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31. 发明公开

KR1020090013207A 다발성 경화증 진단용 생물 표지자 및 그의 제조 방법 无效
标题翻译：用于诊断多发性硬化症的生物标志物及其方法
公开(公告)号：KR1020090013207A
公开(公告)日：2009-02-04
申请号：KR1020087028999
申请日：2007-05-24
申请人： 페노미넘 디스커버리스 인코포레이티드
发明人： 쿡리사
IPC分类号： G01N33/487 , G01N33/50 , G01N33/483 , C07C59/62
CPC分类号： C07F9/103 , C07C59/46 , C07C59/62 , C07C235/08 , C07C2601/16 , C07D311/72 , C07F9/106 , G01N33/53 , G01N33/564 , G01N33/6848 , G01N33/6893 , G01N33/72 , G01N2800/28 , G01N2800/285 , G01N2800/56
摘要： The present invention describes methods for the diagnosis and differential diagnosis of the different forms of multiple sclerosis The methods measure the intensities of specific small molecules called metabolites in samples from patients with clinically diagnosed relapsmg-remittmg or primary-progressive forms of multiple sclerosis and compare these intensities to the intensities observed in a population of healthy individuals, thus identifying markers of multiple sclerosis A method is also provided for the differential diagnosis of subjects afflicted with relapsing-renitting multiple sclerosis from secondary-progressive multiple sclerosis.
摘要翻译：本发明描述了用于多发性硬化症的不同形式的诊断和鉴别诊断的方法。该方法测量来自具有临床诊断的复发或复发性多发性硬化症的患者的样品中的特定小分子的代谢物的强度，并将其比较对健康个体群体观察到的强度的强度，从而确定多发性硬化症的标志物。还提供了一种方法用于鉴别诊断患有复发性多发性硬化症的受试者从继发性进行性多发性硬化症。

32. 发明公开

KR1020060130699A 장쇄 고도 불포화 지방산을 구성요소로서 포함하는 인지질의 제조방법, 및 그 이용 有权
标题翻译：生产包含长链聚氨酯脂肪酸的磷脂的方法及其利用
公开(公告)号：KR1020060130699A
公开(公告)日：2006-12-19
申请号：KR1020067020350
申请日：2005-02-28
申请人： 산토리 홀딩스 가부시키가이샤
发明人： 카와시마히로시 , 스미다모투 , 시라이시아키고
IPC分类号： A23J7/00 , A23L1/30 , C12P13/00 , C07F9/00
CPC分类号： C12P9/00 , A23J7/00 , A23L33/115 , C07F9/103 , C12P7/6481 , C12P13/06
摘要： It is intended to provide a process for efficiently and stably producing an LCPUFA-PL. More specifically speaking, a process for producing a phospholipid which is a phospholipid containing a long chain polyunsaturated fatty acid (LCPUFA) as a constituent thereof (i.e., LCPUFA-PL), starting with a lipid-producing microorganism capable of producing a lipid containing the LCPUFA as a constituent, comprising the PL extraction step wherein the phospholipid (PL) is extracted from defatted microbial cells after extracting triglyceride (TG)-containing fat from the lipid-producing microorganism as described above.
摘要翻译：旨在提供一种有效和稳定地生产LCPUFA-PL的方法。更具体地说，制备作为其长效多不饱和脂肪酸（LCPUFA）作为其成分（即，LCPUFA-PL）的磷脂的磷脂的制造方法，从能够产生含有 LCPUFA作为组分，包括PL提取步骤，其中如上所述从提取含脂肪的微生物中提取含甘油三酯（TG）的脂肪之后，从脱脂微生物细胞中提取磷脂（PL）。

33. 发明公开

KR1020060123100A 포스파티딜세린의 안정화된 제제 有权
标题翻译：磷酸二酯的稳定配方
公开(公告)号：KR1020060123100A
公开(公告)日：2006-12-01
申请号：KR1020067005677
申请日：2004-09-26
申请人： 엔지모테크 리미티드
发明人： 플래트,도리트 , 슐만,아비도르 , 벤드로어,가이 , 쉐인맨,네타 , 트위토,요니 , 주아비,라싼
IPC分类号： A61K31/685 , A61K9/08
CPC分类号： C12P13/06 , A23J7/00 , A23L33/10 , A23V2002/00 , A61K31/685 , A61K45/06 , C07F9/103 , C07F9/106 , C12P9/00 , A23V2250/1852 , A23V2200/322
摘要： Disclosed are stable PS preparations, in powder, liquid and dispersion forms, as well as methods of producing thereof. Most importantly, the stable PS preparations are particularly devoid of residual phospholipase D activity, and the methods of eliminating such activity are also described herein. Lastly, uses of these PS preparations in nutraceuticals or as active agents of pharmaceutical compositions are also provided herein.
摘要翻译：公开了以粉末，液体和分散体形式的稳定的PS制剂，以及其制备方法。最重要的是，稳定的PS制剂特别缺乏残留的磷脂酶D活性，并且本文还描述了消除这种活性的方法。最后，本文还提供了这些PS制剂在营养药物中或作为药物组合物的活性剂的用途。

34. 发明公开

KR1020030084200A 비 유기용매시스템에서의 포스파티딜에탄올아민 및리소포스파티딜에탄올아민의 제조방법 및 그 방법으로제조된 리소포스파티딜에탄올아민을 포함하는 수용성 조성물 无效
标题翻译：使用非有机溶剂系统生产磷脂酰胺（PE）和赖氨基磷酰胺（LPE）的方法和包含生产的赖氨酸二氨基甲酰胺的水溶性组合物
公开(公告)号：KR1020030084200A
公开(公告)日：2003-11-01
申请号：KR1020020022770
申请日：2002-04-25
申请人： 주식회사 두산
发明人： 정국훈 , 한정준 , 양영래 , 정헌민 , 고의찬
IPC分类号： C07F9/10
CPC分类号： C07F9/103 , C12P9/00 , C12P13/001
摘要： PURPOSE: Methods for producing phosphatidylethanolamine(PE) and lysophosphatidylethanolamine(LPE) using a non-organic solvent system and a water-soluble composition comprising the lysophosphatidylethanolamine produced by the same method are provided, thereby producing high purity PE and LPE without using an organic solvent. CONSTITUTION: A method for producing phosphatidylethanolamine(PE) and lysophosphatidylethanolamine(LPE) using a non-organic solvent system is characterized by reacting lecithin with ethanolamine in the presence of phospholipase D, wherein the lecithin contains at least one selected from phosphatidylcholine, phosphatidylethanolamine, phosphatidylic acid and phosphatidylinositol; and the reaction is carried out under the non-organic solvent system containing potassium chloride and buffer solution. A method for producing phosphatidylethanolamine(PE) and lysophosphatidylethanolamine(LPE) using a non-organic solvent system is characterized by the steps of: reacting lecithin with ethanolamine in the presence of phospholipase D; and adding phospholipase A into the reaction resulting product and reacting them, wherein the lecithin contains at least one selected from phosphatidylcholine, phosphatidylethanolamine, phosphatidylic acid and phosphatidylinositol; and the reaction is carried out under the non-organic solvent system containing potassium chloride and buffer solution.
摘要翻译：目的：提供使用非有机溶剂体系制备磷脂酰乙醇胺（PE）和溶血磷脂酰乙醇胺（LPE）的方法以及通过相同方法制备的包含溶血磷脂酰乙醇胺的水溶性组合物，从而在不使用有机溶剂的情况下生产高纯度PE和LPE 。构成：使用非有机溶剂体系制备磷脂酰乙醇胺（PE）和溶血磷脂酰乙醇胺（LPE）的方法的特征在于磷脂酶D存在下使卵磷脂与乙醇胺反应，其中卵磷脂含有选自磷脂酰胆碱，磷脂酰乙醇胺，磷脂酰胆碱酸和磷脂酰肌醇; 反应在含有氯化钾和缓冲溶液的非有机溶剂体系下进行。使用非有机溶剂体系制备磷脂酰乙醇胺（PE）和溶血磷脂酰乙醇胺（LPE）的方法的特征在于以下步骤：在磷脂酶D存在下使卵磷脂与乙醇胺反应; 并将磷脂酶A加入反应产物并使其反应，其中卵磷脂含有选自磷脂酰胆碱，磷脂酰乙醇胺，磷脂酰肌醇和磷脂酰肌醇中的至少一种; 反应在含有氯化钾和缓冲溶液的非有机溶剂体系下进行。

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