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    • 38. 发明公开
    • 감송향 추출물을 유효성분으로 함유하는 혈전성 질환의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품
    • 将包含NARDOSTACHYS CHINENESISIS作为有效成分的药物组合物用于预防或治疗与包含其相关的血栓形成和健康功能食物相关的疾病的预防或治疗
    • KR1020140106875A
    • 2014-09-04
    • KR1020130021067
    • 2013-02-27
    • 안동대학교 산학협력단주식회사 케미메디황성연
    • 손호용황성연
    • A61K36/84A61P7/02A61P7/00
    • The present invention relates to a pharmaceutical composition and a functional health food, which contain an extract of Nardostachys chinenesis as an active ingredient for preventing or treating thrombotic diseases, and more specifically, to a pharmaceutical composition containing a hot-water extract of Nardostachys chinenesis as an active ingredient for preventing or treating thrombotic diseases, and to a functional health food containing the extract. As verified through examples of the present specification, the extract of Nardostachys chinensis, as an active ingredient of the pharmaceutical composition and the functional health food for preventing or treating thrombosis-related diseases, is produced by preparing an extract from Nardostachys chinenesis through hot-water extraction and fractionizing the extract with hexene. The hexene fraction exhibiting an antithrombotic activity through a blood coagulation factor inhibiting effect and a platelet aggregation inhibiting effect can efficiently suppressing thrombosis, and can be used to prevent and treat thrombosis, such as ischemic stroke and hemorrhagic stroke, through the improvement of blood circulation. Particularly, the extract of Nardostachys chinensis of the present invention does not show acute oral toxicity, has excellent thermal stability, and does not exhibit the loss of an antithrombotic effect even under an acidic condition of pH 2 and in the plasma, thereby being processed into various types, such as an extract, a powder, a pill, and a tablet, and thus being prepared in a form that can be taken at normal times. Therefore, the present invention is very useful in the pharmaceutical industry and food industry.
    • 本发明涉及含有Nardostachys chinenesis提取物作为预防或治疗血栓性疾病的活性成分的药物组合物和功能性保健食品,更具体地涉及含有Nardostachys chinenesis的热水提取物的药物组合物, 用于预防或治疗血栓形成疾病的活性成分,以及含有该提取物的功能保健食品。 如通过本说明书的实施例所证实的,作为药物组合物的有效成分的Nardostachys chinensis的提取物和用于预防或治疗血栓形成相关疾病的功能保健食品是通过热水制备Nardostachys chinenesis的提取物 用己烯提取和分级提取物。 通过凝血因子抑制效果和血小板聚集抑制作用显示出抗血栓活性的己烯级分可以有效地抑制血栓形成,并且可以通过改善血液循环来用于预防和治疗诸如缺血性中风和出血性中风的血栓形成。 特别地,本发明的Nardostachys chinensis的提取物不显示急性口服毒性,具有优异的热稳定性,即使在pH2的酸性条件下和血浆中也不表现出抗血栓形成作用的丧失,从而被加工成 各种类型,例如提取物,粉末,丸剂和片剂,因此以可以在正常时间摄取的形式制备。 因此,本发明在制药工业和食品工业中非常有用。