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21. 发明授权

KR101746157B1 반변련 추출물을 포함하는 아토피 피부염을 개선시키기 위한 조성물 및 그의 용도 有权
标题翻译：用于改善特应性皮炎的组合物，包括半流变提取物及其用途
公开(公告)号：KR101746157B1
公开(公告)日：2017-06-13
申请号：KR1020160086404
申请日：2016-07-07
申请人： 한국과학기술연구원
发明人： 김수남 , 김진철 , 김형자 , 이주영 , 박노준 , 봉심규 , 이설림 , 정유정 , 이다혜 , 장준휘 , 윤경노
IPC分类号： A61K36/34 , A23L1/30 , A61K8/97 , A61Q19/00
CPC分类号： A61K36/34 , A23L33/105 , A23V2002/00 , A23V2200/318 , A61K8/97 , A61K2800/81 , A61Q19/00
摘要： 반변련추출물을유효성분으로서포함하는아토피피부염을개선시키기위한조성물및 그의용도를제공한다.
摘要翻译：包含抗类风湿药提取物作为有效成分的改善特应性皮炎的组合物及其用途。

22. 发明授权

KR101611851B1 항염증 활성이 우수한 섬쑥부쟁이 분획물 및 이로부터 분리된 활성화합물 有权
标题翻译： Aster glehni级分或其分离的化合物具有抗炎活性
公开(公告)号：KR101611851B1
公开(公告)日：2016-04-14
申请号：KR1020140121177
申请日：2014-09-12
申请人： 한국과학기술연구원
发明人： 김형자 , 진창배 , 손민정 , 이용섭 , 육창수 , 이경태 , 이재열
IPC分类号： A61K31/7034 , A61K36/28 , A61P29/00
摘要： 본발명은항염증활성이우수한섬쑥부쟁이 () 분획물및 이로부터분리된화합물에관한것이다. 본발명의섬쑥부쟁이의에틸아세테이트분획물과상기분획물로부터분리된활성화합물로서 6'--카페오일로세오사이드 (6'--caffeoylroseoside), 6'--카페오일디히드로시린진 (6'--caffeoyldihydrosyringin), 글레노사이드 (glehnoside)는강력한자유라디칼소거능에의한항산화을가지며, 동시에리포폴리사카라이드 (LPS)에의해유도되는염증성대사산물인 NO (Nitric oxide)과프로스타글란딘 E(PGE), TNF-α (tumour necrosis factor alpha), IL-6 (interleukin-6) 및 IL-1β (interleukin-1beta) 등과같은염증유발성사이토카인 (cytokine)의생성을억제하므로, 염증질환의치료, 예방및 개선이필요한의약품, 화장품, 건강식품등의활성성분으로유용하게사용될수 있다.

23. 发明授权

KR101437641B1 층꽃풀로부터 분리된 페놀계 화합물을 함유하는 간보호용 조성물 有权
标题翻译：包含从CARYOPTERIS INCANA分离的酚化合物的保护性药物组合物
公开(公告)号：KR101437641B1
公开(公告)日：2014-09-05
申请号：KR1020130069884
申请日：2013-06-18
申请人： 한국과학기술연구원
发明人： 진창배 , 김형자 , 이용섭 , 정서윤
IPC分类号： C07D493/00 , A61K31/7016 , A61K31/7028 , A61K36/85
摘要： 본 발명은 층꽃풀로부터 분리된 페놀계 화합물을 함유하는 간독성 질환 예방 및 치료용 조성물에 관한 것이다.
본 발명의 층꽃풀(
Caryopteris incana ) 추출물, 이의 분획물 및 이로부터 분리된 화합물은 제3급-부틸히드로퍼옥시드(t-BHP, tertiary-butyl hydroperoxide)와 같은 독성 물질에 의하여 간 독성이 유발되었을 때 간세포 보호 효과가 우수하므로 간 질환의 예방 및 치료에 탁월한 효과를 기대할 수 있다.

24. 发明授权

KR101321879B1 층꽃풀 추출물 또는 이로부터 분리된 화합물을 함유하는 간독성 질환 예방 및 치료용 조성물 有权
标题翻译：包含来自阴囊炎的提取物的化学保护性药物组合物及其分离的化合物
公开(公告)号：KR101321879B1
公开(公告)日：2013-10-28
申请号：KR1020110036866
申请日：2011-04-20
申请人： 한국과학기술연구원
发明人： 진창배 , 김형자 , 이용섭 , 정서윤
IPC分类号： A61K36/85 , A61P1/16 , A61P1/00
CPC分类号： A61K36/53
摘要： 본 발명은 층꽃풀 추출물, 이의 분획물 또는 이로부터 분리된 화합물을 함유하는 간독성 질환 예방 및 치료용 조성물에 관한 것이다.
본 발명의 층꽃풀(
Caryopteris

incana ) 추출물, 이의 분획물 및 이로부터 분리된 화합물은 제3급-부틸히드로퍼옥시드(t-BHP, tertiary-butyl hydroperoxide)와 같은 독성 물질에 의하여 간 독성이 유발되었을 때 간세포 보호 효과가 우수하므로 간 질환의 예방 및 치료에 탁월한 효과를 기대할 수 있다.

25. 发明公开

KR1020130109504A 에스쿨린을 포함하는 조성물 无效
标题翻译：含有ESCULIN的组合物
公开(公告)号：KR1020130109504A
公开(公告)日：2013-10-08
申请号：KR1020120031261
申请日：2012-03-27
申请人： 한국과학기술연구원
发明人： 김수남 , 김형자 , 이우정 , 함정엽 , 정유정 , 전영식 , 황예란 , 배애님 , 강기성
IPC分类号： A61K31/7048 , A61K31/7034 , A61K31/70 , A61P3/10
CPC分类号： Y02A50/478 , Y02A50/479 , A61K31/7048 , A23L33/125 , A61K31/704 , Y10S514/866
摘要： PURPOSE: A composition containing esculin is provided to prevent or treat diseases caused by hyperglycemia and renal diseases. CONSTITUTION: A composition for reducing blood glucose contains 0.001-10 wt% of esculin, an esculin derivative, a pharmaceutically acceptable salt thereof, or a solvate thereof as an active ingredient. The composition is a pharmaceutical composition or a health food composition. The composition is used for preventing or treating hyperglycemia or diabetes.
摘要翻译：目的：提供含有esculin的组合物，以预防或治疗由高血糖症和肾脏疾病引起的疾病。构成：用于降低血糖的组合物含有作为有效成分的三角蛋白的0.001-10重量％，七叶树素衍生物，其药学上可接受的盐或其溶剂合物。该组合物是药物组合物或保健食品组合物。该组合物用于预防或治疗高血糖或糖尿病。

26. 发明公开

KR1020130086580A 층꽃풀로부터 분리된 페놀계 화합물을 함유하는 간보호용 조성물 有权
标题翻译：包含从CARYOPTERIS INCANA分离的酚化合物的保护性药物组合物
公开(公告)号：KR1020130086580A
公开(公告)日：2013-08-02
申请号：KR1020130069884
申请日：2013-06-18
申请人： 한국과학기술연구원
发明人： 진창배 , 김형자 , 이용섭 , 정서윤
IPC分类号： C07D493/00 , A61K31/7016 , A61K31/7028 , A61K36/85
摘要： PURPOSE: A Caryopteris incana extract, a fraction thereof, and a compound isolated from the extract or the fraction, and a composition containing the same for protecting liver are provided to protect liver cells from hepatotoxicity caused by toxic materials and to prevent and treat liver diseases. CONSTITUTION: A pharmaceutical composition for a liver protective agent contains one or more kinds of compounds selected among compounds of chemical formulas 1-3, 5, and 8-10. The compounds protect liver cells from toxicity induced by tertiary-butyl hydroperoxide (t-BHP). A food composition for protecting liver contains one or more kinds of compounds selected among the compounds of chemical formulas 1-3, 5, and 8-10. The compound of chemical formula 1 or 2 is isolated from Caryopteris incana.
摘要翻译：目的：提供Caryopteris incana提取物及其一部分，从提取物或级分分离的化合物和含有该化合物的组合物用于保护肝脏，以保护肝细胞免受有毒物质引起的肝毒性并预防和治疗肝脏疾病。构成：用于肝保护剂的药物组合物含有选自化学式1-3,5和8-10的化合物中的一种或多种化合物。该化合物可保护肝细胞免受叔丁基过氧化氢（t-BHP）诱导的毒性。用于保护肝的食品组合物含有选自化学式1-3,5和8-10的化合物中的一种或多种化合物。化学式1或2的化合物从ary is分离。

27. 发明公开

KR1020070056601A 신규한 플라본 유도체, 그의 제조 방법 및 이를 포함하는뇌신경계 질환의 예방 및 치료용 조성물 失效
标题翻译：新型FLAVONE衍生物，其制备方法及其含有预防和治疗脑神经系统疾病的组合物
公开(公告)号：KR1020070056601A
公开(公告)日：2007-06-04
申请号：KR1020050115501
申请日：2005-11-30
申请人： 한국과학기술연구원
发明人： 이용섭 , 진창배 , 김형자 , 김승환
IPC分类号： C07D311/30
摘要： A novel flavone derivative is provided to show excellent antioxidative effect, neuron protecting effect and neuroethological effect, thereby being usefully used for preventing and treating various neurodegenerative diseases such as stroke, chronic degenerative disease, Parkinson's disease and Alzheimer's disease. The flavone derivative is represented by the formula(1), wherein R1 is H or C1-4 alkoxy, R2 is H or hydroxy, each R3 and R4 is independently H or R5, R5 is glucose or -(CH2)mR6(m is from 0 to 3), and R6 is tetrahydrobenzopyran, tetrahydrobenzopyranylalkylacetate or tetrahydrobenzopyranylalkoxyalkyl substituted by at least one substituent selected from the group consisting of C3-7 heterocyclic compound including at least one of N and O; amino which is substituted or unsubstituted by at least one C1-4 alkyl; hydroxy; and hydroxyalkyl. The method for preparing the flavone derivative according to the reaction formula(1) comprises the steps of: (a) synthesizing a compound represented by the formula(VI) from a compound of the formula(I); and (b) after introducing at least one amine or glucose into the compound of the formula(VI) to prepare a compound represented by the formula(VII), deprotecting the compound of the formula(VII) to synthesize the compound of the formula(1). In the reaction formula(1), each R1 to R6 is same as defined above, X is halogen or alkyl halogen, MOM is methoxymethyl, and Bn is benzyl.
摘要翻译：提供了一种新型的黄酮衍生物，以显示优异的抗氧化作用，神经元保护作用和神经听觉效果，从而有效地用于预防和治疗各种神经变性疾病如中风，慢性退行性疾病，帕金森病和阿尔茨海默病。黄酮衍生物由式（1）表示，其中R1是H或C1-4烷氧基，R2是H或羟基，R3和R4独立地是H或R5，R5是葡萄糖或 - （CH2）mR6（m是 0至3），R6为四氢苯并吡喃基烷基乙酸酯或四氢苯并吡喃基烷氧基烷基，其被至少一个选自由以下组成的组的C3-7杂环化合物所取代：包括N和O中至少一个的杂环化合物; 被至少一个C 1-4烷基取代或未取代的氨基; 羟基; 和羟烷基。根据反应式（1）制备黄酮衍生物的方法包括以下步骤：（a）由式（I）化合物合成由式（VI）表示的化合物; 和（b）在将至少一种胺或葡萄糖引入式（VI）化合物中以制备式（Ⅶ）表示的化合物之后，将式（Ⅶ）化合物脱保护，合成式 1）。在反应式（1）中，每个R 1至R 6与上述定义相同，X为卤素或烷基卤素，MOM为甲氧基甲基，Bn为苄基。

28. 发明公开

KR1020050001900A 항바이러스 활성을 가지는 화합물 및 이를 포함하는 국화 추출물 失效
标题翻译：具有抗病毒活性的化合物和包含可能用于治疗由艾滋病引起的疾病或疾病症状的疾病的同种异黄酮的化合物
公开(公告)号：KR1020050001900A
公开(公告)日：2005-01-07
申请号：KR1020030042253
申请日：2003-06-26
申请人： 한국과학기술연구원
发明人： 이용섭 , 이재열 , 김형자
IPC分类号： C07D407/12
摘要： PURPOSE: A compound having anti-viral activity and an extract of Chrysanthemum morifolium comprising the same are provided, which compound and Chrysanthemum morifolium extract are useful for treatment of diseases caused by HIV(Human immunodeficiency virus) or alleviation of symptom of the diseases. CONSTITUTION: The compound having anti-viral activity represented by formula (1) and pharmaceutically acceptable salts thereof are provided. The extract of Chrysanthemum morifolium having anti-viral activity is obtained by using water and organic solvent, wherein the organic solvent is selected from alcohol, ethyl acetate, dichloromethane and acetone; the extract of Chrysanthemum morifolium comprises compounds of formula (1) to formula (5) as active components wherein R1 is hydrogen, hydroxyl, glucose or rhamnos, R2 is hydrogen or hydroxyl and R is a compound 8.
摘要翻译：目的：提供具有抗病毒活性的化合物和包含其的菊花提取物，该化合物和菊花提取物可用于治疗由HIV引起的疾病（人类免疫缺陷病毒）或减轻疾病症状。构成：提供了由式（1）表示的具有抗病毒活性的化合物及其药学上可接受的盐。通过使用水和有机溶剂获得具有抗病毒活性的菊花提取物，其中有机溶剂选自醇，乙酸乙酯，二氯甲烷和丙酮; 菊花提取物包括式（1）至式（5）的化合物作为活性组分，其中R 1是氢，羟基，葡萄糖或鼠李糖，R2是氢或羟基，R是化合物8。

29. 发明公开

KR1020050001899A 항산화 및 항바이러스 활성을 가지는 화합물 및 이를포함하는 감국 추출물 失效
标题翻译：具有抗氧化剂或抗病毒活性的化合物，含有化合物的提取物提取物，提取物的化合物的分离方法和化合物的使用
公开(公告)号：KR1020050001899A
公开(公告)日：2005-01-07
申请号：KR1020030042252
申请日：2003-06-26
申请人： 한국과학기술연구원
发明人： 이용섭 , 김형자 , 서선희 , 이재열
IPC分类号： C07C69/757
摘要： PURPOSE: Provided are a compound having an antioxidant or antivirus activity or its pharmaceutically acceptable salt, Chrysanthemum indicum extract containing the compound, a separation method of the compound from the extract, a pharmaceutical composition containing the compound for treating or preventing HIV or the disease due to the oxidation of cell components, an antioxidant food additive containing the compound and an antioxidant cosmetic containing the compound. CONSTITUTION: The compound is represented by the formula 1, wherein R1 and R2 are H or a caffeoyl group; and R3 is a specific caffeoyl group represented by the formula (a). The Chrysanthemum indicum extract is extracted by using water and an organic solvent. Preferably the organic solvent is at least one selected from the group consisting of an alcohol, ethyl acetate, dichloromethane and acetone. The compound of the formula 1 is separated from the extract by carrying out the column chromatography using a filler selected from the group consisting of silica gel, Sephadex, RP-18, polyamide, Toyopearl and XAD resin.
摘要翻译：目的：提供含有抗氧化剂或抗病毒活性的化合物或其药学上可接受的盐，含有化合物的菊花提取物，来自提取物的化合物的分离方法，含有用于治疗或预防HIV或疾病的化合物的药物组合物涉及细胞成分的氧化，含有该化合物的抗氧化食品添加剂和含有该化合物的抗氧化剂化妆品。构成：该化合物由式1表示，其中R1和R2是H或咖啡酰基; R3是由式（a）表示的特定的咖啡酰基。菊花提取物通过使用水和有机溶剂萃取。优选地，有机溶剂是选自醇，乙酸乙酯，二氯甲烷和丙酮中的至少一种。通过使用选自硅胶，Sephadex，RP-18，聚酰胺，Toyopearl和XAD树脂的填料进行柱色谱，从提取物中分离式1的化合物。

30. 发明公开

KR1020030088906A 고삼 추출물을 포함하는 성기능 장애 개선용 조성물 失效
标题翻译：用于治疗含有SOPHORA FLAVESCENS提取物的性功能障碍的组合物
公开(公告)号：KR1020030088906A
公开(公告)日：2003-11-21
申请号：KR1020020026650
申请日：2002-05-15
申请人： 한국과학기술연구원
发明人： 이용섭 , 김동현 , 김형자 , 박호군
IPC分类号： A61K31/353
摘要： PURPOSE: Provided is a composition for treating sexual dysfunction which contains a flavonoid compound represented by the formula 1 or 2, and an extract of Sophora flavescens containing them, as active ingredients. The composition inhibits on cGMP-PDE5 and is thus useful for the prevention and treatment of sexual disfunction. CONSTITUTION: A composition for treating sexual dysfunction is characterized by containing, as active ingredients, a flavonoid compound represented by the formula 1 or 2, wherein R1 is a unsubstituted or hydroxy group-substituted linear or branched alkenyl group; R2 is hydrogen, hydroxy or C1-C3 alkoxy; R3 and R4 are individually hydrogen or a hydroxy group; and a dotted line represents single or double bond, and its pharmaceutically acceptable salt, hydrates, solvate, isomer or their mixture.
摘要翻译：目的：提供一种用于治疗性功能障碍的组合物，其含有由式1或2表示的类黄酮化合物和含有它们的苦参皂甙提取物作为活性成分。该组合物抑制cGMP-PDE5，因此可用于预防和治疗性功能障碍。构成：用于治疗性功能障碍的组合物的特征在于，含有作为活性成分的由式1或2表示的类黄酮化合物，其中R1是未取代的或羟基取代的直链或支链烯基; R2是氢，羟基或C1-C3烷氧基; R3和R4分别是氢或羟基; 虚线表示单键或双键，以及其药学上可接受的盐，水合物，溶剂合物，异构体或它们的混合物。

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