11-20
申请号：KR1020160164441
申请日：2016-12-05
申请人： 대한민국(농림축산식품부 농림축산검역본부장) , 충남대학교산학협력단
发明人： 박종현 , 이광녕 , 이종수 , 김철중 , 구완서
IPC分类号： C07K14/005 , C12N15/70 , A61K39/135
摘要： 본발명은혈청형이서로다른구제역바이러스의 VP1 단백질내 주요항원성에피토프들을코돈최적화하여연결한후 특이미생물발현시스템을이용하여융합단백질항원 (Multi-VP1 epitopes)을가용성의단백질 (Soluble protein)로발현시키는벡터, 이에의해형질전환된 미생물, 상기미생물로부터발현·정제된가용성 Multi-VP1 epitope 단백질및 상기단백질의백신목적으로의이용에대한것으로, 더욱자세하게는대장균의코돈에최적화되게유전자서열을변환한 O, A, Asia1 type 구제역바이러스혹은각각의동일혈청형내 서로다른지역형구제역바이러스의 VP1 단백질내 주요항원에피토프들을연결한유전자를포함하는대장균발현벡터, 상기의벡터로형질전환된 특이재조합대장균및, 상기의대장균으로부터발현및 정제된가용성의 Multi-VP1 epitope 단백질을유효성분으로하는구제역바이러스감염예방을위한백신에관한것이다.

48. 发明公开

KR20180064158A 구제역 바이러스의 가용성 다가 항원단백질 및 이의 용도 有权
公开(公告)号：KR20180064158A
公开(公告)日：2018-06-14
申请号：KR20160164441
申请日：2016-12-05
申请人： 대한민국(농림축산식품부 농림축산검역본부장) , 충남대학교산학협력단
发明人： 박종현 , 이광녕 , 이종수 , 김철중 , 구완서
IPC分类号： C07K14/005 , A61K39/135 , C12N15/70
摘要： 본발명은혈청형이서로다른구제역바이러스의 VP1 단백질내 주요항원성에피토프들을코돈최적화하여연결한후 특이미생물발현시스템을이용하여융합단백질항원 (Multi-VP1 epitopes)을가용성의단백질 (Soluble protein)로발현시키는벡터, 이에의해형질전환된 미생물, 상기미생물로부터발현·정제된가용성 Multi-VP1 epitope 단백질및 상기단백질의백신목적으로의이용에대한것으로, 더욱자세하게는대장균의코돈에최적화되게유전자서열을변환한 O, A, Asia1 type 구제역바이러스혹은각각의동일혈청형내 서로다른지역형구제역바이러스의 VP1 단백질내 주요항원에피토프들을연결한유전자를포함하는대장균발현벡터, 상기의벡터로형질전환된 특이재조합대장균및, 상기의대장균으로부터발현및 정제된가용성의 Multi-VP1 epitope 단백질을유효성분으로하는구제역바이러스감염예방을위한백신에관한것이다.

49. 发明公开

KR20180046968A H5 조류 인플루엔자 바이러스 유사입자 백신 및 그 제조방법 有权
公开(公告)号：KR20180046968A
公开(公告)日：2018-05-10
申请号：KR20160142093
申请日：2016-10-28
申请人： 성신여자대학교 산학협력단 , 충남대학교산학협력단 , 충북대학교 산학협력단
发明人： 송재민 , 신옥 , 김철중 , 최영기 , 박영찬
IPC分类号： C07K14/005 , A61K39/145
CPC分类号： C07K14/005 , A61K39/145 , C12N2760/16123 , C12N2760/16134 , C12N2760/16151
摘要： H5N8으로부터유래한헤마글루티닌(HA) 단백질및 뉴라미니다제(NA) 단백질를포함하고, H1N1으로부터유래한 M1 단백질을포함하는바이러스유사입자백신이개시된다. 상기바이러스유사입자백신은근육주사뿐만이아니라호흡주사를통해서도면역반응을유도할수 있다.

50. 发明授权

KR100457791B1 암억제 단백질을 발현하는 알파바이러스계 발현 벡터, 이의 제조 방법 및 용도 有权
标题翻译： 암억제단백질을발현하는알파바이러스계발현벡터，이의제조법법및및용도
公开(公告)号：KR100457791B1
公开(公告)日：2004-11-18
申请号：KR1020010008201
申请日：2001-02-19
申请人： 충남대학교산학협력단
发明人： 김철중 , 이승훈 , 홍석일 , 부하령 , 신광순 , 이종수
IPC分类号： C12N15/86
摘要： PURPOSE: An Alphavirus expression vector capable of expressing a cancer-inhibiting protein, its producing method and its use are provided, thereby effectively inhibiting and preventing the growth of a cancer cell. CONSTITUTION: The Alphavirus expression vector capable of expressing a cancer-inhibiting protein contains a first cancer-inhibiting gene which is operably linked under operation of a first subgenomic promoter, a second cancer-inhibiting gene which is operably linked under operation of a second subgenomic promoter, and a third cancer-inhibiting gene which is operably linked under operation of a third subgenomic promoter, in which the cancer-inhibiting gene is selected from pRb/p110 or its homologue p107 and p120, p53 protein, p21 protein, p21 protein(WAF-1), bak, BRCA1, BRCA2, PTEN, APC, DCC, NF-1, NF-2, WT-1, MEN-I, MEN-II, zac1, p73, VHL, FCC and MCC; and the Alphavirus is Sindbis virus or Semliki Forest virus(SFV).
摘要翻译：目的：提供一种能够表达癌症抑制蛋白的甲病毒表达载体，其生产方法及其用途，由此有效地抑制和预防癌细胞的生长。构成：能够表达癌症抑制蛋白的甲病毒表达载体含有第一种癌症抑制基因，该基因在第一亚基因组启动子的操作下可操作地连接，第二癌基因是在第二亚基因组启动子操作下可操作地连接的和在第三亚基因组启动子的操作下可操作连接的第三癌抑制基因，其中所述癌抑制基因选自pRb / p110或其同源物p107和p120，p53蛋白，p21蛋白，p21蛋白（WAF -1），bak，BRCA1，BRCA2，PTEN，APC，DCC，NF-1，NF-2，WT-1，MEN-1，MEN-II，zac1，p73，VHL，FCC和MCC; 而α病毒是辛德毕斯病毒或塞姆利基森林病毒（SFV）。

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