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21. 发明公开

KR1020070100236A 프로가스트린에 대한 모노클로날 항체 有权
标题翻译：单克隆抗体对PROGASTRIN
公开(公告)号：KR1020070100236A
公开(公告)日：2007-10-10
申请号：KR1020077009115
申请日：2005-09-21
申请人： 리셉터 바이오로직스 인크
发明人： 그라임스스티븐
IPC分类号： C07K16/26 , A61K39/395 , G01N33/53
CPC分类号： G01N33/6893 , A61K2039/505 , C07K16/26 , C07K2317/34 , G01N33/74 , G01N2333/595 , G01N2800/06
摘要： The present invention provides progastrin-binding molecules specific for progastrin that do not bind gastrin-17(G17), gastrin-34(G34), glycine-extended gastrin-17(G17-Gly), or glycine-extended gastrin-34(G34-Gly). Further, the invention provides monoclonal antibodies (MAbs) selective for sequences at the N-terminus and the C-terminus of the gastrin precursor molecule, progastrin and the hybridomas that produce these MAbs. Also provided are panels of MAbs useful for the detection and quantitation of progastrin and gastrin hormone species in immuno-detection and quantitation assays. These assays are useful for diagnosing and monitoring a gastrin-promoted disease or condition, or for monitoring the progress of a course of therapy. The invention further provides solid phase assays including immunohistochemical (IHC) and immunofluorescence (IF) assays suitable for detection and visualization of gastrin species in solid samples, such as biopsy samples or tissue slices. The progastrin-binding molecules are useful therapeutically for passive immunization against progastrin in progastrin-promoted diseases or conditions. Also provided are surrogate reference standard (SRS) molecules that are peptide chains of from about 10 to about 35 amino acids, wherein the SRS molecule comprises at least two epitopes found in a protein of interest of greater than about 50 amino acids. Such SRS molecules are useful as standards in place of authentic proteins of interest.
摘要翻译：本发明提供了不结合胃泌素-17（G17），胃泌素-34（G34），甘氨酸延长胃泌素-17（G17-Gly）或甘氨酸延长胃泌素-34（G34）的泌乳素特异性的前胃泌素结合分子 - 甘氨酸）。此外，本发明提供对胃泌素前体分子的N-末端和C末端的序列选择性的单克隆抗体（MAb），前导肽和产生这些MAb的杂交瘤。还提供了用于在免疫检测和定量测定中检测和定量前胃泌素和胃泌素激素物质的MAb的小组。这些测定法可用于诊断和监测胃泌素促进的疾病或病症，或用于监测治疗过程的进展。本发明进一步提供固相测定法，包括免疫组织化学（IHC）和免疫荧光（IF）测定法，其适用于固体样品例如活组织检查样品或组织切片中胃泌素种类的检测和可视化。促胃泌素结合分子可用于治疗前列腺素促进的疾病或病症中针对前胃泌素的被动免疫。还提供了作为约10至约35个氨基酸的肽链的替代参考标准（SRS）分子，其中SRS分子包含在大于约50个氨基酸的目的蛋白中发现的至少两个表位。这样的SRS分子可用作代替感兴趣的真实蛋白质的标准物。

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