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    • 28. 发明公开
    • 세포 및 세포 배양물의 평가 방법
    • 评估细胞和细胞培养的方法
    • KR1020090127153A
    • 2009-12-09
    • KR1020097020856
    • 2008-04-03
    • 젠자임 코포레이션
    • 랍코,스티븐,엠.두가이,스티븐,제이.
    • C12Q1/68G01N33/50G01N33/68
    • G01N33/5044G01N33/6887G01N2333/4722G01N2400/40G01N2800/10C12Q1/6844C12Q1/6851
    • Methods of evaluating the composition of a cell culture (e.g., to distinguish chondrocytes from fibroblasts) and methods for evaluating the phenotype of an individual cell (e.g., as a chondrocyte) are disclosed. The methods may be used, for example, for assessing chondrocyte cultures used for treatment of cartilage defects. In some embodiments, the invention involves identifying cell culture composition or the identity of a cell based on expression level of a fibroblast marker. In other embodiments, the invention involves comparing expression levels of at least one chondrocyte marker and at least one fibroblast marker in a cell culture sample or in an individual cell. In illustrative embodiments, the chondrocyte marker is hyaluronan and proteoglycan link protein 1 (HAPLN1), and the fibroblast marker is microfibrillar associated protein 5 (MFAP5).
    • 公开了评价细胞培养物的组成(例如,将软骨细胞与成纤维细胞区分开)的评估方法和用于评价个体细胞(例如软骨细胞)的表型的方法。 所述方法可用于例如用于评估用于治疗软骨缺陷的软骨细胞培养物。 在一些实施方案中,本发明涉及基于成纤维细胞标志物的表达水平鉴定细胞培养物组成或细胞的身份。 在其他实施方案中,本发明涉及比较细胞培养物样品或个体细胞中至少一种软骨细胞标志物和至少一种成纤维细胞标志物的表达水平。 在说明性实施例中,软骨细胞标志物是透明质酸和蛋白聚糖连接蛋白1(HAPLN1),成纤维细胞标记是微原纤维相关蛋白5(MFAP5)。
    • 29. 发明公开
    • 혈관 종양 마커
    • 血管肿瘤标志物
    • KR1020080102408A
    • 2008-11-25
    • KR1020087023111
    • 2007-02-21
    • 필로겐 에스.피.에이.
    • 네리,다리오뢰슬리,크리스토프레이백,자샤-니콜라이
    • G01N33/574C07K16/00G01N33/68G01N33/53
    • G01N33/566G01N33/57438G01N2333/515G01N2500/00G01N2800/10G01N2800/323G01N2800/7028
    • The present invention relates to a method for identifying neovascular structures in mammalian tissue, wherein said neovascular structures are identified by the detection of at least one specific protein in said tissue. It also relates to a method for identifying diseases or conditions associated with neovascularization, methods for targeting and/or imaging neovascular structures and methods for targeting diseases or conditions associated with neovascularization. Furthermore, the present invention is directed to the the use of novel and/or known ligands, preferably antibodies, directed against novel and/or known target proteins for identifying tumor cells in mammalian tissue, preferably mammalian kidney tissue, more preferably mammalian vascular kidney tissue. The present invention also relates to novel ligands, preferably antibodies, fusion proteins comprising said ligands or antibodies, pharmaceutical and diagnostic compositions comprising said ligands, antibodies or fusion proteins, diagnostic and therapeutic methods as well as novel proteins and corresponding polynucleotides, vectors and host cells.
    • 本发明涉及用于鉴定哺乳动物组织中的新生血管结构的方法,其中所述新生血管结构通过检测所述组织中的至少一种特定蛋白来鉴定。 它还涉及用于鉴定与新生血管形成相关的疾病或病症的方法,用于靶向和/或成像新生血管结构的方法和用于靶向与新血管形成相关的疾病或病症的方法。 此外,本发明涉及针对新颖和/或已知靶蛋白的新型和/或已知配体,优选抗体用于鉴定哺乳动物组织,优选哺乳动物肾组织,更优选哺乳动物血管肾组织中的肿瘤细胞的用途 。 本发明还涉及新型配体,优选抗体,包含所述配体或抗体的融合蛋白,包含所述配体,抗体或融合蛋白的药物和诊断组合物,诊断和治疗方法以及新型蛋白质和相应的多核苷酸,载体和宿主细胞 。